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NFL Betting Picks for Week 10 - Best Bets, Expert Odds and Predictions

Deebo Samuel - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Mitch Blatt gives his picks against the spread, over/under, and on the money line. These are the best bets for Week 10. Who will win in the game of the week? Who will win on Monday Night Football? Who should you bet on?

The Miami Dolphins have shown once again that they can't score points against top-tier teams.

They only scored 14 points in Frankfurt, Germany, and lost to the Chiefs by the margin of a Tyreek Hill fumble that was returned for a touchdown. It's likely they would have lost, anyway, because Patrick Mahomes would probably have put together a game-winning drive at the end of regulation or in overtime if he had to. The lack of scoring--just 35 points in a game with the line set at 50--was expected by readers of this column. We took the under, and now we're 8-2 on picking over/under results this season.

What else is good? We also took a win on the moneyline. Bryce Young couldn't build on his Week 8 victory over C.J. Stroud and had his worst game yet, throwing three interceptions, including two that Kenny Moore returned for touchdowns. It's time to move on to this week's games so let's see what I have in mind, shall we?

Be sure to check all of our fantasy football rankings for 2025:

 

Week 10 NFL Betting Picks - Moneyline

Last Week: 1-0 on Moneyline, 0-1 Against the Spread, 1-0 on Over/Under Picks

Season-long Record: 3-5 on Moneyline, 3-12 Against the Spread, 8-2 on Over/Under Picks

New York Jets @ Las Vegas Raiders (NYJ -1 / NYJ -112)

Sunday, 8:20 pm | O/U: 37

New Raiders coach Antonio Pierce looked better than Josh McDaniels in his coaching debut. The Raiders destroyed the New York Giants by a score of 30-6 last week. The Raiders players are happy to play for him. They are rallying around Pierce and rookie quarterback Aidan O'Connell. O'Connell has improved in each of his three starts. He is learning. He eliminated turnover-worthy plays in his game against the Giants.  For him to play better than Zach Wilson will be a low bar to meet.

The Jets' defense is tough, but the Raiders are getting more out of Josh Jacobs and Davante Adams now. The Jets offensive line is falling apart, and Maxx Crosby, who made three sacks last week against the other New Jersey team, is going to have his way with them. Zach Wilson was sacked eight times last week by the Chargers, and Crosby is considerably better than both Joey Bosa and Khalil Mack.

Pick: Raiders over Jets on the ML (-102)

 

Week 10 NFL Betting Picks - Against the Spread

Atlanta Falcons @ Arizona Cardinals (ARI +1.5)

Sunday, 4:05 pm | O/U: 43

Kyler Murray is a home underdog against Taylor Heinicke's Falcons in his return to football. Heinicke may have been an improvement over Desmond Ridder, but the Falcons haven't looked much improved with him. They're 0-2 in the two games Heinicke played, and their total yardage in both games has been below what it was in the three previous games.

Part of the reason the Falcons' offense keeps struggling is that Arthur Smith is making baffling play calls. Look, it is annoying when fantasy people complain about how many touches their guys get because it denies them points. But the points come from the real success of the players on the field, and Bijan Robinson really has been playing better than Tyler Allgeier by most metrics--even on his few touches inside of the Red Zone.

It's not wrong for the Falcons to throw to TE2 Jonnu Smith if he is having success. It is wrong to give the backup tight end a carry inside the five when he has shown no success anytime in his career as a running back. Maybe Arthur Smith is having fantasies about a certain other "tight end" in his division who could have executed that kind of play better than Jonnu Smith.

Pick: Cardinals (+1.5) over Falcons (-110)

 

Week 10 NFL Betting Picks - Over/Under

San Francisco 49ers @ Jacksonville Jaguars (ARI +1.5)

Sunday, 1:00 pm | O/U: 45

Both teams are gaining more yards per pass attempt than average. The 49ers are still leading the whole league with an unreal 9.0 yards per attempt, 0.4 more than the No. 2 Dolphins and almost a full yard per attempt more than the No. 3 Texans, even after a couple of off games for Brock Purdy in which key offensive stars were injured.

Now in Week 10, Deebo Samuel is practicing in full and is ready to go. Tackle Trent Williams logged a limited practice on Thursday and has an outside chance of playing. And Purdy is rested after the bye. The 49ers defense is fierce, but the Jaguars will do their part, too, to put this game over 45.

Pick: Over 45 (-110)

 

Other Over/Under Picks

TEN @ TB - Over 39 (-110)

Will Levis should bounce back (somewhat) the week after struggling against Pittsburgh, one of the toughest teams for a rookie to face. Both teams allow significantly more yards and estimated points per pass attempt than the league average. They are both among the ten worst defenses overall. Baker and Levis will exchange aerial volleys in a fun showdown at the bay.



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REAL-TIME FANTASY NEWS

Owen Power

Joins Team for Trip to Boston
Zach Benson

Remains Out Saturday
Josh Norris

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Luke Evangelista

Set for Season Debut Saturday
Mackenzie Blackwood

Back at Practice
Dmitry Kulikov

Placed on Injured Reserve
Jonathan Drouin

Suspended for Saturday's Game
CFB

Texas RB CJ Baxter Will Miss Today's Game Against No. 6 Oklahoma In Dallas
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Syracuse QB Steve Angeli Will Miss Significant Time
Ja'Marr Chase

Expected to Play Against Packers
Cody Bellinger

Plans to Opt Out of Contract
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Munetaka Murakami Will be Posted This Winter
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Questionable to Suit Up in Week 6
Brock Purdy

to Miss his Fourth Game of the Year in Week 6
Zay Flowers

Questionable to Play in Week 6 Against Rams
CeeDee Lamb

Officially Ruled Out for Week 6
Miles Sanders

Moved to Season-Ending Injured Reserve
Brock Bowers

Ruled Out For Week 6
Terry McLaurin

Misses Practice Again on Friday
Kyler Murray

Questionable for Week 6
Calvin Austin III

Ruled Out for Week 6
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has Hernia Surgery, Should be Ready for Spring Training
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Set to Return on Sunday
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Looks To Win Back-To-Back Fights
Quentin Johnston

Questionable to Play in Week 6 Due to Hamstring Injury
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Looks To Get Back In The Win Column
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Questionable to Play in Week 6 Due to Ankle Injury
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Returns to Practice on Friday, Expected to Play in Week 6
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VJ Edgecombe

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Expected to Miss at Least a Month
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Unlikely to Play in Next Two Preseason Games
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Doesn't Need Surgery, Sidelined at Least Five Weeks
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Questionable for Week 6 With Illness
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in Line to Play in First Preseason Game
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Ruled Out for Week 6
Mike Evans

Out for Another Week
Bucky Irving

Out for Week 6 Against 49ers
Chris Godwin

Week-to-Week With Fibula Injury
Lamar Jackson

to Miss a Second Straight Game
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North Carolina's Caleb Hood Retiring from College Football
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Jeff Sims Likely to Start Against Utah
Filip Gustavsson

Shuts Door on Blues Thursday
Kyle Connor

Celebrates Extension With Seventh Career Hat Trick
Igor Shesterkin

Collects 22nd Career Shutout
Josh Norris

Sustains Upper-Body Injury Against Rangers
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Suffers Hand Injury
Hampus Lindholm

Exits With Injury Versus Blackhawks
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Hurt Against Bruins
Vincent Trocheck

Exits Early Thurday
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Syracuse QB Steve Angeli Will Miss Remainder of 2025 Season With Torn Achilles
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Sam Leavitt Not Expected to Play for Arizona State on Saturday
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John Mateer Upgraded to Probable Ahead of Saturday's Red-River Shootout
VJ Edgecombe

Misses Practice Thursday
Jaylen Wells

To Have an Expanded Role in the Offense?
Drake Powell

Appears Ready for His Exhibition Debut
Egor Demin

Will Miss Friday's Exhibition Game
Joe Ingles

Shut Down for a Week
Tristan Jarry

Takes Over Penguins Crease Thursday
Pyotr Kochetkov

Unavailable Thursday
LeBron James

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Jalen Suggs

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Battling Knee Issue
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Dealing With Knee Problem
Jaylen Brown

Looks Sharp in Preseason Opener
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John Mateer Officially Questionable Ahead of Saturday's Game vs. Texas
Will Smith

Catching in Game 3 of NLDS
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North Carolina Discussing Buyout Option Of Coach Bill Belichick
Trendon Watford

Held Out of Practice on Wednesday
Joel Embiid

Takes Part in Practice on Wednesday
Paul George

Moving Closer to Return
Jackson Chourio

Back in Lineup for NLDS Game 3
Roki Sasaki

"Definitely the Primary Option" in Save Situations for Dodgers
T.J. McConnell

Sustains Hamstring Injury in Preseason Opener
Sahith Theegala

Still Uneven Heading to Japan
Nicolai Hojgaard

Trying to Pick Up Pieces After Last Three Efforts
Vince Whaley

Tries to Add on From Sanderson Farms Performance
Adam Scott

Struggling Some Heading to Baycurrent Classic
PGA

Chris Gotterup Expects to Contend at Baycurrent Classic
Si Woo Kim

Primed for Baycurrent Classic
Garrick Higgo

Finishes Second at Sanderson Farms Championship
Max Homa

Finishes Tied for 18th at Sanderson Farms Championship
Wyndham Clark

Misses The Cut at Omega European Masters
Rasmus Hojgaard

Finishes Tied For Third at Sanderson Farms Championship
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Christopher Bell

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Kyle Larson

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Joey Logano

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Chris Buescher

Scores a Strong Top-Five Finish at Charlotte Roval
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in Starting Lineup for NLDS Game 2
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Jermod McCoy Unlikely to Play Against Arkansas
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Conner Weigman in Concussion Protocol
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Florida State's Quindarrius Jones Set for Season-Ending Surgery
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Merab Dvalishvili Dominates Cory Sandhagen
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Jiri Prochazka Scores Comeback Win
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Suffers Third-Round Knockout Loss
Youssef Zalal

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Josh Emmett

Suffers First-Round Submission Loss
Abus Magomedov

Gets Submitted
Ryan Preece

Is A Favorable DFS Option for the Charlotte Roval
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Cole Custer

Is Cole Custer Playable In DFS Lineups for the Charlotte Roval?