👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

NFL

Cameron Ward is "Perfectly Healthy"
James Cook III

Absent From OTA Practices This Week
Darnell Washington

Is it Time to Drop Darnell Washington in Dynasty Leagues?
Fernando Mendoza

a Top Dynasty Target Even if He Doesn't Start Week 1?
Tyreek Hill

Dynasty Outlook Dependent on Landing Spot
Mack Hollins

Should Managers Trade for Mack Hollins Amid Roster Questions?
Michael Wilson

a Prime Dynasty Sell Candidate
Jake Ferguson

Insurance Upside Makes Him a Borderline TE1 in Dynasty
Brock Bowers

One of the Most Valuable Assets in Dynasty
Devin Vassell

Contributes 22 Points in Wednesday's Loss
Mike Gesicki

Still Provides Some Dynasty Insurance as His Standalone Value Fades
Stephon Castle

Tallies Team-High 25 Points in Game 2 Loss
Victor Wembanyama

Records Eighth Postseason Double-Double
Philadelphia Eagles

Nolan Smith Arrested for Speeding and Reckless Driving
Isaiah Hartenstein

Bounces Back With Double-Double
Shai Gilgeous-Alexander

Leads Thunder to Game 2 Victory WIth 30 Points
Dylan Harper

Exits Game 2 Early Due to Right-Leg Injury
Jalen Williams

Suffers Another Hamstring Injury
Valeri Nichushkin

Ends Scoring Slump in Game 1 Loss
Nathan MacKinnon

Extends Point Streak With an Assist
Brett Howden

Pots Another Goal in Game 1 Win Against Avalanche
Tomas Hertl

Extends Point Streak to Four Games
Pavel Dorofeyev

Scores in Fourth Straight Outing
Carter Hart

Records Third Consecutive Win
Timothy Liljegren

Capitals Re-Sign Timothy Liljegren to Two-Year Extension
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
New York Giants

Giants Offense to be a Run-First Unit?
Joshua Palmer

Working Out on the Side at OTAs
Maxx Crosby

Raiders "Counting" on Maxx Crosby Being Ready for Training Camp
Kirk Cousins

the First Up in OTA Practice on Wednesday
Chicago Bulls

Jerry Stackhouse Emerges as Bulls Head-Coach Candidate
Cooper Flagg

Kon Knueppel Headline All-Rookie Team
De'Aaron Fox

is Ruled Out for Game 2 on Wednesday
Jiri Kulich

Aims to Return Next Season
Jeremy Lauzon

Not Expected to Play Wednesday
Brock Bowers

Klint Kubiak Calls Brock Bowers a "Football Robot From Heaven"
Mark Stone

Likely to Remain Out Wednesday
Scott Wedgewood

Starting Western Conference Finals for Avalanche
Sam Malinski

Set to Return Wednesday
Artturi Lehkonen

Expected to Play Wednesday Night
Cale Makar

Will Miss Game 1 Against Golden Knights
Malachi Fields

Appears Well-Positioned for Rookie Year Breakout in New York
Aaron Rodgers

Plans to Retire Following 2026 Season
Anthony Richardson Sr.

Is Anthony Richardson Sr. Worth Buying Low on in Deeper Dynasty Formats?
DJ Giddens

Does DJ Giddens Carry Dynasty Buy-Low Appeal into 2026?
AJ Barner

Enters 2026 as a Dynasty Sell-High Candidate
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
James Harden

Struggles in Eastern Conference Finals Opener
Evan Mobley

Bags Second Consecutive Double-Double
Donovan Mitchell

Produces Top Two-Way Performance in Game 1 Loss
OG Anunoby

Plays Key Role in Comeback Win
Mikal Bridges

Remains Efficient in Game 1 Against Cavaliers
Karl-Anthony Towns

Extends Double-Double Streak to Four Games
Jalen Brunson

Leads Knicks to Historic Comeback Win
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Dean Wade

Returns to Starting Unit Tuesday
OG Anunoby

Starting on Tuesday
Tobias Harris

May Remain in Motown
Jalen Duren

Pistons Eager to Keep Jalen Duren
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Mattias Samuelsson

Picks Up an Assist in Season-Ending Loss
Rasmus Dahlin

Nets Fourth Postseason Goal
Jakub Dobes

Records 37 Saves in Game 7 Win
Lane Hutson

Contributes Power-Play Assist in Game 7 Victory
Nick Suzuki

Extends Road Point Streak
Alex Newhook

Scores Series-Clincher in Overtime
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan