👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

Break The Slate: NFL DFS DraftKings Lineup Picks - Week 16 (Main Slate)

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 16. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hi RotoBallers and thanks for joining me for Week 16! With three games on Saturday this week, we'll be dealing with an 11-game main slate. While Week 15 offered us tons of great DFS options - and some ridiculously-high DraftKings scores - the pickings are a bit slimmer this week. That said, we still have some intriguing matchups with players that are in great spots.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are some great plays available, so read on to find out which players are the best for Week 16.

Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 16 Picks

Lamar Jackson - BAL @ CLE ($8,000)

If the Ravens are playing on the main slate, then Lamar Jackson is in consideration for me. It sounds simple, but Jackson has been the "DFS MVP" of this season, showing an unbelievably-consistent combination of floor and ceiling from week to week. The Ravens QB is once again expensive, but there have been very few weeks this year when you would have been disappointed to roster him, as he's averaging almost 30 DK points per game this season. Jackson went over 1,100 rushing yards last week, surpassing Michael Vick for the all-time QB rushing record in a season. He should be able to pad that mark this week against a Browns Defense that has allowed opposing QBs to gain 300 yards on the ground this season and appears to be sleepwalking down the stretch.

Drew Brees - NO @ TEN ($5,900)

Drew Brees heads into Week 16 on a tear. The Saints veteran has posted DK scores of 31.3 and 43.1 over his last two games, and heads to Nashville to face a Titans Defense that is 25th in the NFL in yards allowed per pass. We prefer Brees at home, but we've also seen this Saints offense go on unbelievable high-scoring runs in the past, which makes me content to continue riding the wave in this spot. This matchup carries a projected O/U of 51 with a tight spread and is one of the best games to target on the main slate.

 

DraftKings DFS Running Backs - Week 16 Picks

Joe Mixon - CIN @ MIA ($6,600)

It took 10 weeks, but the Bengals appear to have finally realized what type of player they have in Joe Mixon. Mixon has logged a massive 130 carries since Week 10, which he's converted into 605 rushing yards and three TDs. He brings that hot hand into a beautiful matchup against a Dolphins Defense that has allowed the most rushing yards in the NFL to opposing RBs and is fresh off relinquishing yet another 100-yard game to Saquon Barkley last week. We're getting a quality player in a tremendous matchup at a reasonable price here and I consider Mixon to be one of the top overall plays on this slate.

Deandre Washington - OAK @ LAC ($4,000)

A great opportunity for salary savings here with Oakland's DeAndre Washington. Rookie Josh Jacobs tried to tough it out last week, but won't be active for this matchup against the Chargers, which will throw Washington back into the primary-back role that he served in Jacobs' absence in Week 14. Washington thrived in the role two weeks ago against Tennessee, logging 53 rushing yards and a TD, as well as 43 receiving yards on six catches. We can expect a similar workload for him against a Chargers Defense that's 22nd in the league in DK points allowed to opposing RBs, which makes him a tremendous value option at just $4k.

 

DraftKings DFS Wide Receivers - Week 16 Picks

Michael Thomas - NO @ TEN ($9,300)

No need to get cute here...if you can afford Michael Thomas, roster him. Maybe it sounds like an oversimplification, but like we touched on when discussing Lamar Jackson earlier, if you had rostered Thomas every week this season there would be very few weeks you'd walk away disappointed. The Saints wide receiver has been the most consistent pass catcher in the NFL this season. He leads the league in overall targets at 159 - reeling in an eye popping 133 catches- and is averaging a ridiculous 11.4 targets per game. This Titans secondary has been plagued with injuries and has no one that can challenge Thomas in this matchup, which provides a clear path to another huge outing for the Saints star.

Courtland Sutton - DET @ DEN ($6,200)

Courtland Sutton has ascended to the number-one receiver role for the Denver Broncos over the course of this season thanks to the combination of his explosive play and the departure of Emmanuel Sanders. Sutton has been targeted 107 times this year with a healthy aDOT of 12 yards. It's been a mixed bag for him since Drew Lock stepped into the QB role for the Broncos, as Sutton has snagged 13 of 22 targets for 187 yards and two TDs in Lock's three starts. He draws his best matchup of the "Lock Era" this week against a Lions Defense that has been routinely torched as of late. Detroit ranks 31st in the NFL in receiving yards allowed to opposing WRs and is fresh off a Week 15 game against the Bucs in which they allowed over 100 yards to not one, but TWO Tampa receivers. Sutton is a very explosive player in a prime spot against the Lions...the only concern is the erratic play of his QB.

Mike Williams - OAK @ LAC ($5,000)

I've been banging the Mike Williams drum for several weeks now and DraftKings just refuses to bump his price up enough to make me jump ship. Williams comes in at $5k this week, which is still a pittance to pay for a player with his type of significant downfield role. His aDOT of 18 yards leads the NFL among players with 50 or more targets and his 1,460 total air yards ranks ninth in the league. He gets a gasoline-to-fire matchup against an Oakland Raiders Defense that is allowing an NFL-worst 9.68 yards per target to opposing wide receivers. Williams has had some scary-low volume games this year, but his downfield role against this Raiders secondary makes him an awesome boom-or-bust tournament option this week.

 

DraftKings DFS Tight Ends - Week 16 Picks

Zach Ertz - DAL @ PHI ($6,400)

It's always nice to bargain shop, but one of the main reasons I'm willing to pay up in a DFS roster is "guaranteed" volume. Over Philly's last six games, Zach Ertz has target counts of: 10/13/6/14/11/11. This is the type of usage that I'll gladly spend up for. Dallas has a solid overall defense, but they also funnel targets to opposing tight ends. The Cowboys rank seventh in the league in DK points allowed to the WR position, but just 27th in DK points allowed to TEs. This is a must-win game for the Eagles and their receiving corps has been ridiculously depleted by injuries, which leads me to believe that Eagles QB Carson Wentz will rely on Ertz heavily in this spot.

Austin Hooper - JAX @ ATL ($4,400)

Austin Hooper was in the midst of a career year before being derailed by an injury in Week 10. He's been underwhelming since returning to the Falcons lineup two weeks ago, but this is a great buy-low spot on the talented TE that is priced at just $4.4k, his lowest tag since Week 4. Hooper has been targeted six times in each of his last two games and is set to take on a Jacksonville defense that has flopped in a huge way this year for a Jags organization that appears to be in turmoil. Jacksonville is tied for the fourth-most TDs relinquished to the TE position and most likely just wants this season to be over. He has been dormant recently, but Hooper possesses as much upside as any tight end on this slate.

 

DraftKings DFS Defenses - Week 16 Picks

Denver Broncos Defense - DET @ DEN ($3,500)

Vic Fangio's first year as head coach of the Broncos hasn't exactly been smooth sailing, but the defensive guru has kept Denver playing hard. Despite tons of injuries to this defensive unit, we know that the Broncos are always a capable unit at Mile High Stadium. That is especially true this week against a Lions team that has been spiraling down the drain since Matthew Stafford went down with an injury. The Broncos will get to square off against David Blough, who is 0-3 since taking over the Lions starting job. I look for Denver to force the inexperienced QB into some mistakes this week.

Washington Redskins Defense - NYG @ WAS ($2,800)

It doesn't really matter who ends up starting at QB for the Giants this week, I'll be comfortable saving salary with this Redskins unit in a home matchup. Washington has been competent on the defensive side of the ball...and that's truly all that's needed against this turnover-prone New York squad. The 'Skins have amassed 19 sacks over their last four games and should have no trouble adding to the tally against a Giants O-line that has struggled all season.

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Sam Merrill

Listed as Questionable for Thursday
Geno Smith

Frank Reich Says Geno Smith is the "Perfect Fit" for his Offense
Aaron Rodgers

Cardinals Interest in Aaron Rodgers Isn't Real
Luke Kennard

Tagged as Questionable for Game 2 Against Thunder
Travis Hunter

Expected to Play Both Ways in Year 2
Jarred Vanderbilt

Considered Doubtful for Thursday
Jalen Williams

Still Out Thursday
Carter Bryant

Available Wednesday Night
Luka Dončić

Luka Doncic Reveals Recovery Timeline
Anthony Edwards

Cleared for Game 2 Against Spurs
Mitchell Robinson

is Ruled Out for Game 2 on Wednesday
Kevin Huerter

is Doubtful for Game 2 on Thursday
Brandon Miller

has Successful Shoulder Surgery
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Ayo Dosunmu

is Cleared to Play in Game 2
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Joel Embiid

is Downgraded to Out for Game 2
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Nils Hoglander

Will Miss World Championship Due to Injury
Christian Dvorak

Likely to Play in Game 3 Against Hurricanes
Owen Tippett

a Game-Time Decision Thursday
Noah Cates

to Miss Rest of Round 2
Arber Xhekaj

Rejoins Canadiens Lineup Wednesday
Brendan Gallagher

Scratched on Wednesday
Logan Stanley

Returns to Action Wednesday
Framber Valdez

Suspended Six Games
Tyler Glasnow

Exits Early on Wednesday With Back Pain
Russell Wilson

Jets Offer a Contract to Russell Wilson
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
C.J. Stroud

Makes Changes to his Diet as he Looks to Bounce Back
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
Bhayshul Tuten

the Preferred Dynasty Running Back in Jacksonville?
CFB

Tanook Hines Stepping into WR1 Role for USC
De'Zhaun Stribling

49ers See Something Special in De'Zhaun Stribling
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Brandon Woodruff

has Fluid Drained From his Right Shoulder
Brandon Woodruff

to Resume Throwing on Saturday, Return Imminent?
Joe Mixon

Remains an Enormous Question Mark
RJ Harvey

Still the Leader in a Crowded Backfield?
Carlos Correa

to Have Season-Ending Ankle Surgery
Baker Mayfield

Looking to Bounce Back in Contract Year
Brian Robinson Jr.

a Dynasty Target as Handcuff with Standalone Upside
Sam LaPorta

Remains an Intriguing Dynasty Target Post-Injury
Minnesota Vikings

Vikings Request to Interview Terrance Gray for GM Job
Kenneth Walker III

Could be More Involved as Pass-Catcher With Chiefs
Jacob Misiorowski

Listed as Friday's Probable Starter
Logan Webb

Dealing With Knee Discomfort
Carlos Correa

Expected to Miss Significant Time With Ankle Injury
Collin Morikawa

Withdraws From Truist Championship
Jakobi Meyers

Is Jakobi Meyers the Most Mispriced Jaguars Receiver in Dynasty Leagues?
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Jayden Higgins

How Much Growth Can be Expected of Jayden Higgins in Year 2?
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
D'Andre Swift

an Underrated Dynasty Buy for Contending Managers
Adam Scott

Brings Strong Form to Quail Hollow
Woody Marks

A Role Change Could Be Key to Salvaging Woody Marks' Dynasty Value
Robert MacIntyre

a Steady Option at Truist Championship
Ray Davis

Offers Almost No Standalone Value as a Fading Dynasty Asset
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Chet Holmgren

Leads Thunder to Victory in Game 1 Against Lakers
LeBron James

Scores Game-High 27 Points in Tuesday's Loss
James Harden

Finishes Game 1 Loss With 22 Points
Cade Cunningham

Posts 23 Points in Game 1 Win
Jalen Duren

Records Second Consecutive Double-Double
Sam Merrill

Status Unclear for Game 2
Jarred Vanderbilt

Dislocates Finger in Game 1 Loss
Mats Zuccarello

Extends Point Streak to Five Games
Kirill Kaprizov

Nets Third Playoff Goal
Scott Wedgewood

Returns to Form in Game 2 Against Wild
Gabriel Landeskog

Picks Up Two Power-Play Points Tuesday
Martin Necas

Has Second Straight Multi-Point Outing
Nathan MacKinnon

Joins Exclusive List With Another Three-Point Performance
TOR

Maple Leafs Win Draft Lottery
Emilio Pagán

Emilio Pagan Headed for Injured List With Hamstring Injury
Stefon Diggs

Found Not Guilty of Assault, Strangulation
Emilio Pagán

Emilio Pagan Carted Off With Apparent Hamstring Injury on Tuesday
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Merrill

Heads to Locker Room in Game 1
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Anthony Edwards

Iffy for Game 2
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
MLB

Cardinals-Brewers Game Postponed on Tuesday
Roman Anthony

Day-to-Day With Wrist Sprain
Radko Gudas

to Remain Sidelined Wednesday
Sam Carrick

Upgraded to Day-to-Day
Noah Cates

Considered Day-to-Day
Alexander Nikishin

Cleared to Play in Game 3 Against Flyers
Josh Manson

Expected to Remain Out Tuesday
Filip Gustavsson

Starting Game 2 Against Avalanche
Victor Hedman

Reveals Reason for Absence
Travis Kelce

Dynasty Value Fading Entering 2026
Jacob Misiorowski

"All Things Look Good" for Jacob Misiorowski to Start on Wednesday
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
MLB

Rockies-Mets Game Postponed Due to Inclement Weather
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
Raisel Iglesias

Braves Officially Reinstate Raisel Iglesias From Injured List on Tuesday
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
Roman Anthony

Pulled Early on Monday After Tweaking his Wrist
Jhoan Duran

to Come Off the Injured List on Tuesday
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
CFB

Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Tim Elliott

Drops Decision At UFC Perth
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
William Byron

Might have the Speed to Compete for the Win at Texas
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Tyler Reddick

One of the Favorites to Win at Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
NASCAR

Bubba Wallace Wrecks in Practice at Texas
Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF