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San Francisco 49ers running back Christian McCaffrey (calf) is officially listed as questionable for the Week 1 season opener on Sunday against the division-rival Seattle Seahawks due to a calf issue, according to Cam Inman of the Bay Area News Group. After reports that CMC was fully healthy and looking like his MVP self in training camp this summer, the oft-injured RB popped up on Thursday's injury report and was limited in practice. On Friday, the 29-year-old didn't take part in drills with the rest of the team and was seen on a side field rehabbing. He was questionable entering last year's season opener and ended up missing the first eight games with bilateral Achilles tendinitis. It's a different year, but things could be trending toward him sitting out in Week 1 again. We hope you handcuffed Brian Robinson Jr. or Isaac Guerendo if you took the plunge on McCaffrey in drafts this year.--Keith Hernandez
Source: Bay Area News Group - Cam Inman
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