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Casey Wilson's top DraftKings and FanDuel MLB DFS picks for today, Tuesday, 4/21/26. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.
We have a nine-game Wednesday night slate starting at 6:40 p.m. ET tonight on both sites. We have been red hot in DFS this week, and tonight looks like another opportunity to take a contest down. If you are a premium sub, make sure you get in Discord, as there are a ton of tidbits along the way that will help you become a better DFS player.
If you have not had a chance to check out my model, I will refer to it throughout this article. To get a better sense of where I am at not only on today's slate but every slate, please give it a look. My plays are solely based on numbers, and this model is the brain behind the operation.
This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 4/22/2026, with the slate starting at 6:40 p.m. ET on DraftKings and FanDuel. The lineup picks will showcase elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.
Top MLB DFS Pitcher for DraftKings, FanDuel
Braxton Ashcraft, SP - PIT ($8.2K DK/$9.8K FD)
Tonight's slate is tough for starting pitching. There is no sure-fire arm to spend up on or an SP1 that I want to invest heavily in. With that being said, I am going to be overweight on Braxton Ashcraft in this spot. He gets a nice matchup against the Texas Rangers at Globe Life Field, which is a pitching-friendly ballpark.
The Rangers tonight have a 3.6 implied run total in my model, which is good for the bottom three on tonight's slate. They have a 23.0% K% with a .759 OPS and a 115 wRC+ against RHP this season.
Ashcraft has been fantastic in 2026. He has pitched to a 2.96 xFIP, 28.7% K%, 13.5% SwStr%, 1.06 WHIP, and has yet to allow a home run. He has a 29.2% FB% and a 24.0% Hard Hit% allowed over his last two starts.
Career-high 9⃣ Ks for Braxton Ashcraft. pic.twitter.com/nQsxq6HNu9
— Pittsburgh Pirates (@Pirates) April 11, 2026
My model has Ashcraft projected for a 26.4% K% and 6.00 strikeouts, making him a great value on tonight's slate.
Top MLB DFS Stack for DraftKings, FanDuel
Atlanta Braves (Model Projected IRT (Implied Run Total)- 6.2) vs. Zack Littell
The Atlanta Braves will visit Zack Littell and the Washington Nationals at Nationals Park this evening. It will be in the mid-60s, with a slight breeze blowing in, making these slightly lower-than-average hitting conditions.
I am very intrigued by this matchup for the Braves against a struggling Zack Littell. Littell has posted a 4.34 xFIP, 1.74 WHIP, and a 3.32 HR/9 this season. Over his last two starts, he has allowed a 2.00 WHIP and a 5.00 HR/9 with a 41.7% Hard Hit%. If he does this again against this Braves offense, it is going to get ugly.
The Braves in 2026 have a .791 OPS and a 121 wRC+ against RHP, and yes, over their L14, they are even better if that's possible, with a .853 OPS and a 140 wRC+ against that split. I have them projected for 6.2 implied runs tonight, which is second only to the Padres at Coors Field. Fire up the Braves in all formats.
Favorite Targets: Drake Baldwin, Matt Olson, Dominic Smith, Michael Harris II, Ozzie Albies, Mike Yastrzemski, Ronald Acuna Jr.
Top MLB DFS Hitter for DraftKings, FanDuel
Ketel Marte, 2B - ARI ($5.5K DK/$3.0K FD)
Ketel Marte is a lefty masher flat out and someone I always want in my lineups against southpaws, especially ones like Anthony Kay. Kay has allowed a .458 SLG, 13.6% Brl%, and a 52.3% Hard Hit% this season to RHH. Marte is heating up with a 1.200 OPS against the split over the last seven days. He slashed .275/.373/.512 with a .885 OPS against LHP in 2025.
The White Sox were my top stack last night, along with a game stack with the Diamondbacks. The path was right there. First takedown of the season! Link to sign up is in the comments. If you're an SE entry player, like most of us are. There's no better place to be.
50% off using… pic.twitter.com/iRStcG4D88
— Casey Wilson (@CaseyW22) April 22, 2026
