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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




REAL-TIME FANTASY NEWS

J.J. McCarthy

Holding J.J. McCarthy in Dynasty Leagues Will Require Patience
Harold Fannin Jr.

Does Harold Fannin Jr. Have Top-Three Upside in Dynasty Leagues?
Jaylen Waddle

the Top Receiver to Roster in Denver?
Josh Downs

Climbing Up the Dynasty Rankings with Bigger Role Ahead?
Jalen McMillan

Has Been 'Slightly Better' Than Teammate During OTAs
Mike Evans

a Risky Upside Buy for Contending Dynasty Managers
Justin Herbert

Is Justin Herbert Entering His True Dynasty Prime?
Oronde Gadsden

Can Talent Overcome Situation for Oronde Gadsden II?
David Njoku

a Short-Term Dynasty Buy
Devin Neal

a Dynasty Hold Until the Depth Chart Ahead of Him Settles
Ricky Pearsall

Is Ricky Pearsall a Dynasty Breakout Candidate?
Tank Dell

Is Tank Dell a Player to Target in Dynasty Leagues?
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Sean Tucker

Is Sean Tucker an Undervalued Dynasty Trade Target?
Donovan Mitchell

Remains Cleveland's Top Priority
Puka Nacua

Is Puka Nacua the WR1 in Dynasty Leagues?
Adou Thiero

Remains a Lakers Development Project
Jalen McMillan

to Play All Three Receiver Positions?
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Kyrie Irving

Reports He's Nearing Full Strength in ACL Recovery
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Mitchell Robinson

Plans to Play in Game 1 After Finger Surgery
Ajay Mitchell

Ruled Out for Game 7
Jalen Williams

Unavailable in Decisive Game 7
NBA

Magic Finalizing Hire of Sean Sweeney as Head Coach
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Alec Pierce

Dynasty Hype May Be Creating a Sell-High Opportunity
Drake London

Quarterback Uncertainty Creating a Buy-Low Window for Drake London?
Davante Adams

: Dynasty Sell-High Candidate Entering Age-34 Season
Rhamondre Stevenson

Dynasty Outlook Clouded by Crowded New England Backfield
Bo Nix

Is Bo Nix Currently Undervalued in Dynasty Formats?
Rico Dowdle

Dynasty Value Fading Ahead of First Season in Pittsburgh?
Deiveson Figueiredo

Set For UFC Macau Main Event
MMA

Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
CFB

Maryland, Baylor Schedule Home-and-Home
CFB

Taron Dickens Decommits From North Carolina
Jalen Williams

Limited in Game 6 Return
Jared McCain

Provides Bench Spark in Game 6 Loss
Shai Gilgeous-Alexander

Posts Lowest-Scoring Night of His MVP Season
De'Aaron Fox

Struggles From the Field Thursday
Stephon Castle

Controls the Spurs Offense in Game 6 Win
Dylan Harper

Finds His Rhythm Thursday
Victor Wembanyama

Drops 28 to Force a Winner-Take-All Game 7
Jalen Williams

is Active for Game 6
Thomas Sorber

is Optimistic About Playing in Summer League
NBA

Terry Rozier Gets Hit with New Charges
NBA

NBA Approves New Anti-Tanking Rules
MLB

MLB Proposes Hard Salary Cap as Part of Next CBA
Kenley Jansen

Tigers Place Kenley Jansen on Injured List With Pelvic Inflammation
Teoscar Hernández

Teoscar Hernandez Heading to Injured List With Hamstring Strain
MON

Lane Hutson Struggles in Game 4 Loss
CAR

Logan Stankoven Nets Eighth Postseason Goal
CAR

Sebastian Aho Pots Game-Winner on Power Play
CAR

Nikolaj Ehlers Tallies Two Helpers in Impressive Road Win
CAR

Shayne Gostisbehere Records Two Assists in Game 4 Win
CAR

Frederik Andersen Establishes Hurricanes New Postseason Shutout Record
Yordan Alvarez

Continues Homer Barrage With Two More Long Balls on Wednesday
Cristopher Sánchez

Cristopher Sanchez Makes History With Seven More Shutout Innings Against Padres
Teoscar Hernández

Teoscar Hernandez Lifted From Wednesday's Game Early With Hamstring Strain
Kenley Jansen

Exits Relief Appearance on Wednesday With Groin Injury
Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
CFB

Drew Mestemaker a Top Big 12 Quarterback Right Away?
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
Russell Henley

a Top Option at Colonial
Harry Hall

Hoping Putter Carries Him at Colonial
Rickie Fowler

Looks to Regain Momentum at Colonial
Pierceson Coody

Looking to Stay Hot at Colonial
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF