👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Rashee Rice

Chiefs Have No Plans to Sign Rashee Rice to Long-Term Extension
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Cole Payton

Dynasty Managers Will Have to be Patient with Cole Payton
Taylen Green

Does Taylen Green's Speed Get Him on the Dynasty Radar?
Jack Endries

Is Jack Endries the Tight End of the Future in Cincinnati?
CJ Daniels

a Developmental Stash in Dynasty Leagues
Garrett Nussmeier

a Low-Risk Target with Upside in Dynasty Leagues?
Jam Miller

Has Sneaky Value if He Can Earn a Roster Spot
Justice Hill

a Dynasty Drop Candidate Wherever He's Still Rostered
J'Mari Taylor

Is J'Mari Taylor Worth a Taxi-Squad Spot in Deep Dynasty Leagues?
Greg Dulcich

Has a Lack of Competition Made Greg Dulcich a Dynasty Sleeper?
Carson Beck

a Worthy Investment in the Later Rounds of Rookie Drafts
Devon Toews

Logs Two Assists In Game 3 Defeat
Brett Howden

Nets 10th Postseason Goal
Mitchell Marner

Delivers Two Assists in Comeback Victory
Mark Stone

Returns With Multi-Point Effort
Valeri Nichushkin

Exits Early Sunday
Nathan MacKinnon

Hurt in Game 3 Loss
Isaiah Hartenstein

Provides Steady Production in Defeat
Chet Holmgren

Has a Quiet Offensive Night on Sunday
Shai Gilgeous-Alexander

Held Under 20 Points in Game 4
Stephon Castle

Hands Out Six Assists in Game 4 Win
Devin Vassell

Tallies 13 Points in Game 4 Win
De'Aaron Fox

Records Double-Double as Spurs Even Series
Victor Wembanyama

Sets Tone Early as Spurs Force a Pivotal Game 5
Isaac Guerendo

Could be a Drop Candidate in Dynasty Leagues in 2026
Jayden Higgins

' Dynasty Arrow is Pointing Up With Clear Path to WR2 Role in Houston
Jakobi Meyers

a Sell-High Candidate in Dynasty Formats?
Drake Maye

to Make a Big Leap in 2026 in Second Season With Josh McDaniels?
Jamal Murray

Earns First Career All-NBA Selection
Kevin Durant

Becomes First Player to Make All-NBA Team With Five Franchises
Shai Gilgeous-Alexander

Victor Wembanyama Lead All-NBA First Team
Taylor Hall

Enjoying Life in Carolina
Mark Stone

Returns to Action Sunday
Cale Makar

Rejoins Avalanche Lineup Sunday
Cason Wallace

Joins Starting Unit Sunday
De'Aaron Fox

Doesn't "Feel Great" Entering Game 4
Jalen Williams

Won't Play Sunday
Christian Watson

Is Christian Watson on the Verge of a Legitimate Breakout?
Khalil Shakir

Dynasty Value in Decline
Travis Hunter

Still a Risky Buy, Even at his Sunken Dynasty Cost
Gunnar Helm

a Dynasty Sleeper with Room to Grow
Drake Maye

Is Drake Maye Becoming the Most Valuable Player in Superflex Dynasty Leagues?
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Pat Freiermuth

Steelers Restructure Pat Freiermuth's Contract
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
Evan Mobley

Tallies Series-High 24 Points on Saturday
Donovan Mitchell

Struggles at the Line Saturday
Karl-Anthony Towns

Continues Playmaking Surge on Saturday
OG Anunoby

Delivers Clean Shooting Line Saturday
Mikal Bridges

Fills Box Score in Game 3 Win
Jalen Brunson

Pushes Knicks Closer to NBA Finals
Orlando Magic

Magic Interview Jeff Van Gundy for Head-Coaching Position
Phillip Danault

Extends Point Streak to Three Games
Josh Anderson

Nets Two Goals in Painful Loss
Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Nazem Kadri

Contributes an Assist in Losing Effort
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays