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Will Brock Purdy play in Week 2 for fantasy football? Is Brock Purdy injured or hurt heading into Week 2 of 2025? Read the latest Brock Purdy injury report.
San Francisco 49ers quarterback Brock Purdy (toe/shoulder) played just one game in 2025 before suffering toe and shoulder injuries. The 49ers have a long history of constantly being decimated by injury issues, and this season, they already have three offensive starters who played in Week 1 affected by injury issues.
Purdy, tight end George Kittle (hamstring), and wide receiver Jauan Jennings (shoulder) all are now in danger of missing time, with Kittle already having been placed on injured reserve. He'll miss the next four games, at minimum. Purdy and Jennings' situations are less clear.
It would obviously be a huge blow for San Francisco to not have its starting QB. His backup, Mac Jones, hasn't had a great NFL career and bounced around the league a bit as a backup before landing in his current spot. So, what's the status of Purdy's injuries? And will he play in Week 2?
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Brock Purdy Fantasy Football Injury Update
A very recent update on Purdy didn't bring good news. Reports are that he's a "long shot" to play in Week 2 now because of his injuries. Additionally, it was reported that he could be facing a "multi-week" ailment, meaning he could miss even more time after next week.
#49ers QB Brock Purdy (toe, shoulder) is a "longshot" to play on Sunday vs. the #Saints, which means Mac Jones would start.
It could be a multi-week injury, per HC Kyle Shanahan. pic.twitter.com/aAExAfVlkc
— Ari Meirov (@MySportsUpdate) September 10, 2025
49ers head coach Kyle Shanahan tends to send his players out even when they're dealing with injury issues, so the news about Purdy isn't great, and we should treat it as such. If you have Purdy in fantasy leagues, you should prepare for him to miss at least two weeks, if not three. He hasn't been placed on injured reserve, though.
That would at least indicate that he's unlikely to miss four weeks. A tentative return date of Week 4 seems to be conservative, then. We don't have the details of what his specific injuries are, but it seems reasonable to guess he could be dealing with something in his throwing shoulder. So, he'll need time to heal up.
Is Brock Purdy Playing in Week 2?
It's highly unlikely at this point. It wouldn't make sense for the team to rush him back after Shanahan indicated that he's a long shot. This team would be very unlikely to make the playoffs without Purdy, especially with the other injuries it is dealing with.
“I think it’s a long shot.”
Kyle Shanahan on Brock Purdy’s chances of playing on Sunday after suffering a toe injury in Week 1 pic.twitter.com/SCIYpceCG8
— 95.7 The Game (@957thegame) September 10, 2025
You can see Shanahan's comments on Purdy's injury above for yourself. Interestingly, Shanahan indicated that the toe seems to be a more pressing issue than his shoulder injury. He could have a fracture or break, or possibly turf toe, but we just don't know yet, if we'll ever know.
Brock Purdy Fantasy Football Outlook for Week 2
If he does play in Week 2, it might be hard for him to be fantasy-relevant. Obviously, it's much more likely that he doesn't take the field, but if he does, he'll probably be hobbled due to his ailments. San Francisco does have a pretty easy matchup against the New Orleans Saints, who struggled in Week 1, though.
One of my favorite things to do going back through film is to watch what happens when TEs or RBs try to block Demario Davis. Be ready for violence.
Cam Jordan sets the edge perfectly and the pursuit finishes the play. Demario is just a fun guy to watch. #Saints pic.twitter.com/p36aoGhtk2
— Jeff Nowak (@Jeff_Nowak) September 9, 2025
The Saints have solid personnel on defense, but the ineffectiveness of their offense could mean they're forced to be on the field far more than they're comfortable with. Humans tend to get tired the more they work their bodies, and there's no exception to this for NFL players.
Still, it's hard to trust starting Purdy in Week 2 if he does play. He won't have Kittle, his top tight end, and Jennings could be out, leaving just Ricky Pearsall healthy of the team's top-4 pass-catchers. Jennings could play through his injury, but it could be a struggle. Outside of deep Superflex/2QB leagues, I'd avoid starting Purdy in Week 2 if he takes the field for some reason.
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Who Should I Start? Who Should I Sit? Some common Week 2 fantasy football lineup decisions are regarding players like Brock Purdy. But not to worry, we are here to help make these decisions and build winning lineups in Week 2. Set your optimal fantasy football lineups for Week 2 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start ... all free! Get your winning lineups set, and make the right decisions.
Week 2 Player Decisions. Today's focus is on Brock Purdy. He is one of the most common searches for fantasy football lineups in Week 2.
Using The Tool. This is a simple tool, but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player's name. In the second box, search for the second player's name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
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Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, half-PPR scoring, or standard (non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circles), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 2 Searches. Curious to see some tough lineup decisions for Week 2 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 2 Searches - Start/Sit Player Comparisons
Below are some popular Week 2 searches and comparisons from our 'Who To Start' tool for Brock Purdy compared to others:
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