Fantasy Football FLEX Rankings - Week 6 Early Updates

October 7, 2025

Fantasy football Week 6 rankings for RB, WR, TE. Read RotoBaller's FLEX rankings for Week 6, 2025 to set winning lineups.

Injuries and bye weeks will be factors for fantasy managers to consider for the next several weeks, so let us help set your lineups with our Week 6 fantasy football FLEX rankings for 2025. To see where key RBs, WRs, and TEs such as Stefon Diggs, Quentin Johnston, Cam Skattebo, Quinshon Judkins, Jaylen Warren, Ricky Pearsall, Juwan Johnson, and more stand for the sixth fantasy football slate of the year, dig into the rankings below.

Our FLEX fantasy football rankings for Week 6 are put together by Nick Mariano. Below the rankings, you will also find a summary of the important FLEX fantasy football news for this week. There are always key injuries and developments to keep track of, so check back throughout the week for updates.

Be sure to bookmark our fantasy football rankings portal and check back regularly for updates. Most importantly, our free mobile app is a must-have - download it and configure your push notifications. We deliver all the top NFL news, injuries, and fantasy analysis 24x7 with our free push notification alerts... all for free!

Week 6 FLEX Rankings for Fantasy Football

Bookmark our PPR rankings, Half-PPR rankings, and standard (non-PPR) rankings 

Week 6 FLEX Rankings Outlooks

Ricky Pearsall, San Francisco 49ers

San Francisco 49ers wide receiver Ricky Pearsall (knee) wasn't spotted at Monday's practice, according to Cam Inman of the Bay Area News Group. Although the 49ers didn't hold an official practice on Monday, it's not a great sign that Pearsall isn't on the field after he was inactive for last Thursday night's win over the Los Angeles Rams due to a minor PCL injury that he suffered in Week 4.

Both Pearsall and Jauan Jennings (ankle, ribs) did not play last Thursday, allowing Kendrick Bourne to go off for 10 catches and over 100 yards. Jennings was on the field on Monday, though, signaling that Jennings might be closer than Pearsall in terms of being available in Week 6 to face the Tampa Bay Buccaneers. If the 25-year-old Pearsall doesn't return to the team's first practice on Wednesday, he'll be on track to miss a second straight game.

Darius Slayton, New York Giants

New York Giants wide receiver Darius Slayton (hamstring) was listed as a non-participant in practice on Monday's injury report. Slayton left late in New York's Week 5 loss to the New Orleans Saints with a hamstring injury and did not return. The Giants have a short week in Week 6 as they prepare to take on the Philadelphia Eagles on Thursday night, so it could be tough for Slayton to recover in time to play.

The 28-year-old recorded three catches for 31 yards on six targets before getting hurt in New York's first full game without star wideout Malik Nabers (knee). If Slayton is sidelined for Week 6, Giants wide receivers Wan'Dale Robinson and Jalin Hyatt would likely see an uptick in targets.

Jacory Croskey-Merritt, Washington Commanders

Washington Commanders running back Jacory Croskey-Merritt stepped up in Week 5 against the Chargers, taking 14 carries for 111 rushing yards and two touchdowns. The other running backs were less involved, with Chris Rodriguez Jr. only getting five carries for seven yards and Jeremy McNichols only one carry for six yards. Croskey-Merritt played a season-high 47% of snaps, while McNichols and Rodriguez only played 25% each. The seventh-round pick from Arizona seemed to gel well with returning QB Jayden Daniels and helped the team secure a big road win over the Chargers.

This week, Croskey-Merritt and the Commanders are home against the Bears on Monday Night Football, which should be a good matchup for the rookie to continue to assert himself as the leader of the backfield going forward. He's definitely the most dynamic option of the group with the highest fantasy upside.

Jaylen Warren, Pittsburgh Steelers

Pittsburgh Steelers running back Jaylen Warren (knee) was back in individual drills during Monday's practice after he missed the Week 4 win in Dublin, Ireland, over the Minnesota Vikings, according to Brian Batko. Warren was a surprise inactive in Week 4, leading the way for backup Kenneth Gainwell to be featured heavily in Pittsburgh's offense as both a rusher and receiver. The Steelers had a well-timed bye in Week 5, giving the 26-year-old Warren a good chance to make it back in Week 6 against the division-rival Cleveland Browns after missing only one game. We'll have a better idea of Warren's Week 6 status once the Steelers start officially practicing on Wednesday.

Warren has been a must-start in fantasy through three games, rushing for 132 yards on 43 carries while also catching 11 passes for 142 yards and a score. However, Warren will be a fade candidate in DFS against a tough Browns defense this weekend if he returns.

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