September 13, 2025
Baltimore Ravens wide receiver
DeAndre Hopkins proved why he's a three-time All-Pro with an amazing one-handed grab against the Buffalo Bills for a touchdown. While his days of 100+ targets per season are in the rearview mirror, he can still play that outlet role whenever called upon. The biggest issue for fantasy managers is that it's nearly impossible to predict which games he'll be more involved in compared to the others. In Week 2, he'll go up against the Cleveland Browns, who do have a better and more aggressive defensive unit. Hopkins might be viable in very deep leagues, but he likely won't receive more targets than
Mark Andrews again, which would leave him around fourth in the target pecking order. So managers in 12-team leagues can safely leave him on the bench.
--Alex Fischbein - RotoBallerSource: RotoBaller
September 13, 2025
Indianapolis Colts running back
Jonathan Taylor will host the Denver Broncos in Week 2. Taylor turned in a solid, if unspectacular, Week 1 performance in a win over the Miami Dolphins, rushing for 71 yards and catching three passes for 27 yards. He will look to find the end zone against a talented Denver defense that allowed just the 21st-most fantasy points per game to running backs in 2024. The Broncos continued that trend in Week 1 as they shut down the running game of the Tennessee Titans, holding
Tony Pollard to 3.3 yards per carry. Taylor should see plenty of volume, but the tough matchup downgrades him to more of a low-end RB1 in fantasy this weekend.
--Matt TerelleSource: NFL.com
September 13, 2025
Carolina Panthers rookie wide receiver
Tetairoa McMillan led the Panthers with 68 receiving yards and five receptions on nine targets in their Week 1 loss to the Jacksonville Jaguars. Considering the poor play of quarterback
Bryce Young and the Panthers' offense as a whole, McMillan's fantasy output in PPR leagues wasn't terrible (11.8 PPR points). However, if you roster McMillan in fantasy, you likely need him to produce WR2 numbers, which he didn't quite do in Week 1. Heading into Week 2 against the Arizona Cardinals, McMillan will once again have opportunities, as he was on the field for 83% of the Panthers' offensive plays in Week 1, leading all Panthers wideouts. The question is whether the Panthers' offensive line can give Young enough time to get the ball downfield for big plays to the big-bodied McMillan. If Young can improve in Week 2, it is expected that McMillan will outscore his Week 1 total. McMillan is a solid WR3/Flex option with WR2 upside heading into Week 2 against Arizona.
--Jp SticcoSource: ESPN
September 13, 2025
The Kansas City Chiefs defense will have all they can handle facing the Philadelphia Eagles in Week 2. The Chiefs defensive unit just allowed 27 points to the Los Angeles Chargers in their Week 1 loss. Despite giving up nearly 30 points to a division rival, the Chiefs defense came away with three sacks in this contest. This defensive unit yielded 40 points to Philadelphia in the Super Bowl, so fantasy managers should be a little hesitant about trusting them in this spot. The Kansas City Chiefs are the 23rd-best defense in our RotoBallers rankings this week, making them a unit you should likely avoid. Fantasy managers would be wise to find a suitable alternative at this position.
--Joshua CostelloSource: NFL.com
September 13, 2025
Kansas City Chiefs kicker
Harrison Butker will face the Philadelphia Eagles on Sunday in Week 2. This Super Bowl rematch could prove beneficial for Butker's fantasy relevance because of the strong Eagles defense. If the Kansas City offense is unable to complete drives, Butker could be asked to pick up the points with his leg. The veteran kicker knocked through all three of his field goal attempts in their Week 1 loss to the Los Angeles Chargers, but ultimately missed the extra point attempt following a rushing touchdown from
Patrick Mahomes in the third quarter. Butker has been one of the most consistent kickers in the league since his debut, and he will hope to continue the trend in Week 2. Butker is ranked K13 in our RotoBaller rankings this week, making him a fringe starter in a 12-team league.
--Joshua CostelloSource: NFL.com
September 13, 2025
Kansas City Chiefs tight end
Travis Kelce will face the Philadelphia Eagles in a Super Bowl rematch this Sunday. The 35-year-old reeled in just two passes for 47 yards and a touchdown in their Week 1 loss to the Los Angeles Chargers. 37 of Kelce's 47 yards came on his long touchdown catch and run in the fourth quarter. Despite salvaging his fantasy day with a long scoring play, the usage for Kelce in last week's game was concerning, to say the least.
Xavier Worthy was knocked out early in the first quarter when he and Kelce collided. Despite the loss of Worthy and the absence of
Rashee Rice due to suspension, Kelce was still only targeted four times in 39 pass attempts for
Patrick Mahomes. The veteran tight end will have to take on the Eagles, who held him to four catches for 39 yards in the Super Bowl. Kelce is ranked TE5 in our RotoBaller rankings this week, making him a mid-range TE1 despite the matchup. Kelce should still be considered a TE1, but his floor could be much lower than it has been in years past.
--Joshua CostelloSource: Kansas City Chiefs - Twitter
September 13, 2025
The San Francisco 49ers defense/special teams has a juicy Week 2 matchup against the New Orleans Saints. Exploiting second-year quarterback
Spencer Rattler's inexperience will be key to San Francisco's success. Rattler has averaged 33.2 pass attempts per game but has a 57.3% completion rate in his young career. In Week 1, he let it rip 46 times but completed only 27 of those passes. That's a lot of balls that miss their mark. With any luck, the 49ers' secondary can bring in at least one of those errant throws on Sunday. The team shouldn't have a problem keeping points off the board, either. Rattler's Saints have averaged 12.4 points per game in his seven career starts. If San Francisco's D/ST is still on your league's wire, they are worth streaming on Sunday.
--Dan StephensSource: NFL.com
September 13, 2025
Kansas City Chiefs running back
Kareem Hunt will take on the Philadelphia Eagles at home this Sunday. Hunt received an identical workload to
Isiah Pacheco and produced similar results. The veteran back was less efficient with his carries but picked up more receiving yards in his three opportunities. It is also important to note that Hunt appeared to be the preferred back on passing downs and short yardage situations. If this usage continues, Hunt could end up being the more fantasy-relevant player in this backfield. The Chiefs deployed Hunt in goal-line situations last season, and he was successful in that role, so it's possible that he retains that job. That said, the backfield usage was split 50/50, and it will be a difficult situation to deal with unless one player starts commanding more touches. Hunt will have to face a stout Eagles defense this week, so even if he gets more work, it could be hard to get anything going. Hunt is ranked RB48 in our RotoBaller rankings this week, making him a deeper league flex option. It might be best to wait and see how this backfield shakes out.
--Joshua CostelloSource: NFL.com
September 13, 2025
Kansas City Chiefs running back
Isiah Pacheco will face the Philadelphia Eagles in Week 2. The defending Super Bowl champions defeated the Chiefs in their last matchup, and Pacheco only had seven rushing yards on three carries. The 26-year-old will have the chance to exact some revenge, but he must first overcome the timeshare he's in with
Kareem Hunt. Pacheco and Hunt had the same number of opportunities in Week 1; both handled five carries and two catches on three targets. The former ultimately finished with more total yards, but it was not an impressive performance by either back. Pacheco did manage 5.0 yards per carry when given the opportunity, so maybe he can build on that efficiency with more usage. That said, the Eagles defense was one of the toughest in the league to run against last season, and that looks to be the case again this year. Pacheco will have his work cut out for him if he wants to carve out a larger role in the Kansas City backfield. Pacheco is ranked RB35 in our RotoBaller rankings this week, making him an RB3/Flex option. He'll be a tough player to trust this week.
--Joshua CostelloSource: NFL.com
September 13, 2025
Kansas City Chiefs quarterback
Patrick Mahomes will take on the Philadelphia Eagles in Week 2 for a Super Bowl rematch. The last time these two teams matched up, the Eagles ended up taking home the Lombardi trophy.
Jalen Hurts and the gang are coming off a Thursday night win over the Dallas Cowboys in Week 1, while the Chiefs suffered a one-possession loss to the Los Angeles Chargers on Friday. The 29-year-old had a decent performance against the Chargers, passing for 258 yards and a touchdown while adding 57 yards and a score on the ground. That said, Mahomes will have the odds stacked against him on Sunday, facing one of the best defenses in the league without two of his top offensive weapons.
Rashee Rice is still serving his suspension, and
Xavier Worthy is listed as doubtful for the upcoming matchup. Despite playing at Arrowhead this weekend, Mahomes and the Chiefs are home underdogs against the Eagles. The Chiefs quarterback is ranked QB11 in our RotoBaller rankings this week, making him a fringe-QB1.
--Joshua CostelloSource: Kansas City Chiefs - Twitter
September 13, 2025
San Francisco 49ers kicker
Eddy Pineiro signed with the team on September 10, in the wake of the release of
Jake Moody. Pineiro does not have Moody's leg strength, but he is certainly more accurate. Despite attempting twice as many field goals as Moody in his career (126 to 62), Pineiro has one fewer miss (15 to Moody's 16). San Francisco's offense has been bitten by the injury bug, including quarterback
Brock Purdy (toe, shoulder), who has been ruled out for Sunday's game against the Saints. With
Mac Jones at the helm, the offense's potential takes a step back, placing greater reliance on the team's kicker to put up points, however possible. Consider Pineiro a serviceable streamer for Week 2.
--Dan StephensSource: NFL.com
September 13, 2025
San Francisco 49ers tight end
Jake Tonges was the hero of the team's Week 1 victory over the Seattle Seahawks. Tonges stepped in for an injured
George Kittle (hamstring) and caught the go-ahead touchdown with just over a minute and a half left in the game. With Kittle now on injured reserve, Tonges is now the favorite to act as San Francisco's first-string tight end. Unfortunately, quarterback
Brock Purdy (toe, shoulder) has been ruled out for the 49ers' next game, meaning
Mac Jones will be under center when they face the Saints on Sunday. Tonges had the play of the game but saw only two other targets in Kittle's stead last week. Fantasy managers looking for streaming tight end options can probably find a more reliable option on the wire for Week 2.
--Dan StephensSource: NFL.com
September 13, 2025
Wide receiver
Kendrick Bourne signed a one-year deal with the San Francisco 49ers on September 9, returning to the team that gave him his start in the NFL in 2017. The signing was in light of injuries sustained in Week 1 by key pass catchers
George Kittle (hamstring), who is now on injured reserve, and
Jauan Jennings (shoulder), who is questionable for Week 2. Quarterback
Brock Purdy (toe, shoulder) is also dealing with injuries and has been ruled out for Sunday's game against the Saints. Taking over the offense will be
Mac Jones, who was Bourne's teammate for three years in New England, from 2021 to 2023. Bourne should not be in starting lineups but could be a bench stash in deeper leagues in case he shows renewed chemistry with Jones, given Purdy might be facing a multi-week absence.
--Dan StephensSource: NFL.com
September 13, 2025
San Francisco 49ers wide receiver
Skyy Moore stands little chance of making an impact in Week 2, despite the injury bug biting key players on offense. Even though tight end
George Kittle (hamstring) is on injured reserve and wide receiver
Jauan Jennings (shoulder) is questionable for Sunday's game against the Saints, veterans
Marquez Valdes-Scantling and
Kendrick Bourne stand in Moore's way on the depth chart. Moore played just three snaps in Week 1, and even if he does see a greater run on Sunday, the offense will be helmed by
Mac Jones and not
Brock Purdy (toe, shoulder), who has been ruled out. Moore's only path to fantasy relevance is in leagues that count return yards. Last week against Seattle, he fielded one kickoff and four punts, totaling 63 return yards.
--Dan StephensSource: NFL.com
September 13, 2025
San Francisco 49ers wide receiver
Marquez Valdes-Scantling saw zero targets on 15 routes run in Week 1. With
George Kittle (hamstring) now on injured reserve and
Jauan Jennings (shoulder) tagged as questionable for San Francisco's Week 2 matchup against the Saints, it is possible that Valdes-Scantling plays a bigger role on Sunday. Unfortunately,
Brock Purdy (toe, shoulder) has been ruled out so it will be
Mac Jones under center, limiting Valdes-Scantling's upside even if he does see more playing time. MVS does have the ability to stretch the field but Jones' career completion rate on passes of 20 or more air yards is a mere 30%, effectively negating that threat. If it were Purdy running the show, Valdes-Scantling would have more potential but as it is, he has little viability in Week 2.
--Dan StephensSource: NFL.com
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