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Must-Start Defenses (D/ST) for Week 4 Fantasy Football (2025)

Matt's must-start fantasy football waiver wire defenses (D/ST) to stream and start for Week 4 of the 2025 season. His fantasy defense start 'em, sit 'em picks.

The fantasy football season rolls into Week 4. Get these high-impact defenses on your roster now! RotoBaller analyst Matt Donnelly drops his fantasy football must-start defenses (D/ST) for Week 4 of the 2025 season.

As we head to the end of September, the NFL season is in full swing. As a result, fantasy football decisions are coming at a furious pace. We are here to help with your Week 4 D/ST streamers, to give you the tools needed to set those winning lineups.

Be sure to tune into RotoBaller Radio on SiriusXM (channel Sirius 210, XM 87) - every weekday morning at 6:00 AM ET. You can also find new weekly shows on YouTubeSpreaker, SpotifyiTunes and on the site under RotoBaller Radio podcasts. Win more in 2025 with RotoBaller!

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2025 Fantasy Football: Week 4 Defenses To Start (D/ST)

Matt Donnelly drops his top Defenses for Week 4 of the 2025 fantasy football season:

Thanks for listening to today's episode! Be sure to tune in throughout the week, and to also follow RotoBaller on Twitter, YouTube, Spotify and iTunes for the latest fantasy news and analysis.

 

Week 4 Fantasy Football Outlooks

  • Kenny Moore II Expected to Miss Multiple Weeks
  • Jets Place Quincy Williams on Injured Reserve With Shoulder Injury
  • Blake Cashman Expected to Miss Extended Time
  • Mykel Williams Day-to-Day With Wrist Injury
  • Jets Acquire Jarvis Brownlee From Titans on Tuesday
  • Darius Slay Dealing With "Leg Contusion," Expected to be Available in Week 4
  • Texans Release C.J. Gardner-Johnson on Tuesday
  • DaRon Bland Trending Towards Playing in Week 4
  • Jaylon Johnson to Have Core-Muscle Surgery, Should Return This Year

 

Who Should I Start Tool

Not sure who to start? Check out the Who Should I Start tool:

Who Should I Start for 18?

Compare up to four players and we'll tell you who to start...

Who To Start?
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Who Should I Start? Who Should I Sit? Some common Week 4 fantasy football lineup decisions are regarding defenses like the Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST. But not to worry, we are here to help make these decisions and build winning lineups in Week 4. Set your optimal fantasy football lineups for Week 4 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

Week 4 Player Decisions. Today's focus is on specific defenses like Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST. These are some of the most common searches for fantasy football lineups in Week 4.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed, our Who Should I Start? tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!

How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 4 Searches. Curious to see some tough lineup decisions for Week 4 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

 

Popular Week 4 Searches - Start/Sit Player Comparisons

Below are some popular Week 4 searches and comparisons from our 'Who To Start' tool for the Texans DST, Commanders DST, Rams DST, Patriots DST, Browns DST, and Jaguars DST compared to others:

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REAL-TIME FANTASY NEWS

CFB

Kewan Lacy Expected to Be Full-Go Against Georgia
Stefon Diggs

Facing Strangulation, Assault Charges
Kevin Love

Sits Out Meeting With Celtics
Ace Bailey

Out for Second Straight Game
Jock Landale

Questionable Tuesday
CFB

Chip Kelly Named Northwestern Offensive Coordinator
Nikola Jokić

Nikola Jokic May Have Avoided Major Injury
Alex Lyon

Bags Another Victory Monday
Riley Leonard

Will Start Against the Texans
Marcus Johansson

Matches Career High With Four-Point Effort
Steven Stamkos

Shines Monday Night With Three Points
Dylan Strome

Extends Point Streak in Loss
Sam Reinhart

Leads Charge Against Capitals With Three Points
Troy Terry

Enjoys Three-Point Night Against Sharks
Macklin Celebrini

Remains Hot Against Ducks
Kentavious Caldwell-Pope

Out Tuesday
Jaxson Hayes

Off the Injury Report Tuesday
Rui Hachimura

Sits Out Tuesday's Game
Caris LeVert

Unlikely to Play Tuesday
Drew Eubanks

Available Tuesday
Keegan Murray

Questionable to Face Clippers
Zach LaVine

Remains Out Tuesday
John Collins

Uncertain for Tuesday
Bijan Robinson

Explodes for 229 Total Yards, Two Touchdowns on Monday Night
Robert Williams III

Active on Monday Night
Kris Murray

Out on Monday
Pelle Larsson

Exits With Ankle Injury Monday
Josh Giddey

to Miss Rest of Monday's Action
Coby White

Ruled Out for Rest Of Monday's Game
Nikola Jokić

Nikola Jokic Won't Return Monday
Brandon Williams

Available Monday Night
Anthony Davis

Out Against Trail Blazers
Coby White

Questionable to Return Monday
Davante Adams

Officially Out on Monday Night
Drake London

Active Against Rams
Jake DeBrusk

to Miss Monday's Game as Healthy Scratch
Shane Pinto

Available Monday
Pius Suter

to Miss at Least Four Weeks
Pyotr Kochetkov

Likely Done for the Season
Josh Morrissey

Expected to Play Monday
Karel Vejmelka

Moved to Injured Reserve
Rasmus Dahlin

Expected to Rejoin Sabres Lineup Monday
Yegor Chinakhov

Penguins Acquire Yegor Chinakhov From Blue Jackets
Justin Herbert

Won't Face Broncos in Week 18
Marcus Mariota

Considered "a Stretch" to Play in Week 18
Geno Smith

Dealing With Significant Ankle Injury
Dak Prescott

Will Play in Week 18
Lamar Jackson

Week 18 Status "to be Determined"
Joe Mixon

Won't Return This Season
T.J. Watt

a Long Shot to Play in Week 18?
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
Joe Burrow

Will Play in Week 18 Against the Browns
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
Luther Burden III

Set to Undergo Additional Testing on Quad Injury
Kirill Marchenko

Scores Twice in Sunday's Win
Justin Brazeau

Pots First Career Hat Trick Sunday
Juraj Slafkovsky

Collects Season-High Three Points in Sunday's Loss
Eeli Tolvanen

Continues Scoring Surge With Three-Point Effort
Jack Eichel

to Remain Out Monday
Adam Fox

Nearing Return, Considered Day-to-Day
D'Andre Swift

Finds End Zone Twice in Sunday Night Loss
Luther Burden III

Posts Season-High 138 Yards, Touchdown in Loss
Christian McCaffrey

Racks Up 181 Total Yards, Touchdown in Win Over Bears
Brock Purdy

Delivers Second Straight Five-Touchdown Performance
Parker Washington

Leads Jaguars in Targets, Receptions, and Receiving Yards
Wan'Dale Robinson

Posts Season-High 11 Receptions in Week 17
Josh Allen

Seen Limping From X-Ray Room, Says Foot Injury Didn't Affect Him
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator
CFB

Michigan Targeting Kyle Whittingham as Next Head Coach
CFB

Texas Leading Rusher Quintrevion Wisner Set to Transfer

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