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Who Should I Start for Fantasy Football Week 16? Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce

Tyler Warren - Fantasy Football Rankings, Draft Sleepers, NFL Rookies

Who Should I Start for Week 16? Fantasy Football outlooks for Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce.

Who Should I Start? Who Should I Sit? Some of the most common Week 16 MNF fantasy football lineup decisions involve players like Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 16. Set your optimal fantasy football lineups for Week 16 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

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Fantasy Football Matchup Outlooks

Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting for Week 16 MNF:

Brock Purdy, QB, San Francisco 49ers

San Francisco 49ers quarterback Brock Purdy is in line for another strong showing in Week 16 when he takes on the Indianapolis Colts on Monday night. The Colts' defense will be a tougher test than he saw against Tennessee last week, but there is room for optimism.
 
Indianapolis has allowed the third most passing yards this season, and over their last four games, they have given up an average of 286.5 yards per game. Purdy may be missing a weapon if Ricky Pearsall (knee/ankle) is held out, but he will have the trio of Christian McCaffreyJauan Jennings, and George Kittle at his disposal. Purdy projects as a QB1 for the semifinal round of the fantasy football playoffs and can be plugged into starting lineups.
 
Philip Rivers, QB, Indianapolis Colts
 
Indianapolis Colts quarterback Philip Rivers will be a risky fantasy asset when he lines up with the visiting San Francisco 49ers on Monday Night Football in Week 16. The 44-year-old made an improbable return to the field a week ago, leading the team under center in his first action since the 2020 campaign. Rivers and the Colts ultimately lost 18-16 to the Seahawks, although he actually looked pretty decent considering the long layoff.
 
While the box score may have left owners wanting, and the veteran has lost significant zip on his balls, he was accurate and decisive, operating efficiently in the short and intermediate areas. With all that in mind, Rivers' current play style hinders his fantasy upside, relegating him to a low-end desperation play in superflex and 2QB formats. The 22-year NFL vet comes in as RotoBaller's QB30 for his outing with San Francisco.
 
Christian McCaffrey, RB, San Francisco 49ers
 
San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night.
 
With Ricky Pearsall (knee/ankle) unable to play, CMC will likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.
 
Jonathan Taylor, RB, Indianapolis Colts
 
Indianapolis Colts running back Jonathan Taylor is a superb fantasy start for his Monday night home matchup with the San Francisco 49ers. Taylor remained the Colts' workhorse in Week 15's loss to the Seahawks, notching his eighth game of the campaign with at least 80 rushing yards, handling his second-highest carry total of the season (25). It's worth noting that veteran backfield mate Ameer Abdullah has seen an increased snap share across the previous two weeks, though it shouldn't affect Taylor's position as a locked-in RB1, even against a sound 49ers' rush defense.
 
San Fran has been stingy to opposing ground games, yielding the twelfth-fewest rushing yards per contest (106.1). That said, they've allowed RBs to rack up the second-most receptions of any squad (78). Veteran signal-caller Philip Rivers adds an extra variable to the equation, but that should mean that Indy will continue to rely on the rushing attack as they try to remain in playoff contention. Fantasy managers can fire up the 26-year-old as RotoBaller's PPR RB6 for Week 16's slate of action.
 
Tyler Warren, TE, Indianapolis Colts
 
Indianapolis Colts tight end Tyler Warren has been in a slump over the last few weeks, falling under the 5.0 PPR point mark in each contest. Over the last three games, Warren has finished with 22 yards or fewer in every contest, but did manage to find the back of the end zone in Week 13, which salvaged his fantasy day. The change to 44-year-old Philip Rivers at quarterback doesn't seem to be doing this passing attack any favors, as he only caught three passes for 19 yards in Sunday's loss to the Seahawks.
 
Warren has seen six targets in two straight games, so the target share remains high, but his production has remained low. He'll head into a plus-matchup against the San Francisco 49ers defense in Week 16, facing a defense that has allowed nine touchdowns to opposing tight ends this season. Warren has enough upside to be plugged in as a low-end TE1 for this Monday Night matchup in 12-team formats.
 
Jauan Jennings, WR, San Francisco 49ers
 
San Francisco 49ers wide receiver Jauan Jennings tallied two more touchdowns in Week 15 but again turned in a low-yardage game with just 37 yards against the Titans. Jennings has at least one touchdown in five of the 49ers' last six games, but is averaging 47.2 yards per game during that stretch. He could be in store for a more productive day in Week 16, when San Francisco faces the Indianapolis Colts, which has surrendered more receiving yards to slot targets than any other team.
 
Jennings has played out of the slot more frequently than any other receiver for San Francisco this season. With Ricky Pearsall (knee/ankle) ruled out for Week 16, Jennings should likely see a slight bump in targets on Monday, as well. Jennings projects as a WR2 and can be plugged into starting lineups in Week 16.
 
Michael Pittman Jr., WR, Indianapolis Colts
 
Indianapolis Colts wide receiver Michael Pittman Jr.'s fantasy value takes a modest slide ahead of his clash with the San Francisco 49ers on Monday Night Football. For the most part, the USC product has been a stellar fantasy asset in 2025, working his way to a current WR13 standing in PPR formats. However, Pittman's viability becomes murkier with 44-year-old Philip Rivers calling signals for the Colts. In Rivers' first action in nearly half a decade in Week 15,
 
Indianapolis fell 18-16 to Seattle. While the QB was efficient, he failed to push the ball downfield and evenly distributed his pass attempts, targeting four pass-catchers at least five times. Unfortunately, a wideout like Pittman, who thrives on volume, may find it challenging to produce at the level that fantasy managers had become accustomed to over the majority of the season. The offense may adapt and evolve as Rivers continues to shake off the rust, but all Colts' skill players take a fantasy hit in the meantime. As for Pittman, he'll rank as RotoBaller's PPR WR37 for Monday's contest.
 
Alec Pierce, WR, Indianapolis Colts
 
Indianapolis Colts wide receiver Alec Pierce was a disappointment for fantasy managers in Week 15's loss to the Seahawks, and he won't be any easier to trust for this Monday's bout with the visiting San Francisco 49ers. Pierce corralled his lone target (16 yards) in last Sunday's loss to Seattle and was the only Colts' pass-catcher to command fewer than four looks. The former Cincinnati Bearcat made his money all season on downfield throws, while also evolving his game in the intermediate area of the field.
 
However, his value will take a considerable hit with quarterback Philip Rivers manning the offense. At 44 years of age, the veteran's arm strength is limited, and that showed in spades during last week's contest. Considering Pierce's archetype doesn't precisely line up with Rivers' capabilities, he's perhaps the riskiest fantasy play of all Colts' wideouts, ranking as RotoBaller's PPR WR66 for his Monday Night Football matchup.

 

Who Should I Start Tool

You can also see the Who Should I Start tool here.

Week 16 MNF Player Decisions. Today's focus is on specific players - Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce. These are some of the most common searches for fantasy football lineups in Week 16.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!

How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 16 Searches. Curious to see some tough lineup decisions for Week 16 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

 

Popular Week 16 Searches - Start/Sit Player Comparisons

Below are some popular searches and comparisons from our Who To Start tool for Week 16 MNF for Brock Purdy, Philip Rivers, Christian McCaffrey, Jonathan Taylor, George Kittle, Tyler Warren, Jauan Jennings, Michael Pittman Jr., Alec Pierce:

Brock Purdy
vs
Kyle Monangai
Brock Purdy
vs
Jayden Reed
Brock Purdy
vs
J.K. Dobbins
Brock Purdy
vs
Wan'dale Robinson
Brock Purdy
vs
Chris Godwin Jr.
Brock Purdy
vs
Patrick Mahomes II
Brock Purdy
vs
Michael Pittman Jr.
Brock Purdy
vs
Quentin Johnston
Brock Purdy
vs
Makai Lemon
Brock Purdy
vs
Blake Corum
Brock Purdy
vs
Kyle Pitts Sr.
Brock Purdy
vs
Matthew Stafford
Brock Purdy
vs
Dak Prescott
Brock Purdy
vs
Josh Downs
Brock Purdy
vs
Sam Laporta
Brock Purdy
vs
Bo Nix
Brock Purdy
vs
Trevor Lawrence
Brock Purdy
vs
Kyler Murray
Brock Purdy
vs
Ricky Pearsall
Brock Purdy
vs
Dalton Kincaid
Brock Purdy
vs
Josh Allen
Brock Purdy
vs
Lamar Jackson
Brock Purdy
vs
Jayden Daniels
Brock Purdy
vs
Drake Maye
Brock Purdy
vs
Joe Burrow
Brock Purdy
vs
Jalen Hurts
Brock Purdy
vs
Caleb Williams
Brock Purdy
vs
Justin Herbert
Christian McCaffrey
vs
Ja'Marr Chase
Christian McCaffrey
vs
Jaxon Smith-Njigba
Christian McCaffrey
vs
Bijan Robinson
Christian McCaffrey
vs
CeeDee Lamb
Christian McCaffrey
vs
Puka Nacua
Christian McCaffrey
vs
Jonathan Taylor
Christian McCaffrey
vs
Jahmyr Gibbs
Christian McCaffrey
vs
Amon-Ra St. Brown
Christian McCaffrey
vs
Justin Jefferson
Christian McCaffrey
vs
De'Von Achane
Christian McCaffrey
vs
James Cook III
Christian McCaffrey
vs
Saquon Barkley
Christian McCaffrey
vs
Drake London
Christian McCaffrey
vs
Malik Nabers
Christian McCaffrey
vs
Ashton Jeanty
Christian McCaffrey
vs
Kenneth Walker III
Christian McCaffrey
vs
Trey McBride
Christian McCaffrey
vs
Rashee Rice
Christian McCaffrey
vs
Derrick Henry
Christian McCaffrey
vs
Omarion Hampton
Christian McCaffrey
vs
Chase Brown
Christian McCaffrey
vs
Jeremiyah Love
Christian McCaffrey
vs
Josh Jacobs
Christian McCaffrey
vs
Kyren Williams
Christian McCaffrey
vs
Travis Etienne Jr.
Christian McCaffrey
vs
Breece Hall
Christian McCaffrey
vs
Javonte Williams
Christian McCaffrey
vs
Bucky Irving
Jonathan Taylor
vs
CeeDee Lamb
Jonathan Taylor
vs
Amon-Ra St. Brown
Jonathan Taylor
vs
Jaxon Smith-Njigba
Jonathan Taylor
vs
Justin Jefferson
Jonathan Taylor
vs
Christian McCaffrey
Jonathan Taylor
vs
De'Von Achane
Jonathan Taylor
vs
Ja'Marr Chase
Jonathan Taylor
vs
James Cook III
Jonathan Taylor
vs
Bijan Robinson
Jonathan Taylor
vs
Saquon Barkley
Jonathan Taylor
vs
Puka Nacua
Jonathan Taylor
vs
Drake London
Jonathan Taylor
vs
Jahmyr Gibbs
Jonathan Taylor
vs
Malik Nabers
Jonathan Taylor
vs
Ashton Jeanty
Jonathan Taylor
vs
Kenneth Walker III
Jonathan Taylor
vs
Trey McBride
Jonathan Taylor
vs
Rashee Rice
Jonathan Taylor
vs
Derrick Henry
Jonathan Taylor
vs
Omarion Hampton
Jonathan Taylor
vs
Chase Brown
Jonathan Taylor
vs
Jeremiyah Love
Jonathan Taylor
vs
Josh Jacobs
Jonathan Taylor
vs
Kyren Williams
Jonathan Taylor
vs
Travis Etienne Jr.
Jonathan Taylor
vs
Breece Hall
Jonathan Taylor
vs
Javonte Williams
Jonathan Taylor
vs
Bucky Irving
George Kittle
vs
Oronde Gadsden II
George Kittle
vs
Jalen Coker
George Kittle
vs
KC Concepcion
George Kittle
vs
Jake Ferguson
George Kittle
vs
Dallas Goedert
George Kittle
vs
Khalil Shakir
George Kittle
vs
Jared Goff
George Kittle
vs
Baker Mayfield
George Kittle
vs
Jordan Love
George Kittle
vs
Xavier Worthy
George Kittle
vs
Aaron Jones Sr.
George Kittle
vs
Matthew Golden
George Kittle
vs
Dalton Kincaid
George Kittle
vs
Jacory Croskey-Merritt
George Kittle
vs
Kyler Murray
George Kittle
vs
Travis Kelce
George Kittle
vs
Bo Nix
George Kittle
vs
Malik Willis
George Kittle
vs
Josh Downs
George Kittle
vs
Romeo Doubs
George Kittle
vs
Trey McBride
George Kittle
vs
Brock Bowers
George Kittle
vs
Colston Loveland
George Kittle
vs
Harold Fannin Jr.
George Kittle
vs
Tucker Kraft
George Kittle
vs
Sam Laporta
George Kittle
vs
Kyle Pitts Sr.
George Kittle
vs
Kenyon Sadiq
Tyler Warren
vs
Jordyn Tyson
Tyler Warren
vs
Parker Washington
Tyler Warren
vs
Alec Pierce
Tyler Warren
vs
Christian Watson
Tyler Warren
vs
Drake Maye
Tyler Warren
vs
Chuba Hubbard
Tyler Warren
vs
Courtland Sutton
Tyler Warren
vs
Marvin Harrison Jr.
Tyler Warren
vs
Carnell Tate
Tyler Warren
vs
DK Metcalf
Tyler Warren
vs
David Montgomery
Tyler Warren
vs
RJ Harvey
Tyler Warren
vs
Jadarian Price
Tyler Warren
vs
Rhamondre Stevenson
Tyler Warren
vs
Quinshon Judkins
Tyler Warren
vs
Joe Burrow
Tyler Warren
vs
Jayden Daniels
Tyler Warren
vs
Michael Wilson
Tyler Warren
vs
TreVeyon Henderson
Tyler Warren
vs
Jalen Hurts
Tyler Warren
vs
Trey McBride
Tyler Warren
vs
Brock Bowers
Tyler Warren
vs
Colston Loveland
Tyler Warren
vs
Harold Fannin Jr.
Tyler Warren
vs
Tucker Kraft
Tyler Warren
vs
Sam Laporta
Tyler Warren
vs
Kyle Pitts Sr.
Tyler Warren
vs
Dalton Kincaid
Jauan Jennings
vs
Rachaad White
Jauan Jennings
vs
Hunter Henry
Jauan Jennings
vs
Daniel Jones
Jauan Jennings
vs
Brenton Strange
Jauan Jennings
vs
Tyrone Tracy Jr.
Jauan Jennings
vs
Woody Marks
Jauan Jennings
vs
Omar Cooper Jr.
Jauan Jennings
vs
Jonathon Brooks
Jauan Jennings
vs
Jordan Mason
Jauan Jennings
vs
Rashid Shaheed
Jauan Jennings
vs
Mark Andrews
Jauan Jennings
vs
Calvin Ridley
Jauan Jennings
vs
C.J. Stroud
Jauan Jennings
vs
Denzel Boston
Jauan Jennings
vs
Kenyon Sadiq
Jauan Jennings
vs
Brian Robinson Jr.
Jauan Jennings
vs
Chris Rodriguez Jr.
Jauan Jennings
vs
Isaiah Likely
Jauan Jennings
vs
Sam Darnold
Jauan Jennings
vs
Juwan Johnson
Jauan Jennings
vs
Puka Nacua
Jauan Jennings
vs
Ja'Marr Chase
Jauan Jennings
vs
Jaxon Smith-Njigba
Jauan Jennings
vs
CeeDee Lamb
Jauan Jennings
vs
Amon-Ra St. Brown
Jauan Jennings
vs
Justin Jefferson
Jauan Jennings
vs
Drake London
Jauan Jennings
vs
Malik Nabers
Michael Pittman Jr.
vs
Makai Lemon
Michael Pittman Jr.
vs
Chris Godwin Jr.
Michael Pittman Jr.
vs
Kyle Pitts Sr.
Michael Pittman Jr.
vs
J.K. Dobbins
Michael Pittman Jr.
vs
Dak Prescott
Michael Pittman Jr.
vs
Kyle Monangai
Michael Pittman Jr.
vs
Sam Laporta
Michael Pittman Jr.
vs
Brock Purdy
Michael Pittman Jr.
vs
Trevor Lawrence
Michael Pittman Jr.
vs
Jayden Reed
Michael Pittman Jr.
vs
Ricky Pearsall
Michael Pittman Jr.
vs
Wan'dale Robinson
Michael Pittman Jr.
vs
Jaxson Dart
Michael Pittman Jr.
vs
Patrick Mahomes II
Michael Pittman Jr.
vs
Justin Herbert
Michael Pittman Jr.
vs
Quentin Johnston
Michael Pittman Jr.
vs
Tucker Kraft
Michael Pittman Jr.
vs
Blake Corum
Michael Pittman Jr.
vs
Jakobi Meyers
Michael Pittman Jr.
vs
Matthew Stafford
Michael Pittman Jr.
vs
Puka Nacua
Michael Pittman Jr.
vs
Ja'Marr Chase
Michael Pittman Jr.
vs
Jaxon Smith-Njigba
Michael Pittman Jr.
vs
CeeDee Lamb
Michael Pittman Jr.
vs
Amon-Ra St. Brown
Michael Pittman Jr.
vs
Justin Jefferson
Michael Pittman Jr.
vs
Drake London
Michael Pittman Jr.
vs
Malik Nabers
Alec Pierce
vs
Drake Maye
Alec Pierce
vs
Jordyn Tyson
Alec Pierce
vs
Courtland Sutton
Alec Pierce
vs
Tyler Warren
Alec Pierce
vs
Carnell Tate
Alec Pierce
vs
Parker Washington
Alec Pierce
vs
David Montgomery
Alec Pierce
vs
Christian Watson
Alec Pierce
vs
Jadarian Price
Alec Pierce
vs
Chuba Hubbard
Alec Pierce
vs
Quinshon Judkins
Alec Pierce
vs
Marvin Harrison Jr.
Alec Pierce
vs
Jayden Daniels
Alec Pierce
vs
DK Metcalf
Alec Pierce
vs
TreVeyon Henderson
Alec Pierce
vs
RJ Harvey
Alec Pierce
vs
Bhayshul Tuten
Alec Pierce
vs
Rhamondre Stevenson
Alec Pierce
vs
DJ Moore
Alec Pierce
vs
Joe Burrow
Alec Pierce
vs
Puka Nacua
Alec Pierce
vs
Ja'Marr Chase
Alec Pierce
vs
Jaxon Smith-Njigba
Alec Pierce
vs
CeeDee Lamb
Alec Pierce
vs
Amon-Ra St. Brown
Alec Pierce
vs
Justin Jefferson
Alec Pierce
vs
Drake London
Alec Pierce
vs
Malik Nabers

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Scottie Scheffler

The Leading Favorite at Cadillac Championship
Collin Morikawa

Still a Smash Play at Cadillac Championship
Viktor Hovland

Showed at Augusta He Can Finish Well
Sepp Straka

Attempting to Finish Better in Miami
PGA

J.J Spaun Enduring Roller Coaster Start to 2026
Min Woo Lee

Seeks to Make Adjustments at Cadillac Championship
Max Homa

May Struggle at Old Doral This Weekend
Ben Griffin

Rebounds From Rough Stretch as Miami Looms
Shane Lowry

Searching For Answers at Cadillac Championship
Russell Henley

Daunting Test at Doral Likely Not a Place For Russell Henley
Justin Rose

Returns to Action After Finishing Third at Masters Tournament
Hideki Matsuyama

Has The Approach Game to Win at Cadillac Championship
Junior Caminero

Suffers Jaw Contusion on Tuesday, Considered Day-to-Day
CFB

Brendan Sorsby Facing Potential Permanent Loss of Eligibility
Carson Hocevar

Scores his First Career NASCAR Cup Series Victory at Talladega
Chris Buescher

Misses out on Winning at Talladega by Finishing Second
Alex Bowman

Earns First Top-Five Finish at Talladega Since Returning From Injury
Chase Elliott

Scores A Fourth-Place Finish at Talladega
Zane Smith

Nabs First Top-Five Finish of the 2026 Season at Talladega
CFB

Texas Tech Quarterback Brendan Sorsby Enters Rehab
Youssef Zalal

Suffers Unanimous-Decision Loss
Aljamain Sterling

Wins Back-To-Back Fights
Norma Dumont

Drops Decision At UFC Vegas 116
Joselyne Edwards

Scores Upset Win
Alexander Hernandez

Gets Dominated
Alexander Hernandez

Rafa Garcia Dominates Alexander Hernandez
Adrian Luna Martinetti

Unsuccessful In His UFC Debut
Davey Grant

Gets Back In The Win Column
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF