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FanDuel Lineup Picks (Week 10) - NFL DFS Advice

FanDuel NFL DFS lineup picks and start 'em, sit' em for Week 10. Daily fantasy football sleepers and lineups cheat sheet for FanDuel DFS GPPs and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 10 of the NFL season. In this article I will be taking you through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more.

Good luck with your FanDuel DFS lineups!

Be sure to check all of our fantasy football rankings for 2025:

 

FanDuel Quarterbacks - Week 10 DFS Picks

Ryan Fitzpatrick (vs. NYJ, $6,100)

Ryan Fitzpatrick will be behind center for the Buccaneers this week and for the foreseeable future. The combination of price and matchup (plus a little narrative) make it difficult to pass in this spot despite the fact that Mike Evans won’t be on the field this week. The Jets are ranked 21st in pass DVOA and the price will allow spending up at other spots on the slate.

Matthew Stafford (vs. CLE, $8,200)

If you’re feeling a safer option than Fitzpatrick this week, Stafford is the quarterback to turn to. Stafford has been good lately, passing for multiple touchdowns in two of his past three games and over 300 yards in all three. He should be able to do each of those things against a hapless Browns pass defense that ranks 28th in pass DVOA for the season. The only risk for Stafford is that the Lions pull ahead quickly without those scores coming through the air, but with the ineptitude of their ground game that seems unlikely.

 

FanDuel Running Backs - Week 10 DFS Picks

Carlos Hyde (vs. NYG, $6,700)

Carlos Hyde hasn’t been anything special on the ground this season which is obviously not a great statement in reference to a running back. On the other hand, he has been very involved in the pass game which has kept his floor at a safe level. When the 49ers have lost by 10 points or less this season, Hyde has seen an average of 23 touches per game. The Giants are just as inept as the 49ers, if not more, so this should be a close game between two bad teams and allow Hyde to see a healthy dose of touches.

Bilal Powell (@TB, $6,000)

With Matt Forte officially out this week, we can look to Powell as a bargain running back that paves the way to Antonio Brown, LeVeon Bell, or Gronk. While the narrative has been that the Jets rushing attack has been an unreliable mess in terms of workload, the absence of Forte should open sufficient volume for Powell to take advantage of. The Bucs are far from tough on opposing running backs, allowing big games to Adrian Peterson, LeSean McCoy, and the Saints running back committee of late, opening up some more nice value at the running back position.

 

FanDuel Wide Receivers - Week 10 DFS Picks

A.J. Green (@TEN, $7,900) 

A.J. Green has been a story this week, but not because of his play. He should be motivated to perform as a result and he’s in a decent spot to do so. Though Tennessee has shown improvement on defense, most of that improvement has come against opposing rushing attacks. If the Bengals are smart, that’s a big if, they will pepper A.J. Green with targets as has a six-inch height advantage over otherwise impressive rookie Adoree’ Jackson.

Marvin Jones (vs. CLE, $6,400)

Golden Tate has been a reliable option this season, but the price disparity between he and Marvin Jones on FanDuel doesn’t make much sense. Over the past three games, in which Matt Stafford has gotten on track, Jones has put up 18.6, 15.8, and 26.2 FD points respectively. In an A+ matchup there’s no reason to go away from Jones.

 

FanDuel Tight End - Week 10 DFS Pick

Rob Gronkowski (@DEN, $8,100) 

Gronk is a relatively easy choice this week, assuming the ability or desire to pay up at the position. The Broncos still can’t cover opposing tight ends, as they have allowed 14.47 FD points per game to them on the season. Coming off of a bye week, the Patriots will be prepared to take advantage of that huge edge making Gronk worth the premium.

 

FanDuel Defense - Week 10 DFS Pick

Chicago Bears (vs. CIN, $4,300)

The Bears have been a respectable defense all season, especially at home, and the Packers offense has been non-existent since the loss of Aaron Rodgers. It comes as little surprise that they have an implied total of just 16.25 The Bears will be the chalk defense of the week, but at this price point there is good reason why.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Matthew Stafford

Expected to Start in Week 1
Edward Cabrera

Heading to Injured List With Elbow Sprain
Najee Harris

Cleared for Contact, Could Play in Week 1
Denny Hamlin

Ends Eventful Day at Darlington in Seventh Place
NASCAR

Bubba Wallace Almost Earns a Top-Five Finish at Darlington
John Hunter Nemechek

has His Best 2025 Performance at Darlington
Ryan Blaney

Has An Underwhelming Performance At Darlington
Josh Berry

Crashes Early and Suffers A Playoff Setback at Darlington
Harry Ford

Called Up for Major-League Debut
Victor Scott II

Activated From Injured List
Fernando Tatis Jr.

Dealing With Hamstring Tightness, Expects to Play Monday
Giannis Antetokounmpo

"Staying in Milwaukee"
Thanasis Antetokounmpo

Agrees to a One-Year Contract with Milwaukee
Kyrie Irving

"Healing Up Great"
Dante Exum

Mavs Agree on a One-Year Deal
Jaylen Warren

Agrees to Two-Year Extension With Steelers
De'Von Achane

Practicing Monday, on Track to Play in Week 1
Quinshon Judkins

Could Report to Browns This Week
Kansas City Chiefs

Chiefs, Trent McDuffie Not Expected to Finalize Extension
Chase Elliott

Under Playoff Pressure After 17th-Place Darlington Finish
Kyle Larson

Despite Hendrick Mediocrity, Kyle Larson Remains Pretty Safe in Playoffs
Alex Bowman

Opening-Lap Crash and Botched Pit Stop May Have Sunk Alex Bowman's Playoff Hopes
Erik Jones

Darlington Master Erik Jones Comes Up Short but Still Finishes Third
AJ Allmendinger

A.J. Allmendinger Impresses at Southern 500
Dameon Pierce

Ahead of Schedule, Ready for Season
Jordan Love

May Wear Thumb Brace During Season
Chicago Bears

Bears Head Coach Admits Offense Could Face Learning Curve
Matt Chapman

Leaves Early on Sunday, Expects to Play Monday
A.J. Brown

Says He'll Be Active For Season Opener
Luis Garcia

to Make Season Debut on Monday
Max Scherzer

Exits Due to Back Tightness
Taylor Ward

Exits Early After Collison
Braelon Allen

Says He Has a Lot Left to Prove
Sal Stewart

Reds Promoting Sal Stewart to Majors
Daniel Suarez

is A DFS Risk for Darlington Lineups?
Randy Rodríguez

Randy Rodriguez to Undergo Tommy John Surgery
Noah Gragson

Should Fantasy Managers Roster Noah Gragson for Darlington?
Ty Dillon

is an Excellent Punt Option for Darlington DFS Lineups
Bogdan Bogdanović

Bogdan Bogdanovic to Miss the Rest of EuroBasket
Denny Hamlin

Picking Up Where He Left Off At Darlington
Kyle Larson

The Sky Is The Limit for Kyle Larson at Darlington
Ryan Blaney

a Strong DFS Play at Darlington This Weekend
Tyler Reddick

Shouldn't Be Overlooked at Darlington This Weekend
Alex Bowman

An Easy Place-Differential Play in DFS This Weekend
Ty Gibbs

Could Be Strong at Darlington This Weekend
Erik Jones

Has Best Darlington Qualifying Effort Since Last Win
Zane Smith

Hopeful For Another Solid Run At Darlington
Aroldis Chapman

Agrees to Contract Extension
Juan Soto

Homers Twice in Loss
Nick Kurtz

Avoids Serious Injury
MacKenzie Gore

Placed on 15-Day Injured List
Jazz Chisholm Jr.

Reaches 25-Homer, 25-Steal Milestone
Chris Sale

Activated on Saturday
Dansby Swanson

Homers Twice, Drives in Six in Win
Nick Kurtz

Leaves Game With Oblique Soreness
Joe Burrow

Bengals Feel Joe Burrow Just had "the Best Training Camp of his Career"
Randy Rodríguez

Tommy John Surgery Recommended for Randy Rodriguez
Corey Seager

Placed on Injured List
Jackson Chourio

to Return From Injured List on Saturday
Dallas Mavericks

Olivier-Maxence Prosper Waived by the Mavs
Lauri Markkanen

Dominant in Win Over Great Britain
Nikola Jović

Nikola Jovic Leads Serbia to a Win
Nikola Jokić

Nikola Jokic Shines Versus Portugal
De'Von Achane

Should be Ready for Week 1
Jose Alvarado

"Good" After Recent Fall
Green Bay Packers

Packers Acquire Micah Parsons, Sign him to Four-Year Extension
Jauan Jennings

Remains Sidelined at Practice
Chris Godwin

to Miss First Month of Season, Possibly More
Quinshon Judkins

Not Considering Return to College
A.J. Brown

Returns to Practice, Expected to Play in Week 1
Jaylen Wright

Undergoes Surgery, Could be Back "Septemberish"
Tyreek Hill

on Track to Play in Week 1
Kyren Williams

to See Reduced Workload?
Lauri Markkanen

Torches Sweden
Neemias Queta

Dominates in EuroBasket Opener
Kawhi Leonard

Clippers Not Allowing Kawhi Leonard to Play Back-to-Backs
Dallas Mavericks

Mavericks Looking to Trade Olivier-Maxence Prosper
Tyrese Haliburton

Expects to Return in 15 Months
Terance Mann

Confident About Having a Big Year in Brooklyn
Zaccharie Risacher

Aims to Improve Ball-Handling Skills
NBA

Pistons And Timberwolves Join Race for Malik Beasley
John Tonje

Signs Two-Way Deal With Jazz
Max Strus

to Miss 3-4 Months After Surgery

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