X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (4/21/22): Today's Top MLB DFS Lineups

Dylan Cease - Fantasy Baseball Rankings, MLB Injury News, DFS and Betting Picks

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on April 21st, 2022. Brian Entrekin's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. Today we have a 7-game slate on DK and a 6-game slate on FD as DK has added the AZ/WAS game at 4:05 pmEST. When looking at pitching, it's simple for me. Just pay up for Cease and pair with one of three other options listed below. You can try and get cute if you want, but take the elite pitching options and take some chances with your bats. 

It's a getaway day for all teams, leading to exciting lineups. There are some primary teams to target, such as the Yankees and Dbacks, but more targets will be based on lineups on this slate. The interesting game is TOR/BOS in a game between Kevin Gausman and Tanner Houck with the highest projected game total on the slate. It should be another fun game with a ton of value opening up when lineups are released, meaning paying for studs should not be a problem. 

This article will provide my daily fantasy baseball lineup picks for Fanduel and DraftKings on 4/21/2022. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Black Friday Special! Save 50% on any Big-4 Sports Premium Pass using discount code SMASH. Win more with our DFS, Betting and Season-Long Premium Pass, get expert tools and advice for NBA, NFL, MLB, NHL from from proven winners! Dan Palyo leads the team with exclusive picks for DFS picks, Props, betting. Enhance your game with industry-leading tools like our Lineup Optimizers, Team Sync Platform, DFS Cheat Sheets and more. GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dylan Cease - P, CWS at CLE ($10,100 DK, $10,300 FD)

Cease has been as advertised to start the season. Throwing at least five innings in each of his two starts, allowing one run in each start and striking out eight in each start. He has allowed zero barrels to start the season with a 35% hard-hit rate. He is limiting any good quality of contact while making hitters look foolish, thanks to a 15.3% SwStr and 31.2% CSW. It only gets better for Cease as he faces the woeful Guardians today. Look for Cease to continue his excellent start to the season with another dominating performance.

Paul Blackburn - P, OAK vs. BAL ($8,600 DK, $7,600 FD)

Blackburn has put together a great start to the 2022 season. He has thrown at least five innings in each start, allowing only two runs versus the Jays and striking out ten over both starts. Blackburn's velocity increase this season has been a significant factor in his success, and he will look to continue that in an outstanding matchup versus the Orioles. An Orioles team is striking out 26% of the time versus RHP this season with a horrible .196 batting average against and .088 ISO. Nevertheless, Blackburn should be popular, and I am willing to give him another shot today at a friendly price tag.

Other options: Joe Ryan at KC ($9,300 DK, $8,200 FD), Jordan Montgomery at DET ($6,900 DK, $7,800 FD)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Anthony Rizzo - 1B, NYY at Michael Pineda ($4,300 DK, $3,500 FD)

On Wednesday, Rizzo went 2-4 with a double and a home run. Rizzo's fourth home run was excellent, but he is only hitting .231. The average may struggle, but his .359 ISO and .412 OBP, thanks to a 15.7% walk rate, help rack up the fantasy points. Rizzo and the Yankees will face Pineda today, making his first start of the season. Last season, Pineda allowed LHH to hit .290 with 1.6 HR/9. Rizzo and the Yankees are the top stack today, so stack accordingly.

Jeff McNeil - 2B, NYM vs. Anthony DeSclafani ($3,800 DK, $3,300 FD)

After a down year, McNeil appears to be finding his footing again. He has hit safely in seven of 11 games to start the season with a .293 batting average. The power is still not back for McNeil, as he has one home run to go with a .098 ISO, but he is walking 10.6% of the time, which helps him set the table for the big bats. Over the last five games, McNeil has hit leadoff four times and third once. He brings a lovely cash game floor into play and a piece of a sneaky Mets stack.

Maikel Franco- 3B, WAS vs. Zach Davies ($2,800 DK, $N/A FD)

For most of the spring, it did not appear Franco would even have an everyday role with the Nationals. However, after an injury to Carter Kieboom, Franco is back and playing well. On Wednesday, he was 1-4, giving him a five-game hitting streak. He is hitting .280 with a home run and nine RBI. Today, Franco and the Nats face Davies, who has been bad to start the season. He has allowed seven runs over 9.1 innings with two home runs. So, when stacking the Nats, do not just look at the lefties and remember Franco as an excellent value piece hitting in the middle of the order.

Tim Anderson- SS, CWS at Zach Plesac ($5,900 DK, $3,900 FD)

Today's slate's shortstop position is less than ideal, so it is all about paying up for Anderson. He has been on fire to start the season, hitting safely in six of eight games for a .375 batting average. He is only striking out 12.1% of the time, leading to more balls in play. He will face Plesac today, who has been decent but still pitching to a lot of contact as he only has a 15.9% strikeout rate. He also allows a 13.9% barrel rate and 50% hard-hit rate, meaning a blowup should be coming soon. Pay up for Anderson today and potentially stack up some White Sox for some contrarian action.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Brandon Nimmo- OF, NYM vs. Anthony DeSclafani ($3,900 DK, $3,600 FD)

I mentioned the Mets as an intriguing stack today, and Nimmo also fits that mix. On Wednesday, he went 2-5, which raises his batting average to .323. Nimmo is still walking a ton like he always does, 15.8% of the time, but has also flexed some muscle with four extra-base hits, two of which were home runs. He will face Tony Disco tonight, who has allowed LHH to hit .417 in a small 2022 sample, but over his career, has allowed over 1 HR/9 versus LHH. So do not forget Nimmo tonight.

Aaron Hicks - OF, NYY at Michael Pineda ($3,400 DK, $2,700)

Hicks has gotten off to a solid start to the season, hitting .303 with a home run and a stolen base. He is also walking 16.7% of the time while only striking out 14.3%. Over the last four games, his fantasy value has only gone up as he is leading off for the Yankees. That is quite the discounted price tag for the Yankees leadoff hitter in a juicy matchup versus Pineda. Hicks is a great cash game value and a lock-in all Yankees' stacks.

Joc Pederson- OF, SF at Carlos Carrasco ($3,100 DK, $3,400 FD)

JOC JAMS!!!! Joc has been scorching hot to start the season as one of the Giants RHP mashers. He is hitting .310 to go with three home runs, a .310 ISO, and .976 OPS. He has scored double-digit fantasy points in five of his last six games and comes into a juicy matchup today at quite a discount. He will face Carrasco, who has been solid enough to start the season, but that has not stopped Joc as he took Cylor deep on Tuesday. Joc makes for a great tournament play today.

 

DraftKings, FanDuel MLB DFS Stacks

 New York Yankees at Detroit Tigers (Michael Pineda, RHP)

The Yankees are my top stack today. They will probably be popular, but I do not care. They get to face Pineda, so let's stack them up. You can target Aaron Judge and Giancarlo Stanton, but do not forget about the likes of Joey Gallo to be a bit different. Whatever you do, make sure to have Hicks and Rizzo in your builds.

Washington Nationals vs. Arizona Diamondbacks (Zach Davies, RHP)

Davies has been bad to start the season and pitches to a ton of contact. Juan Soto is a lock, so pair him up with Franco and more. Josh Bell may be out with injury, but there is always Nelson Cruz. Some sneakier plays like Keibert Ruiz and Yadiel Hernandez could make for a contrarian build.

New York Mets vs. San Francisco Giants (Anthony DeSclafani, RHP)

Most will not look to target DeSclafani, which means more contrarian fun for us. McNeil and Nimmo are critical pieces for me, and I will look to pair them with Pete Alonso and Francisco Lindor.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Cooper Flagg

Won't Play Wednesday
Bam Adebayo

Cleared to Play Wednesday
Tre Mann

Ruled Out Wednesday
Sam Merrill

Ruled Out for Wednesday
Jabari Smith Jr.

Active Against Cavaliers
Buddy Hield

Good to Go Wednesday
Jonathan Kuminga

Misses Fourth Consecutive Game
Alexandre Sarr

Unavailable on Wednesday
Draymond Green

Out Wednesday
Jimmy Butler III

Misses Meeting With Heat
Conor Garland

to Return on Thursday
Thomas Harley

to Miss Road Trip
Eetu Luostarinen

Out Week-to-Week After Barbecue Accident
Curtis Lazar

to Miss at Least Three Games
Al Horford

Ruled Out For Wednesday Against Miami
Vladimir Tarasenko

Misses Third Consecutive Game
Mikael Granlund

Remains Out Wednesday
Jaden McDaniels

Out Wednesday
Charlie McAvoy

Out Indefinitely After Facial Surgery
Joel Embiid

Unavailable Wednesday Against Raptors
Stephen Curry

Sidelined on Wednesday
Joe Burrow

to Potentially Return in Week 12?
Aaron Rodgers

Out on Wednesday, Hopes to Practice Thursday
Jaylen Warren

Not Seen at Wednesday's Practice
Dak Prescott

Lands on Injury Report Ahead of Week 12 With Hip Injury
Rhamondre Stevenson

Targeting a Return in Week 12?
Isiah Pacheco

Returning to Practice on Wednesday
Brian Thomas Jr.

Jaguars "Optimistic" About Brian Thomas Jr.'s Week 12 Status
Josh Jacobs

Will Not Practice on Wednesday
Sahith Theegala

Looking to Continue Fall Run at RSM Classic
Jayden Daniels

Commanders Considering Shutting Down Jayden Daniels?
Stephan Jaeger

Looking to Bounce Back at RSM Classic
Tom Hoge

Looking to Regain Form at RSM Classic
Joe Highsmith

Searching for Turnaround at RSM Classic
Adam Hadwin

Looking to Build on T11 Finish in Bermuda
Austin Eckroat

Searching for Momentum at RSM Classic
Joel Dahmen

Trying to Find Form at the RSM Classic
Marvin Harrison Jr.

Ruled Out Again in Week 12
Drake London

Falcons Hoping That Drake London Will Return in Week 13
CFB

Garrett Nussmeier Doubtful to Play Against Western Kentucky
Michael Penix Jr.

Needs Reconstructive Surgery on Torn ACL
Jaxson Dart

Expected to Return to Practice on Wednesday
Shedeur Sanders

Will Start Against Raiders
Dalton Kincaid

Ruled Out Against Texans
Connor Bedard

Continues Tear With Hat Trick
Macklin Celebrini

Pots Hat Trick in Tuesday's Win
Jake Guentzel

Records Eighth Career Hat Trick
Sammy Blais

Injured Versus Blues
Alexander Romanov

Injured in Tuesday's Win
Ryan Hartman

Considered Week-to-Week
Michael Thorbjornsen

Hopes to End 2025 Campaign With Another Solid Finish
Saddiq Bey

Uncertain for Meeting With Nuggets
Sam Merrill

Iffy for Wednesday
Andrew Novak

Looks to End 2025 Season on High Note at RSM Classic
Dereck Lively II

Likely to Play Wednesday
Daniel Gafford

on Track to Return Wednesday
Jaden McDaniels

Uncertain for Wednesday
Jalen Smith

Expected to Play Wednesday
Tre Jones

Questionable for Wednesday
Harry Higgs

Teetering for PGA Tour Card in 2026
PGA

Nico Echavarria has the Potential to Contend at the RSM Classic
Sam Stevens

Finishing Out Year in Georgia
Seamus Power

Playing Better at the Right Time
Beau Hossler

Roller Coaster Comes to Saint Simons Island
Quade Cummins

The Time is Now for Quade Cummins in Georgia
Austin Cook

Needs a Win at the RSM Classic
Cameron Champ

on the PGA Tour Card Bubble
Grayson Rodriguez

Shipped to Angels
Taylor Ward

Orioles Acquire Taylor Ward From Angels
Shota Imanaga

Accepts Cubs Qualifying Offer
Brandon Woodruff

Returning to Milwaukee in 2026
Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Mackenzie Hughes

a Good Bounce-Back Candidate at RSM Classic
Harris English

Making 14th Start at This Week's RSM Classic
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Gleyber Torres

Accepts Tigers Qualifying Offer
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Jamie Benn

Makes Season Debut Tuesday
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
Auston Matthews

to Miss at Least Two More Games
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
CFB

Sam Leavitt Set to Enter Transfer Portal?
Jose Altuve

Undergoes Foot Surgery
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
CFB

James Franklin to be Virginia Tech's Next Head Coach
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP