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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Kyle Anderson

Likely Out Monday
Cedric Coward

Remains Out Vs. Kings
Kawhi Leonard

Cleared to Play Sunday
Jalen Suggs

Misses Second Straight Game
Shohei Ohtani

Throws Live Batting Practice on Sunday
Patrick Williams

Available Against Knicks
Rhys Hoskins

Guardians Sign Rhys Hoskins to Minor-League Deal
Deni Avdija

Good to Go Against Suns
Tre Jones

Josh Giddey, Tre Jones Facing Minute Caps Sunday
Jack Brannigan

Exits After Getting Hit in the Face
Nick Richards

Active Sunday Against Knicks
Dairon Blanco

Being Evaluated for Head Injury
Grayson Allen

Jalen Green Active, Grayson Allen Sidelined Sunday
Aidan Miller

is Dealing with Back Soreness
Keyonte George

Faces Game-Time Decision Monday
Naz Reid

Out, Joan Beringer to Start Vs. 76ers
Lauri Markkanen

Probable to Return Monday
Jusuf Nurkić

Jusuf Nurkic Out Monday Against Rockets
Jamal Murray

Good to Go on Sunday
Brandon Lowe

Could Be Poised for Banner Year in Pittsburgh
TJ Friedl

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Bryson Stott

Remains a High-Floor, Low-Ceiling Second Base Option
Anfernee Simons

Won't Face the Knicks
Mitchell Robinson

Sitting on Sunday
Jeremy Peña

Jeremy Pena Set to Return to the Leadoff Spot in 2026
Myles Turner

Back on Sunday
Ronald Acuña Jr.

Ronald Acuna Jr. Will Bat Leadoff in 2026
Kristaps Porzingis

Ruled Out on Sunday
Joey Logano

Will Be Popular DFS Pick at EchoPark Speedway
Tyler Reddick

on Pole After Qualifying Rained Out at EchoPark Speedway
Chase Elliott

Could Chase Elliott Be Worth Rostering At EchoPark Speedway?
Ryan Blaney

Is Ryan Blaney Worth Rostering for DFS at EchoPark Speedway?
Christopher Morel

is Getting Comfortable at First Base
Taylor Walls

is Making Spring Debut on Sunday
Lenyn Sosa

Likely Headed Towards Bench Role
Joe Ryan

is Dealing with Back Inflammation
William Byron

Is William Byron Worth Rostering for DFS at EchoPark Speedway?
Jordan Westburg

has Uncertain Timetable to Return
Rondale Moore

Passes Away
Denny Hamlin

Is Worth Consideration for EchoPark Speedway DFS Lineups
Brad Keselowski

Is A Tournament Option for DFS At EchoPark Speedway
NASCAR

Is Bubba Wallace Rosterable In DFS At EchoPark Speedway?
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Should DFS Players Roster Austin Cindric At EchoPark Speedway?
Ross Chastain

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Ricky Stenhouse Jr

Is Ricky Stenhouse Jr. Worth Rostering for DFS at EchoPark Speedway?
Alex Bowman

Will Start Towards the Rear At EchoPark Speedway
Anfernee Simons

Exits Early In Loss To Detroit
Kristaps Porzingis

On Track To Play Sunday
Shaedon Sharpe

Remains Unavailable Sunday
Tyler Samaniego

Dealing with Back Tightness
Cam Schlittler

Throws Bullpen Session on Saturday
Cody Freeman

to Miss Significant Time with Back Fracture
Javonte Williams

Cowboys Sign Javonte Williams to Three-Year, $24 Million Extension
Logan Gilbert

to Make Spring Debut on Monday
Jonathon Long

Exits With Left-Elbow Sprain
Joel Armia

Wraps Up Olympics With Three-Point Performance
Daniil Tarasov

Available for Panthers
Evan Rodrigues

Set to Return Next Week
Aaron Ekblad

Expected to Play Thursday
Pavel Zacha

Cleared for Action
VAN

Jonathan Lekkerimaki Needs Season-Ending Shoulder Surgery
Mikko Rantanen

Misses Bronze-Medal Game With Lower-Body Injury
Joe Ryan

Scratched From Grapefruit League Start With Back Tightness
Blake Coleman

Activated From Injured Reserve
Matt Rempe

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a Game-Time Call for Olympic Final
Josh Morrissey

Won't Play Sunday
Filip Chytil

Out Indefinitely With Facial Fracture
Connor McDavid

Makes History With Another Multi-Point Outing
Tage Thompson

Expected to Play in Olympic Final
Travis Etienne Jr.

has "Legitimate Interest" in Joining Chiefs
Zach Charbonnet

Undergoes Knee Surgery on Friday
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Curt Cignetti Agrees to New Deal With Indiana, Will Earn $13.2 Million Per Year
Ukko-Pekka Luukkonen

Returns to Practice
Josh Morrissey

Remains Out Against Finland
Sidney Crosby

Won't Play Friday
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Sean Strickland

Looks To Get Back In The Win Column
Uros Medic

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Geoff Neal

Looks To Get Back In The Win Column
Melquizael Costa

A Favorite At UFC Houston
Dan Ige

An Underdog At UFC Houston
Logan Cooley

Sheds Non-Contact Jersey
Maxwell Crozier

to Miss 10 Weeks After Surgery
Kirill Marchenko

Dealing With Lower-Body Injury
Petr Mrazek

Undergoes Season-Ending Surgery
Rashee Rice

Accused of Assault by Long-Time Girlfriend
Ben Griffin

Looking to Return to Top Form at Riviera
Keegan Bradley

Looking to Build Momentum at Riviera
J.J. Spaun

Putting a Major Concern at Riviera
Sepp Straka

May Have Tough Time at The Genesis Invitational
Shane Lowry

Trending Up Entering the Genesis Invitational
Justin Rose

Off Most Radars at The Genesis Invitational
Robert MacIntyre

a Long Hitter to Watch at Riviera Country Club
Jake Knapp

Red-Hot Heading to Riviera
Min Woo Lee

Attempts to Build Momentum After Pebble Beach
Harry Hall

an Unknown for The Genesis Invitational
Matt Fitzpatrick

Has Favorable Path to Success at Riviera This Week
Wyndham Clark

Not Likely to Contend at Genesis Invitational
Ludvig Aberg

Might Find the Genesis Invitational More Challenging
Harris English

Carries Strong Form to Riviera
Patrick Cantlay

Eyes Another Strong Week at The Genesis Invitational
Daniel Berger

Needs Short Game to Show Up at Riviera
Sam Burns

Hopes Return to Form Continues at Riviera
Collin Morikawa

Riding Wave of Victory Into Riviera
Hideki Matsuyama

Looks to Have Repeat Success at The Genesis Invitational
Scottie Scheffler

Looks to Find Paydirt at Riviera
Xander Schauffele

Rounding into Form Before Genesis Invitational
Mike Evans

Will Return in 2026
Kenneth Walker III

Seahawks Not Expected to Use Franchise Tag on Kenneth Walker III
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