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Should I Start Christian McCaffrey in Week 10? Fantasy Football Start 'Em, Sit 'Em Picks

2025 Fantasy Football Early-Round Best Ball Busts, Overvalued

Should I start or sit Christian McCaffrey for fantasy football in Week 10? Read our fantasy football start 'em, sit 'em picks and fantasy lineup recommendations.

San Francisco 49ers running back Christian McCaffrey (Achilles, calf) has been a thorn in the side of fantasy managers for years. In previous seasons, he was a force to be reckoned with by any team that faced him. This season, he's scored exactly zero fantasy points all year.

The injuries he came into the season with have kept him out of eight games so far, and the team just had its bye week in Week 9. He returned to practice earlier this week, and things are trending toward his return to play soon, much to the relief of fantasy managers who drafted him near-universally with top-5 picks.

So should you start CMC in Week 10?

Be sure to check all of our fantasy football rankings for 2025:

 

Christian McCaffrey Fantasy Football Outlook

He's one of the best in the league at his position, and while Baltimore Ravens running back Derrick Henry looks like the best RB in the league this year, McCaffrey is one of the few that could give him a run for his money, the other being Philadelphia Eagles back Saquon Barkley.

His upside is tremendous. He's a league-winner when he's healthy -- the question of how healthy he truly is remains, but that's something that won't be answered until we see what he can do on the field in his return.

 

Should I Start Christian McCaffrey in Week 10?

You can't bench anyone this talented. While Shanny is obviously coy about his usage, availability, and really anything that could give opposing teams more information about his team, if No. 23 plays, you just have to start him in your fantasy lineups if you want to give your team the best chance at winning.

He's so good at what he does that he fundamentally changes the way opposing teams play defense against the 49ers. Shanahan could always pull one of his tricks, like designating CMC as active for the game only to not give him much work, but fantasy managers will have to take the risk of that happening.

 



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REAL-TIME FANTASY NEWS

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Issued Three-Game Suspension
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Dealing With Minor Foot Injury
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Suffers Apparent Hand Injury
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Felix Bautista has Surgery on Torn Rotator Cuff
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Looks to Bounce Back at Tour Championship
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Looking to Reverse Struggles at East Lake
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Could Begin Season on PUP List
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Stays Hot Ahead of Tour Championship
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Aims for Complete Game at East Lake
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Back in Action at East Lake
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a Strong Value Play at East Lake
Bubba Chandler

to Join Pirates on Friday
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Chasing Another Win at East Lake
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Finishes Tied for 30th at BMW Championship
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Finishes Tied For Seventh at BMW Championship
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Finishes Tied for 33rd at BMW Championship
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Finishes Tied for 17th at BMW Championship
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Finishes Second at BMW Championship
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Finishes Tied for 23rd at BMW Championship
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Wins BMW Championship
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Not Expected to Play for Commanders This Year
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Considered Day-to-Day With a "Physical" Injury
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Could be Facing 4-6 Game Suspension?
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Hot at the Right Time for Tour Championship
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has One Weakness Heading to Atlanta
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Nikola Vucevic Not Expecting to Be Moved Before the Season
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a Long Shot to Win Tour Championship
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Bulls Not Interested in Sign-and-Trade Deal Involving Josh Giddey
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Trying to Crack Top 20 at Tour Championship
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Attempts to Bounce Back in Atlanta
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Wizards Add Skal Labissiere for Training Camp
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Needs Thumb Surgery, May Play Through Injury
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Out With Side Soreness on Tuesday
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on Track to Play in Week 1
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Being Skipped in Rotation Due to Shoulder Fatigue
Adley Rutschman

Scratched on Tuesday With Abdominal Discomfort
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Brendan Smith Joins Blue Jackets on Tryout Deal
STL

Milan Lucic Joins Blues for Tryout
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Red Wings Pick Up Travis Hamonic
Austin Riley

Doesn't Appear Ready to Return Any Time Soon
Aaron Judge

Unikely to Throw Normally Again This Year
Jalen McMillan

Could be Out Through Week 9 Bye
Indiana Pacers

Pacers Coach Rick Carlisle Agrees to a Multiyear Contract Extension on Tuesday
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John Wall Retires After 11 NBA Seasons
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Named as Colts Starting Quarterback
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Will Not Be Ready for Season Opener
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Hornets Have High Hopes for Collin Sexton
Rui Hachimura

Likely to Start Season Without Contract Extension
Jaime Jaquez Jr.

Hopes to Bounce Back in 2025-26
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Ready to Go for New Season
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Luka Doncic Cleared to Play on Tuesday Night
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Pulled With Hamstring Tightness
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Game 2 of Brewers-Cubs on Monday Postponed
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to be Activated on Tuesday
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to Get Multiple Days Off
Shane Bieber

to Make Season Debut on Friday
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Could Start Season on NFI List
Zack Wheeler

has Surgery to Remove Blood Clot
De'Von Achane

Unlikely to Practice This Week
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Returning to Practice
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Bucs Chris Godwin Likely to Start Season on PUP List
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Browns Name Joe Flacco as Their Week 1 Starter
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Scores an Upset Victory at Richmond
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Pit-Road Struggles Impede Denny Hamlin's Chances of a Top Finish at Richmond
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Suffers Knockout Loss In His UFC Debut
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Scores Stunning First-Round Knockout
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Earns Promotion to Double-A
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Finalizing Deal with Boston
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Suffers First-Round Knockout Loss
Ketel Marte

Arizona Could Trade Ketel Marte in the Offseason
Carlos Prates

Gets Back In The Win Column
Michael Page

Dominates At UFC 319
Jared Cannonier

Gets Outclassed
Tim Elliott

Gets Submission Win
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Still Winless In The UFC
Austin Cindric

has Arguably his Best Run of the Season at Richmond
Ryan Blaney

Contends for First Richmond Win but Comes Up Short
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Finishes Second but Loses Ground in Playoffs
NASCAR

Bubba Wallace Sets Personal Laps-Led Record at Richmond
Chris Buescher

Falls Out of Playoffs After Miserable Richmond Run
Coby White

Bulls Not Interested in Trading Coby White
Dereck Lively II

Expected to be Ready for Camp
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Placed on 10-Day Injured List
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Olivier Rodrigue Signs KHL Deal
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