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Who Should I Start for Week 16? Fantasy Football outlooks for Courtland Sutton, Darnell Mooney, Brian Robinson Jr., Tyjae Spears, Kendrick Bourne, Samaje Perine, Keon Coleman, James Cook.
Who Should I Start? Who Should I Sit? Some of the most common Week 16 fantasy football lineup decisions involve players like Courtland Sutton, Darnell Mooney, Brian Robinson Jr., Tyjae Spears, Kendrick Bourne, Samaje Perine, Keon Coleman, James Cook. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 16. Set your optimal fantasy football lineups for Week 16 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Compare up to four players and we'll tell you who to start...
Fantasy Football Matchup Outlooks
Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting in Week 16:
James Cook, RB, Bills
Buffalo Bills running back James Cook put up a dominant performance in his team's critical Week 15 win over its division rival, the New England Patriots, on Sunday. Cook recorded 22 carries for 107 yards and two touchdowns, and two receptions for four yards and a score. The 26-year-old has now racked up 1,686 yards from scrimmage and 12 touchdowns on 302 touches across 14 games this season. Cook has topped 100 scrimmage yards in five straight games and 11 out of 14 total contests in 2025.
He also continues to dominate backfield touches in Buffalo, logging 22 of the team's 26 rushing attempts by running backs in Week 15. Cook profiles as a must-start fantasy running back heading into a Week 16 matchup against the Cleveland Browns.
Courtland Sutton, WR, Broncos
Denver Broncos wide receiver Courtland Sutton heads into Week 16 action as the WR11 in half-PPR scoring with 63 catches on 100 targets for 886 yards and six touchdowns in 14 games. He has scored two of his six TDs in the last three weeks, and he's also had back-to-back 10-target games. In Sunday's 34-26 win over the Green Bay Packers, the 30-year-old had seven receptions for 113 yards and a touchdown.
It was only the second time in 2025 that Sutton went over 100 yards receiving, and it happened to come with rookie wideout Pat Bryant (hamstring) inactive. Quarterback Bo Nix has spread the ball around pretty evenly this year, but he could start latching onto Sutton more down the stretch. Sutton could lose targets if Bryant makes his return this Sunday versus the visiting Jaguars, but fantasy managers should still consider Sutton a WR2 as Denver's best receiving option.
Samaje Perine, RB, Bengals
Since returning in Week 13 from an ankle injury that caused him to miss two games, Cincinnati Bengals running back Samaje Perine has recorded 135 scrimmage yards on 38 touches across three contests. While Bengals back Chase Brown remains the lead rusher in Cincinnati, Perine plays a third-down role that has led to a consistent snap share this season. He's played at least 37% of Cincinnati's offensive snaps in every game since returning from injury, giving him a chance at standalone fantasy value every week.
Still, Perine's main utility for fantasy managers is as a handcuff option to Brown. If Brown were to go down over the final weeks of the season, Perine would likely dominate backfield snaps in Cincinnati. In fantasy leagues with 12 or more teams, Perine is worth targeting on the waiver wire and stashing in a bench spot.
Keon Coleman, WR, Bills
Buffalo Bills wide receiver Keon Coleman was kept off the stat sheet in a Week 15 win over the Patriots, and has now caught a total of four passes for 25 yards in his three games since returning from a very public benching.
He managed to convert one of those grabs into a touchdown, masking just how bad it's been of late, but he should now be viewed as unplayable in just about all formats, while his dynasty value is at an all-time low. Still only 22 years old and tied to a perennial MVP candidate, this could be viewed as a buy-low opportunity. Unfortunately, he's shown very little to suggest that his value won't stay low for the foreseeable future.
Who Should I Start Tool
You can also see the Who Should I Start tool here.
Week 16 Player Decisions. Today's focus is on specific players - Courtland Sutton, Darnell Mooney, Brian Robinson Jr., Tyjae Spears, Kendrick Bourne, Samaje Perine, Keon Coleman, James Cook. These are some of the most common searches for fantasy football lineups in Week 16.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 16 Searches. Curious to see some tough lineup decisions for Week 16 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 16 Searches - Start/Sit Player Comparisons
Below are some popular searches and comparisons from our Who To Start tool for Week 16 for Courtland Sutton, Darnell Mooney, Brian Robinson Jr., Tyjae Spears, Kendrick Bourne, Samaje Perine, Keon Coleman, James Cook:
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