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Is Joe Mixon out for the season? When is Joe Mixon coming back? The latest Joe Mixon injury update and fantasy football outlook heading into Week 12 of 2025.
Houston Texans starting running back Joe Mixon (foot) has yet to take the field this season due to an offseason injury and is trending towards missing the remainder of the season.
With the second half well underway and him making little progress, he faces a significant uphill battle to return to action this season.
Will Mixon play again this season? Should fantasy managers stash him on their bench during the second half? Let's dive in!
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
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- Dynasty fantasy football rankings
Is Joe Mixon Out for the 2025 Season?
While Mixon has yet to be officially ruled out for the remainder of the season, fantasy managers should not expect him to return this season. Since mid-October, the Texans have not provided any update on his status, and with the season nearing the final stretch, he will face a difficult challenge to return in time.
In October, Nick Caserio, the team's general manager, noted that his status for the season is "in limbo," which is not a positive sign. Given that Mixon has yet to make any progress toward being able to practice, the veteran will likely not return this season.
With his return to practice nowhere in sight, managers should not expect to return to the field this season and should begin to look to alternative fantasy options for the second half.
No Timetable for Joe Mixon's Return https://t.co/Hib7RlCrYy
— RotoBaller NFL (@RotoBallerNFL) October 20, 2025
Joe Mixon 2025 Fantasy Football Outlook
Given his lack of any substantial progress, Mixon carries near minimal fantasy value heading into Week 12 of the NFL season. As a result, managers in all redraft formats should feel comfortable cutting ties with the 29-year-old in favor of alternative options on the waiver wire.
When looking at potential running backs to target, managers should pivot to a high-upside stash option. This weekend, managers see Sean Tucker (Tampa Bay's No. 2 RB) enjoy a breakout showing, which suggests he will hold the lead role in the backfield until Bucky Irving (foot) returns. Other high-upside handcuffs to target are Blake Corum, Ray Davis, Devin Neal, or Isaiah Davis, who could all carry top-20 on a weekly basis if their starter were to miss time.
Managers in need of a WR should look to pick up Michael Wilson, who enjoyed a breakout showing on Sunday with Marvin Harrison Jr. (appendix) sidelined, or Alec Pierce, who is beginning to claim the No. 2 role in Indianapolis.
Michael Wilson Peppered With 18 Targets Amid Teammate's Absence https://t.co/QMoKh2Pjmf
— RotoBaller NFL (@RotoBallerNFL) November 17, 2025
With Mixon trending toward missing the remainder of the season, rookie running back Woody Marks should remain Houston's lead back while veteran Nick Chubb continues to handle most of the short-yardage opportunities.
Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
Compare up to four players and we'll tell you who to start...
Who Should I Start? Who Should I Sit? Some common Week 12 fantasy football lineup decisions are regarding players like Tez Johnson, Woody Marks, Wan'Dale Robinson, Parker Washington, Tre Tucker, Aaron Jones Sr.. But not to worry, we are here to help make these decisions and build winning lineups in Week 12. Set your optimal fantasy football lineups for Week 12 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Week 12 Player Decisions. Today's focus is on specific players - Tez Johnson, Woody Marks, Wan'Dale Robinson, Parker Washington, Tre Tucker, Aaron Jones Sr.. These are some of the most common searches for fantasy football lineups in Week 12.
Using The Tool. This is a simple tool, but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player's name. In the second box, search for the second player's name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, player news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circles), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 12 Searches. Curious to see some tough lineup decisions for Week 12 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 12 Searches - Start/Sit Player Comparisons
Below are some popular Week 12 searches and comparisons from our 'Who To Start' tool for Tez Johnson, Woody Marks, Wan'Dale Robinson, Parker Washington, Tre Tucker, Aaron Jones Sr. compared to others:
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