Week 16 NFL DFS Stacks for FanDuel, DraftKings (Sunday Main Slate)

Mark Kieffer's NFL DFS stacks for FanDuel and DraftKings tournaments for Week 16 of the 2021 NFL season. These GPP stacks are worth considering for daily fantasy football lineups.

Welcome back to another week of NFL DFS GPP Stacks! This is where I talk about the slate and give three stacks you should consider for your GPP lineups!

I generally make 3-5 lineups, because it is hard to nail every stack. I use a different stack for each GPP lineup and hope one of them pops to the top of the standings! If I win a GPP with one lineup and do not cash in the other six, I will still have a very nice day and win a good chunk of cash!

Before just diving into the picks for this week, some reminders about guidelines I use for stacks:

I want games with high point-scoring totals and close point spreads. The scoring part is obvious (more scoring = more fantasy points), but the game being close makes a bring-back player viable and keeps the team that is up playing with urgency throughout the game.

I generally want to fade a stack combination that is projected to be the most popular in the slate. This means I may choose to stack up that team different from the crowd, or I may do an outright fade. With that said, on to the picks!

• 2025 fantasy football rankings
• Running back (RB) fantasy football rankings
• Wide receiver (WR) fantasy football rankings
• Tight end (TE) fantasy football rankings
• Quarterback (QB) fantasy football rankings
• Defense (D/ST) fantasy football rankings
• NFL rookie fantasy football rankings
• Best ball fantasy football rankings
• Superflex fantasy football rankings
• Dynasty fantasy football rankings

Week 16 Slate Context

It is a tough week with all the COVID protocols. It's difficult to know who exactly is playing and who isn't playing at this point in time. Below are my thoughts as of this writing on Thursday, 12/23/2021, information is changing rapidly and I suggest you check lineups up to the minute for the latest news and updates on players' status. Hopefully we do not have any postponed or moved games, but you never know.

We have the Rams-Vikings game with the highest total on the slate at 49 points and then we have 10 other games that are in the low to mid-40s. As a result we will not see as much roster consolidation on plays outside of the Rams-Vikings.

(1) Los Angeles Rams

The Rams are viable to stack each and every week and this one is no different as they take on the Minnesota Vikings, the No. 29 pass defense in the league. The stack has to include Cooper Kupp, someone who has gotten double-digit targets each and every week since Week 8 when he had.... nine targets. Kupp has 44.7% of the wide receiver targets on the season with no slowing down in sight. The question here is whether to add a second player to the stack or not. Odell Beckham Jr. has averaged 5.8 targets per game since joining the Rams and Van Jefferson has also averaged 5.8 targets per game since Week 8 too. This game is the highest total on the slate, Kupp will likely be rostered heavily but not sure if people will look to stack.

(2) Kansas City Chiefs

I only like this stack if at least one of Tyreek Hill or Travis Kelce is active for this game. If they are both out, cross this one out unless you are playing in a huge GPP. Pittsburgh has a reputation for being a good defense, but their pass defense is No. 12, which is pretty close to average. With a great quarterback with Patrick Mahomes and with Hill/Kelce the matchup doesn't really matter. The danger here with this stack is Pittsburgh's run defense is No. 31 in the NFL. If Kansas City is missing a lot of players, they may opt to run the ball heavily and just try to get out of there with a win.

(3) Pittsburgh Steelers

I also really like going the other way in the Kansas City game. Pittsburgh is No. 4 in pass play percentage, they pass on 63.44% of plays, and Kansas City's pass defense is No. 28 in the league allowing 250.9 passing yards per game.  I would pair up Diontae Johnson and Najee Harris with Big Ben in this one. Johnson basically leads the Steelers in targets every game he plays (week three when Harris had 19 targets, Johnson was not active). Harris averages 5.7 targets per game, along with the rushing upside he has. I wouldn't use this stack in single entry GPP but outside of that, I would strongly consider.

Thanks for reading, and I wish you the best of luck with your Week 16 DFS Stacks!

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