👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

MLB DFS Lineup Picks - Early Slate (5/22/21): DraftKings, FanDuel Daily Fantasy Baseball

Jorge Pucks highlights the top FanDuel and DraftKings MLB DFS lineup picks for the "Afternoon" slate on 5/22/21, and a couple of sleepers to consider while building daily rosters.

Hello there, MLB DFS grinders! It's Saturday, and that means we have yet another split slate of MLB games today with seven games in the afternoon and six games on the main evening slate.

While most of our MLB DFS coverage here at RotoBaller is geared towards the main slate, I wanted to give you some of my favorite pitchers and bats for these early games that will help you cash in tournaments and cash game contests. I'll highlight my favorite pitching options here first and then give you some hitters at each price tier to consider as well as my favorite teams to stack up! You can read our DraftKings DFS lineup picks for the main slate and FanDuel DFS lineup picks for the main slate as well.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel and DraftKings afternoon slate at 4:05 PM on 5/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's MLB DFS lineup picks for the main slate here, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

MLB DFS Pitchers

Shane Bieber vs. MIN ($11,500 FD, $11,200 DK)

Bieber is the top arm option on this early-only slate and if Nelson Cruz sits again, that only gives another bump to rostering him. When looking at all of his starts this season, Bieber has recorded at least sevens strikeouts in every game and has managed to record a quality start in eight of his nine starts as well. Minnesota is averaging .234 as a team against right-handed pitchers and has a 23.6% strikeout rate against this handedness so there is some strikeout upside in this matchup for Bieber. Rostering Bieber might be tough to do in tournaments but he would be someone to plug in for your cash game lineup and build around.

Matthew Boyd vs. DET ($8,200 FD, $7,700 DK)

Despite having a 2-4 record, Boyd has gotten off to a strong start this season as he has a 2.45 ERA and is generating a 19.5% strikeout percentage in just 47.2 innings pitched. Boyd is the third-highest priced pitcher on FD but is the sixth-highest priced pitcher over on DK but is in play on both sites in all formats. The Royals are only batting .239 against lefty pitchers this season and while they only have 80 strikeouts in 403 plate appearances, they have only managed to hit seven home runs against lefties which is the second-lowest total in the league.

Others to consider: Lance McCullers Jr. vs. TEX, Sonny Gray vs. MIL

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

MLB DFS "Bats Worth Paying For"

Trey Mancini – 1B/OF, TB @ WSH ($3,900 FD, $5,600 DK)

The hot streak continues for Mancini as he has now recorded a hit in eight straight games while hitting three home runs during that stretch. The Orioles will face off against Jon Lester and several of their batters fare very well against lefties with Trey Mancini leading the charge. He is batting .333 against lefties and leads the team with six home runs off of this handedness. Mancini has a .480+ ISO against both of Lester's fastball and cutters which he throws roughly over 60% of the time against right-handed batters so if he sees one he likes, he could take Lester out of the park.

Jose Ramirez – 3B, WSH @ CHC ($3,700 FD, $5,500 DK)

Ramirez has arguably the most upside at the third base position on this slate as he could double-dong at any given moment and this seems like a game where he could take Maeda yard. Ramirez is batting .264 against righties this season but has also taken them deep 10 times this season. Ramirez has an ISO of .268 against righties and profiles well against Maeda as he has a .349+ XwOBA against all three main pitches that Maeda throws against lefty hitters.

Nick Castellanos – OF, CIN vs. MIL ($4,300 FD, $5,600 DK)

Castellanos is definitely one to consider as he has been swinging a hot bat all season long and has fared very well against left-handed pitching which is what he will get against Brett Anderson. Castellanos is hitting .346 against lefties this season with three home runs and sporting an ISO of .321 against this handedness. He is riding a nine-game hitting streak so there is no reason to not consider him in all formats for this matchup.

 

MLB DFS Values

Ozzie Albies – 2B, ATL vs. PIT ($2,700 FD, $5,200 DK)

Albies is an absolute steal on FD at $2,700 while the DK pricing has him all of the way up in the $5,000 range. Albies is coming off of a strong performance at the plate on Friday night where he recorded two hits in five at-bats while recording a home run and three RBIs. Lefties have an ISO of .193 against Keller this season and Albies profiles extremely well against Keller as he has an ISO of .472+ and an XwOBA of  .364+ against his fastball and cutter which he throws for a combined 70% of the time against lefty batters.

Austin Riley – 3B, ATL vs. PIT ($2,800 FD, $4,200 DK)

If you're wanting to get a tad different with your Braves stack, you should look to include Austin Riley in them. He should come in lower owned than the likes of Acuna, Freeman, and Albies but still provides a very good bat against Keller. Riley is hitting .321 against righties this season which leads the Braves in batting average against this handedness and has five home runs against this handedness which is tied for the third-most on the Braves team.

Cedric Mullins – OF, BAL @ WSH ($2,800 FD, $4,500 DK)

While Mullins has been a little cold at the plate over the past couple of games, that should not scare us away from considering him. Mullins has the second-highest batting average on the team against lefties (.311) and leads the team with 13 singles and four doubles against this handedness. While Mullins isn't a big power threat, he is a threat if he gets on the basepaths which is something we like against a pitcher like Lester who has a slow delivery so there could be some stolen base upside with Mullins.

Also Consider: Ryan Mountcastle vs Jon Lester, Eddie Rosario vs. Kenta Maeda 

 

MLB DFS Hitter Stacks

Atlanta Braves vs. Mitch Keller

The Braves are coming off of an epic night at the plate as they scored 20 runs so we might as well go right back to the well and consider them against Mitch Keller. Keller has struggled in eight appearances this season as he has a 7.16 ERA and both sides of the plate are hitting .290+ against him. The Braves have the second-most home runs against right-handed pitchers and as a team is sporting an ISO of .209 against right-handed pitchers so looking at some of their power bats like Acuna, Ozuna, Freeman, Albies, and Riley would be the way to go with this team.

Cincinnati Reds vs. Brett Anderson

When the Reds play at home, they definitely get placed into consideration and with Brett Anderson on the hill for the Brewers, they become a team to really consider stacking. Anderson has a 4.50 ERA in 24 innings pitched this season and has gotten roughed up from both sides of the plate. The Reds do come into this matchup pretty banged up so guys like Castellanos, Winker,  Stephenson, and Suarez would be the guys to focus on from Cincinnati.

Other stacks: Baltimore Orioles vs. Jon Lester, Cleveland Indians vs. Kenta Maeda



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Dalton Kincaid

Load Management a Possibility for Dalton Kincaid
J.K. Dobbins

is Fully Healthy for 2026
Jauan Jennings

49ers Acknowledge Jauan Jennings Won't Return
LeBron James

Set to Play in Cleveland Matchup
Jayson Tatum

Cleared to Play Wednesday
Neemias Queta

Returns Against Miami
De'Anthony Melton

Ruled Out Against Spurs
Kristaps Porzingis

Ruled Out Wednesday
Pascal Siakam

Expected to Suit Up Wednesday
Andrew Nembhard

Sitting Out Wednesday
Olivier-Maxence Prosper

Off Injury Report Wednesday
Ty Jerome

to Miss Fifth Straight Game
Caris LeVert

Available Tuesday Against Raptors
Miles McBride

to Suit up on Tuesday
Collin Murray-Boyles

Cleared to Play Tuesday
Marcus Sasser

is Available on Tuesday
Brandon Ingram

Returns Vs. Detroit
Ziaire Williams

Moves into Starting Five
Duncan Robinson

Active Vs. Toronto
Jalen Duren

is Back in Action on Tuesday
Tobias Harris

Available Tuesday
Marvin Bagley III

to Miss Second Straight Game
Ryan Rollins

Good to Go Tuesday
Klay Thompson

is Resting on Tuesday
Seiya Suzuki

to Begin a Rehab Assignment Soon
Simon Holmstrom

Misses Tuesday's Action
Alexandre Carrier

Out 2-4 Weeks With Upper-Body Injury
Jordan Spieth

a Horse for Course History at TPC San Antonio
Mason Lohrei

Misses Second Consecutive Game Tuesday
Tyler Myers

Unavailable Against Bruins
Robert MacIntyre

Has One Flaw to Overcome at Valero Texas Open to be a Must-Play
Michael Bunting

to Sit Out Tuesday's Game
Maverick McNealy

In Exceptional Form This Season
Michael Thorbjornsen

Playing Well But Still Searching For A Win
Hideki Matsuyama

Playing Well Heading to the Valero Texas Open
Si Woo Kim

Heads to Valero Texas Open For Final Tune-Up Before Masters
Nikita Kucherov

a Game-Time Decision Tuesday
Evgeni Malkin

Ready for Action Tuesday
Sam Bennett

Rejoins Panthers Lineup Tuesday
Cody Ponce

Diagnosed With ACL Sprain, to Miss "Significant Time"
Tank Dell

Uncertain for OTAs, But Expected to Play in 2026
Alvin Kamara

Saints Still Want to Address Alvin Kamara's Contract
George Pickens

Cowboys Have "Long-Term Plans" for George Pickens
Kyle Pitts Sr.

Falcons Not Ruling Out Potential Kyle Pitts Sr. Trade
Jordan James

the "Front-Runner" to be Top Backup RB
A.J. Brown

Patriots Still Not Ruling Out an A.J. Brown Trade
Aaron Rodgers

Planning to Re-Sign With Steelers?
Seattle Seahawks

Mike Washington Jr. Would Fill a Big Need for Seahawks
Los Angeles Rams

Kenyon Sadiq a Good Fit With the Rams?
Green Bay Packers

Packers to "Strip Everything Down" on Offense
Anthony Richardson Sr.

to Stay With Colts?
NFL

Ty Simpson has Visits With Cardinals, Dolphins, Browns
Aaron Rodgers

Mike McCarthy, Aaron Rodgers Touch Base
Cameron Ward

Mechanical Tweaks are Focused on his Footwork
Jaylen Waddle

to Play the Slot And Outside
Geno Smith

Aaron Glenn Thinks Geno Smith Will Lead Jets to "Promised Land"
Mason Taylor

Jets Expecting a "Hell of a Year" From Mason Taylor
Collin Morikawa

Withdraws From Valero Texas Open
PGA

Stephan Jaegar Still Looking For Consistency at Valero Texas Open
Nicolai Hojgaard

is Red-Hot Coming to TPC San Antonio
Tony Finau

a Risky Proposition at Valero Texas Open
Ludvig Aberg

Looks to Shake Off Collapse at Valero Texas Open
Jacob deGrom

Cleared for Season Debut on Tuesday
Colt Emerson

Signs an Eight-Year Extension with Mariners
James Conner

Role Threatened in Arizona?
William Nylander

Records Four Points Against Ducks
Macklin Celebrini

Becomes Sixth Teenager With 100-Point Season
Jaden Schwartz

Could Return Tuesday
Jordan Greenway

Available Tuesday
Jake Sanderson

Remains Out Tuesday
Cutter Gauthier

Exits Early Against Maple Leafs
Cale Makar

Sustains Upper-Body Injury Monday
Patrick Rodgers

Needs to Make More Birdies in San Antonio
Sepp Straka

Seeks Opportunity in San Antonio This Weekend
Nick Taylor

Could Again Struggle at the Valero Texas Open
Keith Mitchell

Sets Up Solidly for TPC San Antonio
Jose Altuve

Tallies Four Hits, Two Homers in Big Night
Rickie Fowler

a Boom-or-Bust Option at Valero Texas Open
Nazem Kadri

Scores Twice in Blowout Victory
Anthony Mantha

has Three-Point Performance on Monday
Miguel Vargas

Hits Grand Slam, Drives in Six in Win Over Miami
Tanner Bibee

to Start on Tuesday Against Dodgers
Aliaksei Protas

Won't Play Tuesday
Pavel Mintyukov

Returns to Action Monday
Radko Gudas

Ready to Face Maple Leafs
John Klingberg

to Remain Sidelined Monday
Matt McCarty

Seeking to Play into the Weekend in San Antonio
Brian Harman

Looking to Continue Form From The Players Championship
Steven Fisk

Attempting to String Better Rounds Together at San Antonio
Luke Clanton

Still Having Rough Time Contending at Events
Max Homa

Looks to Get Back on Track at Valero Texas Open
Chase Elliott

Takes Advantage of Pit Strategies for Second Career Martinsville Win
Denny Hamlin

Dominates but Finishes Second at Martinsville
Joey Logano

Bounces Back with Third-Place Finish at Martinsville
Ty Gibbs

Gains his Fourth Top-Five Finish of the Season at Martinsville
William Byron

Scores Another Top-Five Finish at Martinsville
Joe Pyfer

Extends His Winning Streak
Israel Adesanya

Loses Fourth Consecutive Fight
Maycee Barber

Suffers Her First Knockout Loss
Alexa Grasso

Scores Highlight-Reel Knockout
Niko Price

Retires After UFC Seattle Loss
Michael Chiesa

Victorious In His Retirement Fight
Julian Erosa

Suffers First-Round Knockout Loss
Lerryan Douglas

Scores First-Round Knockout Win In His UFC Debut
Alex Bregman

Clobbers First Two Homers in Sunday's Loss at Wrigley
Yandy Díaz

Yandy Diaz Records Five Hits, Drives in Four in Win Over Cardinals
Kyle Larson

Is Likely to Pay Off for DFS at Martinsville
Christopher Bell

Could Have Another Top-10 Performance At Martinsville
William Byron

Is A Threat to Win Again at Martinsville
Chase Elliott

is A Solid DFS Option for Martinsville Lineups
Chase Briscoe

has Plenty of Upside for DFS Lineups at Martinsville
Carlos Estévez

Carlos Estevez Unlikely to See High-Leverage Opportunities in Near Future
Jacob deGrom

Feels "Much Better," Hopeful he Can Start This Week
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Martinsville?
Ryan Preece

Is A Solid DFS Option for Martinsville Lineups
Josh Berry

Could Josh Berry Pay Off for Tournament DFS Lineups At Martinsville?
Carson Hocevar

May be Too Inconsistent to Start in Martinsville DFS Lineups
Austin Cindric

Is Austin Cindric Worth Rostering for DFS At Martinsville?
Denny Hamlin

the Favorite to Win at Martinsville
Ryan Blaney

Should Contend at Martinsville
Tyler Reddick

Should Come Back Down to Earth at Martinsville
Joey Logano

Will Be Strong at Martinsville
NASCAR

Bubba Wallace Looking to Rebound at Martinsville
Shane Van Gisbergen

Shane van Gisbergen Showing Progress, Qualifies Fifth at Martinsville
Dylan Cease

Fans 12 in Blue Jays Debut on Saturday
Andrew Vaughn

Needs Hand Surgery, Expected to be Out 4-6 Weeks
Jacob deGrom

"Confident" he Will Make his Next Start
Jacob deGrom

Scratched From Saturday's Start Due to Neck Stiffness
Jeferson Quero

Brewers Calling Up Catching Prospect Jeferson Quero
Deyvison De Los Santos

Marlins Promote Deyvison De Los Santos to Major Leagues
Shea Langeliers

Hits Two Home Runs on Opening Day
Kevin Gausman

Picks Up No-Decision But Strikes Out 11 on Opening Day
Tanner Bibee

Day-to-Day, Could Make his Next Start
Shane Baz

Orioles Agree to Five-Year Extension
Joe Pyfer

Set For UFC Seattle Main Event
Israel Adesanya

Returns At UFC Seattle
Maycee Barber

Looks To Extend Her Win Streak To Eight
Alexa Grasso

Looks To Get Back In The Win Column
Niko Price

In Dire Need Of Victory
Michael Chiesa

Set For Retirement Fight
Lerryan Douglas

Set For His UFC Debut
Julian Erosa

Looks To Bounce Back