X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Shai Gilgeous-Alexander

Leads the Way in Game 4
Jalen Williams

Has a Quality Showing on Friday Night
Charlie Morton

Continues Good Work With 10 Strikeouts
James Wood

Homers, Drives in Four
Agustín Ramírez

Agustin Ramirez Homers Twice to Snap Skid
Isaac Paredes

Astros Hopeful Isaac Paredes Can Avoid the Injured List
Royce Lewis

Dealing With Hamstring Strain
Kodai Senga

Diagnosed With Grade 1 Hamstring Strain
Gleyber Torres

Goes Deep Twice on Friday
Jonathan India

Leaves With Apparent Shoulder Injury
Evan Carter

Leaves Early With Wrist Soreness
Anthony Richardson

Should be Fine for Training Camp
Russell Westbrook

to Decline Player Option
Kevin Durant

Trade Could Happen in the "Next Few Days"
A.J. Puk

Pauses Throwing Program
Matt Chapman

Can Begin Rehabbing in a Week
Logan Gilbert

Next Start Could Come in the Big Leagues
Cam Akers

Joining Saints
Yordan Alvarez

Still Not Hitting
Michael Mayer

to Get More Involved
Aaron Rodgers

DK Metcalf Building Chemistry with Aaron Rodgers
Colston Loveland

Likely to be Primary Tight End
Jacob Wilson

Returns on Friday
Justin Martinez

Out 12-13 Months With UCL Sprain
Will Johnson

Returns to Practice
Harold Fannin Jr.

Could Have Big Role in Rookie Season
Matt Chapman

Could Miss the Rest of June
Quentin Johnston

Still Running With Starters
Rashawn Slater

Takes Part in Minicamp
Jack Bech

Mostly Working With Second-Team Offense
Dont'e Thornton Jr.

Makes Strides This Offseason
Joaquin Buckley

Set For Main Event
Ashton Jeanty

to be Part of Committee Backfield?
Kamaru Usman

An Underdog At UFC Atlanta
Christian McCaffrey

Takes Part in Mandatory Minicamp
Jordan Watkins

has Been Standing Out
Miranda Maverick

Set For Co-Main Event
Rose Namajunas

Looks To Bounce Back
Jacob Cowing

on the Rise
Andre Petroski

Looks To Extend His Win Streak To Four
Demarcus Robinson

a Frequent Target This Spring
Dee Winters

has Been Impressive This Spring
Edmen Shahbazyan

A Favorite At UFC Atlanta
Raoni Barcelos

Set To Take On Former Champion
Cody Garbrandt

Looks To Get Back In The Win Column
Mansur Abdul-Malik

Looks For His Third UFC Win
Cody Brundage

Looks To Win Back-To-Back Fights
Alonzo Menifield

Opens Up UFC Atlanta Main Card
Oumar Sy

Looks To Remain Undefeated
Aaron Civale

Traded to the White Sox
Connor Hellebuyck

Wins Vezina And Hart Trophies
Aleksander Barkov

Records Two Power-Play Assists Thursday
Sam Reinhart

Collects Three Points in Thursday's Loss
Matthew Tkachuk

Notches Three Points in Losing Effort
Calvin Pickard

Joins Exclusive List with Thursday's Win
Mattias Ekholm

Logs Two Assists in Comeback Victory
Leon Draisaitl

Delivers Victory in Overtime Thursday
Myles Turner

Playing Through Illness
Reed Sheppard

Will Play in the NBA Summer League
Kevin Durant

Deal Could Come Sooner Rather Than Later
Jacob Misiorowski

Pulled With Cramps
Framber Valdez

Punches Out 12 in Win
Isaac Paredes

Homers, Exits Early With Hamstring Injury
D.J. Humphries

Rams Sign D.J. Humphries on Thursday
Troy Franklin

has Had a Good Offseason
Jacob Misiorowski

Leaves Game with Ankle Injury
Mike Williams

Expected to be Ready for Training Camp
Trey Benson

Adds Weight, Explosiveness
Dorian Finney-Smith

Undergoes Ankle Surgery
Anze Kopitar

Wins Third Lady Byng Trophy
Sergei Bobrovsky

Heading Out for Win No. 15
John Klingberg

Won't Play in Game 4 Against Panthers
Viktor Arvidsson

Sits Out Game 4 Against Panthers
Stuart Skinner

Remains in Oilers Crease Thursday
Chris Kreider

Ducks Acquire Chris Kreider From Rangers
Jalen Williams

Leads Thunder in Scoring Wednesday
Shai Gilgeous-Alexander

Settles for 24 Points in Game 3 Loss
Pascal Siakam

Does Everything for Pacers Wednesday Night
Tyrese Haliburton

Gets Close to Triple-Double in Game 3 Win
Bennedict Mathurin

Leads All Scorers with 27 Points Wednesday
Brandin Podziemski

Has Second Offseason Surgery
Cale Makar

Wins His Second Norris Trophy
Lane Hutson

Voted NHL's Best Rookie
CGY

Adam Klapka Agrees to Two-Year Extension with Flames
Ryan Nugent-Hopkins

Considered a Game-Time Call Thursday
Jaylen Brown

Undergoes Successful Knee Procedure
Kevin Porter Jr.

Likely to Decline Player Option
Matt McCarty

Comes Off Season-Best Showing at RBC Canadian Open
Justin Thomas

Desperate to Continue Good 2025 Season
Kevin Durant

Knicks Not Looking to Trade for Kevin Durant
Jon Rahm

Seeks Revenge at U.S. Open
Tom Kim

Aiming for Improvement in U.S. Open
PGA

Sungjae Im Expects Solid Performance at Oakmont
Brian Harman

Aims to Rebound From the Memorial
Tony Finau

has Been Up and Down at U.S. Open
Patrick Cantlay

Hoping This is the Year at Oakmont
Akshay Bhatia

Improving in Time for U.S. Open
Xander Schauffele

Primed for Another Major Championship Run
Cameron Young

May Struggle at U.S. Open
Collin Morikawa

Eyeing Third Major Championship Title
Matt Fitzpatrick

Seeks to Avenge Oakmont Collapse
Jordan Spieth

Can Contend at Oakmont
Shane Lowry

a Strong Value Play at U.S. Open
Brooks Koepka

Seeks Another Major Win at Oakmont
Viktor Hovland

Still Can Improve at U.S. Open
Michael Kim

a Boom-or-Bust Value Play at U.S. Open
Russell Henley

Looking to Play the Weekend at Oakmont
Tyrrell Hatton

a Safe Option at U.S. Open
Bryson DeChambeau

Eyeing Third U.S. Open Title
Darius Garland

Kings Targeting Darius Garland
Kevin Durant

Expected to Be Moved Soon
Giannis Antetokounmpo

Reportedly Has "No Trade Market"
Jarace Walker

Remains Out Wednesday
Denny Hamlin

Charges Late to Win at Michigan
Carson Hocevar

Michigan Run is Derailed by A Late-Race Flat Tire
Kyle Larson

Up-and-Down Day Ends With Top-Five Finish at Michigan
Ross Chastain

Quietly Finishes Sixth at Michigan
Corey Perry

Nets Power-Play Goal in Monday's Loss
Stuart Skinner

Gets Pulled in Heavy Game 3 Defeat
Evan Rodrigues

Extends Scoring Streak with Multi-Point Effort
Sam Reinhart

Collects Two Points in Monday's Win
Chris Buescher

Takes Second Place After William Byron Runs Out of Fuel
NASCAR

Bubba Wallace Has a Great Points Day to Build Buffer Over the Playoff Cut Line
Ryan Blaney

Flat Tire Results in Poor Finish for Ryan Blaney
Alex Bowman

Playoffs in Doubt After Stage 2 Crash at Michigan
Sean O'Malley

Submitted For The First Time In His Career
Merab Dvalishvili

Defends Bantamweight Belt At UFC 316
Julianna Peña

Julianna Pena No Longer A Champion
Kayla Harrison

Is The New Champion
Joe Pyfer

Wins Back-To-Back Fights
Kelvin Gastelum

Drops Decision
Patchy Mix

Drops Decision In His UFC Debut
Mario Bautista

Extends His Win Streak
Vicente Luque

Submitted At UFC 316