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Week 16 Warning Signs: Buffalo Bills vs New England Patriots

Dominick Petrillo takes a close look at whether fantasy GMs can trust any players in the Buffalo Bills vs. New England Patriots game in the championship round of the fantasy playoffs.

Congratulations on making it to the championship week of your fantasy league. Whether you are playing for pride or cash, it is always a great feeling to be among the last teams standing in your league.

There are many great matchups this week. The Broncos will have a field day against the hapless Lions. The Buccaneers and the Texans will have a fantasy bonanza on Saturday. As for us? We are going to take a look at the other end of the spectrum. The biggest game to stay away from. The Josh Allen-led Bills heading to Foxborough to take on the Tom Brady-led Patriots.

This will be a great game for real-life fans. As for fantasy fans? Not as much. In a championship matchup, where points are going to be measured down to the last decimal point, this is a game to stay as far away from as possible. So, let’s take a look at the tale of the tape for this one and find out why exactly you should be staying away.

Be sure to check all of our fantasy football rankings for 2025:

 

Buffalo Bills vs New England Patriots: A matchup made of defense

Both of these teams are having good seasons. In the case of the Bills, you could even call it great. But in the case of both of these teams, this is due directly to the elite play of their defenses and not their offenses.

With both teams in the top three in overall defense and pass defense, there is not much chance either of the quarterbacks in this one will put up points conducive to you wanting to start them. Even in a seemingly great matchup against Cincinnati last week, Brady was able to put up less than 200 yards passing. On the other side of the ball, Josh Allen threw a winning touchdown for the Bills but did not do much else against the Steelers on Sunday night.

With both teams having elite corners in Stephon Gilmore and Tre’Davious White, it will also be hard to find a receiver on either side you want to start. John Brown had a good start to the season. In recent weeks though, he has fallen off as the run game with Devin Singletary taking over. With Cole Beasley being solid but not great and the Patriots linebacker group being great, he also will leave a bitter taste in your mouth if he is started.

For the Patriots, Julian Edelman has always been Mr. Reliable. But playing through a knee and rib injury has taken its toll on the No. 1 target for Brady. This culminated last week with his game of two receptions for nine yards. This is not the production you wanted to see in a plus matchup. Now facing the third-ranked pass defense in the NFL, it could be tough to get anything going. The Absence of Rob Gronkowski has made a huge impact on New England, maybe even more than anyone had anticipated. Not only was he the key to how the offense was run, but his incredible blocking ability led to what success they had in the run game. Success they have not been able to find yet in 2019. Ben Watson is not the answer nor is he reliable at this point in his career. With the tight end position being quite possibly the worst in the NFL, Tom Brady has truly looked like a 42-year old quarterback.

 

Can Anyone Run?

Finally, Sony Michel had a decent game last week but 89 yards on 19 rushes isn’t great. When you compare that to his production season to date, it is a gold mine.

The Bills run defense is not the strength of the defense. That is clearly the pass defense. But they are still good at stopping the run. The fact that Tom Brady of 2019 is not Tom Brady of 2009 is also a key. No longer do teams need to fear the GOAT. Sure, he can still beat you, but not to the level he once could. With multiple weeks of disappointing play this season, including last week where he did not even rank as a top-20 quarterback, the passing game is not what it was. And neither is the run game. While never great, the run game was always a constant in New England. But no longer. With the entire offense taking a step back it has been difficult to find anything on the New England offense to be scared of. With the exception of James White and his PPR potential, this week will be no different in an ugly game.

For the Buffalo Bills, Frank Gore has shown us that longevity will lead you to the pinnacle of the record books. This should not be undermined, but he is not the same runner he once was. At his age, no one could be. Devin Singletary has done a lot to be excited about in his rookie year. His future with Josh Allen looks bright. But the pass rush of the Patriots will smother Allen and Singletary, making it hard to get anything going. Especially on the road in Foxborough, it does not look to be a great day for anyone on the Buffalo roster. The Patriots are coming off their first home loss in over two full seasons against the Chiefs. They are also taking on the first team to truly pose a challenge to them in the division in over a decade. They are not going to be taking this game lightly. Because of this and because both defenses are as good as advertised, this game should be a fantasy desert. Barren and dry.

With a defensive struggle ahead, a repeat of the 16-10 score from the first meeting this season is not only a possibility but also a likely outcome. So, don’t get caught up in the dust storm. Find better players in far better matchups to fill your lineup this week. It may not win you the week, but it will certainly keep you from losing it.

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REAL-TIME FANTASY NEWS

CFB

Emmett Johnson Leaving Nebraska for 2026 NFL Draft
Dalton Kincaid

to be Questionable for Week 14
Tee Higgins

Clears Concussion Protocol, is a Full-Go for Sunday
CFB

Jam Miller Unlikely to Play in SEC Title Game
CFB

Penn State Expected to Hire Matt Campbell from Iowa State
Mike Evans

Not Quite Ready to Return This Week
Jayden Daniels

Will Start Against Vikings
Lamar Jackson

Returns to Practice, on Track to Play on Sunday
Kyler Murray

Won't Return This Year, Cardinals Non-Committal on his Future
Trey Benson

Out in Week 14; Could he Miss the Rest of the Season?
Marvin Harrison Jr.

Ruled Out for Sunday's Game
CeeDee Lamb

in the League's Concussion Protocol
Brian Branch

Out with Torn Achilles
Daniel Gafford

Uncertain For Friday's Game
Darius Garland

Ruled Out For Friday Against Spurs
Kristaps Porzingis

Tagged as Questionable Against Nuggets
Jalen Johnson

Could Miss Second Straight Game
LaMelo Ball

Probable To Play Through Wrist Sprain Friday
Detroit Lions

Brian Branch Feared to Have Suffered an Achilles Injury
Tyler Herro

Uncertain For Magic Matchup
CFB

Arkansas Targeting Ron Roberts for Defensive Coordinator Job
Jayden Daniels

Tracking Towards a Week 14 Return
Justin Herbert

Trending in the Right Direction to Play Monday Night
Mathew Barzal

Leads Islanders Past Avalanche
Elias Lindholm

Posts Hat Trick of Assists Thursday
Leon Draisaitl

Notches Season-High Four Points in Thursday's Win
Connor McDavid

Nets 13th Career Hat Trick
Teuvo Teravainen

Expected to Be Fine After Thursday's Exit
Shane Pinto

Exits Loss With Injury
Joseph Woll

Sustains Lower-Body Injury Thursday
Ryan Flournoy

Heavily Involved After Teammate's Exit
Jahmyr Gibbs

Scores Three Times on Thursday Night Football
Josh Jacobs

Remains Limited with Knee Injury
CeeDee Lamb

Suffers Concussion in Week 14 Against Detroit
Jhostynxon Garcia

Pirates Acquire Jhostynxon Garcia From Red Sox
Draymond Green

Won't Return on Thursday Night
Kenneth Walker III

Remains Limited on Thursday
Kyren Williams

Limited Again with Ankle Injury
Davante Adams

Limited in Practice on Thursday
Cody Bellinger

Yankees Pushing Hard to Re-Sign Cody Bellinger
CFB

Penn State Eyeing Iowa State Coach Matt Campbell For Coaching Vacancy
Alex Bregman

Cubs Have Renewed Interest in Alex Bregman
Quinten Post

Set to Suit Up Versus Philadelphia
Amon-Ra St. Brown

Will Play on Thursday Night
Joel Embiid

Back on Thursday Night
Al Horford

Available on Thursday
Jonathan Kuminga

Cleared for Action on Thursday Night
Jusuf Nurkić

Jusuf Nurkic Out of Action Thursday
Terance Mann

Available Versus Utah
Kirill Marchenko

Returns From Four-Game Absence
De'Anthony Melton

to be Capped at 20 Minutes on Thursday
Carter Verhaeghe

Ready to Return Thursday
Scott Wedgewood

Skips Thursday's Game
Paolo Banchero

Upgraded to Questionable for Friday Night
Danila Yurov

Misses Second Straight Game
CFB

Billy Napier Finalizing Deal to Become James Madison's New Head Coach
Andrei Vasilevskiy

Unavailable Thursday
CFB

Buster Faulkner Set to Become Florida's New Offensive Coordinator
Dereck Lively II

to Seek "Multiple Opinions" on Right Foot Treatment
David Pastrnak

Still Out Thursday
Ryan McDonagh

Lightning Sign Ryan McDonagh to Three-Year Extension
Trayce Jackson-Davis

Set to Suit Up Thursday
Ja Morant

Considered Day-to-Day
Jimmy Butler III

Sidelined Thursday
Jaylen Brown

Ruled Out Thursday Against the Wizards
Quentin Grimes

Is Ready to Return on Thursday
CFB

Joe Sloan Expected to be Kentucky's New Offensive Coordinator
CFB

Lane Kiffin Working to Keep Defensive Coordinator Blake Baker at LSU
CFB

Brian Daboll a Candidate for Penn State Head-Coaching Job?
Karel Vejmelka

Records Impressive Shutout
JJ Peterka

Rocks Ducks With Four-Point Effort
Cole Caufield

Extends Point Streak With Power-Play Assist
Matvei Michkov

Delivers Two Assists Wednesday
Jake Oettinger

Grabs Fourth Consecutive Victory With Shutout
Ryan Leonard

Tallies Four Points in Wednesday's Win
Cam York

Exits Win Early
Kyle Tucker

Visits With Blue Jays
Emilio Pagán

Reds Bring Back Closer Emilio Pagan on Two-Year Deal
Cedric Mullins

Rays Agree on One-Year Deal
Freddy Peralta

Brewers Considering Trading Freddy Peralta
Kyle Schwarber

Reds Serious About Adding Kyle Schwarber in Free Agency?
CFB

Brent Key Signing Five-Year Deal to Remain at Georgia Tech
CFB

Brian Hartline Expected to Land USF Head-Coaching Job
CFB

Collin Klein Expected to be Top Target for Kansas State if Head-Coach Job Opens
CFB

Chris Klieman Considering Stepping Down at Kansas State
CFB

D.J. Durkin Staying at Auburn Under Alex Golesh
CFB

Charlie Weis Jr. Permitted to Coach Ole Miss Offense in College Football Playoff
CFB

Five-Star Quarterback Jared Curtis Flips Commitment From Georgia to Vanderbilt
CFB

Florida Hiring Brad White as Defensive Coordinator
Kyle Schwarber

Giants Have Checked in on Kyle Schwarber
Willson Contreras

Willing to Waive his Full No-Trade Clause?
Edwin Díaz

Mets Still Interested in Re-Signing Edwin Diaz
Devin Williams

Agrees to Three-Year Deal With Mets
Cole Ragans

Red Sox Targeting Cole Ragans in a Trade?
CFB

Kentucky Hires Oregon Offensive Coordinator Will Stein As Head Coach
CFB

Kalani Sitake the Top Target for Penn State Coaching Job
CFB

Josh Heupel Says He's Not a Candidate for Penn State Head Coach Job
Zack Wheeler

Likely to Return in May
Ryan Helsley

Agrees to Two-Year Deal With Orioles

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