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San Francisco 49ers quarterback Brock Purdy (toe) has officially been ruled out for Week 6 against the Tampa Bay Buccaneers on Sunday, according to David Lombardi of The Athletic. Purdy was unable to practice all week, although he was seen working on side fields with trainers. The 25-year-old will now miss his second straight game (fourth overall this year) after aggravating a turf-toe injury in Week 4. The Niners have been mum on when Purdy might be able to return to the starting role under center, with his next chance at doing so coming in Week 7 versus the Atlanta Falcons. Backup Mac Jones (knee, oblique) is listed as questionable with multiple injuries this weekend, but he's expected to make his fourth start of the year. Jones has been battling a knee injury since early in the year, but despite that, he's managed to play effectively and efficiently with Purdy out. Fantasy managers shouldn't be expecting a second straight 300-yard game from Jones, but he'll be in play as a low-end QB2 streamer in superflex leagues.--Keith Hernandez
Source: The Athletic - David Lombardi
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Zay Flowers

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Misses Practice Again on Friday
Kyler Murray

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Ruled Out for Week 6
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Set to Return on Sunday
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Looks To Remain Undefeated
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