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Week 10 Start/Sit: Monday Night Football Matchup Analysis

Fantasy football start 'em, sit 'em for MNF - Week 10. Monday Night Football matchups analysis and fantasy start/sit advice for New York Giants at San Francisco 49ers

For some, it's birth. Other's may come in the form of an experience. There are even those few (my aunt) who fall in that weird, I just like their colors category. But, every sports fan has that defining moment which determines "their team". Mine came January 27, 1991 - the infamous Scott Norwood, "wide right" Super Bowl XXV. At six-and-a-half years old, I didn't know much about football -- other than it was fun to play outside with my friends and hurt sometimes -- but, my dad did. My Giants fan dad, that is, and the celebration which ensued following Norwood's botch job is one of the more memorable moments of my early childhood.

I could go into more detail, and turn this into an emotional trip down memory lane, but that's not what I'm going for here. I bring all of this up simply because that Super Bowl victory would not have been possible had the Giants not gone into Candlestick Park a week prior, kicked a million field goals, and defeated the two-time defending champion San Francisco 49ers... In their house (in case you're too young for the Candlestick reference). This was a different time. The Giants were actually good at playing football; as were the 49ers. No longer is this the case. And, when the (1-7) New York Giants head to Santa Clara to face the (2-7) San Francisco 49ers, a trip to the Super Bowl will not be at risk - they'll be playing for draft position.

This game might not have any playoff implications, and the reality is, losing would actually offer more long-term benefit. However, it's only Week 10 and these are prideful men who have a job to do - don't expect them not to come out and play. My job, then, becomes to fill you in on who you should have in your fantasy football lineups and why you should do so. Which is exactly what you'll find below. (Reading, required. Watching, optional.)

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

New York Giants at San Francisco 49ers

Date and Start Time: Monday, November 12th at 8:15 p.m. EST
Game Spread: SF -3
Over/Under: 44
Notable Injuries and Status:

Offensive and Defensive Rankings (per game):

Giants 49ers
Passing Yards 9th 25th
Rushing Yards 31st 4th
Pass Defense 16th 17th
Run Defense 23rd 12th

 

Must Starts

Top Players That You Should Have In Your Lineup

Saquon Barkley (RB, NYG)

He's third among running backs in scrimmage yards. His 84.1-percent carry share (RB carries only) sits fourth at the position. He sees more targets per game than all but 13 wide receivers. He's also very good at playing football.

Odell Beckham Jr. (WR, NYG)

If you checked out that nifty table above, you probably saw that 9th next to passing yards per game, under Giants, and thought that must be a typo. It's not. In fact, Beckham's 98.1 receiving yards per game rank 6th among wide receivers. Problem is, Eli Manning has thrown just eight touchdown passes this season. (So too has Ryan Tannehill - he hasn't played since Week 5.) The 49ers have given up 11 receiving TDs to opposing WRs this season (tied for the sixth-most) so if there's a game to bet on OBJ finding the end zone, this is the one. If not, well, he's gone over 100 yards in five of his eight games.

 

Must Sits

Players To Avoid Putting In Your Lineup

Alfred Morris (RB, SF)

Remember when Jerick McKinnon went down in the preseason and everyone was all, "Alfred Morris is the man..."? That was cute. (I may, or may not, have endorsed Alf.) Not even the season-ending injury to Raheem Mostert justifies Morris being in your lineup at this point. He saw seven carries last week; he put up 13 yards. The Giants allowed 162 rushing yards in their first game without Damon Harrison, and Morris is likely to see some additional run by default, he just hasn't been effective enough at any point this season to trust that he'll capitalize on the opportunity/matchup. If he balls out on your waiver wire (he shouldn't even be on your bench) so be it... I've now seduced myself into considering rolling the dice on him in a DFS contest.

Marquise Goodwin (WR, SF)

There's one guy every week who's not really a must-sit. Not really a solid start either. But, has fantasy relevancy nonetheless. This week, that title is held by Marquise Goodwin, and I have no idea what to do with him. On one hand, Nick Mullens looked incredible. On the other hand, they played Oakland. On the other hand, Mullens attempted only 22 passes. And on the other, only four of them targeted Goodwin - he caught one for 11 yards. The Giants secondary has actually been decent, and I don't trust him. So, yeah. (see Pierre Garcon below)

Solid Options/Sleepers

Which Players Will Have Solid Games and Which Could Surprise?

Solid Option - Matt Breida (RB, SF)

Battling injury the past few weeks, Breida will have rested a full 10 days by the time this one kicks off - the Thursday night game followed by a Monday night'er couldn't have come at a better possible time. As mentioned, the Giants run D looked soft in their first game without Damon Harrison -- they're also dealing with some injuries on the linebacking front -- so Breida should be good for RB2 numbers (at a minimum) in this one... If he can stay on the field.

Solid Option - Sterling Shepard (WR, NYG)

Like Beckham, Shepard has fallen victim to Manning's allergy to throwing passes to receivers which are running (possibly standing) in the portion of the field which is painted a color that's typically not green and includes a word which delivers the home team's moniker. He does, however, offer value in this matchup due to the more than seven targets he sees per game and the fact that, again, San Fran has been rather generous in handing out receiving TDs to opposing WRs.

Solid Option - George Kittle (TE, SF)

Travis Kelce and Zach Ertz are the only tight ends averaging more receiving yards per game than Kittle's 76.9 - he's been balling. Thing is, the Giants held Ertz to 43 yards in Week 6, and only two TEs (Josh Hill and Jordan Thomas) have gone over 50 yards against this defense on the season. The 53.6 yards per game they've allowed to the position falls around the median, but another huge game from Kittle doesn't seem likely - the Giants are one of just five teams to have allowed one or fewer receiving TDs to the TE position as well. Still, 66.7-percent of Kittle's games this season have resulted in a Top-10 fantasy performance, so while the matchup might not be the greatest -- and he's dealing with a "chest" injury -- he should put up solid numbers.

Sleeper - Eli Manning/Nick Mullens (QB)

I do not believe that either of these quarterbacks has Top-10 potential. I also do not believe the final score will be 15-13 like the aforementioned 1991 NFC Championship game. Mullens was all of the rage following his impressive Week 9 debut, but when you consider that he became just the 10th QB this season to attempt 25 or fewer passes and finish the game with at least 20 fantasy points... He played Oakland. As mentioned, Eli puts up yardage, he just doesn't throw touchdowns. Both defenses have been almost identical against QBs (below) -- neither of which is overly dominant -- so I could see either QB having a decent game. I could also see them disappointing. They're in that Marquise Goodwin realm; low-end, 2-QB league options with minimal upside.

Sleeper - Pierre Garcon (WR, SF)

It's been a season to forget for Pierre Garcon. For everyone else, it's been more like forget Pierre Garcon. That was until Nick Mullens emerged from the depths of the underworld and contributed to Garcon's second-highest yardage total of 2018 -- as well as his first TD -- in the first quarter of last week's game against Oakland. The first quarter. Garcon disappeared after that, but here's to hoping it was a sign of things to come. Mullens didn't fare well on passes farther than 10 yards, and his average depth of target was just 6.6 yards (Derek Carr-ish) which tells me this Mullens-Garcon connection might wind up being something special (Garcon isn't exactly a deep-threat at this stage of his career).

Side Note: Garcon did not practice on Thursday.

Sleeper - Evan Engram (TE, NYG)

Engram is like that artist that drops a debut album so fire that you pre-order the sophomore project the moment it comes available. Then, you get the second album, and it's kinda weak but you're convinced that it can't be based on the debut so you force yourself to find reasons to like it. The reasons, in Engram's case, are the 5.2 targets per game (he saw nine last week) and the fact that he's been injured; he has to be getting healthier with each passing week, right? San Fran has allowed four receiving TDs to the TE position (tied for the eighth-most) so if Eli takes his Claritin, maybe there's a chance?

More Fantasy Football Analysis




REAL-TIME FANTASY NEWS

Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

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Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
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NFL Veteran Tom Moore Joins Iowa Coaching Staff
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Can Cam Cook Dominate in Return to Big 12?
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Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
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a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
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to be 49ers' New "F" Receiver?
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Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
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Steelers "Uninstalling" Everything Drew Allar Learned in College
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Kwazi Gilmer Set for Big Impact at Nebraska
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Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

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Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
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Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
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Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

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Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
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Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
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Ty Benefield a Potential Game-Changer for LSU Defense
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Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF