X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

REAL-TIME FANTASY NEWS

CFB

LSU QB Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Tari Eason

Injured on Friday Night
OG Anunoby

Suffers Hamstring Injury on Friday Night
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
NFL

Bill Belichick Won't Pursue NFL Head-Coaching Vacancies
Anthony Davis

Out Again on Friday
Khalil Shakir

in the Clear to Play in Week 11
P.J. Washington

Sidelined Against the Clippers
Dereck Lively II

Officially Active, Will Have a Minutes Cap
Giannis Antetokounmpo

Returning Versus the Hornets
LaMelo Ball

Back in the Lineup on Friday Night
Domantas Sabonis

Good to Play on Friday
Bam Knight

Considered Questionable for Week 11
Brian Thomas Jr.

Tagged as Questionable for Week 11
Christian Braun

To Miss At Least Six Weeks With An Ankle Sprain
Calvin Ridley

Listed as Questionable for Week 11
Zach Edey

Questionable To Make Season Debut
Cedric Coward

Doubtful For Saturday's Game In Cleveland
John Gibson

Fine for Saturday
Kaiden Guhle

Ruled Out for 8-10 Weeks
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Ja Morant

Off The Injury Report, Will Play Saturday
Alex Newhook

to Miss Four Months With Broken Ankle
Marco Rossi

Out Week-to-Week
J.K. Dobbins

Out in Week 11 and for "Foreseeable Future"
Zach Hyman

Set for Season Debut Saturday
Jack Hughes

Sustains Non-Hockey Hand Injury
Quinn Hughes

a Game-Time Decision Friday
Jaden Ivey

Participates in Pistons Morning Shootaround on Friday
Rashod Bateman

Ruled Out for Week 11
Sam LaPorta

Ruled Out for Week 11 With Back Injury
Coby White

Nearing A Return?
Isiah Pacheco

Officially Ruled Out for Week 11
Josh Giddey

Fully Practices On Friday
Day'Ron Sharpe

Available to Play on Friday
Trey Hendrickson

Shemar Stewart Both Out for Week 11
Julian Champagnie

Questionable For Rematch Against Warriors
Jaxson Dart

Officially Ruled Out for Week 11 Due to Concussion
Jonathan Kuminga

Sitting Out Friday's NBA Cup Game
Darius Slayton

Ruled Out for Sunday
Dereck Lively II

Expected To Return To Action Friday
Davante Adams

Questionable for Sunday but Expected to Play
Drake London

Questionable vs Panthers
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Garrett Wilson

Jets Expect Garrett Wilson to Play Again This Season
Michael Morales

Looks To Remain Undefeated
Lamar Jackson

Ready to Roll for Sunday
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Quentin Johnston

Questionable to Play Against Jaguars
Carlos Prates

A Favorite At UFC 322
Jaxson Dart

"on Track" in the Concussion Protocol
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
Chris Godwin

Missing Another Game
Bucky Irving

Officially Ruled Out for Week 11
Darius Slayton

Expected to Miss Week 11
Kawhi Leonard

Out on Friday vs. Mavs
Lauri Markkanen

Drops 40 Points Against Hawks
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Shane Pinto

Lands Four-Year Extension
Thomas Chabot

to Sit Out Two Weeks
William Karlsson

Out Week-to-Week
Alex Newhook

Injured in Big Loss
Jeff Skinner

Hurt Early on Thursday
John Gibson

Exits With Upper-Body Injury Thursday
Kaapo Kakko

Sustains Lower-Body Injury Thursday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Dylan Samberg

Makes Season Debut Thursday
Samuel Girard

Available Thursday
Valeri Nichushkin

Considered Week-to-Week
Boone Jenner

Out Long-Term With Upper-Body Injury
Mikael Granlund

Returns to Action Thursday
Anthony Stolarz

Out Day-to-Day
Auston Matthews

Likely to Miss One Week
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year
CFB

Still No Update on Jermod McCoy's Return Timeline
Sami Valimaki

Riding Momentum Into Bermuda
Matthieu Pavon

Struggling Through a Rough Season
Taylor Montgomery

Hopes to Get Back on Track at Port Royal
Ben Martin

a Risky Play at Bermuda Championship
Mark Hubbard

Primed for a Bounce-Back Week in Bermuda
Lee Hodges

Searching for a Spark in Bermuda
Stephen Vogt

Wins Back-to-Back AL Manager of the Year Honors
Milwaukee Brewers

Pat Murphy Named NL Manager of the Year Again
Patrick Fishburn

Looking to Bounce Back in Bermuda
Eric Cole

Carrying Momentum into Bermuda
Tommy Edman

to Have Ankle Surgery Next Week
Ketel Marte

Diamondbacks Unlikely to Trade Ketel Marte
Roman Anthony

to Have a Normal Offseason
Sahith Theegala

Finishes Tied for 27th at Bank of Utah Championship
Sam Stevens

Finishes Tied for 36th at Baycurrent Classic
Patrick Rodgers

Finishes Tied For Sixth at World Wide Technology Championship
Luke List

Finishes 75th at World Wide Technology Championship
Ben Kohles

Finishes Tied for 63rd at World Wide Technology Championship
PGA

Nico Echavarria Finishes Tied for 14th at World Wide Technology Championship
Luke Clanton

Finishes Tied for 46th at World Wide Technology Championship
Blades Brown

Finishes Tied for 18th at Korn Ferry Tour Championship
CFB

Nic Anderson Could Return for LSU this Season
Randy Brown

Suffers Second-Round TKO Loss
Gabriel Bonfim

Extends His Win Streak
Joseph Morales

Gets First-Round Submission Win
Matt Schnell

Suffers First-Round Submission Loss
Muslim Salikhov

Suffers First-Round TKO Loss
Uros Medic

Wins Back-To-Back Fights
Ismael Bonfim

Loses Back-to-Back Fights
Chris Padilla

Remains Unbeaten In The UFC
Marco Tulio

Suffers His First UFC Loss
Christian Leroy Duncan

Scores Second-Round Knockout Victory