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When will Joe Mixon return and play? Will Joe Mixon be back again this season? Read the latest Joe Mixon injury updates and return date for Week 6 (2025).
Houston Texans starting running back Joe Mixon (foot) has been on the non-football injury/reserve list throughout the opening month of the campaign and has yet to make any significant progress.
Given that Mixon has yet to return to the practice field, his status for the remainder of the season is in limbo.
When will Mixon return to action, and what is his fantasy football outlook when he does? Let's dive in.
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Joe Mixon Injury Update
Earlier this week, Aaron Wilson of KPRC2 provided a much-needed update on Mixon's potential timetable. Texans general manager Nick Caserio noted that his status for the "duration of the season" has not been defined. However, Wilson noted that Caserio did not specify if Mixon has been ruled out for the remainder of the season.
#Texans GM Nick Caserio on Joe Mixon status still in limbo for 'duration of season' didn't say if he will return or not @KPRC2 pic.twitter.com/e9CA1JA88L
— Aaron Wilson (@AaronWilson_NFL) October 7, 2025
While the Texans appear to be leaving the door open for a potential late-season return, fantasy managers should not count on this. Given that Mixon has yet to participate in any practices, he does not appear to be on the verge of a return.
Managers should expect him to remain on the non-football injury/reserve list for the foreseeable future, which will leave Nick Chubb and rookie Woody Marks as the clear running backs in Houston.
Joe Mixon Fantasy Football Outlook
Given his current status and unlear timeline, managers should only consider stashing Mixon in formats that have IR spots. Managers in standard leagues that do not have IR spots should consider cutting Mixon ahead of Week 6, as the team is still unsure of whether he can play a role later in the campaign.
Chubb has settled in quite nicely into the lead role throughout the opening month. In five games, Chubb has posted a strong 4.3 YPC, which is a significant increase from he 3.3 YPC he averaged during his final season in Cleveland in 2024. He has also punched in two touchdowns and logged double-digit attempts in all but one game.
The rookie, Marks, has also begun to carve out a prominent role. While he took the backset in Week 5, in Week 4, Marks scored two touchdowns and tallied an impressive 27.9 PPR points. He is slowly seeing his role as a pass catcher increase, which could limit Mixon's upside if he were to return.
Instead of stashing Mixon, managers should look to stash other IR candidates like Jalen Coker (quadriceps) and Christian Watson (knee), who have a much clearer timetable and have an easier path to make more of an impact this season.
Jalen Coker's Practice Window Opens on Wednesday https://t.co/uL3AHm2WT0
— RotoBaller NFL (@RotoBallerNFL) October 8, 2025
Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
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Who Should I Start? Who Should I Sit? Deciding who to start instead? Some common Week 6 fantasy football lineup decisions are regarding players like Quinshon Judkins, Jacory Croskey-Merritt, Cam Skattebo, Kenneth Gainwell, RJ Harvey, Kendre Miller, Isiah Pacheco. But not to worry, we are here to help make these decisions and build winning lineups in Week 6. Set your optimal fantasy football lineups for Week 6 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
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Popular Week 6 Searches. Curious to see some tough lineup decisions for Week 6 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 6 Searches - Start/Sit Player Comparisons
Deciding who to start instead? Below are some popular Week 6 searches and comparisons from our 'Who To Start' tool for Quinshon Judkins, Jacory Croskey-Merritt, Cam Skattebo, Kenneth Gainwell, RJ Harvey, Kendre Miller, Isiah Pacheco compared to others:
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