September 14, 2025
Cincinnati Bengals rookie first-round defensive end Shemar Stewart (ankle) exited during the fourth quarter of Sunday's Week 2 contest against the Jacksonville Jaguars. He has been ruled out for the remainder of the game. The rookie finishes Week 2 with two tackles. With Stewart sidelined, Myles Murphy should earn more defensive snaps as a rotational piece behind Trey Hendrickson and Joseph Ossai.
--Andersen PickardSource: Cincinnati Bengals
September 14, 2025
Chicago Bears linebacker T.J. Edwards (hamstring) exited Sunday's game against the Detroit Lions and is officially doubtful to return. Edwards was dealing with a hamstring earlier this week, so it's possible that he re-aggravated that same injury. With Chicago trailing by multiple possessions, it's unlikely they'll try to get Edwards back into the contest. Assuming his day is done, he finishes Week 2 with four tackles. Noah Sewell should assume a larger role on defense for the duration of Edwards' absence.
--Andersen PickardSource: Chris Emma
September 14, 2025
Chicago Bears cornerback Jaylon Johnson (groin) has been ruled out for the remainder of Sunday's Week 2 contest against the Detroit Lions. The 26-year-old had been listed as questionable after exiting earlier in the contest. He finishes the game with a pair of tackles. Jaylon Jones and Nahshon Wright will earn more defensive snaps in Johnson's absence.
--Andersen PickardSource: Chris Emma
September 14, 2025
Indianapolis Colts defensive end Laiatu Latu (hamstring) is officially inactive for Sunday's Week 2 contest against the Denver Broncos. NFL Network's Ian Rapoport previously noted that Latu's injury is not believed to be serious, so his absence on Sunday likely indicates the Colts are erring on the side of caution. Samson Ebukam and Tyquan Lewis should earn more defensive snaps in Latu's absence.
--Andersen PickardSource: Stephen Holder
September 14, 2025
Seattle Seahawks cornerback Devon Witherspoon (knee) is officially inactive for Sunday's Week 2 contest against the Pittsburgh Steelers. His absence was widely expected; he missed all three practices this week and was listed as doubtful heading into the weekend. It's a crushing blow for the Seahawks' defense, especially as they prepare for a Steelers receiving corps led by old friend
DK Metcalf. Cornerback Josh Jobe, who allowed just one catch on five targets in Week 1, will likely step up as Witherspoon's replacement on defense.
--Andersen PickardSource: Seattle Seahawks PR
September 14, 2025
Detroit Lions safety Kerby Joseph (knee) is active for Sunday's Week 2 contest against the Chicago Bears. He had been listed as questionable after popping up on Friday's injury report as a limited participant. The 24-year-old played every defensive snap last week but registered just one tackle. He'll look to make a bigger impact this week, and we expect him to return to his 2024 form soon. Last season, he intercepted nine passes and was named a First-Team All-Pro.
--Andersen PickardSource: Detroit Lions
September 14, 2025
The Houston Texans defense actually played fairly well in their Week 1 loss to the Rams, but the offense couldn't get a single touchdown as the team fell, 14-9. The defense forced two turnovers and had three sacks against
Matthew Stafford, with Henry To'oTo'o, Will Anderson Jr., and Folorunso Fatukasi each recording a single sack. In Week 2, they'll face
Baker Mayfield and the Buccaneers on Monday Night Football, and in Week 1, the Bucs gave up just one sack with no turnovers against the Falcons. The Texans have a strong enough pass rush to still be a decent option, and they typically play low-scoring games under coach DeMeco Ryans. They are the No. 14 DST according to the RotoBaller rankings, making them a fringe start in most standard-sized leagues.
--Zach ThompsonSource: NFL.com
September 13, 2025
The Atlanta Falcons defense/special teams ranked in the bottom third in points allowed per game last season (24.9) and struggled to get after the quarterback, finishing with the second-fewest sacks in the NFL (31). Both issues were apparent in Week 1, as the Falcons yielded 23 points to the Buccaneers and sacked the opposing quarterback just once. The defense allowed
Baker Mayfield to toss three touchdown passes but did not record an interception, nor did the defense force any fumbles. The Falcons take on the Vikings on Sunday night, who have
J.J. McCarthy making just his second career start at quarterback, and who threw an interception in Week 1 while taking three sacks, but the Atlanta defense is not the Chicago defense. With Minnesota projected to score 24 points in this one as the favorites, there are many more favorable units to use in Week 2.
--Jarod RuppSource: ESPN
September 13, 2025
The Jacksonville Jaguars take on the Cincinnati Bengals in Week 2, which is bad news for both defenses. The Jaguars D/ST had a good Week 1, finishing with 11 fantasy points against
Bryce Young and the Carolina Panthers, but this week's matchup with
Joe Burrow and the Bengals should be much more difficult on paper. The Bengals do tend to struggle early in the season for whatever reason, but that isn't a risk worth taking, especially after
Ja'Marr Chase had a surprisingly quiet Week 1. Drop or leave the Jaguars D/ST on waivers if streaming a defense in Week 2.
--Seth Quinn - RotoBaller
September 13, 2025
The Los Angeles Chargers D/ST played well last week, beating last year's Super Bowl runner-up, the Kansas City Chiefs. They held their divisional rivals to just 21 points and limited their running backs to only 41 yards. This week, they face the Las Vegas Raiders and quarterback
Geno Smith, who threw for over 300 yards last week. Although Smith is less mobile than
Patrick Mahomes, the Raiders' offense remains strong. The Chargers' defense is steady, but with no turnovers and only one sack in Week 1, they might not offer the explosive upside fantasy managers look for in a D/ST. There could be better streaming options available this week as RotoBaller lists them as the D/ST16.
--Don FanelliSource: RotoBaller
September 13, 2025
The New York Jets defense/special teams gets an unideal matchup in Week 2 when they host the visiting Buffalo Bills at MetLife Stadium. Expectations were high for New York's defensive unit heading into Week 1, but ex-Jet
Aaron Rodgers erupted for a four-touchdown performance as the Steelers edged out a 34-32 win. Things won't be any easier this Sunday when
Josh Allen and the explosive Bills' offense take the field. New York did well to quiet Pittsburgh's rushing attack last weekend, but they didn't have to deal with a mobile quarterback. The Jets can succeed if they force Buffalo to be one-dimensional. However, they'll take a hit this week with the unfavorable matchup, coupled with their poor showing in the previous contest. The unit comes in as RotoBaller's DST31 ahead of Week 2.
--Alex CiullaSource: ESPN
September 13, 2025
The Los Angeles Rams defense/special teams is a top fantasy option for Week 2 against the Tennessee Titans. We've already seen Tennessee face plenty of growing pains, as they were embarrassed on the road last week against the Denver Broncos. In that contest, the Titans achieved just seven first downs, and rookie quarterback
Cameron Ward went 12-for-28 passing with six sacks. The Rams' defense had a solid showing of its own in the season opener, holding the Houston Texans to just nine points. We could be in for a very lopsided game this weekend as the Rams' high-end defense takes on the Titans' low-end offense. Los Angeles' D/ST should be started in all fantasy leagues on Sunday.
--Andersen PickardSource: RotoBaller
September 13, 2025
The New England Patriots defense/special teams is certainly on the fantasy radar for Week 2 against the Miami Dolphins. Miami was embarrassed by the Indianapolis Colts last weekend as
Tua Tagovailoa threw two interceptions and also lost a fumble. While Tagovailoa is historically better playing at home, where he'll be Sunday against New England, last week's atrocious showing against Indianapolis is still enough to sound the panic alarm within the Dolphins organization. Miami couldn't seem to get anything going, and New England has a strong chance to capitalize on that in Week 2, even with Christian Gonzalez (hamstring) sidelined. If the Patriots can rattle Tagovailoa early, they could end up forcing multiple turnovers while keeping Miami to single-digit points. This is a great spot for the Patriots D/ST.
--Andersen PickardSource: RotoBaller
September 13, 2025
The Arizona Cardinals defense/special teams heads into another great streaming opportunity after they were able to start the season against the shaky offense of the New Orleans Saints. The issue is that the Cardinals' defense couldn't quite capitalize to deliver a strong fantasy outing. They didn't force any turnovers and registered just one sack, even though they allowed only 13 points. Now, they take on the Carolina Panthers, who didn't show much growth in their first game against the Jacksonville Jaguars. That should be a great opportunity for this unit, but until the Cardinals' defense shows they can force some turnovers, there will likely be safer options out there.
--Alex Fischbein - RotoBallerSource: RotoBaller
September 13, 2025
The Denver Broncos' defense remains an elite fantasy option heading into Week 2. The unit, which finished as the No. 1 fantasy defense in 2024, dominated in its opener with a 20-12 win over Tennessee, racking up six sacks and two turnovers while finishing as the top-scoring D/ST of Week 1. This week, the Broncos face
Daniel Jones and the Indianapolis Colts, who looked explosive in their opener against Miami's bottom-tier defense. History suggests Jones struggles under heavy pressure, and Denver's pass rush is among the league's best. If the Broncos bring consistent heat, turnovers should follow. The Broncos D/ST is a must-start in all fantasy formats for Week 2.
--Nathan HarveySource: Pro Football Reference
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