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Complete NFL Week 2 betting lines, point spreads, and betting odds analysis. Expert predictions on the best spreads to bet and Las Vegas totals for Sunday's games.
Week 1 of the NFL season is in the books, and the favorites held court for the most part, with only a few underdogs (Chargers, Raiders, and Bills) pulling off minor upsets. I think that trend will change this week, as there are a lot of tight spreads and potentially good spots for upsets brewing.
This article is intended to be a first look at every NFL game in Week 2, providing the spreads, totals, odds, and analysis that you need to start your research for your Week 2 NFL wagers.
Check back later in the week for our writers' favorite bets, props, and picks. But for now, here is a breakdown of every NFL game with some trends and data for your consideration!
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) fantasy football rankings
- Wide receiver (WR) fantasy football rankings
- Tight end (TE) fantasy football rankings
- Quarterback (QB) fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Kicker (K) fantasy football rankings
- Dynasty fantasy football rankings
Thursday Night Football Betting Lines
Washington Commanders (+3) at Green Bay Packers (-170)
- Over/Under (48.5)
- Key Trend(s): Both defenses rank in the top five (DVOA) after one week of action.
The Packers and Commanders both dominated their Week 1 matchups, but it was Green Bay's big win over the Detroit Lions that was a bit more impressive, as the Commanders had the benefit of starting their season against what looked like a hapless Giants team.
The Packers are set to honor former wide receiver and Pro Football Hall of Fame inductee Sterling Sharpe in a special ceremony at halftime of Thursday’s Packers-Commanders game. pic.twitter.com/HncPXahJpP
— Aaron Nagler (@AaronNagler) September 9, 2025
Initial Lean: Under 48.5 total points
I like the under here for a few reasons. For one, both defenses played exceptionally well last week and appear to have improved since last year. The other reason is that a short week usually favors the defense, as offenses have less time to prepare and install game plans. The starting offenses already have fewer reps together because of a shortened preseason, so I give the defenses the edge here.
Sunday Early Games Betting Lines
Seattle Seahawks (+3) at Pittsburgh Steelers (-160)
- Over/Under (39.5)
- Key Trend(s): Pittsburgh was 3-1 ATS as a home favorite last season, while the Seahawks were 4-1 as road underdogs. Something has to give on Sunday!
The Steelers squeaked one out against the Jets thanks to a 60-yard field goal by Chris Boswell, while the Seahawks went down in flames with a Sam Darnold fumble in the red zone as they appeared to be going in for the winning score.
Initial Lean: Over 39.5 total points
The Steelers-Jets total was just 38.5 points last week, but the teams combined for 66 points. One angle here early in the season might be the Steelers' overs as their defense looked very rough last week, and Aaron Rodgers has clearly upgraded their offense, especially in the Red Zone.
L.A. Rams (-5.5) at Tennessee Titans (+190)
- Over/Under (42)
- Key Trend(s): The Rams were 4-0 ATS last season as road favorites.
The Rams held on for an ugly win against the Texans in Week 1, while the Titans held their ground for three quarters against the Denver Broncos before eventually conceding.
Initial Lean: Rams -5.5
As much as I was impressed with Cam Ward in Week 1, he will have to contend with a very good Rams' pass rush that tortured C.J. Stroud last week. The Rams have more firepower on offense than Denver and shouldn't struggle as much as the Broncos did. I like the Rams going away in this one.
Chicago Bears (+6) at Detroit Lions (-235)
- Over/Under (47)
- Key Trend(s): The Lions have only covered this spread against the Bears at home once (a 41-10 win in 2023) in the last five years.
Both teams lost their opener, but the Lions trailed the entire game and looked like the shell of a team that led the league in wins last season. Meanwhile, the Bears dominated the Vikings for three quarters before Minnesota staged a huge comeback and ruined Chicago's home opener.
Bears vs Lions this Sunday. pic.twitter.com/q8yoKOyUhy
— Ben Devine (@Chicago_NFL) September 9, 2025
Initial Lean: Bears +6
I think there is possibly some real trouble in Detroit this season. Green Bay dominated their offensive line, and if they can't run the football, then this offense gets stagnant quickly. The Bears showed some flashes of improvement on offense, but couldn't maintain consistency. I think Chicago can hang with Detroit in this one, even if they don't pull off the upset.
Buffalo Bills (-6.5) at New York Jets (+250)
- Over/Under (45.5)
- Key Trend(s): The Bills went over their game totals at a 63% rate last season, while the Jets were right behind them with a 62% rate.
Buffalo pulled off a miracle comeback against the Ravens in Week 1, but allowed 40 points and 238 rushing yards on defense. The Jets outplayed the Steelers, but a costly fumble on a kickoff return inside their own 20 ultimately doomed them as they lost an unexpected shootout with Pittsburgh.
Initial Lean: Over 45.5 points
I watched the entire Steelers-Jets game and the Bills-Ravens game, too. This Jets offense looked sharp as they ran all over the Steelers. Justin Fields was sharp and poses the same problem for this Buffalo defense that Lamar Jackson does with his legs. I might back the Jets if the spread gets to seven points, but for now, I like the idea of a lot of points being scored, so I'm hitting the over.
New York Giants (+4.5) at Dallas Cowboys (-225)
- Over/Under (44.5)
- Key Trend(s): After one week, the Giants have the 30th-ranked offense (DVOA) and 31st-ranked defense.
Both teams will play an NFC East divisional foe for the second week in a row after they both lost their openers to the Commanders and Eagles, respectively.
Initial Lean: Dallas -4.5
The Giants failed to do much of anything right in Week 1, while Dallas actually had Philadelphia on the ropes until a late fumble by Miles Sanders inside the Red Zone really turned that game. I look for Dallas to dominate here; they have more talent on offense, and Russell Wilson looks "cooked" as the kids these days say!
Cleveland Browns (+11.5) at Baltimore Ravens (-800)
- Over/Under (45.5)
- Key Trend(s): Baltimore was 4-1 ATS last season after a loss.
The Browns nearly pulled off an upset over the Bengals, but their kicker missed a relatively short field goal in the closing minutes. Meanwhile, the Ravens let one slip away as they gave up three scores in the final minutes of their opener to Superman (aka Josh Allen).
Initial Lean: Baltimore -11.5
While the Browns have managed a season split with Baltimore in four straight seasons, I think they could be badly outmatched in this one, and an angry Ravens team coming off a loss is going to be tough to contend with on the road. The Ravens crushed the Browns at home last year, 35-10, and I expect something similar here.
San Francisco 49ers (-4.5) at New Orleans Saints (+200)
- Over/Under (40.5)
- Key Trend(s): San Francisco was just 1-4 ATS last season as a road favorite.
The Niners won in Seattle last week, but needed a strip sack from Joey Bosa to seal the win and a huge catch from their backup tight end as George Kittle was lost to injury earlier in the game.
Brock Purdy had to make a play and delivered 🙌@49ers | @Accenture pic.twitter.com/yiDKdTOn8w
— NFL (@NFL) September 8, 2025
The Saints played the Cardinals tougher than I expected, and perhaps they'll be able to give some good resistance all season.
Initial Lean: Saints +4.5
Brock Purdy looks like he will probably play this week, but Kittle is out, and the Saints showed last week that they're not going to lay down for anyone. The Niners still win here, but it's close.
New England Patriots (+1.5) at Miami Dolphins (-115)
- Over/Under (43.5)
- Key Trend(s): NO TRENDS
Both teams are coming off Week 1 losses, but the Dolphins were thoroughly embarrassed by the Colts, while the Patriots lost a pretty good game against the Raiders.
Initial Lean: Over 43.5 total points
This one is really tough to predict as far as a winner. I do think Miami bounces back, but I am not confident that they'll win either, as I think New England will play better than they did in Week 1, too. Let's go after the over since both defenses struggled last week.
Jacksonville Jaguars (+3.5) at Cincinnati Bengals (-170)
- Over/Under (48.5)
- Key Trend(s): The Bengals were 3-4 ATS last season as home favorites, while Jacksonville was 5-3 as road underdogs.
The Bengals nearly blew it against the Browns and couldn't move the ball the entire second half. The Jaguars won their opener, too, but the Panthers didn't give much resistance. Someone will be handed their first loss this week.
Initial Lean: Jags +3.5
The Bengals certainly did not impress anyone last week on either side of the ball. They struggled to put up points on Cleveland and also allowed a 40-year-old Joe Flacco to move the Browns up and down the field. I like the Jags here to at least cover the spread, and I think they are live dogs on the moneyline, too.
Sunday Afternoon Games Betting Lines
Carolina Panthers (+6.5) at Arizona Cardinals (-295)
- Over/Under (43.5)
- Key Trend(s): Cardinals were 3-2 ATS last season as home favorites.
The Cardinals didn't make it look easy last week, but still ended up covering the spread on the road against the Saints. The Panthers were thoroughly handled by the Jaguars in their opener, struggling to move the ball on offense for much of the game.
Initial Lean: Cardinals -6.5
I look for Arizona to be sharper this week and run the ball more effectively against this terrible Panthers run defense. Arizona's improved defense could feast on Bryce Young, too, if they get up early.
Denver Broncos (-1.5) at Indianapolis Colts (+115)
- Over/Under (43.5)
- Key Trend(s): After one week, these teams have the two top-ranked defenses according to DVOA ratings.
The Colts were big winners at home, dominating the Dolphins and forcing multiple turnovers. Daniel Jones had the offense moving, and this team looked as good as it has in a while. Meanwhile, the Broncos scuffled a little on the road in Tennessee but ultimately pulled out the win.
Initial Lean: Under 42.5 total points
I'd love to see a Colts upset here, and I think it's possible. But my main angle will be the under because of those defenses and both teams wanting to run the football and play a ball-control style of offense.
Philadelphia Eagles (+1) at Kansas City Chiefs (+105)
- Over/Under (46.5)
- Key Trend(s): Since beating the Eagles 38-35 in the Super Bowl two years ago, Philly is 2-0 against the Chiefs, including last year's Super Bowl blowout.
The Eagles struggled with the Cowboys on opening night, but pulled out the win. Meanwhile, the Chiefs were unable to hold off the Chargers and suffered a Week 1 loss while also losing receiving Xavier Worthy for an extended time
Initial Lean: Eagles Moneyline
I like the Eagles here. They have the recent mojo on the Chiefs and enough depth on both sides of the ball to win the key matchups.
Sunday Night Football Betting Lines
Atlanta Falcons (+3.5) at Minnesota Vikings (-200)
- Over/Under (44.5)
- Key Trend(s): Vikings are 2-0 against the Falcons over the last two years.
The Vikings are 1-0 after a big Monday night comeback win over the Bears. Meanwhile, the Falcons are 0-1 after their kicker failed to connect on a game-tying field goal in the final seconds of their Week 1 matchup with the Bucs.
𝗪𝗲𝗲𝗸 𝟮 𝗦𝗰𝗵𝗲𝗱𝘂𝗹𝗲 𝗡𝗼𝘁𝗲
The Vikings, who are 2-0 all-time in @SNFonNBC home openers, defeated the Falcons 42-21 in 2024 at U.S. Bank Stadium. It was the first time the Vikings scored 40+ points in a game under Head Coach Kevin O'Connell and the team's most points… pic.twitter.com/C7owMoGDol— Vikings Communications (@VikingsPR) September 9, 2025
Initial Lean: Minnesota -4.5
I just don't like this matchup for Atlanta at all. The Vikings are tough against the run and could shut down Bijan Robinson, forcing Michael Penix Jr. to beat them in the passing game. Once J.J. McCarthy got his feet under him, he looked just fine, and I think Minnesota will be just fine going forward.
Monday Night Football Betting Lines
Tampa Bay Buccaneers (+2.5) at Houston Texans (-135)
- Over/Under (42.5)
- Key Trend(s): Tampa Bay was 3-1 as road underdogs ATS last season.
The Bucs pulled off a close win against their division rival, the Falcons, in Week 1, while the Texans dropped their opener to the Rams.
Sources: #Texans starting tight end Cade Stover broke his foot against #Rams and is out indefinitely. Stover, who was in a boot after the game, caught a team-high four passes for 22 yards on four targets Sunday @KPRC2 https://t.co/8iRlBx7Nqv
— Aaron Wilson (@AaronWilson_NFL) September 8, 2025
Initial Lean: Buccaneers +2.5 and/or Moneyline
I respect Houston's defense, but their offense was stuck in the mud all game last week, and I have some real doubts about their ability to repeat as the AFC South champs this season. The Bucs have a scrappy quality about them (maybe it's just Baker's aura?) and like their chances of pulling off an upset here.
Los Angeles Chargers (-3) at Las Vegas Raiders (+165)
- Over/Under (46.5)
- Key Trend(s): The Chargers were 5-2 ATS as road favorites in 2024.
The Chargers impressed in last Friday's upset of the Chiefs, while the Raiders also won their opener by beating up on the Patriots on the road.
Initial Lean: Chargers -3
This isn't anything against the Raiders; they looked much improved, and perhaps they will be a tough out for good teams all year; however, I think the Chargers are a rising contender and the better team on both sides of the ball.
