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The Buffalo Bills defense has quietly been one of the league's most effective units this season, combining steady pressure with opportunistic playmaking. Buffalo has forced turnovers on 10% of opponent possessions while holding teams to an NFL-best 125.8 passing yards per game. Although the Bills have shown some vulnerability against the run, that weakness may not be exploited this week, as the Patriots rank just 26th in rushing offense. This matchup sets up as a strength-on-strength battle that favors Buffalo across the board. If Josh Allen and the offense can build an early lead, the Bills' defense should be able to attack aggressively, forcing quarterback Drake Maye into mistakes. They should be viewed as a top-five fantasy defense heading into Week 5, with strong potential for sacks and turnovers.--Shaun Albin
Source: BuffaloBills.com
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REAL-TIME FANTASY NEWS

Malik Nabers

"to Undergo Surgery This Week"
Jayson Tatum

to Return in March?
Justin Faulk

Misses Preseason Finale
Kirill Marchenko

Cleared for Saturday's Action
Macklin Celebrini

Makes Preseason Debut Saturday
Kaiden Guhle

Available Saturday
Noah Dobson

Rejoins Canadiens Lineup Saturday
Samuel Girard

Ready for Game Action
Filip Gustavsson

Wild Sign Filip Gustavsson to Five-Year Extension
Tyjae Spears

Activated, Will Play in Week 5
Taysom Hill

Foster Moreau Activated to Play in Week 5
Brock Bowers

Trending Toward Missing Week 5
Tyreek Hill

Dolphins Expected to Release Tyreek Hill Following 2025 Season
Max Scherzer

Left Off Blue Jays ALDS Roster
Bo Bichette

Officially Out for ALDS
Justin Tucker

Working Out Saturday, Has Interest From Several Teams
Cole Perfetti

Evaluated for Lower-Body Injury
Michael Kesselring

to be Re-Evaluated Next Week
Lukas Dostal

to Start in Preseason Finale
Cole Sillinger

Practices on Friday
J.T. Miller

Returns to Practice
Luke Evangelista

Signs Two-Year Deal With Predators
Michael Carter

Will Play "a Lot of Snaps" in Week 5
Max Homa

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Rangers Hire Skip Schumaker as New Manager
Trevor Megill

Ready for NLDS
Will Smith

Will be Available to Catch in NLDS
Clayton Kershaw

to Pitch Out of Bullpen in NLDS Against Phillies
Lawrence Butler

Undergoes Knee Surgery on Friday
Brandon Woodruff

Will Not Pitch in NLDS
Scott Laughton

Deemed as Week-to-Week
Jayden Daniels

to Return to Starting Role in Week 5
Logan Cooley

Expected to Be Available for Season Opener
Anton Lundell

Considered Day-to-Day
Andrei Vasilevskiy

Ready for Action Saturday
Ukko-Pekka Luukkonen

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Bowen Byram

Available Friday
Lamar Jackson

Officially Ruled Out for Week 5
Brock Bowers

Listed as Questionable, Expected to Play in Week 5
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Listed as Questionable for Week 5
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Good to Go for Week 5
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Questionable for Week 5
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a "Long Shot" to Play in Week 6, Week 7 Return More Likely
Devin Booker

Likely Playing on Friday
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Luka Doncic Won't Play This Weekend
Tyrone Tracy Jr.

Doubtful to Play in Week 5
Josh Giddey

Returns to Full Practice
Matas Buzelis

has Team Optioned Accepted
Calvin Ridley

Questionable for Week 5
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Can Become Two-Time Light-Heavyweight Champion
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Set For His First Title Defense
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Set For His Third Title Defense
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Jiri Prochazka Returns At UFC 320
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Looks To Extend His Win Streak
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Ruled Out Again in Week 5
Joe Pyfer

Looks To Earn Top 15 Ranking
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Officially Out for Week 5 Against Miami
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Set To Open Up UFC 320 Main Card
Mike Evans

to Miss Another Game in Week 5
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Officially Ruled Out With Sprained Foot
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Expected to Miss Week 5, In Danger of Missing Week 6?
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Cam Schlittler

Dazzles in 12-Strikeout Performance, Yankees Advance to ALDS
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Quintrevion Wisner Expected Back vs. Florida
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Emmett Mosley Probable for Longhorns vs. Florida
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to Join the Bucks in Miami
Jaden Ivey

Fully Recovered From Fractured Fibula
Nick Jensen

an Option for Preseason Finale
Lars Eller

Could Be Available Saturday
OG Anunoby

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Joel Embiid

Adem Bona Starts in Place of Joel Embiid on Thursday
Dominick Barlow

Grabs 10 Boards in Abu Dhabi
Miles McBride

Leads the Knicks to an Exhibition Win in Abu Dhabi
VJ Edgecombe

Drops 14 Points in Thursday's Exhibition
Josh Hart

Injured in Exhibition
Shane McClanahan

Expected to be "Fully Ready" for Spring Training
Bo Bichette

Unlikely to be Ready for ALDS
Coby White

Does Some Shooting During Wednesday's Practice
Patrick Williams

Hurts Ankle at Practice
Mark Williams

to Sit Out Preseason Opener
Noah Clowney

Healthy and Bigger Ahead of New Season
Gabe Vincent

Logs Full Practice
LeBron James

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Rudy Gobert

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Bryce Eldridge

to Undergo Wrist Surgery
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Brian Snitker Will Not Return as Braves Manager
Sam Burns

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Tom Kim

Could Be in For Long Week in Mississippi
Max Homa

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Nicolai Hojgaard

an Interesting Play at Sanderson Farms
Davis Thompson

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Nick Dunlap

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PGA

Matti Schmid a Volatile Option at Sanderson Farms
Thorbjorn Olesen

a Solid Play at Sanderson Farms
Stephan Jaeger

a High-Upside Play in Mississippi
Hayden Buckley

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Quade Cummins

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Carson Young

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Matt Kuchar

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Tarik Skubal

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CFB

Behren Morton To Start Against Houston Saturday
Texas Rangers

Rangers, Bruce Bochy Mutually Agree to Part Ways
Minnesota Twins

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San Francisco Giants

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Francisco Alvarez

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Bo Bichette

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Lucas Giolito

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Alex Bregman

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Chase Briscoe

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Kyle Larson

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Joey Logano

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