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Must-Start Defenses (D/ST) for Week 4 Fantasy Football (2025)

Matt's must-start fantasy football waiver wire defenses (D/ST) to stream and start for Week 4 of the 2025 season. His fantasy defense start 'em, sit 'em picks.

The fantasy football season rolls into Week 4. Get these high-impact defenses on your roster now! RotoBaller analyst Matt Donnelly drops his fantasy football must-start defenses (D/ST) for Week 4 of the 2025 season.

As we head to the end of September, the NFL season is in full swing. As a result, fantasy football decisions are coming at a furious pace. We are here to help with your Week 4 D/ST streamers, to give you the tools needed to set those winning lineups.

Be sure to tune into RotoBaller Radio on SiriusXM (channel Sirius 210, XM 87) - every weekday morning at 6:00 AM ET. You can also find new weekly shows on YouTubeSpreaker, SpotifyiTunes and on the site under RotoBaller Radio podcasts. Win more in 2025 with RotoBaller!

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2025 Fantasy Football: Week 4 Defenses To Start (D/ST)

Matt Donnelly drops his top Defenses for Week 4 of the 2025 fantasy football season:

Thanks for listening to today's episode! Be sure to tune in throughout the week, and to also follow RotoBaller on Twitter, YouTube, Spotify and iTunes for the latest fantasy news and analysis.

 

Week 4 Fantasy Football Outlooks

  • Kenny Moore II Expected to Miss Multiple Weeks
  • Jets Place Quincy Williams on Injured Reserve With Shoulder Injury
  • Blake Cashman Expected to Miss Extended Time
  • Mykel Williams Day-to-Day With Wrist Injury
  • Jets Acquire Jarvis Brownlee From Titans on Tuesday
  • Darius Slay Dealing With "Leg Contusion," Expected to be Available in Week 4
  • Texans Release C.J. Gardner-Johnson on Tuesday
  • DaRon Bland Trending Towards Playing in Week 4
  • Jaylon Johnson to Have Core-Muscle Surgery, Should Return This Year

 

Who Should I Start Tool

Not sure who to start? Check out the Who Should I Start tool:

Who Should I Start for 4?

Compare up to four players and we'll tell you who to start...

Who To Start?
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Who Should I Start? Who Should I Sit? Some common Week 4 fantasy football lineup decisions are regarding defenses like the Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST. But not to worry, we are here to help make these decisions and build winning lineups in Week 4. Set your optimal fantasy football lineups for Week 4 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

Week 4 Player Decisions. Today's focus is on specific defenses like Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST. These are some of the most common searches for fantasy football lineups in Week 4.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed, our Who Should I Start? tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!

How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 4 Searches. Curious to see some tough lineup decisions for Week 4 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

 

Popular Week 4 Searches - Start/Sit Player Comparisons

Below are some popular Week 4 searches and comparisons from our 'Who To Start' tool for the Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST compared to others:

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