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Week 10 Start/Sit: Monday Night Football Matchup Analysis

Fantasy football start 'em, sit 'em for MNF - Week 10. Monday Night Football matchups analysis and fantasy start/sit advice for New York Giants at San Francisco 49ers

For some, it's birth. Other's may come in the form of an experience. There are even those few (my aunt) who fall in that weird, I just like their colors category. But, every sports fan has that defining moment which determines "their team". Mine came January 27, 1991 - the infamous Scott Norwood, "wide right" Super Bowl XXV. At six-and-a-half years old, I didn't know much about football -- other than it was fun to play outside with my friends and hurt sometimes -- but, my dad did. My Giants fan dad, that is, and the celebration which ensued following Norwood's botch job is one of the more memorable moments of my early childhood.

I could go into more detail, and turn this into an emotional trip down memory lane, but that's not what I'm going for here. I bring all of this up simply because that Super Bowl victory would not have been possible had the Giants not gone into Candlestick Park a week prior, kicked a million field goals, and defeated the two-time defending champion San Francisco 49ers... In their house (in case you're too young for the Candlestick reference). This was a different time. The Giants were actually good at playing football; as were the 49ers. No longer is this the case. And, when the (1-7) New York Giants head to Santa Clara to face the (2-7) San Francisco 49ers, a trip to the Super Bowl will not be at risk - they'll be playing for draft position.

This game might not have any playoff implications, and the reality is, losing would actually offer more long-term benefit. However, it's only Week 10 and these are prideful men who have a job to do - don't expect them not to come out and play. My job, then, becomes to fill you in on who you should have in your fantasy football lineups and why you should do so. Which is exactly what you'll find below. (Reading, required. Watching, optional.)

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

New York Giants at San Francisco 49ers

Date and Start Time: Monday, November 12th at 8:15 p.m. EST
Game Spread: SF -3
Over/Under: 44
Notable Injuries and Status:

Offensive and Defensive Rankings (per game):

Giants 49ers
Passing Yards 9th 25th
Rushing Yards 31st 4th
Pass Defense 16th 17th
Run Defense 23rd 12th

 

Must Starts

Top Players That You Should Have In Your Lineup

Saquon Barkley (RB, NYG)

He's third among running backs in scrimmage yards. His 84.1-percent carry share (RB carries only) sits fourth at the position. He sees more targets per game than all but 13 wide receivers. He's also very good at playing football.

Odell Beckham Jr. (WR, NYG)

If you checked out that nifty table above, you probably saw that 9th next to passing yards per game, under Giants, and thought that must be a typo. It's not. In fact, Beckham's 98.1 receiving yards per game rank 6th among wide receivers. Problem is, Eli Manning has thrown just eight touchdown passes this season. (So too has Ryan Tannehill - he hasn't played since Week 5.) The 49ers have given up 11 receiving TDs to opposing WRs this season (tied for the sixth-most) so if there's a game to bet on OBJ finding the end zone, this is the one. If not, well, he's gone over 100 yards in five of his eight games.

 

Must Sits

Players To Avoid Putting In Your Lineup

Alfred Morris (RB, SF)

Remember when Jerick McKinnon went down in the preseason and everyone was all, "Alfred Morris is the man..."? That was cute. (I may, or may not, have endorsed Alf.) Not even the season-ending injury to Raheem Mostert justifies Morris being in your lineup at this point. He saw seven carries last week; he put up 13 yards. The Giants allowed 162 rushing yards in their first game without Damon Harrison, and Morris is likely to see some additional run by default, he just hasn't been effective enough at any point this season to trust that he'll capitalize on the opportunity/matchup. If he balls out on your waiver wire (he shouldn't even be on your bench) so be it... I've now seduced myself into considering rolling the dice on him in a DFS contest.

Marquise Goodwin (WR, SF)

There's one guy every week who's not really a must-sit. Not really a solid start either. But, has fantasy relevancy nonetheless. This week, that title is held by Marquise Goodwin, and I have no idea what to do with him. On one hand, Nick Mullens looked incredible. On the other hand, they played Oakland. On the other hand, Mullens attempted only 22 passes. And on the other, only four of them targeted Goodwin - he caught one for 11 yards. The Giants secondary has actually been decent, and I don't trust him. So, yeah. (see Pierre Garcon below)

Solid Options/Sleepers

Which Players Will Have Solid Games and Which Could Surprise?

Solid Option - Matt Breida (RB, SF)

Battling injury the past few weeks, Breida will have rested a full 10 days by the time this one kicks off - the Thursday night game followed by a Monday night'er couldn't have come at a better possible time. As mentioned, the Giants run D looked soft in their first game without Damon Harrison -- they're also dealing with some injuries on the linebacking front -- so Breida should be good for RB2 numbers (at a minimum) in this one... If he can stay on the field.

Solid Option - Sterling Shepard (WR, NYG)

Like Beckham, Shepard has fallen victim to Manning's allergy to throwing passes to receivers which are running (possibly standing) in the portion of the field which is painted a color that's typically not green and includes a word which delivers the home team's moniker. He does, however, offer value in this matchup due to the more than seven targets he sees per game and the fact that, again, San Fran has been rather generous in handing out receiving TDs to opposing WRs.

Solid Option - George Kittle (TE, SF)

Travis Kelce and Zach Ertz are the only tight ends averaging more receiving yards per game than Kittle's 76.9 - he's been balling. Thing is, the Giants held Ertz to 43 yards in Week 6, and only two TEs (Josh Hill and Jordan Thomas) have gone over 50 yards against this defense on the season. The 53.6 yards per game they've allowed to the position falls around the median, but another huge game from Kittle doesn't seem likely - the Giants are one of just five teams to have allowed one or fewer receiving TDs to the TE position as well. Still, 66.7-percent of Kittle's games this season have resulted in a Top-10 fantasy performance, so while the matchup might not be the greatest -- and he's dealing with a "chest" injury -- he should put up solid numbers.

Sleeper - Eli Manning/Nick Mullens (QB)

I do not believe that either of these quarterbacks has Top-10 potential. I also do not believe the final score will be 15-13 like the aforementioned 1991 NFC Championship game. Mullens was all of the rage following his impressive Week 9 debut, but when you consider that he became just the 10th QB this season to attempt 25 or fewer passes and finish the game with at least 20 fantasy points... He played Oakland. As mentioned, Eli puts up yardage, he just doesn't throw touchdowns. Both defenses have been almost identical against QBs (below) -- neither of which is overly dominant -- so I could see either QB having a decent game. I could also see them disappointing. They're in that Marquise Goodwin realm; low-end, 2-QB league options with minimal upside.

Sleeper - Pierre Garcon (WR, SF)

It's been a season to forget for Pierre Garcon. For everyone else, it's been more like forget Pierre Garcon. That was until Nick Mullens emerged from the depths of the underworld and contributed to Garcon's second-highest yardage total of 2018 -- as well as his first TD -- in the first quarter of last week's game against Oakland. The first quarter. Garcon disappeared after that, but here's to hoping it was a sign of things to come. Mullens didn't fare well on passes farther than 10 yards, and his average depth of target was just 6.6 yards (Derek Carr-ish) which tells me this Mullens-Garcon connection might wind up being something special (Garcon isn't exactly a deep-threat at this stage of his career).

Side Note: Garcon did not practice on Thursday.

Sleeper - Evan Engram (TE, NYG)

Engram is like that artist that drops a debut album so fire that you pre-order the sophomore project the moment it comes available. Then, you get the second album, and it's kinda weak but you're convinced that it can't be based on the debut so you force yourself to find reasons to like it. The reasons, in Engram's case, are the 5.2 targets per game (he saw nine last week) and the fact that he's been injured; he has to be getting healthier with each passing week, right? San Fran has allowed four receiving TDs to the TE position (tied for the eighth-most) so if Eli takes his Claritin, maybe there's a chance?

More Fantasy Football Analysis




REAL-TIME FANTASY NEWS

Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Aaron Rodgers

Signs One-Year Deal With Steelers
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

Can Isaac TeSlaa Carve Out a Larger Role in Detroit Going Forward?
Troy Franklin

Facing Uphill Battle for Playing Time in Denver
Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
KC Concepcion

Can KC Concepcion Immediately Assume the WR1 Role in Cleveland?
George Pickens

' Dynasty Outlook Clouded by Uncertain Future in Dallas
Trevor Story

Hits the Injured List With Groin Injury
Brandon Aiyuk

a Huge Question Mark for Dynasty Managers
Deebo Samuel Sr.

Now Only a Gadget Player/Kick Returner?
Elic Ayomanor

Offseason Additions Hurt Elic Ayomanor's Dynasty Outlook
Tyler Warren

a Clear Top-Five Dynasty Tight End
Jonathon Brooks

a Dynasty RB to Target Despite Injury History?
Blake Snell

Likely to Need Elbow Surgery
Tyler Allgeier

Currently in a Dynasty Buy Window Amid Rollercoaster Offseason
A.J. Brown

Timing Becoming Key to Acquiring A.J. Brown in Dynasty
Quentin Johnston

Is Quentin Johnston on the Verge of a Dynasty Breakout?
Jahmyr Gibbs

Is Jahmyr Gibbs the Dynasty RB1?
Isaiah Likely

The Long-Called-For Isaiah Likely Breakout Could Finally Arrive in 2026
Duncan Robinson

Nets 14 Points With Four Triples
Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
Yanic Konan Niederhauser

Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
OG Anunoby

Practices in Full on Friday
Terrence Shannon Jr.

is Tagged as Questionable for Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Luther Burden III

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MarShawn Lloyd

Can MarShawn Lloyd Emerge as a Top Dynasty Handcuff Option?
Emanuel Wilson

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Max Fried

Heading to Injured List With Elbow Bone Bruise
Jaylin Noel

Playing-Time Outlook in Houston Remains Unclear
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Karl-Anthony Towns

Making an Impact as Playmaker in Playoffs
Jalen Duren

Determined to Improve
Kevin Huerter

Tagged as Questionable for Game 6 Against Cavaliers
Caris LeVert

Considered Questionable for Friday
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF