X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Mikhail Sergachev

Has Three Assists in Overtime Loss
George Holani

One of the Draft's Biggest Losers
Brett Howden

Records Three Points in Vital Win
Kendre Miller

Not Guaranteed a Roster Spot with Saints
Rasmus Ristolainen

Registers Two Assists in Game 5 Loss
Arturs Silovs

Helps Penguins Survive for Second Time
Sidney Crosby

Delivers Two Assists in Elimination Game Win
NHL

Predators Pick Up KHL Standout Vitali Pinchuk
Paolo Banchero

Efficiency Woes Continue in Game 4
Julius Randle

Leads Timberwolves With 27 Points Monday
Rickie Fowler

Rides History into the Blue Monster at Doral
Nikola Jokić

Nikola Jokic Records Big Triple-Double as Nuggets Stay Alive
Keegan Bradley

on Good Run Heading into Cadillac Championship
Chet Holmgren

Posts Impressive Double-Double in Game 4 Win
Shai Gilgeous-Alexander

Notches Efficient 31 Points in Closeout Game
Franz Wagner

Scheduled for MRI on Tuesday
Giancarlo Stanton

Heading to Injured List With Calf Strain
New England Patriots

Mike Vrabel Returns to the Patriots on Monday
Tyree Wilson

Heading into Contract Year With New Team
Calijah Kancey

Buccaneers Pick Up Fifth-Year Option on Calijah Kancey
Jalen Carter

Eagles Exercise Fifth-Year Option on Jalen Carter
Philadelphia Eagles

Eagles Pick Up Nolan Smith's Fifth-Year Option
Keon Coleman

Bills Aren't Giving Up on Keon Coleman
Aaron Rodgers

Former Steelers Coach Thinks Aaron Rodgers Will Return to Pittsburgh
Chris Gotterup

Looks to Continue Big-Game Hunting at Cadillac Championship
George Pickens

hasn't Signed his Franchise Tag With Dallas
Jason Day

Looks to Bring Experience Back to the Blue Monster
Nikola Jović

Nikola Jovic Remains Highly Rated by Heat
Aaron Gordon

Won't Play Monday Night
Tyler Herro

to Undergo "Preemptive Procedure" on Foot
Cameron Young

Returns to Action For Cadillac Championship
Travis Bazzana

Guardians Calling Up Former First Overall Pick Travis Bazzana
Bam Adebayo

Remains Untouchable for Heat
Sam Burns

Looks to Have Big Impact at PGA Tour's Return to Doral
Anthony Edwards

Officially Listed as Week-to-Week
Jordan Goodwin

Still Out Monday
Cooper Flagg

Wins Rookie of the Year Award
Kevin Huerter

is Available to Play in Game 4
Joel Embiid

is Probable for Game 5
Austin Reaves

Could Return for Game 5
Luka Dončić

Luka Doncic Officially Won't Play During First-Round Series
Jonathan Isaac

to Remain Out for Game 4
Will Smith

Back in Action in Series Opener Against Marlins
Josh Naylor

Back in Starting Lineup on Monday
Jason Zucker

Probable for Game 5 Against Bruins
Josh Norris

Could Return to Action Tuesday
Nikita Zadorov

Questionable for Game 5
Viktor Arvidsson

Considered Questionable for Tuesday
Nils Lundkvist

Won't Play Tuesday
Yakov Trenin

Could Be an Option Tuesday
Mats Zuccarello

Questionable for Game 5
Carson Hocevar

Scores his First Career NASCAR Cup Series Victory at Talladega
Chris Buescher

Misses out on Winning at Talladega by Finishing Second
Alex Bowman

Earns First Top-Five Finish at Talladega Since Returning From Injury
Chase Elliott

Scores A Fourth-Place Finish at Talladega
Zane Smith

Nabs First Top-Five Finish of the 2026 Season at Talladega
Marvin Harrison Jr.

Does Marvin Harrison Jr. Still Carry High-End Dynasty Upside?
Marquise Brown

Sliding Down Eagles' Depth Chart Following 2026 Draft
Darnell Mooney

Carries Deep-League Buy-Low Upside into 2026
Christian Kirk

Role in San Francisco in Question Following NFL Draft?
CFB

Texas Tech Quarterback Brendan Sorsby Enters Rehab
Youssef Zalal

Suffers Unanimous-Decision Loss
Brashard Smith

Facing an Uphill Battle for Playing Time in Kansas City
Aljamain Sterling

Wins Back-To-Back Fights
Rashee Rice

Can Rashee Rice Put Together a Full Season of Production in 2026?
Norma Dumont

Drops Decision At UFC Vegas 116
Joselyne Edwards

Scores Upset Win
Alexander Hernandez

Gets Dominated
Alexander Hernandez

Rafa Garcia Dominates Alexander Hernandez
Adrian Luna Martinetti

Unsuccessful In His UFC Debut
Davey Grant

Gets Back In The Win Column
Manny Machado

Clubs Two Homers, Starting to Turn Things Around?
Kyren Williams

Becoming a Better Dynasty Value by the Day
Ben Sinnott

Is it Time to Move on From Ben Sinnott?
Sam Darnold

Still a Reliable Dynasty Hold
Brandon Hagel

Pops Up With Two Goals in Sunday's Win
Justin Fields

Could Dynasty Managers See One More Sell Window for Justin Fields?
Nathan MacKinnon

Records Three Points in Series-Clincher
Dallas Goedert

a Dynasty Bargain After Flurry of Eagles' Moves
Bowen Byram

Extends Goal Streak to Three Games
John Carlson

Delivers Two Assists in Game 4 Victory
Connor McDavid

Bags Pair of Power-Play Assists in 100th Playoff Game
Jason Zucker

Makes Early Exit in Blowout Win
De'Aaron Fox

Notches Game-High 28 Points Sunday
Joel Embiid

Returns With Double-Double
Jayson Tatum

Logs 30-Point Double-Double in Sunday's Win
Emil Andrae

Expected to Rejoin Flyers Lineup Monday
Matvei Michkov

Set to Be Scratched for Game 5
Logan O'Hoppe

Placed on 10-Day Injured List Due to Left-Wrist Fracture
Denny Hamlin

Is Denny Hamlin Worth Rostering for Talladega?
NASCAR

Is Bubba Wallace Playable in Talladega DFS Lineups?
Josh Naylor

Absent on Sunday With Quad Tightness
Ryan Helsley

Returns From Bereavement List on Sunday
Steven Kwan

Back in Sunday's Lineup
Brent Rooker

Activated and Starting on Sunday Against Rangers
Roman Anthony

Returns as DH on Sunday
Tyler Reddick

Stay Away From Tyler Reddick at Talladega
Ryan Blaney

Can Ryan Blaney Shake Off The Bad Luck at Talladega?
Austin Cindric

Could Contend For Another Talladega Win
Kyle Busch

an Easy DFS Pick at Talladega
Ricky Stenhouse Jr

. a High-Risk, High-Reward Pick at Talladega
Todd Gilliland

a Sleeper to Watch at Talladega
Brad Keselowski

Is Brad Keselowski Worth Rostering for Talladega Lineups?
Chase Briscoe

Could Chase Briscoe be A Sneaky Tournament Play for Talladega Lineups?
Christopher Bell

Should DFS Managers Trust Christopher Bell at Talladega?
Ty Gibbs

Is A DFS Risk for Talladega Lineups
Boston Red Sox

Red Sox Fire Manager Alex Cora and Other Coaches
Steven Kwan

Scratched With Neck Stiffness
Trey Yesavage

Returning From Injured List on Tuesday
Eugenio Suárez

Eugenio Suarez Heading to the Injured List With Oblique Strain
MLB

Saturday's Mets-Rockies Game Postponed Due to Weather
Giancarlo Stanton

Exits With Leg Tightness on Friday
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Jackson Holliday

Receives Positive Test Results, Will be Shut Down for a Week
Jeff Hoffman

Out as Blue Jays Closer
Youssef Zalal

Set For UFC Vegas 116 Main Event
Aljamain Sterling

An Underdog At UFC Vegas 116
Joselyne Edwards

Set For UFC Vegas 116 Co-Main Event
Norma Dumont

Looks To Extend Her Win Streak
Alexander Hernandez

A Favorite At UFC Vegas 116
Rafa Garcia

Looks For His Third Consecutive Win
Adrian Luna Martinetti

Set For His UFC Debut
Davey Grant

Looks To Get Back In The Win Column
Francisco Lindor

Expected to Miss "Significant Time"
CFB

Beau Pribula Leading Virginia Quarterback Competition
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF