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Week 16 Warning Signs: Buffalo Bills vs New England Patriots

Dominick Petrillo takes a close look at whether fantasy GMs can trust any players in the Buffalo Bills vs. New England Patriots game in the championship round of the fantasy playoffs.

Congratulations on making it to the championship week of your fantasy league. Whether you are playing for pride or cash, it is always a great feeling to be among the last teams standing in your league.

There are many great matchups this week. The Broncos will have a field day against the hapless Lions. The Buccaneers and the Texans will have a fantasy bonanza on Saturday. As for us? We are going to take a look at the other end of the spectrum. The biggest game to stay away from. The Josh Allen-led Bills heading to Foxborough to take on the Tom Brady-led Patriots.

This will be a great game for real-life fans. As for fantasy fans? Not as much. In a championship matchup, where points are going to be measured down to the last decimal point, this is a game to stay as far away from as possible. So, let’s take a look at the tale of the tape for this one and find out why exactly you should be staying away.

Be sure to check all of our fantasy football rankings for 2025:

 

Buffalo Bills vs New England Patriots: A matchup made of defense

Both of these teams are having good seasons. In the case of the Bills, you could even call it great. But in the case of both of these teams, this is due directly to the elite play of their defenses and not their offenses.

With both teams in the top three in overall defense and pass defense, there is not much chance either of the quarterbacks in this one will put up points conducive to you wanting to start them. Even in a seemingly great matchup against Cincinnati last week, Brady was able to put up less than 200 yards passing. On the other side of the ball, Josh Allen threw a winning touchdown for the Bills but did not do much else against the Steelers on Sunday night.

With both teams having elite corners in Stephon Gilmore and Tre’Davious White, it will also be hard to find a receiver on either side you want to start. John Brown had a good start to the season. In recent weeks though, he has fallen off as the run game with Devin Singletary taking over. With Cole Beasley being solid but not great and the Patriots linebacker group being great, he also will leave a bitter taste in your mouth if he is started.

For the Patriots, Julian Edelman has always been Mr. Reliable. But playing through a knee and rib injury has taken its toll on the No. 1 target for Brady. This culminated last week with his game of two receptions for nine yards. This is not the production you wanted to see in a plus matchup. Now facing the third-ranked pass defense in the NFL, it could be tough to get anything going. The Absence of Rob Gronkowski has made a huge impact on New England, maybe even more than anyone had anticipated. Not only was he the key to how the offense was run, but his incredible blocking ability led to what success they had in the run game. Success they have not been able to find yet in 2019. Ben Watson is not the answer nor is he reliable at this point in his career. With the tight end position being quite possibly the worst in the NFL, Tom Brady has truly looked like a 42-year old quarterback.

 

Can Anyone Run?

Finally, Sony Michel had a decent game last week but 89 yards on 19 rushes isn’t great. When you compare that to his production season to date, it is a gold mine.

The Bills run defense is not the strength of the defense. That is clearly the pass defense. But they are still good at stopping the run. The fact that Tom Brady of 2019 is not Tom Brady of 2009 is also a key. No longer do teams need to fear the GOAT. Sure, he can still beat you, but not to the level he once could. With multiple weeks of disappointing play this season, including last week where he did not even rank as a top-20 quarterback, the passing game is not what it was. And neither is the run game. While never great, the run game was always a constant in New England. But no longer. With the entire offense taking a step back it has been difficult to find anything on the New England offense to be scared of. With the exception of James White and his PPR potential, this week will be no different in an ugly game.

For the Buffalo Bills, Frank Gore has shown us that longevity will lead you to the pinnacle of the record books. This should not be undermined, but he is not the same runner he once was. At his age, no one could be. Devin Singletary has done a lot to be excited about in his rookie year. His future with Josh Allen looks bright. But the pass rush of the Patriots will smother Allen and Singletary, making it hard to get anything going. Especially on the road in Foxborough, it does not look to be a great day for anyone on the Buffalo roster. The Patriots are coming off their first home loss in over two full seasons against the Chiefs. They are also taking on the first team to truly pose a challenge to them in the division in over a decade. They are not going to be taking this game lightly. Because of this and because both defenses are as good as advertised, this game should be a fantasy desert. Barren and dry.

With a defensive struggle ahead, a repeat of the 16-10 score from the first meeting this season is not only a possibility but also a likely outcome. So, don’t get caught up in the dust storm. Find better players in far better matchups to fill your lineup this week. It may not win you the week, but it will certainly keep you from losing it.

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REAL-TIME FANTASY NEWS

Brian Thomas Jr.

Limited in Practice on Wednesday
Jerami Grant

Available Wednesday Night
Jalen Brunson

Returns From Two-Game Absence
Jalen Smith

Available to Play Wednesday
Tre Jones

Downgraded to Out
Shaedon Sharpe

Misses Wednesday's Game
Dereck Lively II

Cleared for Action Wednesday
Daniel Gafford

Available Wednesday
Caleb Martin

Won't Play Against Knicks
Raisel Iglesias

Returning to the Braves on One-Year Deal
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Absent Due to Ankle Injury
Marvin Bagley III

Starts on Wednesday
Mike Conley

Joins Starting Unit Wednesday
Saddiq Bey

Cleared for Wednesday's Action
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Returns to Action Wednesday
Aaron Gordon

Out Wednesday
Cooper Flagg

Won't Play Wednesday
Bam Adebayo

Cleared to Play Wednesday
Tre Mann

Ruled Out Wednesday
Sam Merrill

Ruled Out for Wednesday
Jabari Smith Jr.

Active Against Cavaliers
Buddy Hield

Good to Go Wednesday
Jonathan Kuminga

Misses Fourth Consecutive Game
Alexandre Sarr

Unavailable on Wednesday
Conor Garland

to Return on Thursday
Thomas Harley

to Miss Road Trip
Eetu Luostarinen

Out Week-to-Week After Barbecue Accident
Curtis Lazar

to Miss at Least Three Games
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Misses Third Consecutive Game
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Remains Out Wednesday
Charlie McAvoy

Out Indefinitely After Facial Surgery
Joe Burrow

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Out on Wednesday, Hopes to Practice Thursday
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Not Seen at Wednesday's Practice
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Lands on Injury Report Ahead of Week 12 With Hip Injury
Rhamondre Stevenson

Targeting a Return in Week 12?
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Returning to Practice on Wednesday
Brian Thomas Jr.

Jaguars "Optimistic" About Brian Thomas Jr.'s Week 12 Status
Josh Jacobs

Will Not Practice on Wednesday
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Looking to Continue Fall Run at RSM Classic
Jayden Daniels

Commanders Considering Shutting Down Jayden Daniels?
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Looking to Bounce Back at RSM Classic
Tom Hoge

Looking to Regain Form at RSM Classic
Joe Highsmith

Searching for Turnaround at RSM Classic
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Looking to Build on T11 Finish in Bermuda
Austin Eckroat

Searching for Momentum at RSM Classic
Joel Dahmen

Trying to Find Form at the RSM Classic
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Ruled Out Again in Week 12
Drake London

Falcons Hoping That Drake London Will Return in Week 13
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Garrett Nussmeier Doubtful to Play Against Western Kentucky
Michael Penix Jr.

Needs Reconstructive Surgery on Torn ACL
Jaxson Dart

Expected to Return to Practice on Wednesday
Shedeur Sanders

Will Start Against Raiders
Dalton Kincaid

Ruled Out Against Texans
Connor Bedard

Continues Tear With Hat Trick
Macklin Celebrini

Pots Hat Trick in Tuesday's Win
Jake Guentzel

Records Eighth Career Hat Trick
Sammy Blais

Injured Versus Blues
Alexander Romanov

Injured in Tuesday's Win
Ryan Hartman

Considered Week-to-Week
Michael Thorbjornsen

Hopes to End 2025 Campaign With Another Solid Finish
Andrew Novak

Looks to End 2025 Season on High Note at RSM Classic
Harry Higgs

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Nico Echavarria has the Potential to Contend at the RSM Classic
Sam Stevens

Finishing Out Year in Georgia
Seamus Power

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Beau Hossler

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Quade Cummins

The Time is Now for Quade Cummins in Georgia
Austin Cook

Needs a Win at the RSM Classic
Cameron Champ

on the PGA Tour Card Bubble
Grayson Rodriguez

Shipped to Angels
Taylor Ward

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Shota Imanaga

Accepts Cubs Qualifying Offer
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Returning to Milwaukee in 2026
Denny McCarthy

Looking For Another Solid Finish at RSM Classic
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Looking To Use Current Momentum to Flip Script at RSM Classic
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a Good Bounce-Back Candidate at RSM Classic
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Could Compete for Starting Shortstop Job in 2026
Gleyber Torres

Accepts Tigers Qualifying Offer
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Jamie Benn

Makes Season Debut Tuesday
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
Auston Matthews

to Miss at Least Two More Games
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
CFB

Sam Leavitt Set to Enter Transfer Portal?
Jose Altuve

Undergoes Foot Surgery
Alex Bregman

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CFB

James Franklin to be Virginia Tech's Next Head Coach
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Fernando Mendoza the Clear Heisman Trophy Favorite?
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Beau Pribula Has Chance to Face Oklahoma on Saturday
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
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Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
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Virginia Tech Close To Naming James Franklin As Head Coach
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Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

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Jacob deGrom

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Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
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Set For UFC 322 Co-Main Event
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Virginia's Chandler Morris Trending Toward Facing Duke on Saturday

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