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Is Joe Mixon out for the season? When is Joe Mixon coming back? The latest Joe Mixon injury update and fantasy football outlook heading into Week 6 of 2025.
Houston Texans running back Joe Mixon (foot) has remained on the non-football injury/reserve list since the start of the regular season and has yet to return to practice.
While he could have returned to practice before Week 5, Mixon has yet to make any progress, further suggesting he is still several weeks away from a potential return.
Will Mixon play again this season? Should fantasy managers stash him on their bench? Let's dive in!
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Is Joe Mixon Out for the 2025 Season?
While Mixon has not been ruled out of the remainder of the season, he is trending in that direction. Last week, Aaron Wilson of KPRC2 reported that Mixon is still not ready to return to practice, despite being eligible to return. In fact, his sources noted that it will be "much longer" until Mixon can be cleared for action.
Given this update, managers should not expect to return to this season. Although the team has not made it official, given his lack of participation in practices, he is trending in the wrong direction and is fighting an uphill battle to return this season.
#Texans coach DeMeco Ryans specifically indicated that Joe Mixon is not ready to return at this time. Per sources, it will be much longer, if at all, for Mixon to get back on the field this season @KPRC2
— Aaron Wilson (@AaronWilson_NFL) September 29, 2025
Joe Mixon 2025 Fantasy Football Outlook
As a result, managers in any format without IR spots should not consider stashing Mixon. Without any firm timetable, he carries minimal fantasy value and should not be stashed in any format. While managers in leagues that have IR spots could still hold Mixon, they should look to pivot to other "IR" eligible players such as Christin Watson (knee) or Jalen Coker (quadriceps), who have a more defined timeline.
In addition, the Texans have begun to provide more opportunities for rookie Woody Marks, suggesting that they are beginning to turn the page on the Mixon era. In Week 4, Marks enjoyed a breakout showing as he ran for 69 yards and scored on 17 carries and added a score through the air.
While he took a step back in their Week 5 victory over the Ravens this past weekend, his increased usage suggests the team is preparing to remain without Mixon for the rest of the season.
Fantasy managers should only view Mixon as a low-priority stash in deeper 14+ team leagues that have IR spots.
Joe Mixon Not Ready to Return https://t.co/x22mNOdy8w
— RotoBaller NFL (@RotoBallerNFL) September 29, 2025
Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
Compare up to four players and we'll tell you who to start...
Who Should I Start? Who Should I Sit? Some common Week 6 fantasy football lineup decisions are regarding players like Rico Dowdle, Nick Chubb, Kimani Vidal, Hassan Haskins, Kenneth Gainwell, Kendre Miller, Kareem Hunt, Brashard Smith. But not to worry, we are here to help make these decisions and build winning lineups in Week 6. Set your optimal fantasy football lineups for Week 6 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Week 6 Player Decisions. Today's focus is on specific players - Rico Dowdle, Nick Chubb, Kimani Vidal, Hassan Haskins, Kenneth Gainwell, Kendre Miller, Kareem Hunt, Brashard Smith. These are some of the most common searches for fantasy football lineups in Week 6.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 6 Searches. Curious to see some tough lineup decisions for Week 6 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 6 Searches - Start/Sit Player Comparisons
Below are some popular Week 6 searches and comparisons from our 'Who To Start' tool for Rico Dowdle, Nick Chubb, Kimani Vidal, Hassan Haskins, Kenneth Gainwell, Kendre Miller, Kareem Hunt, Brashard Smithcompared to others:
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