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Colts Defense Draws Tough Week 12 Matchup vs. Chiefs

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Nov 21, 2025, 3:48 PM ET

The Indianapolis Colts defense should be well-rested coming out of their Week 11 bye. The team will now head on the road to take on the Kansas City Chiefs in Week 12. The Chiefs have been a tough matchup for D/STs in fantasy, allowing just the 29th-most fantasy points per game to the position this season. While Indianapolis' defense has been one of the better fantasy units this season, this is a tough week to trust them going up against Patrick Mahomes and company as 3.5-point road underdogs in a game with a 50-point over/under. Fantasy managers should look to stream a defense with a better matchup for Week 12.--Matt Terelle
Source: NFL.com
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