X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

LeBron James

Set to Play in Cleveland Matchup
Jayson Tatum

Cleared to Play Wednesday
Neemias Queta

Returns Against Miami
De'Anthony Melton

Ruled Out Against Spurs
Kristaps Porzingis

Ruled Out Wednesday
Pascal Siakam

Expected to Suit Up Wednesday
Andrew Nembhard

Sitting Out Wednesday
Olivier-Maxence Prosper

Off Injury Report Wednesday
Ty Jerome

to Miss Fifth Straight Game
Caris LeVert

Available Tuesday Against Raptors
Miles McBride

to Suit up on Tuesday
Collin Murray-Boyles

Cleared to Play Tuesday
Marcus Sasser

is Available on Tuesday
Brandon Ingram

Returns Vs. Detroit
Ziaire Williams

Moves into Starting Five
Duncan Robinson

Active Vs. Toronto
Jalen Duren

is Back in Action on Tuesday
Tobias Harris

Available Tuesday
Marvin Bagley III

to Miss Second Straight Game
Ryan Rollins

Good to Go Tuesday
Klay Thompson

is Resting on Tuesday
Seiya Suzuki

to Begin a Rehab Assignment Soon
Simon Holmstrom

Misses Tuesday's Action
Alexandre Carrier

Out 2-4 Weeks With Upper-Body Injury
Jordan Spieth

a Horse for Course History at TPC San Antonio
Mason Lohrei

Misses Second Consecutive Game Tuesday
Tyler Myers

Unavailable Against Bruins
Robert MacIntyre

Has One Flaw to Overcome at Valero Texas Open to be a Must-Play
Michael Bunting

to Sit Out Tuesday's Game
Maverick McNealy

In Exceptional Form This Season
Michael Thorbjornsen

Playing Well But Still Searching For A Win
Hideki Matsuyama

Playing Well Heading to the Valero Texas Open
Si Woo Kim

Heads to Valero Texas Open For Final Tune-Up Before Masters
Nikita Kucherov

a Game-Time Decision Tuesday
Evgeni Malkin

Ready for Action Tuesday
Sam Bennett

Rejoins Panthers Lineup Tuesday
Cody Ponce

Diagnosed With ACL Sprain, to Miss "Significant Time"
Tank Dell

Uncertain for OTAs, But Expected to Play in 2026
Alvin Kamara

Saints Still Want to Address Alvin Kamara's Contract
George Pickens

Cowboys Have "Long-Term Plans" for George Pickens
Kyle Pitts Sr.

Falcons Not Ruling Out Potential Kyle Pitts Sr. Trade
Jordan James

the "Front-Runner" to be Top Backup RB
A.J. Brown

Patriots Still Not Ruling Out an A.J. Brown Trade
Aaron Rodgers

Planning to Re-Sign With Steelers?
Seattle Seahawks

Mike Washington Jr. Would Fill a Big Need for Seahawks
Los Angeles Rams

Kenyon Sadiq a Good Fit With the Rams?
Green Bay Packers

Packers to "Strip Everything Down" on Offense
Anthony Richardson Sr.

to Stay With Colts?
NFL

Ty Simpson has Visits With Cardinals, Dolphins, Browns
Aaron Rodgers

Mike McCarthy, Aaron Rodgers Touch Base
Cameron Ward

Mechanical Tweaks are Focused on his Footwork
Jaylen Waddle

to Play the Slot And Outside
Geno Smith

Aaron Glenn Thinks Geno Smith Will Lead Jets to "Promised Land"
Mason Taylor

Jets Expecting a "Hell of a Year" From Mason Taylor
Collin Morikawa

Withdraws From Valero Texas Open
PGA

Stephan Jaegar Still Looking For Consistency at Valero Texas Open
Nicolai Hojgaard

is Red-Hot Coming to TPC San Antonio
Tony Finau

a Risky Proposition at Valero Texas Open
Ludvig Aberg

Looks to Shake Off Collapse at Valero Texas Open
Jacob deGrom

Cleared for Season Debut on Tuesday
Colt Emerson

Signs an Eight-Year Extension with Mariners
James Conner

Role Threatened in Arizona?
Devin Neal

Dynasty Value Slipping Away?
Josh Downs

Headed for More Targets in 2026?
Mike Evans

Still Has WR1 Upside in New Home
William Nylander

Records Four Points Against Ducks
Macklin Celebrini

Becomes Sixth Teenager With 100-Point Season
Jaden Schwartz

Could Return Tuesday
Jordan Greenway

Available Tuesday
Jake Sanderson

Remains Out Tuesday
Cutter Gauthier

Exits Early Against Maple Leafs
Cale Makar

Sustains Upper-Body Injury Monday
Patrick Rodgers

Needs to Make More Birdies in San Antonio
Sepp Straka

Seeks Opportunity in San Antonio This Weekend
Nick Taylor

Could Again Struggle at the Valero Texas Open
Keith Mitchell

Sets Up Solidly for TPC San Antonio
Jose Altuve

Tallies Four Hits, Two Homers in Big Night
Rickie Fowler

a Boom-or-Bust Option at Valero Texas Open
Nazem Kadri

Scores Twice in Blowout Victory
Anthony Mantha

has Three-Point Performance on Monday
Miguel Vargas

Hits Grand Slam, Drives in Six in Win Over Miami
Tanner Bibee

to Start on Tuesday Against Dodgers
Aliaksei Protas

Won't Play Tuesday
Pavel Mintyukov

Returns to Action Monday
Radko Gudas

Ready to Face Maple Leafs
John Klingberg

to Remain Sidelined Monday
Matt McCarty

Seeking to Play into the Weekend in San Antonio
Brian Harman

Looking to Continue Form From The Players Championship
Steven Fisk

Attempting to String Better Rounds Together at San Antonio
Luke Clanton

Still Having Rough Time Contending at Events
Max Homa

Looks to Get Back on Track at Valero Texas Open
Chase Elliott

Takes Advantage of Pit Strategies for Second Career Martinsville Win
Denny Hamlin

Dominates but Finishes Second at Martinsville
Joey Logano

Bounces Back with Third-Place Finish at Martinsville
Ty Gibbs

Gains his Fourth Top-Five Finish of the Season at Martinsville
William Byron

Scores Another Top-Five Finish at Martinsville
Joe Pyfer

Extends His Winning Streak
Israel Adesanya

Loses Fourth Consecutive Fight
Maycee Barber

Suffers Her First Knockout Loss
Alexa Grasso

Scores Highlight-Reel Knockout
Niko Price

Retires After UFC Seattle Loss
Michael Chiesa

Victorious In His Retirement Fight
Julian Erosa

Suffers First-Round Knockout Loss
Lerryan Douglas

Scores First-Round Knockout Win In His UFC Debut
Alex Bregman

Clobbers First Two Homers in Sunday's Loss at Wrigley
Yandy Díaz

Yandy Diaz Records Five Hits, Drives in Four in Win Over Cardinals
Kyle Larson

Is Likely to Pay Off for DFS at Martinsville
Christopher Bell

Could Have Another Top-10 Performance At Martinsville
William Byron

Is A Threat to Win Again at Martinsville
Chase Elliott

is A Solid DFS Option for Martinsville Lineups
Chase Briscoe

has Plenty of Upside for DFS Lineups at Martinsville
Carlos Estévez

Carlos Estevez Unlikely to See High-Leverage Opportunities in Near Future
Jacob deGrom

Feels "Much Better," Hopeful he Can Start This Week
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Martinsville?
Ryan Preece

Is A Solid DFS Option for Martinsville Lineups
Josh Berry

Could Josh Berry Pay Off for Tournament DFS Lineups At Martinsville?
Carson Hocevar

May be Too Inconsistent to Start in Martinsville DFS Lineups
Austin Cindric

Is Austin Cindric Worth Rostering for DFS At Martinsville?
Denny Hamlin

the Favorite to Win at Martinsville
Ryan Blaney

Should Contend at Martinsville
Tyler Reddick

Should Come Back Down to Earth at Martinsville
Joey Logano

Will Be Strong at Martinsville
NASCAR

Bubba Wallace Looking to Rebound at Martinsville
Shane Van Gisbergen

Shane van Gisbergen Showing Progress, Qualifies Fifth at Martinsville
Dylan Cease

Fans 12 in Blue Jays Debut on Saturday
Andrew Vaughn

Needs Hand Surgery, Expected to be Out 4-6 Weeks
Jacob deGrom

"Confident" he Will Make his Next Start
Jacob deGrom

Scratched From Saturday's Start Due to Neck Stiffness
Jeferson Quero

Brewers Calling Up Catching Prospect Jeferson Quero
Deyvison De Los Santos

Marlins Promote Deyvison De Los Santos to Major Leagues
Shea Langeliers

Hits Two Home Runs on Opening Day
Kevin Gausman

Picks Up No-Decision But Strikes Out 11 on Opening Day
Tanner Bibee

Day-to-Day, Could Make his Next Start
Shane Baz

Orioles Agree to Five-Year Extension
Joe Pyfer

Set For UFC Seattle Main Event
Israel Adesanya

Returns At UFC Seattle
Maycee Barber

Looks To Extend Her Win Streak To Eight
Alexa Grasso

Looks To Get Back In The Win Column
Niko Price

In Dire Need Of Victory
Michael Chiesa

Set For Retirement Fight
Lerryan Douglas

Set For His UFC Debut
Julian Erosa

Looks To Bounce Back
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF