September 14, 2025
San Francisco 49ers left tackle Trent Williams (knee) is officially active for Sunday's Week 2 contest against the New Orleans Saints. He had been listed as questionable, and while there was some concern after he missed two practices this week, he was able to return in a limited capacity on Friday. Now, after testing his knee during pregame warmups Sunday, Williams is good to go. His presence will be key for the 49ers as he works to protect the backfield, as well as quarterback
Mac Jones' blindside. Williams being active is refreshing for the 49ers and their fans, who haven't received very much good news on the injury front lately.
Brandon Aiyuk (knee) opened the season on IR, and now
George Kittle (hamstring) and
Brock Purdy (shoulder) are both expected to miss time. This offense should run through
Christian McCaffrey, which is one of many reasons why it's good for the 49ers that Williams is active.
--Andersen PickardSource: San Francisco 49ers
September 14, 2025
Tennessee Titans rookie running back
Kalel Mullings (ankle) has officially been ruled out of Week 2 against the visiting Los Angeles Rams on Sunday. Mullings made his NFL debut in last week's loss to the Denver Broncos as the RB3 behind
Tony Pollard and
Julius Chestnut, but was quickly injured in the first half on special teams. The 22-year-old sixth-rounder didn't see a single touch on offense in the 20-12 loss in Denver. With
Tyjae Spears (ankle) on Injured Reserve and set to miss at least the first four weeks of the season, Tennessee's backfield depth behind Pollard and Chestnut is dangerously thin. Now that Mullings is out, the Titans were forced to bring up
Jordan Mims from the practice squad for Sunday's game against the Rams. He'll operate as the team's No. 3 RB in Week 2.
--Keith HernandezSource: Titans PR
September 14, 2025
Dallas Cowboys running back
Jaydon Blue (coach's decision) is inactive for Sunday's Week 2 contest against the New York Giants. The fifth-round rookie has now been a healthy scratch for each of the Cowboys' first two games of the season. In his absence,
Miles Sanders will serve as the backup running back behind
Javonte Williams. Sanders and Williams are the Cowboys' only two active running backs, but fullback
Hunter Luepke should also see some blocking work in the backfield. Fantasy managers in deeper leagues should be patient with Blue and hold onto him, as it's likely only a matter of time before he's active as the No. 3 running back or leapfrogs Miles Sanders for the backup job.
--Andersen PickardSource: Nick Harris
September 14, 2025
New York Giants left tackle Andrew Thomas (foot) is officially inactive for Sunday's game against the Dallas Cowboys. While Thomas did manage to log two limited practices this week, he still wasn't expected to play as the Giants listed him as doubtful. Thomas missed the season opener, too, so this is his second consecutive absence. James Hudson III will step in as the Giants' starting left tackle as New York looks to slow down Dallas' defense in a divisional rivalry contest.
--Andersen PickardSource: Dan Salomone
September 14, 2025
New York Giants wide receiver
Wan'Dale Robinson (ankle) is officially active for Sunday's Week 2 contest against the Dallas Cowboys. He had been listed as questionable after practicing in a limited capacity on Friday. Having Robinson available will be key for the Giants, as he's their second-best option in the passing game behind
Malik Nabers. The 24-year-old was productive in last week's season opener, catching six of eight targets for 55 yards. He should continue to deliver similar productivity this week against the Cowboys, as the Giants are expected to throw the ball a lot while playing from behind. He ranks as a mid-range WR3/flex, especially in PPR leagues.
--Andersen PickardSource: Dan Salomone
September 14, 2025
Chicago Bears wide receiver
Jahdae Walker (ankle) is officially inactive for Sunday's Week 2 contest against the Detroit Lions. He had been listed as doubtful after missing practice on Friday. The 23-year-old did suit up in last week's season opener, but he only played on special teams. Chicago should have no trouble replacing him on special teams this week, and his absence has no impact on the Bears' offense or fantasy managers' lineups.
--Andersen PickardSource: Chicago Bears
September 14, 2025
For the second straight week to begin the 2025 season, Cincinnati Bengals wide receiver
Jermaine Burton is a healthy inactive for the Week 2 contest against the Jacksonville Jaguars. Burton had a pretty rough rookie season in 2024 that involved some maturity issues, but he got rave reviews during training camp in the summer. For now, though,
Charlie Jones is ahead of him as the team's WR4 behind
Ja'Marr Chase,
Tee Higgins, and
Andrei Iosivas. The 24-year-old former third-rounder caught four passes for 107 yards on 14 targets in 14 games in his rookie season. Burton isn't anywhere close to the fantasy radar in redraft leagues right now.
--Keith HernandezSource: Cincinnati Bengals
September 14, 2025
Detroit Lions safety Kerby Joseph (knee) is active for Sunday's Week 2 contest against the Chicago Bears. He had been listed as questionable after popping up on Friday's injury report as a limited participant. The 24-year-old played every defensive snap last week but registered just one tackle. He'll look to make a bigger impact this week, and we expect him to return to his 2024 form soon. Last season, he intercepted nine passes and was named a First-Team All-Pro.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Detroit Lions running back
Sione Vaki (hamstring) is officially inactive for Sunday's Week 2 contest against the Chicago Bears. He was limited in practice this week but was not expected to play after the Lions listed him as doubtful. The 24-year-old played in 16 games last year, totaling 51 scrimmage yards, but has not yet stepped on the field in his second pro campaign.
Craig Reynolds will continue to operate as the Lions' No. 3 running back behind
Jahmyr Gibbs and
David Montgomery.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Detroit Lions left tackle Taylor Decker (shoulder) is active for Sunday's Week 2 contest against the Chicago Bears. Decker had been listed as questionable, and there was some concern about his availability after he didn't practice this past week. However, in the end, the veteran lineman is healthy enough to suit up. His presence will be quite impactful for the Lions' offensive line as they look to protect
Jared Goff,
Jahmyr Gibbs, and
David Montgomery on Sunday. Decker played all 67 snaps last week, allowing one sack.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Cleveland Browns rookie running back
Quinshon Judkins is slated to see 10-15 snaps in his NFL debut on Sunday. While Judkins was able to practice with the team leading up to this contest against the Ravens, it appears the Browns will closely monitor his workload in this game. Judkins was unable to play in the preseason and participate in training camp as he was facing domestic violence charges. While his prosecutors eventually dropped their charges, he could still face a suspension from the league. However, for now, Judkins should remain a key part of the Cleveland backfield. In Week 1, the Browns relied on fellow rookie
Dylan Sampson and veteran
Jerome Ford. With Judkins now returning, managers should expect Sampson to remain the lead option, with Judkins seeing a few opportunities in short-yardage situations. As a result, Sampson still holds flex appeal while Judkins is a touchdown-dependent high-risk RB3.
--Andy SmithSource: Ian Rapoport
September 14, 2025
New Orleans Saints right tackle Taliese Fuaga (knee) is officially active for Sunday's Week 2 contest against the San Francisco 49ers. He had been listed as questionable but was trending in the right direction prior to gameday. Fuaga has started all 18 games since being drafted, allowing seven sacks and 43 pressures through 1,116 offensive snaps. He'll look to protect
Spencer Rattler and
Alvin Kamara from the impact of a strong 49ers defense.
--Andersen PickardSource: New Orleans Saints
September 14, 2025
San Francisco 49ers wide receiver
Jauan Jennings (shoulder) is officially active for Week 2 against the New Orleans Saints. Jennings had been listed as questionable, but there was increased optimism about his status heading into gameday. The shoulder issue limited Jennings to just 66 percent of the offensive snaps last Sunday as he caught two of five targets for 16 yards. This week, he'll be playing with a quarterback downgrade as
Mac Jones steps in for the injured
Brock Purdy (shoulder). Jones still has a solid arm, and a favorable matchup against the Saints bodes well for Jennings. Plus, the 49ers will also be without
George Kittle (hamstring), creating several vacated targets that could go Jennings' way. He's a solid WR3/flex option this week.
--Andersen PickardSource: Matt Maiocco
September 14, 2025
Los Angeles Rams tight end
Colby Parkinson (shoulder) is officially inactive for Sunday's Week 2 contest against the Tennessee Titans. He had been listed as doubtful after missing all three practices leading up to this weekend's game. Parkinson is working his way back from an AC joint sprain that he suffered last Sunday against the Houston Texans. Parkinson was actually able to finish last week's game after receiving medical attention, but evidently, the Rams aren't going to send him onto the field for Week 2.
Terrance Ferguson is active for his NFL debut and will assist in filling Parkinson's void alongside a tight end committee that also features
Tyler Higbee and
Davis Allen. None of these Rams tight ends can be trusted in fantasy football, but Ferguson is an intriguing stash in dynasty leagues.
--Andersen PickardSource: Gary Klein
September 14, 2025
According to Ian Rapoport of the NFL Network, Kansas City Chiefs wide receiver
Xavier Worthy (shoulder) is hoping to return next week when the Chiefs face the New York Giants. Rapoport noted that if Worthy can suit up, he would be playing with a torn labrum. However, the star wideout intends to wear a harness if he were to play. This week, Worthy was able to return to practice, which is an excellent sign that he is nearing a return. The second-year wideout suffered this injury during the opening possession of the first game of the season against the Chargers. As a rookie, Worthy flashed big-play upside in the Kansas City offense, totaling nine touchdowns with over 700 yards from scrimmage. This weekend,
Marquise Brown and
JuJu Smith-Schuster figure to lead the passing attack.
--Andy SmithSource: Ian Rapoport
RADIO
