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Deebo Samuel Sr. Not Expected to Practice on Wednesday

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Oct 21, 2026, 4:28 PM ET

San Francisco 49ers wide receiver Deebo Samuel Sr. (hamstring) is not expected to practice on Wednesday, per ESPN's Nick Wagoner. Samuel Sr. suffered a hamstring injury in Week 5 that sidelined him in San Francisco's Week 6 win over the Washington Commanders on Monday night. The initial diagnosis for the 30-year-old was a multi-week absence, so Samuel Sr. may be unlikely to play in Week 7 against the Atlanta Falcons as well. Across five games before getting injured, the veteran wideout collected 16 catches for 206 yards and three touchdowns on 20 targets and nine carries for 78 yards. The 49ers may also be without WR1 Mike Evans (Achilles) in Week 7, which would leave the team very shorthanded at wide receiver. If Samuel Sr. remains sidelined, San Francisco wideouts Brandin Cooks, Jordan Watkins, and Jacob Cowing are all candidates for larger workloads.--Will Brady
Source: ESPN - Nick Wagoner

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