FanDuel NFL DFS Lineup Picks for Week 10 - Daily Fantasy Football Targets Include Patrick Mahomes, Tua Tagovailoa, Travis Etienne Jr., Saquon Barkley, Travis Kelce

Dennis Clausen highlights the top FanDuel NFL DFS lineup picks for Week 10 of the 2022 season, and some value sleepers for your daily fantasy football rosters.

So how did everyone like Joe Mixon's performance last Sunday? For those who had him in their lineups, congratulations on your victory. For those who didn't, well, sorry about that. While most expected Mixon to have a breakout performance, few had predicted Justin Fields would do the same. Even Cole Kmet had himself a game, scoring two touchdowns against the Dolphins for his first career multi-score performance.

On the other hand, it wasn't all sunshine, rainbows, and butterflies in Week 9 for players like Josh Allen, who could not lift his team past the New York Jets. Even worse, he suffered an elbow injury. Jonathan Taylor also didn't have a good week, mainly because he didn't play due to his nagging ankle issue.

In this article, I will be providing you with my Week 10 daily fantasy football lineup picks for FanDuel. These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on FanDuel. Be sure to also check out our weekly DraftKings DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Also, feel free to give me a follow on Twitter @DennisMClausen. Let's get started!

• 2025 fantasy football rankings
• Running back (RB) fantasy football rankings
• Wide receiver (WR) fantasy football rankings
• Tight end (TE) fantasy football rankings
• Quarterback (QB) fantasy football rankings
• FLEX fantasy football rankings
• Defense (D/ST) fantasy football rankings
• Kicker (K) fantasy football rankings
• Dynasty fantasy football rankings

FanDuel Quarterbacks - Week 10 DFS Lineup Picks

Patrick Mahomes - vs. JAC ($8,500)

Tagovailoa has taken a beating this season, resulting in the signal-caller missing a few games. However, since returning in Week 7, he’s turned up the volume. He threw for 382 yards and three touchdowns against the Lions in Week 8.

Tagovailoa followed that by once again surpassing the 300-yard mark through the air versus Chicago on Sunday while adding another three passing touchdowns. While the weather is starting to worsen in many parts of the country, Miami has a beautiful forecast, which is always a plus. Nonetheless, the Browns’ defense may not be enough to keep Tagovailoa from having another spectacular fantasy showing.

Also Consider: Matthew Stafford ($6,700)

FanDuel Running Backs - Week 10 DFS Lineup Picks

Saquon Barkley - vs. HOU ($9,500)

Fresh of a bye, Barkley is back and ready to have some fun at Houston's expense. The former Nittany Lion has been on a roll and been one of the best fantasy options all year.

He's amassed a third-best 779 rushing yards and currently leads the NFL with 13 carries of at least 20 yards or more. There's not a team in the league worse than the Texans at defending the running back position, so Barkley should be a lock for DFS managers.

Travis Etienne Jr. - @ KC ($8,000)

Etienne has emerged as one of the top fantasy options going, even more so after James Robinson was traded to the Jets. The rookie is arguably coming off the best game of his young career by compiling 109 yards off 28 carries against the Raiders in Week 9. He also found the end zone twice in that one.

The rookie has now scored at least once in each of his last three games. While the Chiefs’ defense should prove more challenging, the unit has had its share of problems stopping the run.

Also Consider: Derrick Henry ($9,400), Josh Jacobs ($8,400), Jonathan Taylor ($7,000), Devin Singletary ($5,600)

FanDuel Wide Receivers - Week 10 DFS Lineup Picks

Cooper Kupp - vs. ARI ($9,200)

Kupp has played well against the Cardinals over the years. In his nine encounters against Arizona, he’s totaled five touchdowns and has averaged just over 72 receiving yards per game. With the birds banged up on the defensive end, Kupp should remain an elite option for DFS enthusiasts.

Tyreek Hill - vs. CLE ($9,000)

Hill is firing on all cylinders with Tua Tagovailoa back in the lineup. He’s the first receiver to surpass the 1,000-yard mark and is comfortably leading the league with 765 air yards.

With a seemingly healthy signal-caller, Hill should continue to produce. He has combined for 49 fantasy points while amassing 19 catches for 331 yards and a touchdown in the last two weeks, so there is no doubt about it, get him in the lineup.

Also Consider: Jaylen Waddle ($8,200), Amon-Ra St. Brown ($6,900), Zay Jones ($5,500)

FanDuel Tight Ends - Week 10 DFS Lineup Picks

If you thought kickers were depressing, tight ends haven’t been better in 2022-23. Taysom Hill, for example, is the second costliest option on the slate at the position. However, he had just one carry and one Target on Monday night against Baltimore. In addition, the ailing Mark Andrews is on a bye, and Zach Ertz is due for his usual disappearing act.

On the other hand, Kelce has been as efficient as it can get. Sure he hasn’t scored in three weeks. Yet, the veteran hasn’t seen less than seven targets from Patrick Mahomes in any game this season. For those who are sick and tired of taking the constant gamble, Kelce’s got your back.

Also Consider: T.J. Hockenson ($6,00)

More Weekly DFS Analysis