Injury-Plagued San Francisco D/ST A Tough Bet
Source: 49ers.com
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September 27, 2025
The San Francisco 49ers' D/ST has been wracked with injuries this week, with seven players appearing on the team's injury report. Most notably, Nick Bosa (knee) will be out after tearing his ACL in last week's game against the Cardinals. As for the remaining defensive linemen, CJ West (thumb) has been ruled out, Mykel Williams' (wrist) final status is unspecified, and Yetur Gross-Matos (knee) sandwiched a limited practice between two DNPs (though carries no designation for Sunday). In the secondary, starting cornerback Deommodore Lenoir (illness) was limited in practice before finally getting a full session on Friday. His partner on the other side, Renardo Green (neck), was downgraded to DNP after two limited practices and is now listed as questionable. Hosting a dysfunctional Jaguars offense makes for an attractive matchup, but it is hard to envision how the 49ers will apply the necessary pressure to get the sacks and force the turnovers that make for a lucrative D/ST unit in fantasy football.--Dan StephensRead More News
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