Who Should I Start for Fantasy Football Week 10? Rome Odunze, Brian Thomas Jr., Nico Collins, Jaylen Waddle, Travis Etienne Jr., Drake London, Kyren Williams, DaVante Adams, Josh Jacobs, James Cook

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Who Should I Start for Week 10? Fantasy Football outlooks for Rome Odunze, Brian Thomas Jr., Nico Collins, Jaylen Waddle, Travis Etienne Jr., Drake London, Kyren Williams, DaVante Adams, Josh Jacobs, James Cook.

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Who Should I Start? Who Should I Sit? Some of the most common Week 10 fantasy football lineup decisions involve players like Rome Odunze, Brian Thomas Jr., Nico Collins, Jaylen Waddle, Travis Etienne Jr., Drake London, Kyren Williams, Davante Adams, Josh Jacobs, James Cook. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 10. Set your optimal fantasy football lineups for Week 10 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

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Fantasy Football Matchup Outlooks

Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting in Week 10:

Rome Odunze, WR, Chicago Bears

Chicago Bears wide receiver Rome Odunze (ankle/heel) practiced in a limited capacity on Thursday after being held out on Wednesday, per The Athletic's Kevin Fishbain. Odunze followed a similar practice pattern last week and was able to play in Week 9, so he appears to be trending toward playing in Week 10 against the New York Giants.

The 23-year-old is coming off his worst game of the season against the Cincinnati Bengals, as he was held without a reception on three targets. Odunze has been much better for the season overall, recording 31 catches for 473 yards and five touchdowns on 59 targets across eight games.

Assuming he's cleared to play, Rome Odunze profiles as a must-start fantasy wide receiver in Week 10 against the Giants.

Brian Thomas Jr., WR, Jacksonville Jaguars

Jacksonville Jaguars wide receiver Brian Thomas Jr. (ankle) was not seen at the portion of practice open to the media on Thursday, according to Demetrius Harvey of Jaguars.com. If Thomas does not make it onto the field, it will be his second straight missed practice of the week after he picked up a low-grade high-ankle sprain in the Week 9 win over the Las Vegas Raiders.

The Jaguars said earlier this week that they felt the 23-year-old second-year pass catcher had a good chance to suit up this Sunday against the division-rival Houston Texans, but two straight DNPs suggest otherwise.

The Jags also put first-rounder Travis Hunter (knee) on Injured Reserve, so they could be down to Parker Washington, Dyami Brown (concussion), and the newly acquired Jakobi Meyers at WR this weekend against a strong Texans defense. Thomas' Friday status will go a long way in determining whether he's active in Week 10.

Jaylen Waddle, WR, Miami Dolphins

Miami Dolphins wide receiver Jaylen Waddle has enjoyed a fantastic bounce-back season in 2025, leading the team with 41 catches for 586 yards and four touchdowns in nine games.

Waddle had been in plenty of trade rumors with the current state of the Dolphins, but the team is committed to their 26-year-old star wideout and views him as a piece of their future.

Waddle has emerged as the no-doubt WR1 after Tyreek Hill (knee) went down in Week 3, and has been among the most productive wideouts in the league. Waddle ranks as WR13 in PPR points since Week 4, and he should continue to return borderline WR1 fantasy production as one of the most explosive players in the league and the focal point of head coach Mike McDaniel's passing attack.

Josh Jacobs, RB, Green Bay Packers

Green Bay Packers running back Josh Jacobs has been playing through a calf injury in recent weeks, but he looked fully healthy in the Week 9 loss to the Carolina Panthers on Sunday at Lambeau Field. Jacobs led the backfield with 17 carries for 87 yards (5.1 yards per tote) and a touchdown, scoring for the fifth straight week and for the 10th time on the ground in eight games.

Green Bay's loss to the Cleveland Browns back on Sept. 21 was the only time in 2025 so far in which Jacobs has not scored a rushing TD. In the last five games, the veteran back has 354 rushing yards and nine rushing scores. He also caught four of his five targets in the passing game for 13 yards in Sunday's 16-13 loss to Carolina. Jacobs has gone over 100 scrimmage yards in three straight games.

Despite a tough upcoming matchup in Week 10 against the Philadelphia Eagles, Jacobs will remain a must-start RB in fantasy football.

James Cook, RB, Buffalo Bills

Jacobs has gone over 100 scrimmage yards in three straight games. Despite a tough upcoming matchup in Week 10 against the Philadelphia Eagles, Jacobs will remain a must-start RB in fantasy football.

Who Should I Start Tool

You can also see the Who Should I Start tool here.

Week 10 Player Decisions. Today's focus is on specific players - Rome Odunze, Brian Thomas Jr., Nico Collins, Jaylen Waddle, Travis Etienne Jr., Drake London, Kyren Williams, DaVante Adams, Josh Jacobs, James Cook. These are some of the most common searches for fantasy football lineups in Week 10.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!

How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 10 Searches. Curious to see some tough lineup decisions for Week 10 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

Popular Week 10 Searches - Start/Sit Player Comparisons

Below are some popular searches and comparisons from our Who To Start tool for Week 10 for Rome Odunze, Brian Thomas Jr., Nico Collins, Jaylen Waddle, Travis Etienne Jr., Drake London, Kyren Williams, DaVante Adams, Josh Jacobs, James Cook: