X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

Should I Start Isaac Guerendo in Week 15? Fantasy Football Start 'Em, Sit 'Em Picks

San Francisco 49ers - Niners NFL Logo Stock

Should I start or sit Isaac Guerendo for fantasy football in Week 15? Read our fantasy football start 'em, sit 'em picks and fantasy lineup recommendations.

San Francisco 49ers running back Isaac Guerendo (foot) is dealing with a foot injury, but has shown incredible potential in his limited action this season. Due to injuries to the other backs on the team's roster, he's been thrust into a starting role, and he's immediately capitalized on it. 

The first-year player from Louisville has already made it clear that he's extremely athletically gifted, and that talent has translated into immediate production. In his first game with the two RBs ahead of him on the roster injured, he rushed 15 times for 78 yards and two touchdowns and caught both of his targets for 50 receiving yards.

So, what is Guerendo's fantasy football outlook moving forward? Should you start him in Week 15?

Be sure to check all of our fantasy football rankings for 2025:

 

Isaac Guerendo Fantasy Football Outlook

Guerendo is dealing with a foot injury right now, but preliminary indications are that it's not serious. He's actually expected to play on Thursday Night Football.

His fantasy football outlook is very simple -- he can win you your leagues. He was completely overlooked in this year's NFL Draft despite incredibly physical talent he possesses, and he's underrated in the other areas of his game, like vision, patience, anticipation, and decision-making.

Guerendo is simply a better player than 2nd-stringer Jordan Mason (ankle) and Christian McCaffrey (knee) dealing with the after-effects of Achilles tendonitis. It didn't take much time to realize that. In the NFL, speed kills, and the rookie has incredible acceleration to go along with excellent size.

Sometimes it really is that simple. The most athletically gifted RB to come out of college in many years in a good offensive system can smash. He's able to burst through the smallest creases, outrun the inside-crashing linebackers, and get to the second level often. Sometimes, it seems like every carry is a guaranteed 4-6 yards.

 

Should I Start Isaac Guerendo in Week 15?

Update 12/12 7 pm: Isaac Guerendo is officially active for Thursday Night Football.

Yes, you should start him. In general, extremely athletic running backs with great acceleration in Shanahan-esque offensive systems are absolute dynamite. It's strange that he didn't get more opportunities this season. It's been apparent since the first game he got significant touches in that he could be a league-winner.

Of course, in fantasy football, it's easy to write off rookies, and dismiss people who rightfully brand a freshman player a "league-winner" as too hasty, crazy, etc. But 26.8 PPR fantasy points on 56% of the team's offensive snaps is not something you can argue with. Guerendo is a league-winner and has played better than both Mason and McCaffrey this season. Start him.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis

POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

REAL-TIME FANTASY NEWS

Nate Landwehr

Aims To Bounce Back
MMA

Austen Lane Looks To Get Back In The Win Column
Vitor Petrino

Set For His Heavyweight Debut
Tuco Tokkos

Set To Open Up UFC Nashville Main Card
Junior Tafa

Set For Light-Heavyweight Bout
Alex Bregman

Will Return to Red Sox This Weekend
Chris Sale

Braves Won't Consider Trading Chris Sale
Clarke Schmidt

to Undergo Season-Ending Elbow Surgery on Friday
Nick Nash

Unlikely to Make Falcons Active Roster
Lane Johnson

in No Rush To Retire
Jalen Williams

Signs Contract Extension With Thunder
Blake Corum

has "Gotten His Speed Back"
Jarquez Hunter

Picking Up Rams Offense Quickly
Alijah Martin

Agrees to Two-Way Deal With Raptors
Tristan Vukcevic

Set to Return to Washington
Kirk Cousins

Feels Misled by Falcons
Bijan Robinson

Says Falcons Have "Outlandish Goals" for the Running Game
Luther Burden III

Bears Expect Luther Burden III to be Ready for Training Camp
Cole Kmet

an Unlikely Trade Piece
Tony Pollard

Titans Hope to Balance Rushing Attack With Tony Pollard, Tyjae Spears
Byron Buxton

Sitting Thursday
Quentin Johnston

Not Assured of Starting Role
Cordarrelle Patterson

on the Roster Bubble in Pittsburgh?
Shedeur Sanders

Not Assured of Roster Spot in Cleveland?
Wan'Dale Robinson

Hoping For More Downfield Opportunities
Anfernee Simons

Celtics Are "Actively Trying to Trade" Anfernee Simons
NBA

Alex Ducas Heading to Australia
Dominick Barlow

Inks Two-Way Deal With 76ers
Jordan McLaughlin

Spurs Re-Sign Jordan McLaughlin to One-Year Deal
Dylan Harper

Out Thursday, Expected to Play Saturday
Ronald Acuña Jr.

Ronald Acuna Jr. Homers Twice on Wednesday
Mike Trout

Homers Twice in Win Over Rangers
Jazz Chisholm Jr.

Leads Yankees to Victory
Salvador Perez

Crushes Two Homers in Win
Cleveland Browns

Greg Newsome on the Trade Block?
VJ Edgecombe

Diagnosed with a Sprained Thumb
Zach Tom

An Extension Candidate in Green Bay
Devin Booker

Agrees to Extension with Phoenix
Trevor Williams

to Undergo Season-Ending Elbow Surgery
Kyren Williams

Rams Not Willing to Pay Kyren Williams Top-Market Money?
Byron Buxton

Exits After Hit-by-Pitch, X-Rays Negative
Ronald Acuña Jr.

Ronald Acuna Jr. Playing on Wednesday
Alex Bregman

has "Really Good Chance" to Return Before All-Star Break
Christian Kirk

the No. 2 WR in Houston?
Teoscar Hernández

Teoscar Hernandez Expected to Return on Friday
Jerome Ford

the Likely Starter for Cleveland to Begin 2025
Chig Okonkwo

"Poised" for Best Season of Career
Xavier Watts

Falcons High on Xavier Watts
Xavier Restrepo

Training With Star Wideouts
Walter Clayton Jr.

Leads Jazz to Summer League Win
Carter Bryant

Struggles in Summer League Loss
Kyle Filipowski

Drops a Double-Double in Summer League Action on Tuesday
Oklahoma City Thunder

Malevy Leons Logs Impressive Summer League Outing on Tuesday
Dalton Knecht

Collects 25 Points in Lakers Summer League Win
Los Angeles Lakers

Darius Bazley Drops 27 Points in Summer League on Tuesday
Gary Woodland

Looking to Find Rhythm at Scottish Open
Aaron Rai

Brings Consistent Play to Scottish Open
Maverick McNealy

a Solid Value Play at Scottish Open
Aldrich Potgieter

Making Scottish Open Debut
Tom Kim

Looks to Rebound at Scottish Open
Brian Harman

a Safe Option at Scottish Open
Luke Clanton

a Sneaky Value Play at Scottish Open
Sam Burns

Looking to Stay Hot at Scottish Open
Chet Holmgren

Agrees to Rookie Max Extension
Alex Bregman

Not Returning Wednesday
Jhoan Duran

Unavailable Due to Illness
Shane McClanahan

Tosses Clean Frame in First Rehab Appearance
Jacob Wilson

Day-to-Day After HBP
Nicolai Hojgaard

May Feel More at Home in Europe
Harry Hall

Showing Fine Form Heading to Scotland
Ronald Acuña Jr.

Ronald Acuna Jr. to be Reassessed Wednesday
Ryan Fox

Playing Well Since Early Spring Struggles
Malaki Branham

Traded to Washington
Max Greyserman

has Solid History at the Genesis Scottish Open
Blake Wesley

Moves to Washington
Harris English

Aims High for Scotland Next
Corey Conners

Primed for the Genesis Scottish Open
Kelly Olynyk

on the Move Again
Daniel Brown

Attempts the Scottish Swing Again
Anthony Davis

Recovering From Eye Surgery
Jacob Bridgeman

Needs Putter to Work at Genesis Scottish Open
Cal Raleigh

Continues Historic Homer Pace Tuesday
Jacob Wilson

Exits Early On Tuesday With Left Hand Contusion
Scottie Scheffler

Headlines Field at Genesis Scottish Open
Rory McIlroy

a Smart Play for Scottish Open
Adam Scott

Looking to Build on History at The Renaissance Club
NASCAR

Sepp Straka Not Likely to Find Momentum at Scottish Open
Justin Rose

Hopes Month Hiatus Helps Him Bounce Back at Scottish Open
Luis Garcia

Fans Four in Rehab Outing
NHL

Tyler Johnson Retires After 13 NHL Seasons
Jack McBain

Inks New Five-Year Deal with Mammoth
Cam York

Re-Signs with Flyers for Five Years
Jake Knapp

Fits the Mold for Success at The Renaissance Club
Ty Gibbs

Finishes Second at Chicago and Advances in In-Season Challenge
Alex Bowman

Defeats Bubba Wallace in In-Season Challenge, but Not Without Controversy
Alex Bowman

Bubba Wallace Wrecked by Alex Bowman Again, Putting Playoffs in Doubt
Michael McDowell

Throttle Failure Ends Michael McDowell's Chances to Win at Chicago
Austin Hill

Earns First NASCAR Cup Series Top Ten at Chicago
Tyler Reddick

Scores a Strong Third-Place Run at Chicago
Kyle Busch

Matches his Best Career Finish At Chicago on Sunday
Denny Hamlin

Fights his Way to a Top-5 Finish at Chicago
William Byron

has his Worst Weekend of the Season at Chicago
Sonny Milano

on Track to Be Ready for Training Camp
Jakub Dobes

Signs Two-Year Deal with Canadiens
NHL

Hendrix Lapierre Signs One-Year Deal with Capitals
Carson Hocevar

Should DFS Players Consider Carson Hocevar for Chicago Lineups?
Tye Kartye

Kraken Re-Sign Tye Kartye for Two Years
Ross Chastain

May be A Decent DFS Option for Chicago Lineups
Dmitri Voronkov

Signs Two-Year, $8.35 Million Extension with Blue Jackets
Ryan Preece

Should DFS Players Roster Ryan Preece at Chicago?
Austin Dillon

Is Too Great of A Risk to Add to Chicago Lineups
Zane Smith

Is A Value Play Worth Rostering At Chicago
Austin Hill

is A Favorable Value Option for Chicago DFS Lineups
Ty Dillon

Is Ty Dillon A Decent Driver to Add For NASCAR DFS At Chicago?
William Byron

Qualifying Crash Makes William Byron a Likely DFS Must-Have
Alex Bowman

Should Finish Well, but Probably Costs Too Much for Serious DFS Consideration
Joey Logano

Has Been Relatively Mediocre on Road Courses Lately
Ryan Blaney

Doesn't Really Fit Neatly into Optimal DFS Lineups
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF