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Tight end George Kittle enters the 2025 season as one of the premier fantasy options at his position. In 2024, Kittle led the 49ers in receptions, receiving yards, and receiving touchdowns with a 78-1,106-8 line. His 10.6 fantasy points per game led all tight ends last season. Kittle will again operate as one of Brock Purdy's top pass-catching options in an attack that lost Deebo Samuel via trade and Brandon Aiyuk (knee) to the PUP list. San Francisco opens the season against the Seahawks, against whom Kittle recorded five catches for 58 yards and two touchdowns in Week 6 last season. He is a must-start and a favorite for a top-3 finish in Week 1.--Dan Stephens
Source: NFL.com
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