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Fantasy football start em, sit em MNF lineups advice for Chiefs vs. Jaguars on Monday Night Football in Week 5 (2025). NFL matchups analysis and MNF starts/sits.
The final game of the Week 5 NFL slate pits two potential playoff teams against each other in Duval County. The Jaguars are out to a 3-1 start, and a win over Patrick Mahomes and the Chiefs could establish them as a real postseason threat. There are also several key players in this game on the start 'em, sit 'em bubble for fantasy football, so many matchups will be decided on Monday night.
Below, read about the fantasy football outlooks for key players like Xavier Worthy, Brian Thomas Jr., Travis Hunter, Brenton Strange, Travis Kelce, Kareem Hunt, and more. Which Chiefs and Jaguars players should you start or sit in Week 5?
We will bring you Monday Night Football analysis all season, focusing on who to start, who is on the fence, and who should find the bench. Good luck in Week 5, RotoBallers!
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Kansas City Chiefs vs. Jacksonville Jaguars
Monday, October 6th, 8:15 PM ET
Game Total: 45.5
Spread: Chiefs -3.5
Matchups We Love
Xavier Worthy looked great last week, catching five passes for 83 yards while also running two times for 38 yards. With Rashee Rice still on the suspended list, Worthy will remain a solid WR2 for fantasy managers. Jacksonville has allowed some big games to WR1s this year, including Chase (36.5 PPR fantasy points) and Collins (22.4 PPR fantasy points).
Xavier Worthy putting Chidobe Awuzie on skates. pic.twitter.com/oZ6nVmxyRx
— Adam Best (@Arrowhead_Adam) September 29, 2025
Matchups We Hate
Lawrence has struggled to make much of a fantasy impact this season. He has scored under 12 fantasy points in three of four games and could be in for another subpar fantasy day in Week 5. The Chiefs held Hurts to 11.5 fantasy points in Week 2 and Jackson to 11.7 fantasy points through three quarters in Week 4. So, Lawrence is not a great QB2 start.
Brenton Strange should definitely be on fantasy radars at this point in the season. He has caught six passes in back-to-back games and will enter Week 5 with a solid 20.8% target share over the past two weeks. Nevertheless, Strange will be more of a TE2 this week against the Chiefs. Kansas City ranks fourth in fantasy points allowed per game while letting up just 3.8 receptions per game to the position.
Other Notable Matchups
What a start to the fantasy season it has been for Mahomes. He ranks third in fantasy points at the position and has scored above 23 fantasy points in three of four games. Given his strong numbers to begin the year, he will be a solid QB1 play in Week 5. The Jaguars have allowed six passing touchdowns over the past three weeks.
Chiefs RBs
At this point in the season, neither Kareem Hunt nor Isiah Pacheco can be started in most 12-team leagues. Pacheco played a season-low 37% of the team's snaps last week, and Hunt is averaging just 3.19 yards per carry this year. With Brashard Smith expected to see more opportunities moving forward, it's hard to trust any Kansas City RB this week. If you had to start one, Hunt would probably be your best choice. He is the team's goal-line back and has seen double-digit carries in back-to-back weeks.
Travis Etienne has been a nice RB2 play in each of the first four weeks. He is averaging 16.7 PPR fantasy points per game and has rushed for 100 yards in two of four contests. Even though the Chiefs have been known to have a great run defense, they have allowed some big fantasy days to RBs in recent weeks. Since this defense has allowed a top-12 RB finish in three straight games, Etienne should be in most lineups.
TRAVIS ETIENNE 48-YARD HOUSE CALL
JAXvsSF on FOX/FOX Onehttps://t.co/HkKw7uXnxV pic.twitter.com/rw18T7TMD8
— NFL (@NFL) September 28, 2025
Jaguars WRs
All Jaguar WRs have been disappointing this year. Brian Thomas Jr. is averaging just nine PPR fantasy points per game and will likely be matched up against Trent McDuffie for most of this game. McDuffie is allowing just 8.4 yards per reception this year. That makes Thomas more of a WR3 this week. As for Travis Hunter, he is a sit in most cases after catching just four passes over the past two games.
TE Travis Kelce
Travis Kelce hasn't been the best TE1 option through the first four weeks. He has finished outside the top-16 at the TE in back-to-back games, and his 16.1% target share ranks 18th among all TEs. However, he will still be considered a low-end TE1 this week. The Jaguars just allowed Jake Tonges to score 14.8 PPR fantasy points against them last week.
More Chiefs vs. Jaguars Fantasy Football Outlooks
Jacksonville Jaguars running back Bhayshul Tuten (shoulder) doesn't carry an injury designation into Monday's game against the Kansas City Chiefs. Despite being limited all week, Tuten is good to go for Monday night. Possibly, the Jaguars were just managing his reps because they know he's nursing a shoulder issue.
Travis Etienne Jr. remains the workhorse back in Jacksonville, but Tuten continues to get mixed in as well. Through four games, Tuten has rushed 21 times for 88 yards and one touchdown. He has also hauled in three receptions for 40 yards and an additional score through the air. Tuten should be viewed as a touchdown-dependent flex for Week 5.
Kansas City Chiefs kicker Harrison Butker will face the Jacksonville Jaguars in Week 5. Butker was busy in Week 4 against the Baltimore Ravens, nailing seven of his eight kicks. The Chief kicker was perfect on his three field goal attempts under 50 yards, but missed from 56 yards in the second quarter. Butker has made 10 of 13 field goal attempts (77%) and seven of nine extra-point attempts (78%). Butker has a career 88% field goal percentage and 94% extra-point percentage, so his accuracy has taken a dip to begin the season.
The Kansas City kicker may not get many opportunities to right the ship against the Jaguars on Monday night. The Jacksonville defense is allowing the fifth-fewest points per game to opposing offenses, which can limit kicking opportunities. That said, the Chiefs' offense looked rejuvenated with Xavier Worthy back, and they could be back to their high-scoring ways. Butker is ranked K5 in our RotoBaller rankings, making him a strong start at kicker in what could end up being a shootout.
Jacksonville Jaguars kicker Cam Little doesn't have a lot of upside, but could be in for a decent fantasy outing in Week 5 against the Kansas City Chiefs on Monday Night Football. The Chiefs have been one of the better defenses in the NFL to start the season, which could either mean the Jaguars struggle to score at all or struggle to score touchdowns.
That means Little has a chance for a good fantasy outing, but his floor isn't the highest. The Jaguars have offensive firepower that makes them capable of putting up points, but they haven't shown enough so far this season. Little is startable, but there are plenty of better options at kicker in Week 5.
DST Kansas City Chiefs
The Kansas City Chiefs' defense will take on the Jacksonville Jaguars' offense on Monday night in Week 5. These two teams are nearly evenly matched on paper, which could produce a very competitive game. The Chiefs' defense is allowing 19.0 points per game, while the Jaguars' defense is allowing 18.0 points per game.
The Kansas City offense is averaging 24.3 points per game, and the Jacksonville offense is averaging 24.0 points per game this season. The emerging Jaguars offense, led by Liam Coen, could pose a threat to the Chiefs in a game that could turn into a high-scoring, back-and-forth affair. The Kansas City Chiefs' defense is ranked the ninth-best defense in our RotoBaller rankings, making them a start-worthy unit. That said, the Chiefs' defense could have a lower ceiling this week.
Kansas City Chiefs Start/Sit Matchups
See the full stats in our Fantasy Football Matchup Ratings Projections
| Player | Start/Sit | Matchup Rating |
Game Matchup |
| Harrison Butker | Start | 114 | @ JAX |
| Patrick Mahomes | Start | 112.7 | @ JAX |
| Xavier Worthy, WR | Risky Start | 109.6 | @ JAX |
| Marquise Brown, WR | Risky Start | 109.2 | @ JAX |
| Tyquan Thornton, WR | Risky Start | 108.2 | @ JAX |
| Travis Kelce, TE | Risky Start | 108.2 | @ JAX |
| JuJu Smith-Schuster, WR | Risky Start | 105.5 | @ JAX |
| Isiah Pacheco, RB | Risky Start | 102.9 | @ JAX |
| Kareem Hunt, RB | Risky Start | 102.1 | @ JAX |
| Noah Gray, TE | Sit | 101.1 | @ JAX |
| Nikko Remigio, WR | Sit | 97.1 | @ JAX |
| Brashard Smith, RB | Sit | 95.8 | @ JAX |
| Jalen Royals, WR | Sit | 92.4 | @ JAX |
| Jared Wiley, TE | Sit | 92.4 | @ JAX |
| Kansas City Chiefs | Sit | 92.2 | @ JAX |
| Gardner Minshew | Sit | 92.1 | @ JAX |
Jacksonville Jaguars Start/Sit Matchups
See the full stats in our Fantasy Football Matchup Ratings Projections
| Player | Start/Sit | Matchup Rating |
Game Matchup |
| Travis Etienne Jr., RB | Start | 115.7 | vs. KC |
| Brian Thomas Jr., WR | Start | 113.3 | vs. KC |
| Cam Little | Risky Start | 111.6 | vs. KC |
| Brenton Strange, TE | Risky Start | 107 | vs. KC |
| Trevor Lawrence | Risky Start | 107 | vs. KC |
| Travis Hunter, WR | Risky Start | 105.7 | vs. KC |
| Dyami Brown, WR | Risky Start | 104.7 | vs. KC |
| Parker Washington, WR | Risky Start | 104.5 | vs. KC |
| Bhayshul Tuten, RB | Risky Start | 102.5 | vs. KC |
| Jacksonville Jaguars | Risky Start | 101 | vs. KC |
| LeQuint Allen Jr., RB | Sit | 99.3 | vs. KC |
| Hunter Long, TE | Sit | 96.7 | vs. KC |
| Tim Patrick, WR | Sit | 94.4 | vs. KC |
| Johnny Mundt, TE | Sit | 94.3 | vs. KC |
| Cody Schrader, RB | Sit | 94.1 | vs. KC |
Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
Compare up to four players and we'll tell you who to start...
Who Should I Start? Who Should I Sit? Some common Week 5 fantasy football lineup decisions are regarding players like Xavier Worthy, Brian Thomas Jr., Travis Hunter, Brenton Strange, Travis Kelce, Kareem Hunt, more. But not to worry, we are here to help make these decisions and build winning lineups in Week 5.
Week 5 Player Decisions. Set your optimal fantasy football lineups for Week 5 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player's name. In the second box, search for the second player's name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed, we've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!
How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circles), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 5 Searches. Curious to see some tough lineup decisions for Week 5 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 5 Searches - Start/Sit Player Comparisons
Below are some popular Week 5 searches and comparisons from our 'Who To Start' tool:
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