September 14, 2025
Carolina Panthers left tackle Ikem Ekwonu (appendix) is officially active for Sunday's Week 2 contest against the Arizona Cardinals. The 24-year-old has spent several weeks recovering from an appendectomy and missed the Panthers' season opener, so Week 2 represents his season debut. Yosh Nijman (coach's decision) is inactive Sunday, somewhat surprisingly, which means Brady Christensen will operate as Ekwonu's backup.
--Andersen PickardSource: Joe Person
September 14, 2025
Pittsburgh Steelers edge rusher Alex Highsmith (ankle) has been ruled out for the remainder of his team's Week 2 game against the Seattle Seahawks due to an ankle injury. Highsmith is a key piece of Pittsburgh's pass rush opposite star edge rusher T.J. Watt. Without Highsmith, third-year edge rusher/linebacker Nick Herbig is likely to receive more playing time. Herbig had 5.5 sacks in 13 games last season for Pittsburgh.
--Will BradySource: ESPN - Brooke Pryor
September 14, 2025
Cincinnati Bengals quarterback
Joe Burrow (toe) is questionable to return to his team's Week 2 matchup against the Jacksonville Jaguars due to a toe injury, per Ian Rapoport of NFL.com. Burrow was taken into the locker room with assistance from trainers and was limping heavily. It remains to be seen whether Burrow will be able to return on Sunday, but the fact that he was not immediately ruled out by the team has to be considered a positive sign.
--Will BradySource: NFL.com - Ian Rapoport
September 14, 2025
Denver Broncos running back
Jaleel McLaughlin is a healthy scratch for his team's Week 2 game against the Indianapolis Colts. McLaughlin was also inactive in Week 1, so this decision from the team does not necessarily come as a surprise. Without McLaughlin, Denver will roll with the running back trio of
J.K. Dobbins,
RJ Harvey, and
Tyler Badie.
--Will BradySource: Denver Broncos
September 14, 2025
Detroit Lions tight end
Shane Zylstra (ankle) has been downgraded to out for the remainder of his team's Week 2 contest against the Chicago Bears. Zylstra is the Lions' third-string tight end behind
Sam LaPorta and
Brock Wright. His absence may mean a slight uptick in snaps for the remainder of Week 2 for LaPorta.
--Will BradySource: Detroit Lions
September 14, 2025
Chicago Bears cornerback Jaylon Johnson (groin) is questionable to return to his team's Week 2 matchup against the Detroit Lions due to a groin injury. Johnson missed Week 1 due to a groin injury, so this could be a re-aggravation of the existing ailment. Johnson is the Bears' top cover corner, so his absence would make life considerably easier for Lions quarterback
Jared Goff and the rest of the Detroit passing game.
--Will BradySource: Chicago Bears
September 14, 2025
Pittsburgh Steelers edge rusher Alex Highsmith (ankle) is doubtful to return to his team's Week 2 matchup against the Seattle Seahawks due to an ankle injury. Highsmith is a key piece of the Steelers' pass rush, recording 28.5 sacks in 46 games since the start of 2022. If he is unable to return, the job on Sunday will get easier for Seahawks quarterback
Sam Darnold and the rest of the Seattle pass game.
--Will BradySource: Pittsburgh Post-Gazette - Ray Fittipaldo
September 14, 2025
Cincinnati Bengals quarterback
Joe Burrow (leg) was taken to the locker room on Sunday due to an apparent left leg injury. Burrow was limping heavily and required assistance from the training staff to get off the field. More will be known about the injury once the team releases an official update, but a Burrow injury would obviously be a massive blow for both fantasy managers and the Bengals' offense.
--Will BradySource: CBS - Jonathan Jones
September 14, 2025
San Francisco 49ers fullback
Kyle Juszczyk (concussion) has been ruled out for the remainder of his team's Week 2 game against the New Orleans Saints. Juszczyk is a key piece of the San Francisco offense as both a blocker and receiver. The 49ers entered the game already without quarterback
Brock Purdy (toe), tight end
George Kittle (hamstring), and wide receiver
Brandon Aiyuk (knee). Juszczyk's absence may create even more reason for San Francisco to get the ball in the hands of star running back
Christian McCaffrey.
--Will BradySource: San Francisco 49ers
September 14, 2025
The Cleveland Browns announced that wide receiver
DeAndre Carter (concussion) will not return to Sunday's game against Baltimore due to the injury. The veteran made the team out of training camp largely because of his special teams contributions. Primarily the team's kick returner, the absence will leave Cleveland without one of its key special teamers for the rest of the game.
--Nick PiotrowiczSource: Cleveland Browns
September 14, 2025
The Baltimore Ravens have ruled out running back
Rasheen Ali (concussion) from returning to Sunday's game against the Cleveland Browns. A key special teamer for the Ravens will be out of the picture for at least the rest of this week. Additionally, Baltimore did not activate running back
Keaton Mitchell ahead of the game, so the club has only its top two running backs,
Derrick Henry and
Justice Hill, available for the remainder of Sunday.
--Nick PiotrowiczSource: Brian Wacker
September 14, 2025
The Buffalo Bills can exhale after quarterback
Josh Allen (nose) has returned to the game against the New York Jets after taking a shot to the face. The superstar QB departed the game after being bloodied when he was sandwiched between two Jets defenders, a collision that popped him in the nose. Allen wasn't out for long, though, as the Bills' medical staff put gauze up one nostril and got back him on the field. Fantasy managers rostering the QB1 can forge ahead as usual.
--Nick PiotrowiczSource: Tom Pelissero
September 14, 2025
The Detroit Lions said tight end
Shane Zylstra (ankle) is questionable to return to the game Sunday against the Chicago Bears. The reserve came off the field with a bit of a limp after sustaining the injury, which could leave the Lions without a key special teamer. From a fantasy perspective, Zylstra is pretty far off the radar with starting tight end
Sam LaPorta handling the vast majority of the receiving work.
--Nick PiotrowiczSource: Detroit Lions
September 14, 2025
Baltimore Ravens running back
Rasheen Ali (concussion) is being further evaluated after taking a blow to the head on Sunday against the Cleveland Browns, the team announced. Ravens running back
Keaton Mitchell is inactive again for Baltimore, so the team is temporarily down to just
Derrick Henry and
Justice Hill at running back. Ali, also a special teamer for the Ravens, is mostly on the back burner from a fantasy perspective due to a lack of carries behind Henry and quarterback in
Lamar Jackson.
--Nick PiotrowiczSource: Baltimore Ravens
September 14, 2025
The Cleveland Browns said wide receiver
DeAndre Carter (concussion) left Sunday's game against the Baltimore Ravens to be evaluated in the locker room. The veteran does not have a target yet this season, as his primary role for Cleveland is to be a return man, so the Browns likely will have to look elsewhere if he misses any time. In any case, Carter doesn't hold much fantasy value outside of leagues of that have a designated kick returner spot.
--Nick PiotrowiczSource: Cleveland Browns
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