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Oct 5, 2026, 9:28 PM ET

Philadelphia Eagles running back Will Shipley has seen most of his usage on special teams since entering the NFL in 2024, recording just 76 total touches across 35 career games with the Eagles. However, the 24-year-old could get his chance to lead the Philadelphia backfield in the team's upcoming Week 5 matchup against the Jacksonville Jaguars. Eagles running back Saquon Barkley (hamstring) is considered unlikely to play against Jacksonville with a hamstring injury, and RB2 Tank Bigsby (core) is set to undergo core muscle surgery and will be placed on Injured Reserve. As a result, Shipley could be called upon to play a three-down role against the Jaguars. In leagues where he remains available on the waiver wire, Shipley profiles as a must-add running back for fantasy managers.--Will Brady
Source: RotoBaller
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Oct 5, 2026, 9:18 PM ET

Philadelphia Eagles running back Saquon Barkley (hamstring) is "unlikely" to play in his team's Week 5 matchup against the Jacksonville Jaguars, per Jeff McLane of The Philadelphia Inquirer. Barkley suffered a hamstring injury during Philly's Week 4 loss to the Los Angeles Rams and is considered week-to-week. The Eagles also lost top backup running back Tank Bigsby (core) in Week 4, as he suffered a core muscle injury and has been placed on Injured Reserve. Without Barkley and Bigsby against Jacksonville, Eagles RB3 Will Shipley appears likely to be the team's lead back. McLane also notes running backs Dameon Pierce, Jaydon Blue, and Carson Steele are all on the Eagles' practice squad and could be candidates for elevation to the active roster in Week 5.--Will Brady
Source: The Philadelphia Inquirer - Jeff McLane
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Oct 5, 2026, 9:12 PM ET

Miami Dolphins head coach Jeff Hafley said the team is taking it "one day at a time" with rookie wide receiver Caleb Douglas (ankle), according to David Furones of the South Florida Sun-Sentinel. Douglas is not dealing with a significant or long-term ankle injury, but he has now missed back-to-back games after originally getting injured in the Week 2 blowout loss to the San Francisco 49ers. In addition to missing each of the last two games, the 23-year-old third-rounder from Texas Tech has not practiced since getting hurt in Week 2. If he is going to be available to return this Sunday in Week 5 against the Cincinnati Bengals, Douglas is going to first need to return to the practice field later this week. The most likely scenario is that Douglas will miss a third straight game this weekend before getting another week to rest during Miami's Week 6 bye before returning in Week 7 to face the division-rival New York Jets on the road. Douglas caught five passes for 94 yards in the season-opening loss to the Las Vegas Raiders and should have more opportunity for a big pass-catching role in one of the thinnest WR depth charts in the league when he recovers from his ankle injury.--Keith Hernandez
Source: South Florida Sun-Sentinel - David Furones
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Oct 5, 2026, 9:11 PM ET

Cincinnati Bengals rookie wide receiver Dohnte Meyers had a breakout game in his team's Week 4 loss to the Jacksonville Jaguars, recording seven catches for 82 yards on nine targets. Meyers got his chance to play after star Bengals wide receiver Ja'Marr Chase (concussion) was forced to leave the game with a concussion. Coming out of Week 4, Chase is currently in concussion protocol, and fellow Cincinnati wideout Tee Higgins (adductor) is reportedly battling an adductor strain. If both Chase and Higgins can play in the Bengals' Week 5 matchup against the Miami Dolphins, Meyers may be hard-pressed to see fantasy-relevant target volume. However, if one or both of Chase and Higgins is inactive, Meyers could be one of Bengals quarterback Joe Burrow's top targets against Miami. Given the injury uncertainty in Cincinnati, Meyers profiles as a top waiver wire target for fantasy managers ahead of Week 5.--Will Brady
Source: RotoBaller
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Oct 5, 2026, 9:03 PM ET

Pittsburgh Steelers head coach Mike McCarthy said on Monday that defensive end Derrick Harmon (foot) is being placed on Injured Reserve with a foot injury, which means he will be out for a minimum of four weeks, according to Gerry Dulac of the Pittsburgh Post-Gazette. The 23-year-old injured his foot in Thursday night's loss to the division-rival Cleveland Browns and will now be out through the Steelers' Week 9 bye. Pittsburgh's pass rush will be a little short-handed until Harmon is able to return, and the team will be asking Yahya Black to step up in a pass-rushing role going forward. It is a tough break for Harmon, a former first-rounder in 2025 from Oregon after starting his second year in the NFL with 12 tackles (three solo), 1.5 sacks, and a forced fumble in the first four games. Harmon totaled 27 tackles (11 solo), three sacks, five QB hits, and one fumble recovery in 12 games (eight starts) in his first year in the league in 2025.--Keith Hernandez
Source: Pittsburgh Post-Gazette - Gerry Dulac
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Oct 5, 2026, 8:55 PM ET

Minnesota Vikings offensive guard Donovan Jackson (knee) suffered a torn meniscus in the team's Week 4 win over the visiting Miami Dolphins that will require surgery and likely end his 2026 season, according to Dane Mizutani of the St. Paul Pioneer Press. Head coach Kevin O'Connell said on Monday that Jackson will miss at least the remainder of the regular season, so there could be a chance that he could rejoin the Vikings if they make a deep postseason run. The 23-year-old is expected to be replaced at left guard on the Vikings' offensive line by Joe Huber. The former 24th overall pick in the 2025 NFL Draft from Ohio State was inconsistent as the team's starting left guard in his first NFL season, and he will now have to wait until 2027 to get back to work.--Keith Hernandez
Source: St. Paul Pioneer Press - Dane Mizutani
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Oct 5, 2026, 8:47 PM ET

Philadelphia Eagles running back Saquon Barkley (hamstring) is considered week-to-week with the hamstring injury that he suffered in Sunday's Week 4 loss to the Los Angeles Rams, according to the NFL Network's Ian Rapoport and Mike Garafolo. Barkley's injury is not considered to be a long-term injury, but his availability for the Week 5 contest this Sunday's game on the road against the Jacksonville Jaguars is very much in question. Fantasy managers should prepare for the worst, which would probably mean Barkley missing a couple of weeks. Backup Tank Bigsby took over early in Sunday's loss to the Rams, but he suffered an injury as well and will go on Injured Reserve after having core-muscle surgery. With Barkley and Bigsby banged up, Will Shipley will be one of the most popular waiver-wire pickups going into Week 5. Barkley, who led the NFL with 2,005 rushing yards and 13 rushing touchdowns in 2024 in his first year in Philly, has averaged 5.1 yards per carry for 182 rushing yards in four games in 2026, but he has yet to find the end zone. He has added only four catches for eight yards as a receiver. We will have a better idea of Barkley's status for this weekend against the Jags once the Eagles begin practicing on Wednesday.--Keith Hernandez
Source: NFL Network - Ian Rapoport
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Oct 5, 2026, 8:42 PM ET

Chicago Bears quarterback Caleb Williams (hamstring) will not practice this week, head coach Ben Johnson told Courtney Cronin of ESPN. The head coach still believes that Williams is operating on a "week-to-week" timeline as he recovers from a Grade 2 right-hamstring strain that he suffered in the Week 2 loss to the division-rival Minnesota Vikings. Johnson said that Williams is doing well attacking his rehab, but he will miss a third straight game this weekend in a big divisional tilt in Week 5 at Lambeau Field against the division-rival Green Bay Packers. The Bears already announced that backup Tyson Bagent will make the start this weekend in Green Bay after leading the team to victory over the New York Jets this past Sunday. Fantasy managers must remain patient with the former first overall pick from USC, but he will need to return to the practice field in some form next week if he is to have any chance of returning for a Week 6 matchup against the Atlanta Falcons.--Keith Hernandez
Source: ESPN.com - Courtney Cronin
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Oct 5, 2026, 8:14 PM ET

Green Bay Packers superstar linebacker Edgerrin Cooper (Achilles) will miss the rest of the 2026 season after suffering a torn Achilles tendon in Sunday's Week 4 win over the Tampa Bay Buccaneers, according to Ian Rapoport of the NFL Network. It is a massive blow for the Packers' defense for the rest of the year, as Cooper is one of the best young, do-it-all linebackers in the league. The 24-year-old former second-rounder in 2024 from Texas A&M will finish his third year in the NFL with only 30 tackles (18 solo), three sacks, six tackles for loss, an interception, and a pass breakup in four games played. The Packers will not be able to replace Cooper's production in the middle of their defense, but Isaiah McDuffie will do his best right next to Zaire Franklin. Cooper set a career high with 3.5 sacks in his rookie campaign in 2024, so he was well on his way to shattering that number this year before his season-ending injury in Week 4 on Sunday. He had a career-best 118 combined tackles (63 solo) and half a sack in 16 regular-season starts in 2025.--Keith Hernandez
Source: NFL Network - Ian Rapoport
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Oct 5, 2026, 7:48 PM ET

New Orleans Saints tight end Noah Fant (abdomen) is officially inactive for the Monday night game against the division-rival Atlanta Falcons to close out Week 4 action, according to Nick Underhill of NewOrleans.Football. The 28-year-old was limited in practice Thursday through Saturday, but it was not enough to convince the coaching staff that he was ready to play against the Falcons. Fant scored a touchdown in the season opener and caught all four of his targets for 33 yards and two more touchdowns in last week's loss to the Las Vegas Raiders. However, in three games played going into Monday's contest, he has only eight receptions on 12 targets for 66 yards through the air as the clear No. 2 tight end in New Orleans behind Juwan Johnson, who has been a target hog in the early going in the Saints' offense. With Fant sidelined on Monday, Oscar Delp and Treyton Welch will battle for scraps at the position behind Johnson. At best, Fant is a touchdown-dependent TE2 for fantasy managers in deeper leagues when he is healthy.--Keith Hernandez
Source: NewOrleans.Football - Nick Underhill
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Oct 5, 2026, 7:42 PM ET

Los Angeles Chargers head coach Jim Harbaugh said on Monday that wide receiver Ladd McConkey (foot) is "week-to-week" with a foot injury that he suffered in Sunday's Week 4 loss to the Seattle Seahawks, according to Alex Insdorf. McConkey was dealing with a foot injury going into the game on Sunday, but it gave him more problems against Seattle and forced him from the game. The 24-year-old former first-rounder's status for the Week 5 contest at home against the division-rival Denver Broncos is unclear for now, but fantasy managers should be planning for McConkey to miss some time. If he does, Quentin Johnston and Tre' Harris would have higher target ceilings as quarterback Justin Herbert's primary targets in the passing game as the Bolts search for their first win of 2026. Before leaving on Sunday in Seattle, McConkey failed to reel in either of his two targets. He was able to score in the season-opening loss to the Arizona Cardinals and rack up 82 receiving yards, but he caught seven passes on eight targets for 101 scoreless yards in Weeks 2 and 3.--Keith Hernandez
Source: Alex Insdorf
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Oct 5, 2026, 6:36 PM ET

The Seattle Seahawks are signing veteran free-agent running back Joe Mixon on Monday, sources told Jordan Schultz. Mixon will return to the NFL after missing all of the 2025 campaign with the Houston Texans due to a foot injury. He will give Seattle more backfield depth going forward behind George Holani and Emanuel Wilson with rookie first-rounder Jadarian Price (chest) going on Injured Reserve over the weekend. The 30-year-old Mixon has five 1,000-yard rushing seasons in his eight years in the NFL with the Texans and Cincinnati Bengals, including two straight in 2023 and 2024. For now, fantasy managers should expect Mixon to be more of an RB3 for the Seahawks as he learns their system while providing depth behind Holani and Wilson. Eventually, Zach Charbonnet (knee) is expected to join the backfield, and he should eventually be the go-to guy, even when/if Price returns. The signing of Mixon could indicate a much more serious chest injury for Price, so his fantasy managers should not expect him to be ready after missing four games. In deeper fantasy leagues, Mixon is not a bad RB to stash off the waiver wire this week.--Keith Hernandez
Source: Jordan Schultz
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Oct 5, 2026, 6:28 PM ET

The goal is for Washington Commanders quarterback Jayden Daniels (elbow) to have a full week of practice and start on Sunday in the Week 5 contest versus the division-rival New York Giants at home, head coach Dan Quinn told Zach Selby of the team's official website. Daniels dislocated his left (non-throwing) elbow for the second time in the Week 2 loss to the division-rival Dallas Cowboys and has missed the last two games as a result. The 25-year-old former second overall pick from LSU returned to limited practice last week, though, and as long as he can upgrade to full practice this week, he should be in line to play this weekend. It is good timing for the Commanders, too, with veteran backup Marcus Mariota (knee) spraining his MCL in Sunday's blowout loss to the Indianapolis Colts in London in Week 4. Mariota is expected to miss some time going forward after spraining the same knee in the preseason, which means that Athan Kaliakmanis would serve as Daniels' backup under center if he returns to face the Giants.--Keith Hernandez
Source: Commanders.com - Zach Selby
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Oct 5, 2026, 6:19 PM ET

Arizona Cardinals head coach Mike LaFleur said on Monday that the ankle that was giving rookie first-round running back Jeremiyah Love (ankle) discomfort in Sunday's loss to the New York Giants is not the same ankle from the sprain he suffered in the preseason, according to Dani Sureck of the team's official website. The 21-year-old suffered a high-ankle sprain back in August in the early portion of spring training and did not play again until the start of the 2026 regular season. Love limped off the field late in Sunday's game and never returned, finishing with 14 carries for 63 yards while catching his only target for a loss of eight yards. Love has been splitting backfield work with Tyler Allgeier to begin the season, with James Conner (foot) on Injured Reserve and Trey Benson (knee) done for the season. He has not scored since his NFL debut in the Week 1 win over the Los Angeles Chargers, and he has averaged 4.1 yards per carry for 223 rushing yards on his 55 attempts in his first four games. Love has added 11 receptions for 36 yards and another score through the air. We should have a better idea of his status for Week 5 once the Cardinals resume practicing on Wednesday. If Love should miss any time, Allgeier would essentially become a must-start in fantasy.--Keith Hernandez
Source: AZCardinals.com - Dani Sureck
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Oct 5, 2026, 6:08 PM ET

When asked about running back Saquon Barkley's hamstring injury that he suffered in Sunday's loss to the Los Angeles Rams, Philadelphia Eagles head coach Nick Sirianni did not have any real answers on Monday, according to Zach Berman of The Athletic. "We'll see. We'll have more answers Wednesday for you probably with that stuff," Sirianni said. The Eagles' backfield is suddenly very thin after Barkley was injured early in the Week 4 game. Backup Tank Bigsby (core) took over, but he was also injured and is heading to Injured Reserve due to a core-muscle injury that will require surgery. Will Shipley would become the RB1 for the Eagles this weekend on the road against the Jacksonville Jaguars if Barkley is unable to play. Behind Shipley, other options for the Eagles' backfield would be Jaydon Blue, Dameon Pierce, and Carson Steele. Fantasy managers should consider Barkley to be questionable right now for the Week 5 game in Jacksonville. Before getting hurt, Barkley had only two carries for eight yards and caught his only target for a two-yard gain against the Rams.--Keith Hernandez
Source: The Athletic - Zach Berman

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