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There are no afternoon games Friday, meaning it's a normal evening slate of games on DraftKings. With 15 games on the docket, there will be plenty of options to choose from. While some expensive pitching targets exist for Friday, the key will be to find value on the mound in order to afford some big-time hitters. 

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 4/21/17. The DFS lineup picks will range from some of the elite players to mid-priced options and value plays on DraftKings.

You can read our FanDuel and Yahoo DFS lineup picks as well. If you have any questions or comments, feel free to reach out to me on Twitter @barryleonardjr.

Editor's Note: Stay on top of our MLB off-season news and fantasy analysis all year round. Read our daily fantasy columns about MLB prospects, dynasty outlooks, player outlooks and much more. It's always fantasy baseball season here. Let's Go!


DFS Lineup Stacks to Target on DraftKings

Cleveland Indians vs. Jose Quintana (LHP)

The Tribe hitters get a very favorable matchup Friday with Jose Quintana. The Chicago southpaw has really struggled to start the season, posting a record of 0-3 and an ERA of 6.75. He's given up five runs in two of his first three starts. Current Cleveland batters have a lifetime average of .280 against him, with Michael Brantley collecting 13 hits, a homer, and six RBI in 27 at-bats. Righties have been very successful against Quintana this year, so don't be afraid to deploy guys like Francisco Lindor, Edwin Encarnacion.

Milwaukee Brewers vs. Adam Wainwright (RHP)

Wainwright is 0-3 to start the year and has given up a total of nine runs in his last two starts. Friday's task won't be easy, as he'll be going up against the hard-hitting Brewers. Milwaukee is one of the top offensive teams in the league and makes for a great lineup stack. Lefties have crushed Wainwright to the tune of .455 this year, so Travis Shaw and Eric Thames could be in for big games.


DFS Starting Pitchers to Consider on DraftKings

Jeremy Hellickson - vs. Atlanta Braves, $7,300 

Hellickson has started the new season with a record of 2-0 and an ERA of just 1.59. He has pitched in three games against two tough lineups -- Washington and Cincinnati -- and has looked sharp. He won't overwhelm opponents with strikeouts, but his ability to get outs is very valuable for fantasy lineups. With current Atlanta hitters carrying a combined average of .237 against him, Hellickson is in a good spot Friday.

Wily Peralta vs. St. Louis Cardinals, $5,700

This one could be a bit of a sleeper, but the St. Louis lineup hasn't been as dangerous this year as it has been in the past. Peralta has been flying under the fantasy radar a bit this year, but he's 3-0 with a 2.65 ERA. Don't let the fact that he went 0-2 against the Cardinals last year scare you away, he's pitching on a team that's been on of the best offenses to start the year.


DFS Infielders to Consider on DraftKings

Catcher (C)

Buster Posey - SF at COL, $5,100

If you take the above advice and go the cheap pitcher route you'll have some extra cap space for some big hitters. Buster Posey's price tag is higher than normal Friday thanks to the Coors Field effect. Despite missing time with a concussion earlier this year, Posey is off to a good start -- hitting .367 for the year and .444 over the last week. He's just 2-for-18 in his career against opposing starter Tyler Chatwood, but don't shy away. Posey is hitting well and racked up an average of .360 with two home runs and seven RBI at Coors last season.

First Base (1B)

Anthony Rizzo - CHC at CIN, $5,300

Rizzo has been smoking hot lately and is currently riding a nine-game hit streak. He is hitting .400 over the last week and has three straight games with at least 10 points on DraftKings. He has just six career at-bats against opposing pitcher Tim Adleman, but he's got four hits, including a double. Rizzo had six home runs in 40 at-bats at Great American Ballpark a year ago, so that bodes well for his chances Friday.

Second Base (2B)

Jose Ramirez - CLE at CHW, $3,700

Ramirez had a six-game hit streak end on Thursday, but he still enters Friday with a batting average of .345 with four homers and 16 RBI. He's really been hot recently, batting over .500 in the last week. He gets a good matchup with Jose Quintana Friday, as he has a lifetime average of .375 (9-for-24) against him.

Shortstop (SS)

Francisco Lindor - CLE at CHW , $3,900

Lindor went hitless Thursday, but he's still hitting .328 for the year and .370 over the past seven days. He continues to be the best available shortstop from a daily fantasy perspective and is averaging over 11 points a game on DraftKings. He can hit for both power and average, making him a must-start on most days.

Third Base (3B)

Nolan Arenado - COL vs. SF, $5,300

This one will cost you, but it's not wise to fade Nolan Arenado at home, particularly with him on a hot streak. The Colorado slugger is hitting .356 this year with six home runs, including that two that he hit against the Dodgers Tuesday. Arenado has three multi-hit games in his last four contests and is batting .435 over the last seven days. He does face a bit of a tough matchup with Johnny Cueto Friday, but his recent stretch and history at Coors Field should outweigh that. Arenado has been a daily fantasy stud and is a must-start, especially at home.


DFS Outfielders to Consider on DraftKings

 Ryan Braun - MIL vs. STL, $5,000

Braun has turned back the clock a bit to start this season and is hitting over .300 with five home runs. He has two career home runs in his career against Adam Wainwright. Braun could be a savvy pick Friday, as many could stay away from his .213 lifetime average against the St. Louis right-hander and his low average against righties this season. Still, Braun has been hitting well and has been a very reliable source of fantasy points with an average of near 11 a game. 

Charlie Blackmon - COL vs SF, $5,100

Blackmon has struggled this year, particularly over the last week, hitting just .208. However, when hitting at Coors Field, his average is .348 with two home runs. He has also been good in the past against Johnny Cueto, hitting .300 (9-for-30). It's always wise to deploy some Rockies when they are home. Carlos Gonzalez would be the better choice here, but he's dealing with an injury, so go with Blackmon.

Steven Souza Jr. - TB vs HOU, $3,500

Steven Souza Jr. had a huge day Thursday, going 3-for-5 with a home run and three RBI. The outfielder is hitting .349 for the season and slugging .603. He has hit .308 over the last week and enters Friday with 11 hits over the last seven games. Despite being a right-handed batter, Souza has torched righties this year with a .341 average and two home runs.


DFS Hitters to Avoid on DraftKings

Anthony Rendon - WAS at NYM, $3,500

Yes, Rendon has heated up lately, hitting .348 over the last weekbut he faces a very difficult matchup with New York's Jacob deGrom on Friday. In 10 at-bats against him Rendon is hitless and has three strikeouts. While that's a small sample size, there's also the fact that Rendon is hitting barley over .200 against righties this season, and deGrom has limited right-handed hitters to a .212 average.

Trevor Story - COL vs. SF, $4,900

Trevor Story is priced among the most expensive shortstops available on Friday, but he's not worth the price. Sure, the thought of him hitting at Coors Field is enticing, but not when you realize how badly he's struggled this year. Story is hitting just .135 this year and has already struck out 25 times. Also, in his brief career against Johnny Cueto he's just 3-for-12.


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