🖥 CYBER MONDAY - TAP TO SAVE 50% WITH CODE CYBER
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Cyber Week Special! Save 50% on any Premium Pass using discount code CYBER. Win more with our DFS, Betting and Season-Long Premium Pass, get expert tools and advice for NBA, NFL, MLB, NHL from proven winners! Dan Palyo leads the team with exclusive picks for DFS picks, Props, betting. Enhance your game with industry-leading tools like our Lineup Optimizers, Team Sync Platform, DFS Cheat Sheets and more. GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Tyrone Tracy Jr.

Carted Off With Hip Injury on Monday Night
Edwin Díaz

Mets Still Interested in Re-Signing Edwin Diaz
Devin Williams

Agrees to Three-Year Deal With Mets
Cole Ragans

Red Sox Targeting Cole Ragans in a Trade?
CFB

Kentucky Hires Oregon Offensive Coordinator Will Stein As Head Coach
Davante Adams

Not Dealing With a Serious Injury
Brandon Miller

Unavailable on Monday
Kyler Murray

Surgery Not on the Table for Kyler Murray
Duncan Robinson

Absent Against Atlanta
Marvin Harrison Jr.

in Danger of Missing Week 14?
Jalen Duren

Back in the Lineup on Monday Evening
Noah Clowney

Cleared to Play Versus Charlotte
Giannis Antetokounmpo

Active On Monday
Danila Yurov

Won't Play on Tuesday
Michael Porter Jr.

Back in Action on Monday
Sam Merrill

Unavailable Versus Pacers
David Pastrnak

to Remain Out Tuesday
Alexandre Sarr

Won't Play Versus Milwaukee
Adam Gaudette

Iffy for Monday
CFB

Kalani Sitake the Top Target for Penn State Coaching Job
Logan Cooley

a Game-Time Decision Monday
Josh Norris

Available Monday
Neal Pionk

Remains Out Monday
Lonzo Ball

Ruled Out on Monday
Jimmy Snuggerud

to Miss Six Weeks After Wrist Surgery
Justin Herbert

Having Hand Surgery on Monday
Steven Adams

Out Against Jazz
Kyler Murray

Cardinals Won't Open Kyler Murray's Practice Window This Week
Darius Garland

Unavailable Monday
Sauce Gardner

Not a Candidate to Go on Injured Reserve
Kristaps Porzingis

Out of Action Versus Pistons
Jayden Daniels

Not Cleared for Contact, Decision on Week 14 Status Delayed
Daniel Gafford

Sidelined Again on Monday
CFB

Josh Heupel Says He's Not a Candidate for Penn State Head Coach Job
Trey Hendrickson

Doubtful to Return in Week 14
Tee Higgins

Still in the Concussion Protocol
Drake London

"has a Chance" to Play in Week 14
J.J. McCarthy

in Line to Start in Week 14?
Aaron Jones Sr.

Not Dealing With Serious Shoulder Injury, Likely Day-to-Day
Sam Darnold

Dealing With Ankle Injury, "Should be Good" for Week 14
CFB

Will Stein, Brian Hartline the Top Candidates for Kentucky Job?
CFB

Nebraska Fires Defensive Coordinator John Butler After One Season
CFB

UCLA Expected to Hire Bob Chesney as Next Head Coach
Sauce Gardner

Officially Week-to-Week with Strained Calf
CFB

Lane Kiffin to Make $13 Million Salary, Ties Kirby Smart
CFB

Buster Faulkner, Joey Halzle Candidates for Florida Offensive Coordinator Job?
CFB

Kentucky Officially Fires Mark Stoops
Justin Herbert

Has Metacarpal Fracture in Left Hand
Amon-Ra St. Brown

Week 14 Availability Up in the Air
VEG

Carter Hart Expected to Make Golden Knights Debut Tuesday
Andre Drummond

Leaves Early, Status Now in Question
Pyotr Kochetkov

Remains Without Timeline For Return
Boone Jenner

Close to Returning
Tre Mann

Uncertain for Monday's Game Against Nets
Lian Bichsel

Exits With Injury Sunday
Deandre Ayton

Leaves Game With Knee Soreness
Petr Mrazek

Injured in Sunday's Loss
Adam Fox

Placed on Long-Term Injured Reserve
Brandon Williams

Questionable With Adductor Issue
P.J. Washington

Uncertain For Monday's Contest
Daniel Gafford

Expected To Miss Second Straight Game
Zach Ertz

Leads Washington in Receiving in Overtime Loss
James Cook

Handles Career-High 32 Carries for 144 Yards in Win
Egor Demin

Available Against Hornets
Justin Herbert

Planning to Play Through Broken Bone in Left Hand in Week 14
Terance Mann

in Danger of Missing Monday's Game
Sauce Gardner

Likely to Miss a "Couple of Weeks" With Calf Strain
CFB

Lane Kiffin to be Introduced as LSU's Next Head Coach on Monday
CFB

Florida Poised to Land Jon Sumrall as Next Head Coach
CFB

Alex Golesh Taking Over Auburn Head-Coaching Job
CFB

Arkansas Expected to Hire Ryan Silverfield as Next Head Coach
Joel Hofer

Shuts Out Mammoth
Owen Tippett

Amasses Three Points in Saturday's Win
Stuart Skinner

Bounces Back With Shutout
Brock Nelson

Notches Four Points in Big Win
Oliver Ekman-Larsson

Sustains Upper-Body Injury
Logan Cooley

Hurt in Saturday's Loss
Warren Foegele

Not Ready to Return Saturday
Simon Benoit

Won't Play Saturday
Zack Wheeler

Likely to Return in May
Ryan Helsley

Agrees to Two-Year Deal With Orioles
Dylan Cease

Agrees With Blue Jays on Seven-Year, $210 Million Deal
Anthony Rendon

Angels Could Buy Out Final Year of Anthony Rendon's Contract
Josh Hader

Says his Shoulder is "Back to Normal"
Ketel Marte

Diamondbacks "Actively Listening" on Ketel Marte

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP