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John Laghezza's fantasy football bold predictions for Week 10 of the 2025 NFL season. Expert predictions for Jared Goff, TreVeyon Henderson, and more.
It's another Friday. Meaning that I'm out of an A.I.-inspired boldness quote wormhole, and Big John's got a new favorite — "The mind, ever the willing servant, will respond to boldness, for boldness, in effect, is a command to deliver mental resources." Whoa. Deep philosophies aside, forget the projections for one second; we're here to move the needle. Place security over freedom, and you'll lose both while deserving neither.
Welcome back to yet another edition of my RotoBaller bold predictions for the upcoming Week 10 Sunday slate. I'll help put a bow on every workweek with a handful of high-risk, high-reward takes and outlier calls to give you an unexpected boost. At the end of the season, there's only one winner.
A few of the more important fantasy teams, like Kansas City and Dallas, are on bye, adding extra stress to the waves of injuries taxing our rosters. At this point, daring moves make the difference. No guts, no glory.
Editor's Note: Find sleeper picks, undervalued ADPs, and draft targets to help you dominate your fantasy football drafts. Try our free who to draft tool for personalized recommendations.
Jared Goff First Top Five Finish In Seven Weeks
Few teams boasted a better combined team ADP entering 2025 than the Lions. Funny, because despite being the league's second-highest scoring offense, it feels like a bit of a disappointment in fantasy outside of Amon-Ra St. Brown.
Jahmyr Gibbs is the RB8, Jameson Williams is the WR88, Sam LaPorta is the TE8, and Jared Goff is the QB14. Outside of Williams, no one's really killing you, but they're not winning weeks either.
This weekend, that all changes... Washington's already challenged defense rolls into a tough matchup with three-quarters of the secondary's status up in the air. Even if they suit up, it's been all downhill since losing DE Dorance Armstrong.
And talk about going from bad to worse for this Commander's defensive unit, ranking 30th or worse almost all the way across the entire spreadsheet the past month: EPA/dropback (-0.38), opposer passer rating (123.3), passing yards/game (276.8), yards/reception (13.6), yards after contact/catch (7.7), +20-yard completions (19), and passing TD (11). Wow... go get 'em.
Washington's run D has even done its part, allowing just two running backs to eclipse 85 rushing yards all season. Hopefully, this translates into a run funnel, where Dan Campbell's shown a willingness to oblige. Six of the last eight QBs to face the Commanders went over +20 fantasy points — great chance to keep that trend going Sunday.
How did Jared Goff escape this?!
MINvsDET on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/xNFY98CPmg
— NFL (@NFL) November 2, 2025
TreVeyon Henderson's First Career RB1 Performance
One of my all-time favorite trend forecasting quotes is Hemingway's "How did you go bankrupt? Two ways. Gradually, then suddenly." Well, that stuff works in reverse, too.
TreVeyon Henderson's roller coaster rookie arc has gone from stages of irrational exuberance, abject disappointment, and denial to cautious optimism, and finally bona fide hope for a breakout. It took a Rhamondre Stevenson injury (toe) to clear the pathway for a career-high 18 touches versus Atlanta, but the veteran's absent from practice again — giving the former 38th overall pick another crack at the lead role.
Of course, Henderson drafters collectively groaned when it was second-year UDFA Terrell Jennings to stuff it in the end zone from the three on Sunday. With that, it's hard to complain about the usage, especially in the aerial game. Henderson played 89% of New England's passing snaps, and the Pats head down to Tampa as underdogs.
Assuming Stevenson's out, expect Mike Vrabel to follow suit and avoid running right at the Bucs' top-ranked run D (68.1% success, 3.9 yards/rush). Instead, teams continue finding success against TB by stretching the run horizontally — opposing RBs reeled in 21 passes over their last three contests alone. Drake Maye's playing MVP-level ball, Kayshon Boutte's going to be missing, and if they fall behind on the scoreboard, Henderson's going to feast on any negative game scripts.
Rookie TreVeyon Henderson gets a carry for 13 yards
NEvsBUF on NBC
Stream on @NFLPlus + Peacock pic.twitter.com/BzPRW9YMEI— NFL (@NFL) October 6, 2025
Kenneth Walker III Scores +20 Fantasy Points
During the preseason, all anyone could talk about regarding Seattle was the new-look Seahawks' running game under Klint Kubiak. The only question, drafters wondered, was how this dominating ground game would get divvied up. Well, none of that wound up anywhere close to reality — it's about to be Week 10 and the SEA backfield boasts precisely zero 20-point fantasy games. Yikes.
Ken Walker drafters, rejoice! Your time has finally come. Injuries keep piling up in the Cardinals' front seven, who now just also lost their snap and tackle leader, LB Mack Wilson (ribs). The Cardinals' run defense transformed into a sore vulnerability this past month, featuring bottom-5 ranks in success rate (50.0%), yards/attempt (5.2), yards after contact/carry (3.66), and explosive rush rate (11.3%). Mix in the league's worst tackle success (47.7%) that same timeframe, and you've got a perfect storm brewing for home-run-hitting RB.
Seattle's also a TD favorite heading into the weekend, giving us ample game script-related opportunities for Walker's +11% explosive rush rate to exploit Arizona's poor tackling for the long, +50-yard TD run we've waited for all year.
Kenneth Walker with room to run ‼️
TBvsSEA on CBS/Paramount+https://t.co/HkKw7uXVnt pic.twitter.com/BaIezWoL0z
— NFL (@NFL) October 5, 2025
Dalton Schultz Is Week 10's TE1!
Habitually manning the top of the waiver wire, Texans' TE Dalton Schultz probably gets added and dropped as much in the course of a fantasy season as anyone. Not sure if anyone better fits the epitome of a boring tight end archetype. That said, the veteran served his squad reliably as their top pass-catcher to date.
Without face-of-the-franchise C.J. Stroud under center, all eyes turn to backup Davis Mills, who's targeted a tight end on just under one-third of all attempts this season. Jacksonville also deploys a high blitz rate (19.9%) without a high conversion rate to go with it (10 total sacks), which usually means lots of quick releases to shorter routes — another strong data point for Schultz.
Through all my nerdy correlative testing and such, the fact that tight ends remain mostly random checks out by the numbers. In fact, the best predictor of allowing catches to tight ends in the future is allowing catches to tight ends in the past, and where do the Jags rank against the game's most vanilla position? Second-to-last in both receptions (6.9) and TE-fantasy points allowed per game (11.8). Interesting...
Mills takes a ton of flak online for being terrible, along with a million other poorly researched claims. All I'm saying is the guy got plucked off the bench without a single first-team rep and asked to produce against the vaunted Broncos' D. That's a tall task for a good quarterback with preparation — not to mention Mills did a fine job of keeping Houston within striking distance the entire way, losing by just three points on a late FG.
Stroud finds Schultz for a 34-yard gain
📺: #HOUvsKC on ESPN/ABC
📱: Stream on @NFLPlus and ESPN+ pic.twitter.com/Wu8y9DGhNm— NFL (@NFL) January 18, 2025
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