MLB DFS Picks Today: Daily Fantasy Baseball Strategy and Tips For FanDuel, DraftKings (9/15/25)

September 15, 2025

Jamie's top DraftKings and FanDuel MLB DFS picks for today, Monday, 9/15/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.

OK, RotoBallers, let the dust settle from another wild Week 2 in the NFL, and let's prepare for another week of September baseball. We're going to have some really fun matchups to target as the week goes on, starting with a tidy little seven-gamer for Monday.

Thanks to some late charges and collapses from teams, some of these games are VERY meaningful. Who'd have thought the Giants and Diamondbacks (both deadline sellers) would be playing each other in a crucial series this week? The same applies to Houston and Texas, and all of those teams should be on your radar for DFS.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 9/15/2025, with the slate starting at 7:35 PM EST. Keep in mind the FanDuel slate has chopped off the late afternoon games from their main slate. The lineup picks will showcase elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Carlos Rodon, SP - NYY ($9,700 DK/$10,000 FD)

Despite the loss last night, the Yankees have to be feeling good about their situation. They took two of three from their rival Red Sox in Boston and now lead them by 1.5 games in the Wild Card standings. Tonight the Yanks begin a series with the Minnesota Twins, whom they've absolutely owned for the better part of a decade.

Carlos Rodon continues his fantastic season tonight in Minnesota pic.twitter.com/mEBhu0e1y9

— SleeperYankees (@SleeperYankees) September 15, 2025

Carlos Rodon has put together a magnificent season with 16 wins, a 3.11 ERA, and 26% K rate. His 29.4% CSW is elite, and the Twins have had the ninth-highest K rate against LHP over the past 30 games. Other than the platoon threat of Byron Buxton and Luke Keaschall, the Twins' lineup should be easy to navigate for the lefty, and his price tag is great.

Kyle Bradish, SP - BAL ($9,200 DK/$9,800 FD)

On a full slate, we're usually looking for a stud pitcher and a cheap value to complement him. On this seven-gamer, a pairing of Rodon and Kyle Bradish is the cash path. They're not cheap, but also not so price-prohibitive that you can't get the hitters you want as well.

Bradish has been terrific since returning this year, striking out 21 batters over 17 innings pitched (32.3% K rate). His pitch count is right around the mid-80s, but it's been more than enough for him to hit value in his outings. The White Sox have the tenth-highest K rate against RHP, and an IRT of only 3.5 tonight.

Kyle Bradish's 5th and 6th Ks. pic.twitter.com/YTWLp38KHK

— Rob Friedman (@PitchingNinja) September 10, 2025

Others To Consider (Cash/GPP):

• Ranger Suarez, SP - PHI ($9,000 DK/$10,300 FD)
• Sean Burke, SP - CWS ($6,500 DK/$8,000 FD)

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Rafael Devers, 1B (DK), 1B/3B (FD) - SF ($5,400 DK/$4,000 FD)

Outside of Aaron Judge (more on him later), there are no standout bats on this short slate, so you can shop around when the lineups come out later. If you're in the market for a stud infielder though, Rafael Devers leads the way. It's been an odd season for Devers, but he's once again crossed the 30 HR-100 RBI threshold.

The Giants are right in the race for the final wild card spot, so there won't be any lineup shenanigans. Zac Gallen has been better of late, but he's still susceptible to the long ball, especially from lefties. Devers has smacked RHP this year for a .394 wOBA and .272 ISO.

Gunnar Henderson, SS - BAL ($5,100 DK/$3,100 FD)

It's been a lost season for the Orioles, and Gunnar Henderson certainly has not lived up to his first-round ADP back in March. However, we know him to be an elite hitter, and tonight is a night where you can really look to him to give a boost to your middle infield spots.

Baltimore is in a good spot against Sean Burke and the White Sox, even though technically Burke has been their best pitcher this season. He's still allowed 1.62 HR/9 to LHB this season, and Henderson has a .384 wOBA, .235 ISO, and 45.3% HHR against RHB.

Ben Rice, C/1B - NYY ($4,500 DK/$3,100 FD)

The Yankees are the top stack of the day even though they're getting a park downgrade going to Minnesota. Simeon Woods Richardson has struggled keeping the ball out of the air (31.1% GB rate, 1.53 HR/9 allowed), and has also walked just under four batters per nine innings.

Ben Rice (along with Trent Grisham) has been a wonderful surprise for the Yanks at the top of the order. They'll want his .244 average to improve in coming years, but his 23 homers and .807 OPS has exceeded all expectations. He'll likely bat second or third, and Rice has a 42.7% HHR against RHP this season.

• Ketel Marte, 2B - ARI ($5,600 DK/$3,700 FD)
• Junior Caminero, 3B - TB ($5,900 DK/$3,900 FD)
• Miguel Andujar, 1B (DK), 1B/3B/OF (FD) - CIN ($3,600 DK/$2,900 FD)

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Aaron Judge, OF - NYY ($6,500 DK/$4,900 FD)

Aaron Judge is far and away the top overall hitter of the day, and you'll want him to be your first click in cash games. It certainly doesn't hurt that he's sizzling right now, as he's 8-for-14 with four homers over his last four games. Judge will get a crack at five plate appearances on the road against Minnesota, and the Twins bullpen is decimated.

Judge has crushed RHP this season for a .459 wOBA, .346 ISO, and 46.5% HHR this season, and his recent barrel rate and exit velocity is off the charts. I'm betting him to homer tonight, and rostering him in all DFS contests.

Aaron Judge hits his 48th homer of the year! 💪 pic.twitter.com/3aw5JYIoRW

— ESPN (@espn) September 15, 2025

Yordan Alvarez, HOU ($4,400 DK/$3,600 FD)

Yordan Alvarez remains severely underpriced on DK. He's approaching fair value on FD but you can still eke out a lot of upside from that tag. The Astros have fallen out of first place and are in must-win mode now, and they'll welcome in Texas for a huge divisional series.

Jack Leiter is on the hill for the Rangers in this opener, and while he's been solid this year there are still paths to downside. Leiter has walked over four batters per nine innings, while only inducing a 36.4% GB rate. Alvarez has a .363 wOBA and 40.2% HHR against RHP since returning from his long injury.

Joc Pederson, TEX ($2,700 DK/$2,800 FD)

Do you want both pitchers listed above? Do you want Judge and perhaps a stud infielder? Then you need Joc Pederson, who has almost no floor but has an insane amount of ceiling for a sub-$3k price tag. Joc Pederson continues to get premier spots in the order despite his .177 batting average, and Texas has an IRT of 4.3 runs.

Houston pitcher Jason Alexander (whose face I can't picture because all I see is George Constanza) has done a solid job of keeping the ball on the ground for the most part. However, his 4.81 FIP and 15.9% HR/FB still invite stacking against. Pederson is a great one-off for cash that can't kill you even if he puts up a zero, since he's a means to an end.

Others To Consider (CASH/GPP): 

• Byron Buxton, OF - MIN ($6,000 DK/$4,100 FD)
• Trent Grisham, OF - NYY ($4,300 DK/$3,100 FD)
• Dylan Beavers, OF - BAL ($3,300 DK/$2,700 FD)

DraftKings, FanDuel MLB DFS Stacks

1. New York Yankees vs Simeon Woods Richardson

The Yankees are the premier stack and will be the chalkiest on a seven-game slate. However, you'll want exposure at all costs if multi-entering lineups. If you feel like the lineup is going to be duplicated, explore the bottom of the order and get players like Austin Wells, Jose Caballero, etc.

Favorite Combo: Grisham, Judge, Rice, Stanton

2. Arizona Diamondbacks vs Kai-Wei Teng

The Giants take on the Diamondbacks in what has become a critical series for both teams (Arizona, why did you trade everyone away??). Kai-Wei Teng has stunned me this year with his 11.12 K/9, but his there's a lot of luck involved as his swinging strike rate doesn't match the high K/9. With no Coors on the slate, Arizona is the premier hitting environment on the slate. You'll have to spend, but they're immediate pivots off the Yankees.

Favorite Combo: Perdomo, Marte, Carroll, Moreno

3. Houston Astros vs Jack Leiter

Believe it or not, Houston is the "cheap stack" which is not something we're used to seeing. Take advantage of the underpriced Astros and their IRT of 4.6 IRT. Jack Leiter has K upside to neutralize this stack, but he also has the downside to attack. This is especially notable on a short slate, where picking that "one" stack may prove to be the winning strategy.

Favorite Combo: Buxton, Larnach, Keaschall, Clemens (Wallner if no Buxton)

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