Break The Slate: DraftKings NFL DFS Lineup Picks - Week 10

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 10. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hi there, RotoBallers, and welcome back to Break The Slate! If you read this article regularly, then you know what we're about here, but if you are a new reader, let me quickly summarize our goals with this article. We'll spend each week discussing a few plays at each position for the DraftKings main slate that can add tournament-winning upside and/or juicy value to our NFL DFS rosters. I'll highlight my favorite players and breakdown my reasoning behind them.

I try to update the article on Saturdays to reflect any significant injuries or late-breaking news, as the landscape of the slate can change quickly in the NFL, and I definitely recommend you checking those out. Week 10 is shaping up to be a fun slate and I'm excited to dig in! Remember, the NFL is ever-evolving from week to week, which gives us an opportunity to apply what we've learned on the next slate.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available, so read on to find out which players are the best for Week 10. Be sure to also check out our weekly FanDuel DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Good luck with your DraftKings DFS lineups, let's Break The Slate together!

• 2025 fantasy football rankings
• Running back (RB) rankings
• Wide receiver (WR) rankings
• Quarterback (QB) rankings
• Tight end (TE) rankings
• Defense (D/ST) rankings
• Kicker (K) rankings
• FLEX rankings
• Dynasty rankings

DraftKings DFS Quarterbacks - Week 10 Picks

Kyler Murray - BUF @ ARI ($8,000)

Kyler Murray's lowest DraftKings score of the season was a 24.1-point outing against Carolina in Week 4...meaning even if he were priced at his Week 10 salary of $8k, you would still be pretty happy with the 3x return on your investment. Obviously, we want more than 24 points this week, but the point is to illustrate the incredible floor that Murray brings to the table every week. We can attribute that to his elite rushing ability. He leads all NFL QBs with 543 yards on the ground and is tied for the positional league lead with eight rushing TDs.

Murray draws a matchup against a Bills Defense that has regressed this season. Buffalo ranks 28th in the NFL in DK Points allowed to the QB position and have relinquished over 5 yards per carry to opposing QBs. The expected game environment is a great one, as this matchup currently carries the highest projected point total (56.5) and a tight point spread.

Josh Allen - BUF @ ARI ($7,500)

If you can't quite get to Kyler, you can take the $500 discount and roll with the QB on the other side of this intriguing matchup. We highlighted Buffalo's Josh Allen is this article last week and he came through for us with a 39.0-point explosion against the Seahawks. While the matchup against Arizona isn't hardly as juicy, there are still some things to like. Like Murray, Allen's fantasy floor is elevated thanks to his elite rushing ability. The Cards have struggled to slow opposing QBs on the ground and are allowing a massive 6.75 yards per carry to the position - the second-highest mark in the league.

Drew Lock - DEN @ LV ($5,500) 

Despite a 33.2-point eruption last week, we can still grab Denver QB Drew Lock at the discounted price of $5.5k in Week 10. Lock accounted for 313 yards and 2 TDs through the air, as well as 47 yards and a TD on the ground, last week against the Atlanta Falcons. He's now posted a total of 54.0 DK points over two starts since returning from injury. The matchup this week against the Raiders isn't "Falcons-level bad", but it's certainly one that Lock can thrive in. Las Vegas ranks bottom-10 in the league in both DK Points and passing yards allowed to opposing QBs.

DraftKings DFS Running Backs - Week 10 Picks

Aaron Jones - JAX @ GB ($7,100)

We've seen several "slam dunk" situations at RB over the last few weeks, but the Week 10 slate doesn't really have a "Dalvin Cook vs Detroit" type of spot. In the absence of what feels like a "can't miss" play, I'll always go searching for upside. Because of the way this Packer offense operates, Aaron Jones has a much lower floor than most elite backs. However, Jones arguably carries as much upside as any back in football, as his 48.6-point explosion in Week 2 illustrates. He returned from a two-week injury layoff last week to garner 15 carries and five targets in a rout against San Francisco. We can hope for the same amount of volume this week against a Jags defense that ranks 24th in the league in DK points allowed to the RB position. We're embracing volatility in this spot, but Jones' explosiveness both on the ground and through the air offers us a true chance to grab a slate-breaking score.

Duke Johnson - HOU @ CLE ($5,000)

Obviously, this play hinges on the Week 10 availability of David Johnson. Assuming he can't suit up, Duke Johnson would slide into the lead role in this Texans backfield. Duke filled in admirably last week, when David left the game early, garnering 20 touches and accumulating 73 total yards and a TD against Jacksonville. Houston will undoubtedly look to attack Cleveland through the air, but Johnson's role in the pass game guarantees plenty of volume for just $5k.

DraftKings DFS Wide Receivers - Week 10 Picks

Robert Woods - SEA @ LAR ($6,600)

I honestly can't remember the last time I rostered a Rams receiver on a Main Slate. There are a couple of obvious reasons why I tend to shy away from them:

A) The Rams have trended run heavy. B) The target distribution in this receiving corps is tough to predict.

Despite those issues, I'm eager to grab some exposure to the Rams passing attack in this matchup. For the purposes of this writeup I've went with Robert Woods, but you can also pivot to Cooper Kupp if you prefer. The Seahawks have been ABYSMAL against the pass...ranking DEAD LAST in the NFL in total DK Points and DK Points per game allowed to the WR position, while also relinquishing the most receiving yards in the league to opposing WRs. While Sean McVay has shown a willingness to run the football this season, he's a bright offensive mind that's very capable of putting together a gameplan that will attack Seattle's defensive weaknesses.

Jerry Jeudy - DEN @ LV ($5,600) 

Denver's Jerry Jeudy kicks off what's a plethora of explosive, high-volume WRs in the mid-$5k range this week. The rookie posted career highs in both catches and receiving yards last week, making the most of his eye-opening 14 targets. Jeudy has now been targeted 24 times over the Broncos last two games, three more targets than Raiders rookie Henry Ruggs has received all season! The matchup against Las Vegas doesn't really jump off the page, but is nonetheless an intriguing one, as this Raiders secondary is allowing a massive 9.36 yards per target to opposing WRs...the fifth-highest mark in the NFL.

Brandin Cooks - HOU @ CLE ($5,600)

I'm not really sure what Brandin Cooks has gotta do to get a price bump, but I'm going to happily take what feels like a steal this week. Cooks is coming off his fourth-straight game with nine or more targets and has amassed 27 catches for 372 yards and 3 TDs over those four contests. He and the pass-happy Texans head to Cleveland for a Week 10 matchup that is exploitable. The Browns ranks bottom-10 in the NFL in both receiving yards and TDs relinquished to the WR position.

Diontae Johnson - CIN @ PIT ($5,200)

Steelers rookie Chase Claypool has grabbed all of the headlines this season, but second-year receiver Diontae Johnson has quietly been the true workhorse of this Steelers receiving corps. Johnson is coming off yet another double-digit target day in Week 9 - his fourth such game of the season - and heads into an enticing matchup against the Bengals in Week 10. Cincy's Joe Burrow is certainly energizing this franchise, but there's still some issues on a Bengals Defense that's relinquishing 8.91 yards per target to opposing WRs.

DraftKings DFS Tight Ends - Week 10 Picks

T.J. Hockenson - WAS @ DET ($5,100)

As I write this Hockenson is tagged as Questionable, so his status is something we'll keep an eye on. His viability also hinges on the availability of Detroit's Kenny Golladay, a player that's trending in the wrong direction. Hockenson received eight targets with Golladay out of the lineup last week, which brings his total to 18 over Detroit's last two. The second-year TE has converted those opportunities into 12 catches for 104 yards and a TD. He'll square off against a Washington defense that's allowing 10.1 DK points per game to the TE position.

Evan Engram - PHI @ NYG ($4,500)

The athletic, but often injured, Giants TE has been a consistent DFS producer as of late. Engram's production can be tied to his increasing volume of the last three games. He's seen targets counts of 10/10/9 over New York's last three, posting 16 catches for 155 yards and a TD. His Week 10 matchup against the Eagles is a good one, as Philly has allowed a massive 49 receptions to opposing TEs through eight games this season.

More Weekly DFS Analysis