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Who Should I Start for Week 16? Fantasy Football outlooks for Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce.
Who Should I Start? Who Should I Sit? Some of the most common Week 16 MNF fantasy football lineup decisions involve players like Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 16. Set your optimal fantasy football lineups for Week 16 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Compare up to four players and we'll tell you who to start...
Fantasy Football Matchup Outlooks
Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting for Week 16 MNF:
Brock Purdy, QB, San Francisco 49ers
Indianapolis has allowed the third most passing yards this season, and over their last four games, they have given up an average of 286.5 yards per game. Purdy may be missing a weapon if Ricky Pearsall (knee/ankle) is held out, but he will have the trio of Christian McCaffrey, Jauan Jennings, and George Kittle at his disposal. Purdy projects as a QB1 for the semifinal round of the fantasy football playoffs and can be plugged into starting lineups.
Philip Rivers, QB, Indianapolis Colts
While the box score may have left owners wanting, and the veteran has lost significant zip on his balls, he was accurate and decisive, operating efficiently in the short and intermediate areas. With all that in mind, Rivers' current play style hinders his fantasy upside, relegating him to a low-end desperation play in superflex and 2QB formats. The 22-year NFL vet comes in as RotoBaller's QB30 for his outing with San Francisco.
Christian McCaffrey, RB, San Francisco 49ers
With Ricky Pearsall (knee/ankle) unable to play, CMC will likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.
Jonathan Taylor, RB, Indianapolis Colts
San Fran has been stingy to opposing ground games, yielding the twelfth-fewest rushing yards per contest (106.1). That said, they've allowed RBs to rack up the second-most receptions of any squad (78). Veteran signal-caller Philip Rivers adds an extra variable to the equation, but that should mean that Indy will continue to rely on the rushing attack as they try to remain in playoff contention. Fantasy managers can fire up the 26-year-old as RotoBaller's PPR RB6 for Week 16's slate of action.
Tyler Warren, TE, Indianapolis Colts
Warren has seen six targets in two straight games, so the target share remains high, but his production has remained low. He'll head into a plus-matchup against the San Francisco 49ers defense in Week 16, facing a defense that has allowed nine touchdowns to opposing tight ends this season. Warren has enough upside to be plugged in as a low-end TE1 for this Monday Night matchup in 12-team formats.
Jauan Jennings, WR, San Francisco 49ers
Jennings has played out of the slot more frequently than any other receiver for San Francisco this season. With Ricky Pearsall (knee/ankle) ruled out for Week 16, Jennings should likely see a slight bump in targets on Monday, as well. Jennings projects as a WR2 and can be plugged into starting lineups in Week 16.
Michael Pittman Jr., WR, Indianapolis Colts
Indianapolis fell 18-16 to Seattle. While the QB was efficient, he failed to push the ball downfield and evenly distributed his pass attempts, targeting four pass-catchers at least five times. Unfortunately, a wideout like Pittman, who thrives on volume, may find it challenging to produce at the level that fantasy managers had become accustomed to over the majority of the season. The offense may adapt and evolve as Rivers continues to shake off the rust, but all Colts' skill players take a fantasy hit in the meantime. As for Pittman, he'll rank as RotoBaller's PPR WR37 for Monday's contest.
Alec Pierce, WR, Indianapolis Colts
However, his value will take a considerable hit with quarterback Philip Rivers manning the offense. At 44 years of age, the veteran's arm strength is limited, and that showed in spades during last week's contest. Considering Pierce's archetype doesn't precisely line up with Rivers' capabilities, he's perhaps the riskiest fantasy play of all Colts' wideouts, ranking as RotoBaller's PPR WR66 for his Monday Night Football matchup.
Who Should I Start Tool
You can also see the Who Should I Start tool here.
Week 16 MNF Player Decisions. Today's focus is on specific players - Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce. These are some of the most common searches for fantasy football lineups in Week 16.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 16 Searches. Curious to see some tough lineup decisions for Week 16 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 16 Searches - Start/Sit Player Comparisons
Below are some popular searches and comparisons from our Who To Start tool for Week 16 MNF for Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce:
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