X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Brock Faber

Huge Factor in Minnesota Overtime Victory
Matt Boldy

Evens Series Between Minnesota and Dallas in Big Way
Frederik Andersen

Game Changer as Carolina Closed Out Ottawa
Logan Stankoven

Scores Yet Again as Carolina Sweeps Ottawa
Desmond Bane

Nails Seven Triples En Route to 25 Points
Cade Cunningham

Finishes Loss With Nine Turnovers
Shai Gilgeous-Alexander

Drops 42 Points on Suns in Game 3
Karl-Anthony Towns

Joins Exclusive List With Triple-Double
Julius Randle

Tossed From Game 4
Nikola Jokić

Nikola Jokic Ejected in Game 4 Loss
Donte DiVincenzo

Diagnosed With Torn Right Achilles
Anthony Edwards

Injures Left Knee Saturday
Malik Willis

Gets Three New Receivers in the Draft
Antonio Williams

to See Starting Role on Day 1 in Weak Wide Receiver Room?
Terrance Ferguson

No Longer the Unquestioned Future TE1 in Los Angeles?
Brenton Strange

Does Brenton Strange Still Need to Prove Himself in Jacksonville?
KC Concepcion

Already Facing Competition for Targets in Cleveland
Jacory Croskey-Merritt

Remains the Top Option in Washington Backfield?
MLB

Red Sox Fire Manager Alex Cora and Other Coaches
A.J. Lawson

Questionable for Sunday Due to Back Spasms
Kevin Huerter

Injures Left Hip Saturday
Green Bay Packers

Packers Take Kicker Trey Smack with Pick No. 216
Kelly Oubre Jr.

Iffy for Sunday
Victor Wembanyama

Still Questionable on Injury Report
Denver Broncos

Broncos Select Dallen Bentley with 256th Pick
Kevin Durant

Uncertain for Sunday's Action
Austin Reaves

Listed as Questionable for Sunday's Game 4
Aaron Gordon

Active on Saturday
Indianapolis Colts

Colts Select Deion Burks with Pick No. 254
Joel Embiid

Remains Doubtful Ahead of Game 4
New England Patriots

Patriots Select Jam Miller with 245th Pick
Indianapolis Colts

Colts Select Seth McGowan with Pick No. 237
New England Patriots

Patriots Take Quarterback Behren Morton with Pick No. 234
Kansas City Chiefs

Chiefs Draft Garrett Nussmeier With 249th Overall Pick
Cleveland Browns

Browns Draft Carsen Ryan in the Seventh Round
Tennessee Titans

Titans Select Jaren Kanak with Pick No. 225
Washington Commanders

Commanders Take Quarterback Athan Kaliakmanis with Pick No. 223
Houston Texans

Texans Select Lewis Bond with Pick No. 204
Pittsburgh Steelers

Navy's Eli Heidenreich to the Steelers at No. 230 Overall
Jacksonville Jaguars

Jaguars Double Dip at Wide Receiver with C.J. Williams at Pick No. 203
Josh Manson

Not Expected to Play Sunday
Los Angeles Rams

Rams Select CJ Daniels with 197th Pick
Mason Lohrei

Set to Miss Game 4 as Healthy Scratch
Cincinnati Bengals

Bengals Select Jack Endries at No. 221 Overall
Emil Andrae

Won't Play Saturday
Arturs Silovs

Starting Game 4 Against Flyers
Dan Vladar

Cleared for Game 4
Mats Zuccarello

Remains Out Saturday
Nikolaj Ehlers

Dealing With Lower-Body Injury
Steven Kwan

Scratched With Neck Stiffness
Trey Yesavage

Returning From Injured List on Tuesday
Eugenio Suárez

Eugenio Suarez Heading to the Injured List With Oblique Strain
Kirby Dach

Battles and Scores Two Points in Friday Triumph
Connor McDavid

Delivers Mixed-Bag Performance Friday
MLB

Saturday's Mets-Rockies Game Postponed Due to Weather
Karel Vejmelka

Saves Utah With Huge Effort Friday
Lane Hutson

Scores Crucial Overtime Goal in Montreal Win
Lawson Crouse

Cashes in With Two Goals for Utah
Mikael Granlund

Serves Up Trio of Assists in Anaheim Big Win
Giancarlo Stanton

Exits With Leg Tightness on Friday
Isaiah Joe

Likely to Miss Game 3 Against Suns
Peyton Watson

to Remain Sidelined Saturday
Aaron Gordon

Questionable for Saturday's Game 4
Jordan Goodwin

on Track to Return Saturday
Grayson Allen

Listed as Questionable for Saturday
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Troy Terry

Available for Game 3 Against Oilers
Radko Gudas

Misses Second Straight Game Friday
Charle-Edouard D'Astous

Unavailable Friday
Dan Vladar

Considered a Game-Time Call for Saturday
Jackson Holliday

Receives Positive Test Results, Will be Shut Down for a Week
Jeff Hoffman

Out as Blue Jays Closer
Youssef Zalal

Set For UFC Vegas 116 Main Event
Aljamain Sterling

An Underdog At UFC Vegas 116
Joselyne Edwards

Set For UFC Vegas 116 Co-Main Event
Norma Dumont

Looks To Extend Her Win Streak
Alexander Hernandez

A Favorite At UFC Vegas 116
Rafa Garcia

Looks For His Third Consecutive Win
Adrian Luna Martinetti

Set For His UFC Debut
Davey Grant

Looks To Get Back In The Win Column
Francisco Lindor

Expected to Miss "Significant Time"
Francisco Lindor

Mets Officially Place Francisco Lindor on Injured List With Calf Strain
Michael Harris II

Removed Early With Quad Tightness
Francisco Lindor

Likely Headed to the Injured List
Michael Harris II

Continues to Heat Up With Two-Homer Game on Wednesday
Francisco Lindor

Leaves Wednesday's Game Early With Calf Tightness
JR Ritchie

Earns Promotion, Will Make MLB Debut on Thursday
Wyatt Langford

Expected to Go on Injured List With Flexor Strain
Maikel Garcia

Leaves Early on Wednesday With Elbow Soreness
Roman Anthony

Day-to-Day With Sore Back
Juan Soto

Officially Back in Mets Lineup on Wednesday
J.T. Realmuto

Phillies Place J.T. Realmuto on Injured List With Back Injury
CFB

Beau Pribula Leading Virginia Quarterback Competition
Marco Penge

Trending Down Entering Zurich Classic
Sahith Theegala

Eyes Another Strong Week at Zurich Classic
Brooks Koepka

Shane Lowry Teams Up with Brooks Koepka at Zurich Classic
Si Woo Kim

Adds Another Strong Finish at RBC Heritage
Luke Clanton

Hoping to Find Form in New Orleans
Scottie Scheffler

is Starting to Hit His Stride
Brooks Koepka

Looking for Progress in PGA Return With Partner at Zurich Classic
Matt Fitzpatrick

Looks to Share Recent Form at Zurich Classic
CFB

Ashton Daniels Named Florida State's Starting Quarterback
Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
Kyle Larson

Finishes as the Runner-Up at Kansas
Chase Briscoe

Rallies for A New Career-Best Finish at Kansas
Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Gilbert Burns

Retires After UFC Winnipeg Loss
Charles Jourdain

Extends Winning Streak
Kyler Phillips

Drops Decision At UFC Winnipeg
Mandel Nallo

Suffers First-Round TKO Loss In His UFC Debut
Jai Herbert

Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
Jasmine Jasudavicius

Dominates Karine Silva
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF