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Sep 21, 2026, 9:20 PM ET

Indianapolis Colts wide receiver Alec Pierce (heel) is set to miss "several weeks" after reaggravating a heel injury in his team's Week 2 loss to the Kansas City Chiefs, per Ian Rapoport of NFL Network. Pierce had surgery on the affected heel over the offseason. However, Rapoport reports that Pierce will now attempt to rehab the injury rather than opt for a second procedure. Pierce recorded four catches for 61 yards on six targets in Indianapolis' Week 1 loss to the Baltimore Ravens and one catch for 11 yards against the Chiefs before being forced to leave the game. Pierce was expected to take on a starring role in the Colts' offense after the team handed him a four-year, $114 million contract in March. Without him, Colts wide receiver Josh Downs and tight end Tyler Warren have a chance to dominate target share in Indianapolis. Veteran wide receivers Keenan Allen, Laquon Treadwell, and the recently signed Darius Slayton could see larger roles as well.--Will Brady
Source: NFL Network - Ian Rapoport
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Sep 21, 2026, 9:14 PM ET

New York Giants wide receiver Malik Nabers (shoulder) has returned to his team's Week 2 matchup against the Los Angeles Rams, per Ian Rapoport of NFL Network. Nabers briefly left the game with a shoulder injury and was officially deemed questionable to return. However, fantasy managers can collectively breathe a sigh of relief now that the injury has proved to be relatively minor. Nabers is still working his way back to a full workload from the knee injury that ended his 2025 season, so the shoulder injury could further impact his snap count in Week 2. Still, it's obviously a positive sign that the superstar wideout is back on the field.--Will Brady
Source: NFL Network - Ian Rapoport
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Sep 21, 2026, 9:07 PM ET

New York Giants wide receiver Malik Nabers (shoulder) is officially questionable to return in his team's Week 2 matchup against the Los Angeles Rams due to a shoulder injury, per Art Stapleton of NorthJersey.com. Nabers grabbed at the shoulder immediately after attempting to make a contested catch and appeared to be in considerable pain on the sideline. The 23-year-old recorded one catch for one yard on two targets before exiting the game. If he is unable to return, Giants wide receivers Darnell Mooney, Malachi Fields, and Odell Beckham Jr. could all see an increase in targets and playing time.--Will Brady
Source: NorthJersey.com - Art Stapleton
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Sep 21, 2026, 8:37 PM ET

New York Giants quarterback Jaxson Dart (knee) exited Monday's contest with a knee injury and is deemed questionable to return. The team's starting quarterback sustained this injury on their opening drive. After taking a hit, Dart was seen lying on the field in pain before being able to walk to the sidelines on his own power. After spending some time in the blue medical tent, he eventually walked to the locker room. Before exiting, Dart went 3-for-5 with 20 passing yards. Veteran Jameis Winston replaced Dart under center and will remain the starter while Dart is sidelined.--Andy Smith
Source: Art Stapelton
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Sep 21, 2026, 7:55 PM ET

Los Angeles Rams wide receiver Jordan Whittington (quadriceps) is officially inactive for the Monday night game in Week 2 against the visiting New York Giants, the team announced. In addition to Whittington, the Rams will be without All-Pro receiver Puka Nacua due to a groin injury, so their receiving corps will be thinned out beyond veteran Davante Adams. The 25-year-old Whittington was doubtful to play in Week 2 after missing practice all week with a quad injury that he picked up in the season-opening loss to the division-rival San Francisco 49ers in Australia. It remains to be seen if Whittington will be able to play next Sunday night in Denver against the Broncos in Week 3. In the season opener, the former sixth-rounder in 2024 from Texas caught his only target for a pickup of eight yards. Despite L.A.'s explosive offense, Whittington is just a depth piece and is not currently rostered in any Yahoo leagues.--Keith Hernandez
Source: Los Angeles Rams
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Sep 21, 2026, 7:47 PM ET

New York Giants running back Najee Harris, who was a healthy scratch for the season-opening victory over the Dallas Cowboys last Sunday night, is officially active on Monday night to conclude Week 2 against the hosting Los Angeles Rams, according to ESPN's Jordan Raanan. The Giants said that Harris would have a role in their offense at the end of training camp, but then he was active in the season opener. The 28-year-old has plenty of experience in the NFL, though, and he opened his career with four straight 1,000-yard rushing campaigns with the Pittsburgh Steelers after he was drafted in the first round. Harris has gotten a late start to 2026 after tearing his Achilles early in 2025 with the Los Angeles Chargers, but he could quickly overtake Tyrone Tracy Jr. in a backfield that also has plenty of depth in Cam Skattebo and Devin Singletary. He is worth watching in deeper fantasy formats, especially for managers who have Skattebo rostered.--Keith Hernandez
Source: ESPN New York - Jordan Raanan
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Sep 21, 2026, 6:59 PM ET

Los Angeles Rams wide receiver Puka Nacua (groin) is officially inactive for the Monday night contest in Week 2 against the visiting New York Giants, according to ESPN's Adam Schefter. The Rams offense will be without their top playmaker as they look to win their first game of the 2026 season on Monday night. Fantasy managers who rolled the dice and left Nacua in their lineups in Week 2 will now be forced to hit up the waiver wire to add a Rams or Giants receiver. The 25-year-old Nacua caught five of nine targets for 74 yards in the season-opening loss to the division-rival San Francisco 49ers in Australia before tweaking his groin in practice last week. The Rams have decided to err on the side of caution and sit the two-time Pro Bowler in Week 2, and it remains to be seen if he will be ready to go in Week 3 for another primetime matchup on Sunday Night Football on the road against the Denver Broncos. With Nacua out on Monday night, veteran Davante Adams should be peppered with targets, while the Rams could also lean heavily on their tight end group of Terrance Ferguson, Colby Parkinson, and Tyler Higbee. Receivers Konata Mumpfield and Tutu Atwell are probably the best bets for desperate fantasy managers hitting the waiver wire for a body.--Keith Hernandez
Source: ESPN - Adam Schefter
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Sep 21, 2026, 6:43 PM ET

Three-time Pro Bowl tight end Zach Ertz is signing with the Philadelphia Eagles' practice squad on Monday to return to the team that he played for from 2013 to 2021, sources told Adam Schefter of ESPN. The Eagles lost starting tight end Dallas Goedert (knee) to an MCL sprain in their Week 2 win over the Tennessee Titans on Sunday, and he is expected to miss multiple weeks, so Ertz, who helped the Eagles win their first Super Bowl, will give the team some depth at the position going forward. The 35-year-old veteran spent the last two years with the Washington Commanders, catching 116 of his 163 targets for 1,158 yards and 11 touchdowns in 30 starts. The 13-year veteran tore his ACL in Week 14 and was limited to 13 games a year ago. Depending on how quickly Ertz can get his legs back under him this week, he could be elevated to the 53-man roster for the team's Week 3 contest on Monday Night Football against the Chicago Bears. Grant Calcaterra (back) and rookie Eli Stowers (hamstring) are on Injured Reserve, so in addition to Ertz, the Eagles only have Johnny Mundt and E.J. Jenkins at the position outside of Goedert.--Keith Hernandez
Source: ESPN - Adam Schefter
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Sep 21, 2026, 6:07 PM ET

San Francisco 49ers head coach Kyle Shanahan said on Monday that veteran wide receiver Mike Evans (hip) will "have to be managed this week," according to Nick Wagoner of ESPN. Evans had a solid debut for the Niners in the Week 1 win over the division-rival Los Angeles Rams in Australia, catching six of his seven targets for 49 yards and his first touchdown of the year, but he caught all three of his targets for 54 yards before departing on Sunday in the Week 2 blowout win over the Miami Dolphins with a hip injury. The 33-year-old future Hall of Famer was said to be fine by Shanahan after Sunday's game, but he is most likely going to have a cap on his practice reps for much, if not all, of the week as the team prepares to face the division-rival Arizona Cardinals in Week 3. Ricky Pearsall (knee) is out for the year, rookie De'Zhaun Stribling (ankle) is out for around 10 weeks, and Demarcus Robinson is dealing with a high-ankle sprain, so the Niners really need Evans out there. He should be OK to play this weekend, but fantasy managers will want to keep a close eye on his practice status from Wednesday through Friday.--Keith Hernandez
Source: ESPN.com - Nick Wagoner
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Sep 21, 2026, 5:43 PM ET

Los Angeles Chargers head coach Jim Harbaugh said on Monday that tight end Charlie Kolar (forearm) will be placed on Injured Reserve after he suffered a forearm injury on Sunday in the Week 2 loss to the Las Vegas Raiders, according to NFL Network's Taylor Bisciotti. The 27-year-old was spotted in the clubhouse wearing a sling on his left arm after Sunday's game, and he will now have to miss at least the next four games. Kolar drew some training camp buzz for his role in new offensive coordinator Mike McDaniel's scheme before not being targeted in the Week 1 season-opening loss to the Arizona Cardinals. The former fourth-round selection by the Baltimore Ravens in 2022 from Iowa State caught all three of his targets for 21 yards on Sunday against the Raiders before getting injured. With fellow TE David Njoku (leg) also going on IR this week, Oronde Gadsden will now have an excellent opportunity as L.A.'s primary pass-catching tight end, and he should be a popular waiver-wire addition going into the Chargers' Week 3 game against the Buffalo Bills.--Keith Hernandez
Source: NFL Network - Taylor Bisciotti
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Sep 21, 2026, 5:36 PM ET

Los Angeles Chargers head coach Jim Harbaugh said on Monday that tight end David Njoku (leg) will go on Injured Reserve with a fibula injury that he suffered in the Week 2 loss to the division-rival Las Vegas Raiders on Sunday, according to Taylor Bisciotti of the NFL Network. The 30-year-old veteran was carted off the field on Sunday with what was initially being described as a knee injury. Later on, tight end Charlie Kolar left with a forearm injury, and he, too, will head to IR, leaving Oronde Gadsden as the Chargers' clear No. 1 tight end going forward. Njoku was a waiver-wire option following his performance in the season-opening loss to the Arizona Cardinals, in which he caught all five of his targets for 58 yards. He caught one of his three targets for nine yards on Sunday before suffering his injury. At the very least, Njoku will have to miss the next four games, but it is unclear yet if his fibula injury is more serious than that. Fantasy managers looking for depth at TE should definitely set their sights on Gadsden going into Week 3.--Keith Hernandez
Source: NFL Network - Taylor Bisciotti
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Sep 21, 2026, 5:30 PM ET

Carolina Panthers running back Jonathon Brooks (groin) is now considered week-to-week while he gets second opinions on his groin injury, a source told Tom Pelissero of The Ringer. Brooks first injured his groin in training camp and then tweaked it again in the Week 2 win over the division-rival Atlanta Falcons on Sunday. The 23-year-old had four carries for 14 yards and caught one of his two targets for a 48-yard pickup in the Week 1 loss to the Carolina Panthers, and carried the ball five times for 16 yards with one catch for a loss of five yards in Week 2 before being pulled. The former second-rounder from Texas has already suffered two torn ACLs in his short time in the NFL, and he just has not been able to stay healthy. If he is forced to miss any time, starting in Week 3 against the Cleveland Browns, Chuba Hubbard will become a must-start in fantasy football. AJ Dillon would likely become the RB2 for Carolina behind Hubbard. Fantasy managers who took Brooks as a sleeper to eventually take over the Panthers' backfield in 2026 have to be disappointed with the start he has had through two games.--Keith Hernandez
Source: The Ringer - Tom Pelissero
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Sep 21, 2026, 5:23 PM ET

Indianapolis Colts wide receiver Alec Pierce (heel) aggravated something in his heel that he had surgery on, and the Colts are still evaluating him after he left Sunday night's loss to the Kansas City Chiefs in Week 2, head coach Shane Steichen told Jake Arthur of Locked On Colts. The Colts are expected to have more information on Pierce's status later in the week. The 26-year-old hobbled off on Sunday night after catching his only target for an 11-yard gain, and he was unable to put any weight on his leg before being carted to the trainer's room in KC. We will have a better idea of Pierce's Week 3 status later in the week, but as of right now, fantasy managers should not be expecting him to be ready to suit up this Sunday at home against the division-rival Houston Texans. Josh Downs will be Indy's top option at wideout if Pierce misses any time, with veteran Keenan Allen becoming an interesting speculative pickup off the waiver wire this week, even though he could be facing a suspension from the NFL. Through the first two games of 2026, Pierce has caught five of his seven targets for 72 yards and zero touchdowns.--Keith Hernandez
Source: Locked On Colts - Jake Arthur
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Sep 21, 2026, 5:17 PM ET

Philadelphia Eagles tight end Dallas Goedert (knee) suffered a sprained MCL in his knee in the Week 2 win over the Tennessee Titans on Sunday and is expected to miss a few weeks, sources told Ian Rapoport of the NFL Network. It is a big blow for the Eagles' offense going forward, as the next two men up on their TE depth chart are Johnny Mundt and E.J. Jenkins. Goedert's injury will most likely mean more targets all around for receivers DeVonta Smith, Dontayvion Wicks, and rookie first-rounder Makai Lemon. The 31-year-old Goedert had a big game in the Week 1 season-opening victory over the division-rival Washington Commanders, catching four of his five targets for 77 yards and two touchdowns, but he was able to reel in just one pass for four yards on two targets on Sunday against the Titans before his knee injury knocked him out. Because of Goedert's big role in the Eagles' passing game when healthy, fantasy managers should find a way to keep him stashed while he rehabs his MCL sprain.--Keith Hernandez
Source: NFL Network - Ian Rapoport
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Sep 21, 2026, 4:59 PM ET

Minnesota Vikings head coach Kevin O'Connell said that the team will be "talking about options at running back" coming out of Week 2, per ESPN's Kevin Seifert. With Vikings running back Jordan Mason (thumb) on Injured Reserve, veteran back Aaron Jones Sr. recorded 23 carries for 105 yards in the team's Week 2 win over the Chicago Bears. Per Seifert, O'Connell said that Jones Sr. is "a guy that clearly we have a lot of confidence in." However, it appears that the team would prefer not to overload Jones Sr., who is in his age-32 season and will likely surpass 2,000 career touches in 2026. Sixth-round rookie Demond Claiborne and veteran DeeJay Dallas were the primary backups to Jones Sr. against Chicago, but the two combined to record just four touches and 22 scrimmage yards. Seifert mentions veteran back Jerome Ford, who is currently on Minnesota's practice squad, as another potential option while Mason is sidelined. Fantasy managers may want to explore selling Jones Sr. at a relatively high point in his value ahead of what could be a reduced workload in future weeks.--Will Brady
Source: ESPN - Kevin Seifert

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