X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo: Get any DFS Premium Bundle for for 50% off using code SUMMER! Win more with expert advice from proven winners and exclusive DFS tools. Get instant access to RotoBaller's Lineup Optimizers, Research Stations, daily picks and VIP chat rooms across 10 sports! Go Premium, Win More!

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Chris Sale

Placed on 15-Day Injured List
Geor'quarius Spivey

Chiefs Sign Geor'quarius Spivey
Jake Burger

Placed on 10-Day Injured List
Calvin Ridley

Looks Bought in
Cam Ward

Looks Good During Offseason Workouts
Adley Rutschman

Placed on 10-Day Injured List
Jalen Ramsey

Prefers to Move to West Coast
Malik Nabers

Giants Being Extra Cautious With Malik Nabers
Shota Imanaga

to Come Off Injured List and Start Next Week
Mitch Garver

Cracks Two Homers, Drives in Five
Jacob Misiorowski

Takes Perfect Game Into Seventh
Eugenio Suárez

Eugenio Suarez Continues Crushing Baseballs With Two More Dingers
Riley Greene

Keeps Mashing With Pair of Homers
Christian Yelich

Tallies Career-High Eight RBI
Josh Green

Undergoes Shoulder Surgery
Dwight Powell

Exercises Player Option
Xazavian Valladay

Waived by Saints
Tre' McKitty

Released by Browns
Chig Okonkwo

Building Chemistry with Cam Ward
Iván Herrera

Ivan Herrera Placed on 10-Day Injured List
Dallas Cowboys

Cowboys Add Perrion Winfrey.
Jake Ferguson

Hindered by Knee Issue in 2024
Jamahal Hill

Set For UFC Azerbaijan Main Event
Khalil Rountree Jr.

A Favorite At UFC Azerbaijan
Ignacio Bahamondes

Set For UFC Azerbaijan Co-Main Event
Rafael Fiziev

In Dire Need Of Victory
Rizvan Kuniev

Set To Make His UFC Debut
Curtis Blaydes

A Huge Favorite
Tofiq Musayev

Makes His UFC Debut At UFC Azerbaijan
Myktybek Orolbai

Looks To Get Back In The Win Column
Nikolas Motta

Looks For His Third Consecutive Win
Nazim Sadykhov

Looks To Win Back-To-Back Fights
Bogdan Grad

Set For His Second UFC Appearance
Fernando Tatis Jr.

Set for More Testing After HBP
Muhammad Naimov

Set To Open Up UFC Azerbaijan Main Card
Julius Randle

Naz Reid and Julius Randle Expected to Return to the Timberwolves
T.J. McConnell

Keys Pacers Bench in Big Win
Jalen Williams

Struggles in Game 6 Loss
Shai Gilgeous-Alexander

Can't Close Out Pacers
Tyrese Haliburton

Helps the Pacers Push the Thunder to Game 7
Obi Toppin

Drops 20 Points in Pacers Win
Pascal Siakam

Powers Pacers to Game 6 Win
Cristopher Sánchez

Cristopher Sanchez Goes Eight Strong Innings in Win Over Marlins
Andre Granillo

Notches First Career Win, Then First Career Save in Doubleheader
Aaron Rodgers

Steelers Offense Could Look to get the Ball Out of Aaron Rodgers' Hand Quickly
Joe Mixon

to be Ready at Some Point During Training Camp
Alejandro Kirk

Slugs Two Home Runs in Loss
Emery Jones Jr.

Ravens "Hopeful" Emery Jones Jr. Will be Ready for Training Camp
Jac Caglianone

Smacks Two Solo Homers
Tyquan Thornton

Andy Reid Impressed by Tyquan Thornton
James Wood

Blasts Two Homers
Shedeur Sanders

has Multiple Speeding Tickets
Byron Buxton

Homers Twice in Win
Travis Kelce

Chiefs Not Looking to Limit Travis Kelce's Snap Count
Josh Simmons

Will be Ready for Training Camp
Kristian Campbell

Red Sox Sending Kristian Campbell to Triple-A
Sal Cannella

Browns Sign UFL Standout Tight End Sal Cannella
Jonathan Ward

Steelers Release Jonathan Ward
Treylon Burks

Looking to Prove Himself Right
Gabriel Moreno

Diamondbacks Put Gabriel Moreno on 10-Day Injured List With Hand Contusion
Robert Rochell

Agrees on One-Year Deal With Cowboys
Corbin Carroll

Injures Hand on Wednesday, X-Rays Come Back Negative
Michael King

Likely Out Through All-Star Break
Tyrese Haliburton

Officially Questionable for Game 6
Maverick McNealy

May Need To Be Avoided at TPC River Highlands
Wyndham Clark

Avoid Wyndham Clark at the Travelers Championship
Rickie Fowler

a Very Risky Option at TPC River Highlands
Russell Henley

Has Elite Value at TPC River Highlands
Ben Griffin

Once Again a Solid Option for Travelers Championship
Jason Day

an Intriguing Option at TPC River Highlands
PGA

Sungjae Im Still Totally Useless For DFS Ahead of Travelers Championship
Patrick Cantlay

Looking to Bounce Back After Messy U.S. Open
Ryan Fox

Looks to Continue Hot Run at TPC River Highlands
Jordan Spieth

Makes a Strong Case at Travelers Championship
Christiaan Bezuidenhout

Looks to Continue Momentum Into Travelers Championship
Hideki Matsuyama

Searching for Consistency at Travelers Championship
Justin Thomas

Looks to Bounce Back at Travelers Championship
Adam Scott

Looks to Rebound After Disappointing U.S. Open Finish
Collin Morikawa

Eyeing Another Strong Performance at Travelers
Shane Lowry

a High-Upside Play at Travelers
Tommy Fleetwood

Looks to Rebound at Travelers
Corey Conners

Withdraws from Travelers with Wrist Injury
Keegan Bradley

in Solid Form Ahead of Travelers Championship
Gary Woodland

Hit-or-Miss at the Travelers
Sepp Straka

Expected to Contend at Travelers Championship
Tyrese Haliburton

to Be a Game-Time Call Thursday
Roman Josi

Expects to Return for 2025-26 Campaign
Sam Bennett

Wins Conn Smythe Trophy
Matthew Tkachuk

Reveals Multiple Injuries
Aleksander Barkov

Posts Two Assists in Cup-Clinching Win
Carter Verhaeghe

Collects Hat Trick of Assists in Tuesday's Win
Sam Reinhart

Scores Four Goals in Cup-Clincher
John Klingberg

Rejoins Oilers Lineup Tuesday
Kasperi Kapanen

Returns to Oilers Lineup for Game 6
Stuart Skinner

Back in Oilers Crease Tuesday
Chet Holmgren

Has Tough Shooting Night in Game 5 Against Pacers
Shai Gilgeous-Alexander

Outstanding at Both Ends Monday
Jalen Williams

Erupts for 40 Points in Game 5 Win
Pascal Siakam

Has Best Game of Finals Monday
Tyrese Haliburton

Determined to Battle Through Calf Injury
LeBron James

Progressing Well From Knee Injury
Stephen Curry

"Not Even Close" to Retirement
Jonathan Kuminga

Linked to Bulls, Heat
Kevin Durant

Has "No Desire" to be Traded to Minnesota
Jarace Walker

Remains Sidelined for Game 5
Kamaru Usman

Gets Back In The Win Column
Joaquin Buckley

Winning Streak Comes To An End
Miranda Maverick

Drops Decision At UFC Atlanta
Rose Namajunas

Wins Decision At UFC Atlanta
Andre Petroski

Suffers Unanimous-Decision Loss
Edmen Shahbazyan

Wins Back-To-Back Fights
Raoni Barcelos

Wins Third Fight In A Row
Chase Elliott

Ends Mexico City with A Great Finish of Third
Christopher Bell

has A Strong Runner-Up Performance At Mexico City
Chase Briscoe

Wild Day Ends with A Top-10 Finish
Michael McDowell

Leaves Mexico City with A Top-Five Finish
Cody Garbrandt

Loses Back-To-Back Fights
Cody Brundage

Defeated After Accidental Clash Of Heads
Alex Bowman

Delivers Bravura Performance After Michigan Injury
Tyler Reddick

Inexplicably Mediocre on his Once-Best Track Type
John Hunter Nemechek

Canny Strategy Gives John Hunter Nemechek Best Career Road-Course Finish
Cole Custer

Earns Best Finish Since Cup-Series Comeback at Mexico City
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF