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Is Joe Mixon out for the season? When is Joe Mixon coming back? The latest Joe Mixon injury update and fantasy football outlook heading into Week 2 of 2025.
Houston Texans running back Joe Mixon spent the entire 204 season working as the primary workhorse in the Houston backfield. Mixon enjoyed a productive campaign but has been dealing with injuries to begin 2025.
Shortly before the regular season, the Texans placed Mixon on the NFI-reserve list due to a foot injury, which will keep him sidelined for at least the first four games. However, the team has not provided many updates since shifting him to the reserve list.
Will Mixon play again this season? Should fantasy managers stash him on their bench? Let's dive in!
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Is Joe Mixon Out for the 2025 Season?
Even though Mixon will miss the first four games of this season, the veteran running back appears to be in serious danger of missing the vast majority of the season.
When asked about his long-term availability this season, Texans general manager Nick Caserio did not provide much detail, which is not a positive sign. While Mixon could eventually return to practice, seeing that the front office does not have a defined timetable suggests that Mixon will likely miss the majority of the upcoming season.
In fact, given his current status, Mixon could be in danger of sitting out the entire season. Seeing that he has yet to take the practical field, even in a limited capacity, does not bode well for his fantasy outlook this season.
Texans Have No Update on Joe Mixon https://t.co/FnFvmajOoH
— RotoBaller NFL (@RotoBallerNFL) August 25, 2025
Joe Mixon 2025 Fantasy Football Outlook
Fantasy managers should continue to monitor his status, but should begin to look for an alternative solution if they are waiting for Mixon to return. Given that the team has not provided any definitive update on his status, this injury could limit him throughout the remainder of the season.
In Week 1, the Texans ended heavily on veteran Nick Chubb, who signed to a one-year deal in the offseason. Dameon Pierce, Dare Ogunbowale, and rookie Woody Marks filed as the depth options behind the former Brown.
Despite not being the most effective runner in the league (4.1 YPC), Mixon was still a strong RB2 in all leagues last season, as he posted his second-straight 1,000-yard campaign, totaling 1,016 yards and 11 touchdowns on 245 carries. In the receiving game, Mixon added 309 yards with another touchdown.
Managers looking to add a running back in Houston to their roster should prioritize Chubb, as he appears to be the team's primary solution to their lead role. However, Pierce, Ogunbowale, and Marks could eventually see a larger role as Chubb has already dealt with numerous injuries throughout his career.
Managers in shallow leagues without IR spots should feel comfortable dropping Mixon this week. While he is fine stash in leagues that have IR spots, managers should instead opt to use that spot on players with a more defined timeline, like Brandon Aiyuk (knee), George Kittle (hamstring), or Jalen Coker (quadriceps).
Nick Chubb Worth a Pickup After Handling 62 Percent of RB Carries https://t.co/DoVHD77R66
— RotoBaller NFL (@RotoBallerNFL) September 9, 2025
Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
Compare up to four players and we'll tell you who to start...
Who Should I Start? Who Should I Sit? Some common Week 2 fantasy football lineup decisions are regarding players like Zach Charbonnet, Nick Chubb, Tyrone Tracy Jr., Austin Ekeler, David Montgomery, Dylan Sampson. But not to worry, we are here to help make these decisions and build winning lineups in Week 2. Set your optimal fantasy football lineups for Week 2 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Week 2 Player Decisions. Today's focus is on specific players - Zach Charbonnet, Nick Chubb, Tyrone Tracy Jr., Austin Ekeler, David Montgomery, Dylan Sampson. These are some of the most common searches for fantasy football lineups in Week 2.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 2 Searches. Curious to see some tough lineup decisions for Week 2 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 2 Searches - Start/Sit Player Comparisons
Below are some popular Week 2 searches and comparisons from our 'Who To Start' tool for Zach Charbonnet, Nick Chubb, Tyrone Tracy Jr., Austin Ekeler, David Montgomery, Dylan Sampson compared to others:
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