EPL DFS Lineup Picks for DraftKings And FanDuel (11/22/25) - English Premier League Soccer Matchweek 12

Brandon's DraftKings and FanDuel EPL DFS lineup picks for English Premier League Soccer on 11/22/25 (Matchweek 12). His top daily fantasy soccer forwards, midfielders, defenders, goalkeepers.

Welcome back to "The Kick-Off," and welcome to the 2025-2026 season! Another International Break has come and gone with some inspiring outcomes. Scotland’s Troy Parrott scored a hat-trick in the final seconds of the match to qualify Scotland for the World Cup for the first time since 1998, and Curacao became the smallest country to ever qualify for a World Cup. Let's knock off Matchweek Twelve!

The top favorite for this week is Liverpool FC (-240) vs. Nottingham Forest (+600). I will guide you through this five-match slate starting at 10:00 A.M. EST on Saturday, November 22.

If you have any questions on today's slate, bankroll management, GPP strategy, Cash game strategy, or anything else, don't hesitate to contact me at [email protected], via X @df_solutions, or in our Discord chat rooms.

EPL DFS Goalies

Robin Roefs - DK $4.3K || FD $10

Opponent - at Fulham FC

Robin Roefs has been Mr Optimal this season, and that is still the storyline heading to Craven Cottage. In his most recent five domestic appearances, he has made 19 saves, conceded six goals, and recorded one clean sheet. In that timeframe, he produced fewer than five fantasy points twice and also produced double-digit fantasy points twice.

Fulham FC is not the optimal club to attack on this slate for a poor offense, however, they are the third-best. In their last five domestic fixtures, they are the sixth-worst in Goals Per 90, and they sit just outside the bottom-ten in Shots Per 90. This will ultimately come down to whether Roefs can stop the minimal shots he will face.                                                                         

Others To Consider (CASH/GPP):

• Đorđe Petrović (DK $5.6K || FD $12) vs. West Ham United
• Matz Sels (DK $3.9K || FD $7) at Liverpool FC

This save 😱

If the Premier League had an award for best new artist, Robin Roefs would be among the frontrunners 🐈‍⬛ pic.twitter.com/fRfLwjZQdC

— Men in Blazers (@MenInBlazers) October 4, 2025

EPL DFS Forwards

Mohamed Salah - DK $9.2K || FD $22

Opponent - vs. Nottingham Forest

Speaking of clubs with a poor attack, enter Liverpool forward Mohamed Salah. Salah has struggled this season, and this is not new to anyone following Liverpool. He has picked up form, though, in his last five fixtures in all competitions. In his four starts and one brief moment off the bench, he has registered two goals, 16 shots, seven chances created, 14 crosses, three corners, four tackles, two interceptions, and one clearance.

If there is any time to continue his newly found form, it is at home against Nottingham Forest. The visitors from a Per 90 against viewpoint are the worst in Goals, bottom-five in Chances Created and Shots, and bottom-ten in Big Chances Created and In-the-Box Shots in their last five domestic matches. The Tricky Trees are fighting valiantly to stay in the top flight, but they are due for a heavy negative regression. Considering Salah’s new role on set pieces and his potential ceiling in a prime matchup, he is one of the optimal forwards on the slate.            

Others To Consider (CASH/GPP): 

• Antoine Semenyo (DK $12K || FD $21) vs. West Ham United
• Dango Ouattara (DK $6.7K || FD $16) at Brighton & Hove Albion

EPL DFS Midfielders

Yéremy Pino - DK $3.8K || FD $13

Opponent - at Wolverhampton FC

Did someone say optimal? Yéremy Pino may not be the most reliable set piece taker in the English Premier League, but he is involved enough to warrant his spot in a lineup. In the attacking midfielder’s last five domestic appearances–four starts–he has produced five shots, five chances created, 15 crosses, eight corners, seven tackles, and two clearances. The goal for Pino is to reach value, and he should have several opportunities to do that against the lackluster Wolves.

Wolverhampton is struggling in every facet of the game this season. They have the fewest goals scored and the most goals conceded through 11 matchweeks. Furthermore, from a Per 90 against viewpoint in their most recent five matchweeks, they are bottom-ten in Goals, Shots, and Created Chances. With how well Crystal Palace’s offense is clicking right now, it wouldn’t be out of the question for Pino to push past his expected ceiling.                                                                      

Others To Consider (CASH/GPP): 

• Mikkel Damsgaard (DK $7.6K || FD $18) at Brighton & Hove Albion
• Marcus Tavernier (DK $6.8K || FD $17) vs. West Ham United

Yeremy Pino capping off a fine evening in Liverpool 🇪🇸 pic.twitter.com/F3HpLQvidr

— Crystal Palace F.C. (@CPFC) October 30, 2025

EPL DFS Defenders

Defenders

Neco Williams - DK $6.4K || FD $12

Opponent - at Liverpool FC

If there is one player that is a guaranteed ‘LOCK’ in ‘CASH’ type contests this weekend, it is Neco Williams. The versatile wingback is one of the main reasons the Tricky Trees continue to crawl toward safety. Throughout his last five domestic fixtures, he has amassed five shots, five chances created, 21 crosses, six corners, 18 tackles, six interceptions, 13 clearances, and two blocks.

Both Nottingham Forest and Liverpool are performing below expectations right now, and this could turn into a track meet with very few goals. Nevertheless, Williams will be heavily involved throughout the 90 minutes and will have many opportunities to produce at both ends of the pitch. If you include his recent role on set pieces, he becomes invaluable, even as the highest-salaried defender on the slate.                                                               

Others To Consider (CASH/GPP): 

• Trai Hume (DK $5.1K || FD $12) at Fulham FC
• Tyrick Mitchell (DK $4.6K || FD $13) at Wolverhampton FC

Corner Takers

• AFC Bournemouth: Alex Scott/Marcus Tavernier
• West Ham United: Freddie Potts
• Brighton & Hove Albion: Yankuba Minteh/Ferdi Kadıoğlu
• Brentford FC: Mikkel Damsgaard/Dango Ouattara
• Fulham FC: Harry Wilson/Kevin
• Sunderland AFC: Granit Xhaka/Trai Hume
• Liverpool FC: Dominik Szoboszlai/Cody Gakpo/Mohamed Salah
• Nottingham Forest FC: Neco Williams/Elliot Anderson
• Wolverhampton FC: Jhon Arias/Hugo Bueno
• Crystal Palace: Yéremy Pino/Daichi Kamada/Adam Wharton

Thanks for reading The Kick-Off. Good luck in all of your contests today!

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