Fantasy Football Injury Reports For NFL RBs: Week 1 Updates for Christian McCaffrey, De'Von Achane, Jaylen Wright, Kyle Monangai

Fantasy football RB injury updates and reports for Week 1 (2025), as of September 6, including Christian McCaffrey, De'Von Achane, Jaylen Wright, and Kyle Monangai.

Below is our fantasy football injuries report for running backs in Week 1, as of September 6. The injury statuses for various NFL running backs are up in the air for Week 1, including Christian McCaffrey, De'Von Achane, Jaylen Wright, and Kyle Monangai.

As the fantasy football season gets underway, every decision, transaction, and lineup change matters. These are critical running back injuries to keep track of throughout the week. Being up-to-date on NFL injury news can give you an edge over your league mates in fantasy football.

To keep close tabs on all the news across the NFL, favorite or bookmark the fantasy football player news page, or download the free RotoBaller fantasy football mobile app with push notification alerts on all the latest news. Let's look at the updates for some running backs and see whether they may play in Week 1.

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Christian McCaffrey Injury Update

McCaffrey (calf) is suddenly up in the air for Week 1 against the Seahawks. He was a full participant on Wednesday, limited participant on Thursday, and a non-participant on Friday. As it stands, he's officially listed as questionable to play in Week 1, and he's certainly trending in the wrong direction. Brian Robinson Jr. would step up as the Niners' primary running back if McCaffrey misses time.

Here’s the final Seahawks-49ers injury report, with game status designations pic.twitter.com/sTLTBmFD0B

— Dugar, Michael-Shawn (@MikeDugar) September 5, 2025

De'Von Achane Injury Update

Achane (calf) upgraded to a full participant in practice on Friday. As a result, he has been removed from the injury report and will play against the Colts in Week 1, barring a setback. Achane's versatility and high ceiling should keep him in the RB1 tier for the opening week of fantasy football.

Dolphins Colts final injury report pic.twitter.com/dyBYaLm0BY

— Travis Wingfield (@WingfieldNFL) September 5, 2025

Jaylen Wright Injury Update

Wright (knee) has been ruled out for Sunday's game after missing all three practices this week. In his absence, fantasy managers should expect Ollie Gordon II to operate as Achane's backup.

Dolphins Colts final injury report pic.twitter.com/dyBYaLm0BY

— Travis Wingfield (@WingfieldNFL) September 5, 2025

Kyle Monangai Injury Update

Monangai (hamstring) was limited in practice on Friday. It was his second consecutive day logging a limited session. The rookie faces an uphill battle to immediate production in redraft fantasy leagues, but he does have some season-long appeal.

#Bears Friday Injury Report pic.twitter.com/9fd6dzkB8U

— Bears Communications (@BearsPR) September 5, 2025

Kalel Mullings Injury Update

Mullings (angle) popped up on the injury report after being limited in practice on Friday. He is officially questionable to play in Week 1 against the Broncos. Fantasy managers should keep an eye on his status prior to kickoff. Mullings was a candidate to handle a larger workload with Tyjae Spears (ankle) landing on injured reserve.

This week’s final injury report. pic.twitter.com/6icjAEsU2C

— Titans PR (@Titans_Comms) September 5, 2025

Roschon Johnson Injury Update

Johnson (foot) has now missed practice for two days in a row. He could re-join the team Saturday, but as it stands, the backup is trending toward missing Week 1 against the Vikings. If so, Chicago would place a heavy emphasis on Monangai as the direct backup to D'Andre Swift.

#Bears Friday Injury Report pic.twitter.com/9fd6dzkB8U

— Bears Communications (@BearsPR) September 5, 2025

Jordan James Injury Update

James (finger) was a limited participant in all three practices this week, and he may have to wait a little longer for his NFL debut. The rookie running back is officially listed as doubtful heading into Sunday's clash with the Seahawks. If McCaffrey and James are both inactive this week, the Niners would call upon Robinson and Isaac Guerendo to lead their backfield.

Here’s the final Seahawks-49ers injury report, with game status designations pic.twitter.com/sTLTBmFD0B

— Dugar, Michael-Shawn (@MikeDugar) September 5, 2025

Tyler Goodson Injury Update

Goodson (elbow) is officially questionable for Week 1 after being a limited participant for three consecutive practices. This isn't a major loss for the Colts, who presumably intend to proceed with Jonathan Taylor and D.J. Giddens atop their depth chart anyway.

Dolphins Colts final injury report pic.twitter.com/dyBYaLm0BY

— Travis Wingfield (@WingfieldNFL) September 5, 2025

Sione Vaki Injury Update

Vaki (hamstring) has been ruled out for Week 1 against the Packers. Craig Reynolds will slot in as the Lions' No. 3 running back behind Jahmyr Gibbs and David Montgomery.

#DETvsGB injury report presented by Henry Ford Health. pic.twitter.com/AtmijbNy70

— Detroit Lions (@Lions) September 5, 2025

Zavier Scott Injury Update

Scott (ankle) has now missed two consecutive practices, casting doubt on his availability for Week 1 against the Bears. If he does manage to suit up, he'll remain off the fantasy radar as long as Aaron Jones Sr. and Jordan Mason remain healthy.

The Vikings’ estimated participation report today (they only held a walk-through) puts Christian Darrisaw (knee) at full and S Harrison Smith (personal health issue) at limited. It would have been Smith’s first practice participation of any kind since August 11. pic.twitter.com/0dS4hQqQFm

— Kevin Seifert (@SeifertESPN) September 5, 2025

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