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The Tennessee Titans' defense has been fairly average through the first two weeks of 2025, but context matters. They've already generated five turnovers and two sacks as they've faced tough matchups against the Denver Broncos in Week 1 and the Los Angeles Rams in Week 2. Unfortunately, things don't get easier in Week 3. The Titans draw a red-hot Indianapolis Colts offense led by Daniel Jones, who just shredded Denver's elite defense for 29 points and 473 yards without a turnover. While Tennessee's defense may become a useful fantasy option later in the season, this is another matchup to avoid. They're firmly in the must-sit category for Week 3.--Nathan Harvey
Source: Pro Football Reference
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Tyler Warren

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