X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

FanDuel NFL DFS Lineup Picks for Week 6 - Daily Fantasy Football

Patrick Mahomes - Fantasy Football Rankings, DFS Lineup Picks, NFL Injury News

Dennis Clausen highlights the top FanDuel NFL DFS lineup picks for Week 6 of the 2021 season, and some value sleepers for your daily fantasy football rosters.

Week 5 was arguably the most intriguing slate we've seen all year, as it certainly didn't lack excitement. Looking back at some of the more memorable games on the schedule, the Rams and Seahawks kicked things off during a Thursday Night Football showdown. Unfortunately, we witnessed Russell Wilson fracture his finger, which will keep him on the shelf for the foreseeable future. We also observed the Falcons take care of business in London, dispatching the New York Jets 27-10. The Packers also sneaked by with an overtime victory over the Bengals, Chicago got it done in Las Vegas, and the Bills and Chiefs faced inclement weather during Sunday Night Football.

Heading into Week 6, there are a TON of injuries to consider that will make lineup construction nearly impossible until Sunday morning. Nonetheless, now is the time to start looking at how to attack the slate, although there are certainly more than enough variables to consider along the way.

In this article, I will be providing you with my Week 6 daily fantasy football lineup picks for FanDuel’s “Main Slate.” These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on FanDuel. Be sure to also check out our weekly DraftKings DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Feel free to give me a follow on Twitter @DennisMClausen. Also, be sure to check back on Saturday night for updates heading into Week 6.

Be sure to check all of our fantasy football rankings for 2025:

 

FanDuel Quarterbacks - Week 6 Picks

Patrick Mahomes, QB - @ WAS ($9,000)

While the Chiefs have had its fair share of struggles this year, Mahomes can't take all of the blame. Still, his team's shortcomings have been well documented, primarily since Kansas City has been one of the most explosive teams over the last few seasons.

Yet, despite Mahomes' issues throwing interceptions during his first five games on the year, the former MVP has done enough to keep him in the running as the top fantasy quarterback, and he has a good chance to have his most productive game of the season against the Football Team. While Kansas City has had some rough moments on the defensive end, Washington hasn't impressed in that area either. As a result, fantasy managers should save some cap space and roll with Mahomes in Week 6, and with all of the likely value options available, there should be no issue accomplishing that.

Aaron Rodgers, QB - @ CHI ($7,700)

Rodgers had plenty of turmoil surrounding him throughout the offseason. However, he ultimately opted to remain in Green Bay, where he will stay for at least the next 12 games. He didn't start the year off very well, and while he continues to play below the level of what we saw last year during his MVP run, he should command consideration against the Bears in Week 6.

The veteran has gone up against Chicago loads of times during his career. He's played well against the divisional rivals, too, and he has more touchdowns tosses versus the club than against any other team in the league. Rodgers is also carrying some strong projections from Vegas ahead of the matchup, so without a doubt, keep him on the radar for DFS contests of all types.

 

FanDuel Running Backs - Week 6 Picks

Jonathan Taylor, RB - vs. HOU ($7,500)

With the potential absence of so many able-bodied running backs, Taylor deserves mention based on pure availability alone. Yet, we also can't look past the fact that the Colts will square off against Houston, one of the worst teams in all the land.

The sophomore didn't start the year with a bang like many had expected. As a result, some managers were undoubtedly left questioning taking him as a first-round selection during fantasy drafts heading into the 2021-22 campaign. Fortunately, Taylor has gotten off the beaten path and has three touchdowns to his name throughout his previous two games. At this point, it's logical to assume that Indianapolis could take a sizable lead during the bout against the underwhelming Texans, and it could result in the Colts running more often, which of course, is good news for Taylor.

Devontae Booker, RB - vs. LAR ($5,900)

One of the biggest storylines in Week 5 was the injury to Saquon Barkley. The former Nittany Lion was poised for his most productive fantasy outing of the year against the Cowboys, mainly since the Giants were plagued with injuries heading into that one. Yet, Barkley would end up suffering an injury of his own, a low-ankle sprain, so he will likely be sidelined for at least a week, if not longer.

In his stead, Booker has emerged as the favorite to pick up the pieces. He carried the ball 16 times against Dallas, racking up only 42 yards. Still, the backup managed to find the end zone, which salvaged what would have been a rough outing. Nonetheless, with such a generous price tag for a guy who could be a featured offensive option, he shouldn't be ignored. However, this one isn't without risk, especially against an able Rams defense.

 

FanDuel Wide Receivers - Week 6 Picks

Davante Adams, WR - @ CHI ($8,500)

As it relates to the wideout position, those partaking in DFS contests on Sunday really don't have much of a choice than to at least consider Adams. Tyreek Hill is also in danger of missing Week 6, so the veteran is the clear favorite to finish as the leading receiver on the slate once again.

Everyone saw what he did to Cincinnati in Week 5, and with that, he has now grabbed 29 of his 45 targets for a total of 402 yards and two touchdowns throughout the last three weeks. Sure, he's going to be a popular option. However, this is one you can't avoid, especially since passing on him could go terribly wrong.

Ja'Marr Chase, WR - @ DET ($7,800)

Chase is the current favorite to take home Rookie of the Year honors. His teammate, Joe Burrow, was in the same position last season. However, a knee injury ruined things. As a result, Burrow can live vicariously through his former LSU teammate, and he has done a great job helping the wideout become one of the most lethal threats at the position.

Throughout the first five weeks of the season, Chase has racked up five trips to the end zone, scoring at least a touchdown in all but one but one game so far. He also ranks fourth in yards per catch, seventh in total receiving yards, and seventh in yards per game. Many thought that Tee Higgins would be the Bengals top receiver this year. Yet, it's been Chase who's been the man in Cincinnati, and that shouldn't change anytime soon. He has the potential to do some damage on Sunday against the Lions, one of the worst teams in the league.

 

FanDuel Tight Ends - Week 6 Picks

Mark Andrews, vs. LAC ($6,300)

Andrews put on one hell of a performance during the Monday Night victory over the Colts. He had one of the best outings of his career, and he capped off the evening's festivities by accumulating 147 yards off 11 catches. He also had two touchdowns in that one, resulting in a whopping 36.2 fantasy points.

We know that Baltimore LOVES to run the ball. Still, Lamar Jackson has to pass it at some point to keep the defense honest. Andrews is could be the best "receiver" on the team, and he's had at least seven targets now throughout the last three weeks to show for it. To sweeten things even more, the Chargers have struggled against opposing tight ends throughout the season, so now would be a great time for DFS enthusiasts to continue to ride the hot hand heading into Week 6.

 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

REAL-TIME FANTASY NEWS

Rhamondre Stevenson

Rushes Seven Times in Preseason Opener
Lan Larison

Scores Touchdown Against Commanders
Ja'Corey Brooks

Leads Washington in Receiving in Preseason Opener Against Patriots
Efton Chism III

Catches Six Passes in Preseason Opener
Drake Maye

Scrambles for Touchdown in Preseason Opener
TreVeyon Henderson

Opens Preseason With Kick Return Touchdown
Ben Sinnott

Catches Two Balls in Preseason Game Against Patriots
Sam Hartman

Struggles in Preseason Opener
Spencer Rattler

to Start Against Chargers
Edward Cabrera

Punches Out 11 in Victory
Chase Burns

Superb in 10-Strikeout Performance
Jacory Croskey-Merritt

Finishes With 32 Total Yards in Preseason Debut
Ja'Lynn Polk

Exits Early With Shoulder Injury
Chris Olave

Tweaks Ankle at Practice
Salvon Ahmed

Suffers Season-Ending Ankle Injury
Cincinnati Bengals

Dylan Fairchild Impresses in Preseason Debut
Hunter Renfrow

Not Expected to Play on Friday
Drake Maye

Expected to Play in Patriots First Preseason Game
Jerome Ford

Not Expected to Play in Browns First Preseason Game
Quinshon Judkins

Waives Right to Speedy Trial
Najee Harris

' Status for Week 1 Uncertain
Las Vegas Raiders

Raiders First-Team Offense Will See More Snaps in Second Preseason Game
Jake Ferguson

Practices on Friday
Mason McTavish

Several Teams Keeping Tabs on Mason McTavish
LA

Kyle Clifford Hangs Up Skates
Elias Pettersson

Out for "Revenge" in 2025-26
Roman Dolidze

Looks To Extend His Win Streak
Semyon Varlamov

to Start Skating Next Week
Anthony Hernandez

Set For UFC Vegas 109 Main Event
VAN

Vitali Kravtsov Returns to Canucks
Steve Erceg

In Dire Need Of Victory
Iasmin Lucindo

Aims To Bounce Back
Angela Hill

Set For A Main-Card Bout
Christian Rodriguez

A Favorite At UFC Vegas 109
Andre Fili

Set For His 24th UFC Fight
Miles Johns

Looks To Get Back In The Win Column
Jean Matsumoto

Looks To Bounce Back
Christian Leroy Duncan

Looks To Win Back-To-Back Fights
Eryk Anders

Set To Open Up UFC Vegas 109 Main Card
Drake Baldwin

Homers Twice, Drives in Five
Josh Naylor

Day-to-Day With Shoulder Soreness
Michael King

to Return Saturday
Payton Pritchard

Eager to Continue Improving
Austin Reaves

Expected to Receive Massive Pay Raise with Next Contract
Jayson Tatum

Out of Walking Boot
San Antonio Spurs

Spurs Bring in Micah Potter for Training Camp
Harrison Ingram

Re-Signs with Spurs
Zack Wheeler

Pushed Back to Sunday With Shoulder Stiffness
Roman Anthony

Agrees to Eight-Year Extension
NBA

Richaun Holmes Moves to Panathinaikos on Two-Year Deal
Maverick McNealy

Attempts to Bounce Back at Memphis
Bennedict Mathurin

to Become Regular Starter for Pacers
Darius Garland

Cavaliers Not Rushing Darius Garland Back
Kurt Kitayama

Could Get Hot at Memphis
PGA

Sungjae Im a Volatile Risk at FedEx St. Jude
Riley Minix

Signs New Two-Way Deal with Spurs
Harry Hall

Playing Well as Playoffs Approach
Chris Boucher

Signs One-Year, $3.3 Million Deal with Celtics
PGA

Chris Gotterup on Impressive Run Heading to Memphis
Georges Niang

Returns to Utah
Harris English

Ready for the Playoffs
Bud Cauley

Trying to Reverse Course at Memphis
Daniel Berger

Hoping to Contend at FedEx St. Jude
Luke Keaschall

Launches First Career Home Run
Scottie Scheffler

Continues Dominance Ahead of TPC Southwind
Collin Morikawa

Eyes Major Bounce Back at TPC Southwind
Michael Kim

Looking to Find Rhythm at TPC Southwind
PGA

Victor Hovland Eyeing Another Strong Finish at TPC Southwind
Ben Griffin

Brings High-Upside Value to TPC Southwind
Shea Langeliers

Has Three-Homer Evening Tuesday
Matt Fitzpatrick

Staying Red-Hot Entering TPC Southwind
Patrick Cantlay

Eyeing Another Strong Finish at TPC Southwind
Ludvig Aberg

Needs a Complete Week at TPC Southwind
Roman Anthony

to Return on Wednesday
Gleyber Torres

Scratched from Tuesday's Lineup
DAL

Anton Khudobin Announces Retirement
Miro Heiskanen

Back at 100 Percent Ahead of New Season
Matthew Tkachuk

Expected to Miss Start of Season
Nick Lodolo

Reds Place Nick Lodolo on Injured List With Finger Blister
NHL

Jimmy Vesey Moves Abroad
ANA

Sam Colangelo Signs Two-Year Extension
NYI

Matthew Schaefer Signs Entry-Level Contract with Islanders
NBA

Brandon Boston Jr. Inks Deal with Fenerbahce
NBA

Jeff Dowtin Jr. Joins Six-Time EuroLeague Champions
NBA

Lonnie Walker IV Agrees to Three-Year Contract with Maccabi Tel Aviv
Neemias Queta

Working Back From Knee Surgery
Johnny Juzang

Links Up with Timberwolves
Ricky Council IV

Joins Nets on One-Year Contract
Aaron Judge

To Return To Yankees On Tuesday
Michael King

Could Make Next Start With Padres
Michael Soroka

To Go On Injured List
Nick Lodolo

Exits Early With Blister
Roman Anthony

Dealing With Back Tightness
Nikola Vučević

Nikola Vucevic Not a "Buyout Candidate"
Giannis Antetokounmpo

Still Undecided About Future in Milwaukee
Max Muncy

Activated and Starting on Monday
Grayson Rodriguez

to Undergo Season-Ending Surgery
Isaac Paredes

Won't Have Surgery, Hoping to Return This Year
Daniss Jenkins

Agrees to Two-Way Deal Wth Detroit
Washington Wizards

Jaylen Martin Waived by Wizards
Tatsuro Taira

Gets Submission Win
HyunSung Park

Undefeated No More
Mateusz Rębecki

Mateusz Rebecki Drops Decision At UFC Vegas 108
Chris Duncan

Wins Three In A Row
Elves Brener

Loses Three In A Row
Esteban Ribovics

Returns To The Win Column
Nora Cornolle

Gets Dominated At UFC Vegas 108
Karol Rosa

Outclasses Nora Cornolle
J.J. Spaun

Finishes Tied for 23rd at Open Championship
Justin Thomas

Finishes Tied for 34th at Open Championship
Xander Schauffele

Finishes Tied For Seventh at Open Championship
Hideki Matsuyama

Finishes Tied for 19th at Wyndham Championship
Si Woo Kim

Misses The Cut at Wyndham Championship
Elizeu Zaleski dos Santos

Suffers TKO Loss
Austin Riley

Braves Place Austin Riley Back on Injured List
Neil Magny

Gets Back In The Win Column
NASCAR

Bubba Wallace Charges Back to Sixth at Iowa
Chase Briscoe

Finished Second Despite Being Trapped a Lap Down and Causing Two Wrecks
Brad Keselowski

Arguably Had the Best Drive at Iowa but Finished Third
Austin Dillon

Earns a Quiet Top Ten at Iowa
Kyle Larson

Poor Pit Strategy and Clash with Teammate Foil Kyle Larson at Iowa
William Byron

Stretches His Fuel to His Second Victory of 2025 At Iowa
Ryan Blaney

Continues A Strong Run of Success At Iowa
Ryan Preece

Eventful Race at Iowa Results In A Top-5 Finish
Denny Hamlin

Struggled Massively At Iowa
Chase Briscoe

Could Chase Briscoe be A Sneaky Play for Iowa Lineups?
Denny Hamlin

Is A Top Driver to Consider for DFS At Iowa
Ryan Blaney

Is A Favorite to Go Back-To-Back With Iowa Victories
Tyler Reddick

has Plenty of Upside for Sunday's Race at Iowa
Carson Hocevar

What Should Fantasy Players do with Carson Hocevar at Iowa?
Chris Buescher

Is Chris Buescher Worth Rostering For Iowa DFS Lineups?
Ty Gibbs

Could Be A Solid DFS Option for Iowa
Ryan Preece

Offers Plenty of Upside For DFS Lineups At Iowa On Sunday
NASCAR

A.J. Allmendinger Will Start in the Top 10 for the Second Week In A Row at Iowa
Austin Dillon

Could Austin Dillon Be A Decent DFS Option for Iowa?
Michael McDowell

Is Michael McDowell Worth Rostering for Iowa DFS Lineups?
Zane Smith

Should DFS Players Roster Zane Smith At Iowa?
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF