X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jaxson Hayes

Good to Go Thursday Night
Josh Jung

Pulled as a Precaution With Hamstring Injury
Robert Williams III

Donovan Clingan Out, Robert Williams III and Yang Hansen Cleared
Sean Manaea

Trying to Return to Previous Arm Slot
Patrick Williams

Jalen Smith, Patrick Williams Out At Least One Week
Keldon Johnson

is Active on Thursday
Khris Middleton

Available Thursday Against Sacramento
Cody Ponce

Throws an Inning in Spring Debut
Daniel Gafford

Ruled Out Thursday vs. Kings
Nikola Jović

Nikola Jovic Remains Out on Thursday
Stephon Castle

Cleared to Play Thursday vs. Nets
Davion Mitchell

is Available on Thursday
Joel Embiid

is Cleared for Thursday's Game
Shai Gilgeous-Alexander

Off the Injury Report for Friday
Norman Powell

Active On Thursday
Zaccharie Risacher

Available Against Washington
Andrew Nembhard

Set to Suit Up Thursday
Nickeil Alexander-Walker

Won't Play on Thursday
Zack Wheeler

Targeting Early Return?
Obi Toppin

Cleared to Play Thursday
Pascal Siakam

Unavailable Again on Thursday
Nolan McLean

Dominant in First Spring Outing
Dylan Holloway

Rejoins Blues Lineup Thursday
Jalen Suggs

Returning on Thursday Night
Simon Edvinsson

Back in Red Wings Lineup Thursday
Adam Fox

Ready to Face Flyers
Rui Hachimura

Ruled Out Thursday
Igor Shesterkin

Available Thursday
Kris Letang

Returns to Action Thursday
Tim Stützle

Tim Stutzle a Game-Time Call Thursday
Patrick Williams

Will Not Be Available on Thursday
Nathan MacKinnon

Expected to Play Thursday
Malik Monk

Uncertain for Thursday Against Dallas
Merrill Kelly

Diamondbacks Holding Out Hope Merrill Kelly Can Avoid the Injured List
Samuel Basallo

Dealing With Abdominal Discomfort
Konnor Griffin

"Trending Toward Being" Opening Day Shortstop
Royce Lewis

Scratched With Tightness in his Side
Ashton Jeanty

Not in Line for Workhorse Role in 2026?
Samuel Basallo

Injured in Spring Game on Thursday
Ryan Weathers

Looks Sharp in Spring Debut
Mike Trout

Moving Around the Outfield This Spring
Nick Kurtz

A's Offer Long-Term Extension to Nick Kurtz
Shane McClanahan

to Make Spring Debut on Tuesday
Anthony Richardson Sr.

Colts Give Anthony Richardson Sr. Permission to Seek a Trade
Brenton Doyle

Undergoes Imaging on his Wrist
Yuki Matsui

Ruled Out for World Baseball Classic
Pablo López

Pablo Lopez Undergoes Internal-Brace Procedure
Roki Sasaki

Hit Hard in Spring Debut
Yordan Alvarez

to Make Spring Debut Next Week
Josh Hader

Remains Without a Timetable to Return
Giancarlo Stanton

Still Dealing With Elbow Pain, Hopes to Play Full Season
Brock Nelson

Produces 30th Goal of the Campaign
Nikita Kucherov

Extends Point Streak to 11 Games
Tage Thompson

Leads Sabres Past Devils
Wyatt Johnston

Pots Two Goals in Wednesday's Win
Ryan Lindgren

Exits Early Wednesday
Alex Newhook

Expected to Return Thursday
Robert Thomas

Takes Leave of Absence
Kyler Murray

Prefers to be Released
Derek Carr

"Strong Belief" That Derek Carr is "Very Serious" About Unretiring
Mikael Granlund

Leo Carlsson In, Mikael Granlund Out for Ducks Wednesday
Connor McDavid

Ready to Play Wednesday
John Carlson

Out Wednesday
Roope Hintz

Misses Wednesday's Action Due to Illness
Shea Theodore

Unavailable Wednesday
Mark Stone

Mitch Marner Won't Play Wednesday
Logan Cooley

on Track to Return Wednesday
Andy Dalton

Is Andy Dalton Available for a Trade?
Keith Mitchell

Making The Comfortable Return to PGA National
CFB

Chandler Morris Suing NCAA for Seventh Year of Eligibility
Chris Kirk

Searching for a Spark at Cognizant Classic
Brooks Koepka

Making Third PGA Tour Start at Cognizant Classic
Mackenzie Hughes

a Steady Option at Cognizant Classic
Seamus Power

Seeking More Green in Florida
PGA

Haotong Li Back From a Break as Florida Stretch Starts
Stephan Jaeger

Trying to Put Four Rounds Together in Florida
PGA

Nico Echavarria Again Attempting to Make the Weekend
Patrick Fishburn

Looking for a Spark at Cognizant Classic
Blades Brown

Set for Cognizant Classic Debut
Michael Thorbjornsen

Looking to Bounce Back at Cognizant Classic
Maxx Crosby

Raiders Expect Maxx Crosby to Return
Billy Horschel

Looks to Improve Season at Cognizant Classic
Kyle Pitts Sr.

Falcons Place Franchise Tag on Kyle Pitts Sr.
Joe Highsmith

Returns to Defend at Cognizant Classic
Quinshon Judkins

Out of Walking Boot, Will be Ready for Training Camp
Breece Hall

Jets Will Use Franchise Tag on Breece Hall if Extension isn't Reached
Joel Dahmen

Needs Better Consistency Heading Into The Florida Swing
Daniel Berger

Looks to Improve Putting as PGA Tour Begins Its Florida Swing
Kirk Cousins

Falcons Plan to Release Kirk Cousins
Zach Ertz

Plans to Return for 14th Season
Davis Thompson

Struggling to Find Birdies as Florida Looms
Tom Kim

Not Quite Cutting It in 2026
Nicolai Hojgaard

Wants to Build Momentum from Scottsdale
Christiaan Bezuidenhout

Returns After Extended Break for Florida Event
CFB

Gunner Rivers Follows His Father, Commits To North Carolina State
Will Zalatoris

Set to Make Tournament Debut at Cognizant Classic
Rasmus Hojgaard

Trending Up at the Cognizant Classic
Anthony Hernandez

Suffers Third-Round TKO Loss
Sean Strickland

Gets Back In The Win Column
Kyle Pitts Sr.

Falcons Planning to Use Franchise Tag on Kyle Pitts Sr.
Geoff Neal

Suffers Back-To-Back Knockout Losses
Uros Medic

Shines At UFC Houston
Dan Ige

Gets Finished For The First Time In His Career
Melquizael Costa

Extends His Win Streak To Six
NASCAR

Bubba Wallace Falls Short of Victory at EchoPark Speedway
Carson Hocevar

Rallies to Fourth At EchoPark Speedway After Early Struggles
Ross Chastain

Finishes Third At EchoPark Speedway
Chase Briscoe

Scores First Career Top-Five Finish at EchoPark Speedway
Tyler Reddick

Nabs His Second Win of the Season At EchoPark Speedway
Joey Logano

Will Be Popular DFS Pick at EchoPark Speedway
Tyler Reddick

on Pole After Qualifying Rained Out at EchoPark Speedway
Chase Elliott

Could Chase Elliott Be Worth Rostering At EchoPark Speedway?
Ryan Blaney

Is Ryan Blaney Worth Rostering for DFS at EchoPark Speedway?
William Byron

Is William Byron Worth Rostering for DFS at EchoPark Speedway?
Rondale Moore

Passes Away
Denny Hamlin

Is Worth Consideration for EchoPark Speedway DFS Lineups
Brad Keselowski

Is A Tournament Option for DFS At EchoPark Speedway
NASCAR

Is Bubba Wallace Rosterable In DFS At EchoPark Speedway?
Austin Cindric

Should DFS Managers Roster Austin Cindric at EchoPark Speedway?
Ross Chastain

Is Ross Chastain A Sneaky DFS Option for EchoPark Speedway?
Ricky Stenhouse Jr

Is Ricky Stenhouse Jr. Worth Rostering for DFS at EchoPark Speedway?
Alex Bowman

Will Start Towards the Rear At EchoPark Speedway
Javonte Williams

Cowboys Sign Javonte Williams to Three-Year, $24 Million Extension
Travis Etienne Jr.

has "Legitimate Interest" in Joining Chiefs
Zach Charbonnet

Undergoes Knee Surgery on Friday
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF