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The San Francisco 49ers officially ruled out quarterback Brock Purdy (toe) for the Week 8 game at the Houston Texans this Sunday, according to Adam Schefter of ESPN. Mac Jones will make yet another start. Purdy has not played since aggravating his turf-toe injury in Week 4 and has only played in two games so far in 2025. While he's been improving, Purdy has yet to upgrade to a full practice. His next chance to return will be in Week 9 on Sunday, Nov. 2, against the New York Giants. While it's been a frustrating year for anyone who drafted the 25-year-old signal-caller in fantasy, Purdy should be in play as a top-12 fantasy QB as soon as he's ready to return to the starting gig. In the meantime, Jones will make his sixth start of the year. The former first-rounder has been adequate as a fill-in for San Fran, but he's mostly been a low-end QB2 in fantasy with only six touchdown passes and four interceptions.--Keith Hernandez
Source: ESPN - Adam Schefter
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