X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Isaiah Collier

Returning to Jazz Lineup Monday
Tage Thompson

Picks Up Four Points Against Lightning
Trent McDuffie

Signs Record Four-Year, $124 Million Extension With Rams
Moritz Seider

has Three-Point Performance on Sunday
De'Anthony Melton

Available Against Jazz
Moses Moody

to Remain Out Monday Night
Al Horford

Won't Play Against Jazz
Kristaps Porzingis

to Skip Monday's Game
Alex Caruso

Iffy for Monday
Collin Murray-Boyles

to Sit Out At Least Two More Games
Grayson Allen

Misses Meeting With Hornets
Tarik Skubal

Could Make Another Start in World Baseball Classic
Nelson Velázquez

Nelson Velazquez Could Get Increased Reps
Porter Hodge

to be Placed on Injured List
Jackson Chourio

Should Return to WBC Lineup on Monday
Dairon Blanco

Rangers Claim Dairon Blanco Off Waivers From Royals
Byron Buxton

"Fine" After Being Hit by Pitch
Kyle Higashioka

to Return on Monday
Travis Kelce

Appears "Motivated" to Return for a 14th NFL Season
Josh Giddey

is Returning on Sunday
Matas Buzelis

is Available on Sunday
Deni Avdija

Returns With Minutes Restriction
Ajay Mitchell

Set to Return on Monday
Kyle Kuzma

Misses Sunday's Action
Chet Holmgren

Questionable to Suit Up Monday
Isaiah Hartenstein

Won't Play Against Nuggets
Egor Demin

to Remain Sidelined on Monday
Jamal Murray

Considered Questionable for Monday
Michael Porter Jr.

Won't Suit up on Monday
VJ Edgecombe

Listed as Questionable for Monday
Jonathan Isaac

to Miss Third Straight Game
Anthony Black

Sits Out Sunday's Game
Andrew Abbott

Gets Opening Day Nod
Shane Smith

is Named Opening Day Starter
Merrill Kelly

Throws Batting Practice Session on Sunday
Gavin Lux

to Make Spring Debut on Tuesday
Cedric Mullins

Resumes Baseball Activities
Yandy Díaz

Yandy Diaz Remains Out with Hand Soreness
Zack Littell

Nationals Agree to a Deal
Bryce Miller

to Throw a Bullpen on Sunday
Emil Lilleberg

to Miss Two Weeks Due to Facial Fracture
Spencer Knight

Won't Play Sunday
John Carlson

Not Ready for Ducks Debut Sunday
Zach Whitecloud

Injured Saturday Night
Khalil Mack

Returning to the Chargers for 2026
Jaden Schwartz

Forced to Exit Early After Taking Skate Blade to Face
Jake Sanderson

Sustains Upper-Body Injury Versus Kraken
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
Kyle Larson

Is Always a Threat at Phoenix
NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
Andrei Vasilevskiy

Defeats the Maple Leafs on Saturday
Nikita Kucherov

Picks Up Four Assists
Romy Gonzalez

Could Require Surgery
Kyle Tucker

is Expected to Return on Sunday
Brandon Woodruff

Wants to be Ready for Opening Day
Orion Kerkering

Throws Successful Bullpen Session
Chandler Simpson

Rays Being Overly Cautious with Chandler Simpson
Roope Hintz

to Miss At Least a Couple of Weeks
Dylan Larkin

Ruled Out for Sunday
Adam Larsson

Ryan Lindgren Iffy for Saturday
Travis Konecny

Remains Out Saturday
Mikhail Sergachev

a Game-Time Call Saturday
Mason Marchment

Ready to Face Mammoth
Zach Werenski

Available Saturday
Brandon Woodruff

Making Cactus League Debut on Saturday
Andrei Kuzmenko

Done for Regular Season
Josh Morrissey

Activated From Injured Reserve
Jiri Kulich

Unlikely to Return This Season
Shayne Gostisbehere

Exits Early Friday
Maxx Crosby

Traded to Baltimore in Blockbuster Deal
Dalton Schultz

Texans, Dalton Schultz Agree on One-Year Extension
Joe Mixon

Texans Release Joe Mixon
Max Holloway

A Favorite At UFC 326
Charles Oliveira

Set For BMF Title Fight
Las Vegas Raiders

Raiders Prefer Not to Start Fernando Mendoza Immediately?
Reinier de Ridder

Reinier De Ridder Looks To Bounce Back
Caio Borralho

Set For UFC 326 Co-Main Event
Rob Font

Looks To Get Back In The Win Column
Raul Rosas Jr.

Looks For His Fifth Consecutive Win
Drew Dober

Returns At UFC 326
Michael Johnson

Looks To Extend His Win Streak
Geno Smith

Raiders Release Geno Smith
Danielle Hunter

Texans, Danielle Hunter Agree to One-Year, $40.1 Million Extension
DJ Moore

Bears Working to Finalize Deal to Send DJ Moore to Buffalo
Stefon Diggs

Patriots Releasing Stefon Diggs
Trent McDuffie

Chiefs Sending Trent McDuffie to Rams in Blockbuster Deal
Taylor Moore

Looking to Build on Cognizant Classic Finish
Robert MacIntyre

Brings Solid Form to Bay Hill
Scottie Scheffler

the Tournament Favorite at Bay Hill
Xander Schauffele

Trending Well Ahead of API
Si Woo Kim

Looking to Return to Top Form at Bay Hill
Ben Griffin

Looking to Return to Form at Arnold Palmer Invitational
PGA

Nico Echavarria Looks to Build on Cognizant Classic Win at Arnold Palmer
Sam Burns

Searching for Consistency at Arnold Palmer Invitational
Daniel Berger

Offers Sneaky Upside at Bay Hill
Justin Thomas

Making Season Debut at API Following Lower-Back Surgery
NASCAR

Collin Morikawa Hopes To Better Last Year's Runner-Up Finish at API
Tommy Fleetwood

Isn't As Confident of a Start at Bay Hill as Previous Weeks
Kyler Murray

Will be Released
Trey Hendrickson

Bengals Not Using the Franchise Tag on Trey Hendrickson
Daniel Jones

Colts Place Transition Tag on Daniel Jones
Adam Scott

Might Endure Tough Times at Bay Hill
Aldrich Potgieter

Extremely Risky When it Comes to Bay Hill
PGA

Sungjae Im to Make Season Debut at Arnold Palmer Invitational
Jordan Spieth

an All-or-Nothing Option at Bay Hill
Harry Hall

Trying to Rebound After the Genesis Invitational
Ryan Gerard

Needs Better Start at Bay Hill
Kenneth Walker III

Won't Get the Franchise Tag
Patrick Cantlay

Still Plagued by Bad Putting Ahead of Arnold Palmer Invititational
Daniel Jones

Colts Expected to Use Transition Tag on Daniel Jones
Breece Hall

Jets Placing Franchise Tag on Breece Hall
CFB

Mark Stoops Joining Texas Coaching Staff
Jason Day

Attempts to Bounce Back from The Genesis Invitational
Jacob Bridgeman

Rolling into Arnold Palmer Invitational
Russell Henley

Looks to Defend Title at the Arnold Palmer Invitational
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF