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QB vs Pass Rush Matchups To Watch - Week 16

Gage Bridgford (@GbridgfordNFL) identifies quarterbacks to watch in Week 16 based on the opposing pass rush defense. These QBs could be players to fade and avoid or to start and stream in fantasy football leagues.

Week 16 is here, and fantasy championships are on the line. Some teams head into the fantasy finals as big favorites but others are scrapping to pull off a big win as underdogs. Real teams start at quarterback, and the position is pretty important for fantasy as well.

Quarterbacks have changed the game for fantasy football this year with guys like Lamar Jackson and Josh Allen taking full advantage of their running ability to stress defenses. It gives you more viable options on a week-to-week basis.

Right now, these are the weeks that we've spent months preparing and competing for. There's no room for an error, and it's not time to get cute. We have to set our best lineups to win because we aren't coming back next week if we don't.

Be sure to check all of our fantasy football rankings for 2025:

 

Look Away Before It Gets Ugly

Jared Goff @ San Francisco 49ers

You're telling me that Los Angeles Rams quarterback Jared Goff has to go on the road in a do-or-die game against one of the best teams in the conference. I don't like his odds. His offensive line has struggled to generate time for their quarterback despite only giving up 21 sacks this season. In the previous matchup between these two teams, Goff was taken down four times. So, one-fifth of his sacks came in one game, and that was at home.

One issue for the San Francisco 49ers Defense is that they're dealing with several injuries to their pass rush. However, they're still trotting out one of the most fearsome fronts in football from Nick Bosa to Arik Armstead and everyone in between. They have 47 sacks on the year, and, with two games remaining, they would have finished as a top-10 team in sacks last season. This group gets after the quarterback, and, in their fight for playoff seeding, they'll be wanting to make a statement on Saturday night.

 

Sam Darnold vs Pittsburgh Steelers

This Pittsburgh Steelers team is not the best in football, but, with the collection of players that they've been trotting out, they're playing far better than anyone would have expected. It's been largely on the back of their defense. They've gotten an NFL best 49 sacks thus far, and they'll likely be adding to that total in Week 16. They control their playoff destiny if they're able to win in each of the final two weeks. Week 17 isn't guaranteed against a hot Baltimore Ravens team, but they can make life a lot easier with a win this week.

New York Jets quarterback Sam Darnold has been hit a lot this year, as the team has given up 48 sacks on the season. He's also been extremely inconsistent. After seeing ghosts against the New England Patriots, he had a hot few games, but they've also lost to two winless teams (at the time) in the Miami Dolphins and Cincinnati Bengals. They're eliminated from playoff contention, and they have nothing to play for other than draft positioning. Additionally, the dynamic between him and head coach Adam Gase will be interesting to watch after their sideline blowup last week.

 

Daniel Jones @ Washington Redskins

First things first, why are the New York Giants playing Daniel Jones (ankle) despite his high ankle sprain? You just spent a first-round pick on the guy, and you're bringing him back literally two weeks after an injury that typically takes multiple weeks to recover from. This offensive line has allowed 38 sacks this season, and his mobility will likely be limited by the injury. New York just lost tight end Evan Engram (foot) for the remainder of the season, and these final two weeks will not be an amazing swan song.

The Washington Redskins have shown life in recent weeks with quarterback Dwayne Haskins under center, and their defense has also shown some improvement. They're fifth in the NFL with 42 sacks, and they want to see what they have in this rookie with the year nearly over. This is an audition for their next head coach whether that is Urban Meyer or someone else. In a battle of two terrible teams in lost seasons, I think Washington gets after Jones early and often.

 

That's More Like It

Gardner Minshew @ Atlanta Falcons

I would like Jaguars quarterback Gardner Minshew a lot more if this were a home game, but, I still like him this week. No longer under the reign of the almighty Tom Coughlin, this Jaguars team is going to come out and make a statement, and a lot of that is going to be by running the ball and throwing against an overmatched Falcons Defense. The Jaguars are in the top half of the NFL in sacks allowed. Additionally, both of his starting wide receivers are expected to be healthy for this dome contest with D.J. Chark apparently over an ankle injury that cost him the previous game.

The Falcons are led by a defensive-minded head coach, but they've been a lot more bark than bite for a few years. This season, they have just 24 sacks through 14 games. The strength of their pass rush is on the inside with stud defensive tackle Grady Jarrett, but the strength of the Jaguars offensive line is on the interior. The matchups aren't in their favor, and, in a sneaky shootout, the odds favor the Jaguars in this one.

 

Kyler Murray @ Seattle Seahawks

Arizona Cardinals quarterback Kyler Murray has performed about as well as one could have hoped entering the year. He has used his running ability to keep his fantasy floor high, and, despite playing behind a struggling offensive line, he gets the ball out to his receivers. The team is averaging about 22 points per game, and they're going to be forced to score a lot against one of the NFL's top-10 offenses.

Thankfully for Murray and Arizona, the Seahawks don't have the fierce pass rush that they had earlier in the decade. They have just 24 sacks this season, and they're giving up over 24 points per game. This defense allows points, and the offense is often tasked with bailing them out. Murray will find his opportunities to score despite his offensive line's struggles.

 

Drew Lock vs Detroit Lions

Fading the Detroit Lions Defense has been a good strategy for most of the year. They don't have any form of a pass rush, and their secondary, outside of veteran cornerback Darius Slay, can't cover anyone. Drew Lock came back to earth last week against a sneaky good Kansas City Chiefs Defense, but he has the matchup to rebound this week. His offensive line has only allowed three sacks in the three games he has played, and the Lions aren't the type of group that could drastically increase that total.

The Lions have 27 sacks this season with 14.0 of those sacks coming from two players in the forms of Trey Flowers and Devon Kennard. Outside of those two, the next-highest player on the team has just two. If Denver can slow down those two, it's going to be next to impossible for Detroit to generate any pressure. Lock isn't an ideal play, but he's far from the worst on this week's slate.

More Weekly Lineup Prep




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REAL-TIME FANTASY NEWS

Jimmy Butler III

Expected to Return on Sunday
Jayden Daniels

Questionable to Return in Week 14 With Left-Elbow Injury
Immanuel Quickley

Now Probable Versus Boston
Bhayshul Tuten

Returns in Week 14 After Injury Scare
Shai Gilgeous-Alexander

Will Miss First Game of the Year on Sunday
De'Von Achane

Questionable to Return in Week 14 with Rib Injury
Joel Embiid

Upgraded to Probable Against Lakers
Bhayshul Tuten

Being Evaluated For Concussion
Daniel Jones

Ruled Out After Non-Contact Achilles Injury
Ja Morant

Doubtful Against Portland
Robert Williams III

Now Questionable Versus Memphis
Donovan Clingan

Questionable Versus Grizzlies
Pittsburgh Steelers

Steelers Won't Fire Mike Tomlin This Year
Chris Olave

Officially Active in Week 14
Dalton Kincaid

Suiting Up Against Bengals
CFB

Kendal Briles a Candidate for South Carolina Offensive Coordinator Job
CFB

James Madison Playoff-Bound After Duke Wins ACC Title?
CFB

Notre Dame, Miami, Alabama on College Football Playoff Bubble
Garrett Wilson

Still Expected to Return and Contribute in 2025
CFB

Brent Pry Could Return to Virginia Tech as Defensive Coordinator
Mike Evans

Could Return in Week 15
Trey Benson

Might Not Return This Season
Darcy Kuemper

Ends Losing Streak With Shutout Performance
Nikolaj Ehlers

Collects Three Points in Saturday's Win
Ilya Sorokin

Ties Franchise Record With 25th Shutout
Sam Bennett

Bags Season-High Four Points Saturday
Jordan Kyrou

Sustains Lower-Body Injury Saturday
Dominic James

Hurt on Saturday
Maxx Crosby

Trending Toward Playing Against Broncos
Chris Olave

Set to Play Vs. Bucs
LaMelo Ball

Won't Suit Up Against Denver
Immanuel Quickley

Questionable for Sunday Afternoon
Deshaun Watson

Expected to Stay With Browns Next Year
Klay Thompson

Downgraded Versus Houston
Alperen Sengün

Alperen Sengun Out Again on Saturday Evening
Tyler Herro

Will Miss Another Game on Saturday
Jimmy Butler III

Out Again on Saturday Night
Draymond Green

Ruled Out Versus Cleveland
Jose A. Ferrer

Mariners Acquire Jose A. Ferrer from the Nationals
Mason Marchment

Expected to Return Saturday
Danila Yurov

Returns From Two-Game Absence Saturday
Jesperi Kotkaniemi

Available Saturday
Harry Ford

Traded to the Nationals
Shane Pinto

to Miss Two Weeks
David Pastrnak

Misses Fifth Consecutive Game Saturday
Andrei Vasilevskiy

Remains Out Saturday
Nikita Kucherov

Out on Saturday
Jayden Reed

Activated Off Injured Reserve, Will Play in Week 14
Omarion Hampton

Activated From IR, Faces Uncertain Workload Monday Night
Cody Bellinger

Drawing Interest From the Phillies
MacKenzie Gore

Will the Nationals Trade MacKenzie Gore?
Justin Herbert

Officially Listed as Questionable for Monday Night Football
Justin Herbert

Chargers "Expecting" Justin Herbert to Play in Week 14
Yves Missi

Trending Toward Game-Time Decision
Khris Middleton

Questionable With Knee Soreness Against Hawks
Noah Clowney

On Track To Suit Up Against Pelicans
De'Anthony Melton

Questionable With Knee Management
Draymond Green

Questionable With Mid-Foot Sprain
Jimmy Butler III

Day-To-Day As Warriors Prepare For Cleveland
Mikko Rantanen

Picks Up Three Points Against Sharks
Kyle Connor

Scores in Fourth Consecutive Game
Beckett Sennecke

Notches Two Points in Friday's Win
Ryan Leonard

Suffers Upper-Body Injury Friday
Carter Hart

Day-to-Day With Lower-Body Injury
Brayden Point

Questionable for Saturday
Victor Hedman

Expected to Return Saturday
Byron Buxton

Twins Not Planning to Trade Joe Ryan, Byron Buxton
Patrick Williams

Dalen Terry Available Versus Pacers
Ozzy Wiesblatt

to Miss 8-10 Weeks With Upper-Body Injury
Rome Odunze

has Fractured Foot, Labeled Week-to-Week
Sauce Gardner

Ruled Out for Sunday
Petr Yan

Looks To Reclaim Bantamweight Belt
Merab Dvalishvili

Set For His Fourth Title Defense
Joshua Van

Can Become The New Flyweight Champion
Aaron Jones Sr.

Cleared to Play in Week 14
Alexandre Pantoja

Set For Fifth Title Defense At UFC 323
Tatsuro Taira

Looks To Win Back-To-Back Fights
Brandon Moreno

Searches For His Third Win In A Row
Payton Talbott

A Favorite At UFC 323
Henry Cejudo

Set For His Retirement Fight
Jan Blachowicz

Set To Open Up UFC 323 Main Card
Bogdan Guskov

Looks To Extend His Win Streak
CFB

Emmett Johnson Leaving Nebraska for 2026 NFL Draft
CFB

Jam Miller Unlikely to Play in SEC Title Game
CFB

Penn State Expected to Hire Matt Campbell from Iowa State
CFB

Arkansas Targeting Ron Roberts for Defensive Coordinator Job
Jhostynxon Garcia

Pirates Acquire Jhostynxon Garcia From Red Sox
Cody Bellinger

Yankees Pushing Hard to Re-Sign Cody Bellinger
CFB

Penn State Eyeing Iowa State Coach Matt Campbell For Coaching Vacancy
Alex Bregman

Cubs Have Renewed Interest in Alex Bregman
CFB

Billy Napier Finalizing Deal to Become James Madison's New Head Coach
CFB

Buster Faulkner Set to Become Florida's New Offensive Coordinator
CFB

Joe Sloan Expected to be Kentucky's New Offensive Coordinator
CFB

Lane Kiffin Working to Keep Defensive Coordinator Blake Baker at LSU
CFB

Brian Daboll a Candidate for Penn State Head-Coaching Job?
Kyle Tucker

Visits With Blue Jays
Emilio Pagán

Reds Bring Back Closer Emilio Pagan on Two-Year Deal
Cedric Mullins

Rays Agree on One-Year Deal
Freddy Peralta

Brewers Considering Trading Freddy Peralta
Kyle Schwarber

Reds Serious About Adding Kyle Schwarber in Free Agency?
CFB

Brent Key Signing Five-Year Deal to Remain at Georgia Tech
CFB

Brian Hartline Expected to Land USF Head-Coaching Job
CFB

Collin Klein Expected to be Top Target for Kansas State if Head-Coach Job Opens
CFB

Chris Klieman Considering Stepping Down at Kansas State
CFB

D.J. Durkin Staying at Auburn Under Alex Golesh
CFB

Charlie Weis Jr. Permitted to Coach Ole Miss Offense in College Football Playoff
CFB

Five-Star Quarterback Jared Curtis Flips Commitment From Georgia to Vanderbilt
Kyle Schwarber

Giants Have Checked in on Kyle Schwarber
Willson Contreras

Willing to Waive his Full No-Trade Clause?
Edwin Díaz

Mets Still Interested in Re-Signing Edwin Diaz
Devin Williams

Agrees to Three-Year Deal With Mets
Cole Ragans

Red Sox Targeting Cole Ragans in a Trade?

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