Week 13 DraftKings NFL DFS Picks - Main Slate (2025)

Jamie's DraftKings NFL DFS Week 13 picks, value plays, DFS sleepers for the main slate (2025). His top DK plays and value picks for daily fantasy football lineups.

12 weeks down, and I'm still #1 in the FantasyPros rankings! It was a tricky one this week, as we were forced to rank a ton of important Thanksgiving Day players, but we'll see where the week takes us. On that note, Happy Thanksgiving to all of our RotoBallers! I'm thankful for you and the time you give to read our content.

It's a smaller-than-usual slate this week thanks to three games running on Thanksgiving and one on Black Friday, so ownerships should condense as a result. Keep that in mind when choosing certain positions, and it looks like this might be a week to pay heavy, heavy money to the big-time RBs.

Be sure to jump into our RotoBaller Discord! We have so many different channels devoted to whatever you're playing in fantasy football. We also have lots of great NFL DFS articles and NFL DFS tools to help you win MORE this season! Good luck with your DraftKings DFS lineups -- let's dominate this Week 12 slate together!

DraftKings Quarterbacks - Week 13 DFS Picks

TOP PLAY

Josh Allen, BUF @ PIT ($7,500)

Josh Allen leads Buffalo into a critical Week 13 matchup against the Steelers after the Bills dropped their last game to Houston. Allen had a season-low 10.1 fantasy points last week, but is in a get-right spot against a Steelers squad that is in the bottom 10 in pressure rate despite getting much healthier in recent weeks.

"He's one of the five best football players I've ever seen."@colincowherd explains just how valuable Josh Allen is to the Buffalo Bills pic.twitter.com/iALsAK3Rzy

— Herd w/Colin Cowherd (@TheHerd) November 20, 2025

Allen is (once again) the QB1 in all of fantasy, and posts ceiling scores on an almost weekly basis thanks to his efficiency as a passer and red-zone equity in the running game. The Steelers have allowed the fifth-most FPPG to opposing QBs this year, and the Bills currently have a solid road implied total of 25.5.

VALUE PLAY

Jacoby Brissett, ARI @ TB ($5,800)

It's highly possible that Jacoby Brissett will be my cash QB for the fourth straight week. He has been a top-12 QB in every week since taking over for Kyler Murray, and has found chemistry with every one of his receivers in what has become an incredibly condensed offense. DraftKings still hasn't caught up to his production, as Brissett is still priced under $6k.

Brissett has thrown the ball an incredible 150 times over the past three weeks, and that shouldn't change at all against Tampa, which is a notoriously pass-funnel defense. The Bucs have allowed the fourth-highest YPA and the fourth-most FPPG to opposing QBs, and Brissett is force-feeding Michael Wilson and Trey McBride (more on them later).

Other options - Justin Herbert, Sam Darnold, Trevor Lawrence

DraftKings Running Backs - Week 13 DFS Picks

TOP PLAY

De'Von Achane, MIA vs NO ($8,300)

De'Von Achane has an absolutely elite role that doesn't reflect his price tag, as he's the fourth-highest priced RB on the slate. Since Tyreek Hill went down, Achane's usage is through the roof, and he's making the most of the touches as well. In that span, Achane is averaging 93.4 rushing YPG, 5.74 YPC, and five targets per game.

De’Von Achane’s speed was on full display in Week 10 🏎️ pic.twitter.com/1fwj5NsgNh

— NFL (@NFL) November 11, 2025

It's a rare thing this year to see the Dolphins favored by 5.5 points, so Achane should be guaranteed a higher rushing floor than usual (he's gamescript-proof anyway, thanks to his receiving usage). The Saints have allowed 5.2 YPC and the 10th-most FPPG to opposing RBs. He arguably offers more bang for your buck than the guys priced above him.

VALUE PLAY

Breece Hall, NYJ vs ATL ($6,000)

If you're playing Breece Hall, you know what you're getting - an uber-talented player in a terrible offense. Fortunately, he has a few things working in his favor this week. He's facing the most run-funnel team in the NFL (Atlanta), and he should be leaned on at home as the only legitimate weapon (QB included) that the Jets have.

Hall is averaging 19.5 touches per game over the last four, and the Falcons have allowed the most rush attempts per game, along with the seventh-most FPPG to the position. Anticipate an incredibly run-heavy approach, with the Jets leaning on him in the red zone as well.

Other options - Jonathan Taylor, Kyren Williams, Travis Etienne, Jaylen Warren

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DraftKings Wide Receivers - Week 13 DFS Picks

TOP PLAY

Jaxon Smith-Njigba, SEA vs MIN ($9,500)

Jaxon Smith-Njigba is approaching $10k territory, which is a scary prospect, but he's worth it this week with a good amount of stud receivers playing on Thanksgiving Day. The matchup isn't ideal with Minnesota allowing the third-fewest FPPG to WRs, but JSN's usage is through the roof, and he's leading the league in almost every relevant receiving category.

Smith-Njigba is first in air yards share (49.7%), first in target share (34.4%), first in receiving yards per game (119.4), first in yards per route run (4.56), tied for first in targets per route run (0.36), and tied for second in receptions (80). He has unbelievable chemistry with Sam Darnold and has only one game this year under 20 DK points.

VALUE PLAY

Michael Wilson, ARI @ TB ($5,900)

Where in the world did Wilson come from?? He has been absolutely bonkers in the last two games without Marvin Harrison Jr., and has managed to maintain elite usage even with McBride continuing to do what he does. Wilson's price tag has gone from $3,800 to $4,800 to $5,900, but he's still worth every penny.

Michael Wilson talking about how his and Jacoby Brissett’s chemistry has gotten better due to Jacoby’s attention to detail in preparation and his communication. He mentions how Jacoby sends him a ton of clips of other WR’s and what he would want to implement. Impressive stuff🔥 pic.twitter.com/2MSZpYRld8

— K1SinceDay1 (@KSzn2021) November 26, 2025

Over the past two games, Wilson has 25 catches on 33 targets with a 53.1% air yards share. He's also logged an elite 3.16 yards per route run and 61.3 DK points in that span. Continue to roll him out in all contests against a Bucs team that has allowed the ninth-most FPPG to opposing WRs.

Other options - Puka Nacua, Ladd McConkey, Khalil Shakir, Greg Dortch

DraftKings Tight Ends - Week 13 DFS Picks

TOP PLAY

Trey McBride, ARI @ TB ($7,800)

There is no argument anymore that Trey McBride is the TE1, and until this week, he's been the undisputed best per-dollar option as well, since DraftKings had refused to price him to where he belongs. That's finally changed this week as McBride is priced at $7,800, making it an actual decision as to whether you need him or not.

McBride has double-digit targets in five of his last six games and has one of the most bankable floors in fantasy. Tampa protects against the TE position better than they do receivers, so it's intriguing how we'll use McBride this week. He's still worth his price tag, but there's at least a debate as to whether he's as needed.

VALUE PLAY

Gunnar Helm, TEN vs JAX ($2,600)

We're totally dumpster-diving this week for the value spot at TE. Gunnar Helm is fresh off leading his Titans team in receiving a week ago (6-51-0 on seven targets), but keep in mind he only ran a 44% route participation share. This was less than fellow TE Chig Okonkwo, so there is definitely a scary floor here.

That TE-by-committee approach is baked into Helm's near-minimum price tag, and it's worth taking a shot on him to help you fit some of the high-end RBs and WRs on this slate that are in smash spots. The Jaguars have been decimated by TEs all season, allowing the second-most FPPG to the position.

Other options - Oronde Gadsden II, Kyle Pitts Sr., Brenton Strange, Dalton Schultz

DraftKings D/ST - Week 13 DFS Picks

Top Five Defenses For Cash Games

1. Cleveland Browns ($3,000)
2. Houston Texans ($2,900) - move to #1 if Daniel Jones sits
3. Seattle Seahawks ($3,900)
4. New York Jets ($2,400)
5. Jacksonville Jaguars ($3,700)

Thanks for reading, and good luck in your contests this weekend!

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