College Football Betting Picks: Futures Predictions Include Win Totals, Conference Champions, and CFP Odds (2025)

August 22, 2025

Mike's college football betting futures picks and expert predictions for win totals, conference champions, and CFP. His top bets to make for 2025 college football.

I don't usually get too involved with college football futures bets, but the massive realignment that happened just over a year ago offers a chance to make some serious coin if you know where to look. With unbalanced conference schedules come chances to catch people sleeping on certain teams. For example, Virginia doesn't play a single team that is ranked in the preseason.

It is critical to look at the revamped schedule when analyzing these bets. You know Vegas has. Do your research as well. Take the power back! An informed bettor is Vegas's worst nightmare. We can work together to make that happen! The smartest money isn't always chasing the well-known teams. Looking at non-power schools that got power transfers can seriously alter the future of those smaller school teams.

I will highlight my best over/under college football futures bets for regular-season win totals in 2025. Some bets that I like, for example, Georgia over 9.5 wins and Texas over 9.5 wins, were left off because the juice is so high. I'm trying to win us the most money with the least risk. If we're betting on something that's -180 or higher (like those bets are), that's too little of a return to take a risk on. If you have a specific question on a team that isn't listed here, reach out on X or in the RotoBaller Discord, and I will answer! I will also include an honorable mention section and a few long shots that I would throw a small wager on. Who knows...we may even throw in a couple of bets to make the playoffs!

College Football Futures - Best Over/Under Win Total Bets

Liberty over 9.5 wins (-120):

Schedule: vs. Maine, at Jacksonville State, at Bowling Green, vs. James Madison, at Old Dominion, at UTEP, vs. New Mexico State, vs. Delaware, vs. Missouri State, at Florida International, at Louisiana Tech, vs. Kennesaw State

Last 3 seasons of Liberty football: averaged 9.6 wins
Beat BYU, Arkansas, and had 2 wins versus half of Vanderbilt’s roster. Undefeated against the Sun Belt. And an appearance in the Fiesta Bowl.

— Aaron (@pplcallmeblue) August 12, 2025

Where are the three losses coming from? The Flames take on BOTH new additions to FBS this year. Bowling Green no longer has human highlight reel Harold Fannin Jr. All that the Flames have to do is win two of the three tough road games (Jacksonville State, Old Dominion, and Louisiana Tech) and beat JMU at home. That's not only doable, but likely.

Clemson over 9.5 wins (-160):

Schedule: vs. LSU, vs. Troy, at Georgia Tech, vs. Syracuse, at North Carolina, at Boston College, vs. SMU, vs. Duke, vs. Florida State, at Louisville, vs. Furman, at South Carolina.

Clemson is BACK

- 80% roster retention
- Dabo using the portal
- 4300 yards of offense coming back
- New defensive coordinator

This 2025 national championship run is going to be special 🙏🏽💉 pic.twitter.com/IvleapErC2

— 🐅Kuzzi🐅 (@MMAKuzzi) January 8, 2025

Even if Clemson loses to both SEC teams, we cash this bet. If Cade Klubnik and company are truly that much better than the rest of the ACC, this is easy money.

Indiana over 8.5 wins (+135):

Schedule: vs. Old Dominion, vs. Kennesaw State, vs. Indiana State, vs. Illinois, at Iowa, at Oregon, vs. Michigan State, vs. UCLA, at Maryland, at Penn State, vs. Wisconsin, at Purdue

Indiana plays three of the top 12 teams, with two of those on the road. Even if they lose all three of those, we still cash this bet. With no other team (and certainly no OOC team) looking like a threat, this is easy money. I wouldn't be surprised if Indiana is even better than last year. I'm hammering this at plus money.

Buffalo over 7.5 wins (-120):

Schedule: at Minnesota, vs. St. Francis (PA), at Kent State, vs. Troy, vs. Connecticut, vs. Eastern Michigan, at Massachusetts, vs. Akron, at Bowling Green, at Central Michigan, vs. Miami (OH), vs. Ohio

Former @PennStateFball quarterback Ta'Quan Roberson will transfer to Buffalo, per @PeteNakos_.

Buffalo will be Roberson's fourth program in his seventh year of college football.https://t.co/5dDsvUmEet

— Onward State (@OnwardState) January 12, 2025

Buffalo added former Penn State, UConn, and Kansas State QB Ta'Quan Roberson. I love the experience that he brings to the Bulls, and Al-Jay Henderson is another in a long line of great Buffalo backs.

Even if Buffalo loses to Minnesota, they can still lose three more. That's not happening with Kent, Akron, EMU, and UMass on the schedule. Bowling Green doesn't have Harold Fannin Jr. anymore. The Bulls just need to win one out of UConn, Miami, and Ohio to cash this. I think it happens.

Nebraska over 7.5 wins (-155):

Schedule: vs. Cincinnati, vs. Akron, vs. Houston Christian, vs. Michigan, vs. Michigan State, at Maryland, at Minnesota, vs. Northwestern, vs. USC, at UCLA, at Penn State, vs. Iowa

Folks, it's the absolute best time of year.

When everyone totally forgets we lost 5 of 6 games to finish the season.

Over a 9 month off-season, once we get the Koolaid flowing and the hype train rolling, there is absolutely no stopping us.

From outside the Top 25 to the CFB… pic.twitter.com/N0DCLtZSzJ

— HuskGuys (@HuskGuys) August 18, 2025

Matt Rhule's M.O. is a big leap in Year 3. Look at that schedule. It could happen at Nebraska as well. The Huskers could start 8-0 before a meeting with USC at Memorial Stadium.

After a neutral-site game with Cincinnati, the Huskers don't leave the state again until the Maryland game in October. The road games are the easiest part of the schedule, and Nebraska only faces two ranked teams. If everything breaks right, this team wins nine games.

Baylor over 7.5 wins (-125):

Schedule: vs. Auburn, at SMU, vs. Samford, vs. Arizona State, at Oklahoma State, vs. Kansas State, at TCU, at Cincinnati, vs. Central Florida, vs. Utah, at Arizona, vs. Houston

This is one of my favorite bets and I might take o8.5 at +120. The Bears won six straight to end last season and return Sawyer Robertson and Bryson Washington. This schedule is heavily front-loaded, so that experience will come in handy.

Even if Baylor loses to the three ranked teams (with two of those coming at home, I doubt they lose all three. The toughest game after that is the Revivalry. Baylor could win six in a row to close 2025 as well!

Iowa State over 7.5 wins (+120):

Schedule: vs. Kansas State, vs. South Dakota, vs. Iowa, at Arkansas State, vs. Arizona, at Cincinnati, at Colorado, vs. BYU, vs. Arizona State, at TCU, vs. Kansas, at Oklahoma State

I will not stand for this Rocco Becht slander! Becht returns, as does most of the defense and the entire RB room. Even if the Cyclones lose Farmageddon, they are at worst 5-1 entering the Colorado game. The schedule lines up for the Cyclones to win as many as 10 games! I love getting plus money here.

Vanderbilt over 5.5 wins (+130):

Schedule: vs. Charleston, at Virginia Tech, at South Carolina, vs. Georgia State, vs. Utah State, at Alabama, vs. LSU, vs. Missouri, at Texas, vs. Auburn, vs. Kentucky, at Tennessee

Vandy should beat Charleston, Georgia State, and Utah State. We only need three more wins. That should come in home matchups against Missouri, Auburn, and Kentucky. I love getting plus money here, especially since Virginia Tech and Tennessee are winnable games as well. I feel like we have a lot of play here since Vandy could win eight games, and I wouldn't be surprised.

College Football Futures - Over/Under Win Total Bets Still Worth Taking

Ohio State under 10.5 wins (-150):

Schedule: vs. Texas, vs. Grambling, vs. Ohio, at Washington, vs. Minnesota, at Illinois, at Wisconsin, vs. Penn State, at Purdue, vs. UCLA, vs. Rutgers, at Michigan

Expecting a team with a new starting quarterback and new running backs to win 10 games is a bit optimistic, especially considering they play the No. 1 and No. 3 ranked teams. Both are at home, but at No. 12 Illinois won't be easy, and they close the season at Michigan, a team they haven't beaten since 2019.

Memphis over 8.5 wins (EVEN):

Schedule: vs. Chattanooga, at Georgia State, at Troy, vs. Arkansas, at Florida Atlantic, vs. Tulsa, at UAB, vs. South Florida, at Rice, vs. Tulane, at East Carolina, vs. Navy

Vegas slept on Memphis last year, and I cashed the bet for Memphis winning the AAC Championship Game. I'm pulling up short of that one this year, but there is no reason this team can't win nine games. Arkansas, South Florida, Tulane, and Navy are all at home. If Memphis gets two of those, along with one of the road games at Georgia State or East Carolina, that's an easy nine wins.

Colorado State over 6.5 wins (+135):

Schedule: at Washington, vs. Northern Colorado, vs. UTSA, vs. Washington State, at San Diego State, vs. Fresno State, vs. Hawaii, at Wyoming, vs. UNLV, at New Mexico, at Boise State, vs. Air Force

This is a front-heavy schedule, but both Washington schools are beatable. SDSU, Fresno, and New Mexico are down from last year. Assuming the Rams take care of those three and Northern Colorado, they only need three more wins. Wyoming, Air Force, Hawaii, and one of the Washington schools, or UTSA, get us there.

Texas A&M under 7.5 wins (+145): 

Schedule: vs. UTSA, vs. Utah State, at Notre Dame, vs. Auburn, vs. Mississippi State, vs. Florida, at Arkansas, at LSU, at Missouri, vs. South Carolina, vs. Samford, at Texas

If the Aggies lose all five to ranked teams -- which is possible considering they are ranked lower than all of them -- we cash this bet without even worrying about the road games against Missouri and Arkansas. These are great odds if you aren't an Aggie believer. I'm surprised it's this high. Vegas is counting on the Aggies beating either Florida or South Carolina at home. I'm not.

Auburn under 7.5 wins (+135): 

Schedule: at Baylor, vs. Ball State, vs. South Alabama, at Oklahoma, at Texas A&M, vs. Georgia, vs. Missouri, at Arkansas, vs. Kentucky, at Vanderbilt, vs. Mercer, vs. Alabama

I've seen enough of Jackson Arnold to know that Auburn has a better-than-average chance of starting the season 2-4. I think they'll be 3-3 at best with road games against Arkansas and Vanderbilt coming. Auburn likely loses at least one of those. I'll say it now: rivalries are weird, but there's no way this team beats Alabama. Kentucky and Mercer are the only sure wins after Week 3.

Illinois over 8.5 wins (+135): 

Schedule: vs. Western Illinois, at Duke, vs. Western Michigan, at Indiana, vs. USC, at Purdue, vs. Ohio State, at Washington, vs. Rutgers, vs. Maryland, at Wisconsin, vs. Northwestern

I see six sure wins on the schedule. That means Illinois just needs to win three of Duke, Indiana, USC, Ohio State, Washington, and Rutgers. If this is indeed the 12th-best team in the country, that shouldn't be a problem.

South Carolina over 7.5 wins (+145):

Schedule: vs. Virginia Tech, vs. South Carolina State, vs. Vanderbilt, at Missouri, vs. Kentucky, at LSU, vs. Oklahoma, vs. Alabama, at Mississippi, at Texas A&M, vs. Coastal Carolina, vs. Clemson

I ranked South Carolina in the top 10, so you know I'm betting the over. The bad news is that this schedule is brutal. The Cocks have a great chance at entering the LSU game at 5-0, but the only sure win after that is Coastal Carolina. They need to beat two of the six ranked teams they play. I like those odds.

North Carolina over 7.5 wins (+145): 

Schedule: vs. TCU, at Charlotte, vs. Richmond, at Central Florida, vs. Clemson, at California, vs. Virginia, at Syracuse, vs. Stanford, at Wake Forest, vs. Duke, at North Carolina State

Gio Lopez is going to be must watch TV for UNC this fall. pic.twitter.com/dPEItsEmhA

— Just Means Less ACC (@JML_ACC) August 19, 2025

I believe in Gio Lopez, especially when he has a reliable target like Kobe Paysour out there to catch for him. Charlotte, Richmond, Cal, Wake, Virginia, and Stanford should all be wins. That means the Heels only need to beat two of TCU, UCF, Clemson, Syracuse, Duke, and NC State. I'm taking plus money with the likelihood of that happening.

Western Kentucky over 7.5 wins (-130): 

Schedule: vs. Sam Houston, vs. North Alabama, at Toledo, vs. Nevada, at Missouri State, at Delaware, vs. Florida International, at Louisiana Tech, vs. New Mexico State, vs. Middle Tennessee State, at LSU, at Jacksonville State

Where are the five losses coming from? LSU is the sure one. Toledo, Louisiana Tech, and Jacksonville State are tough road games. Even if the Hilltoppers lose all four of those, where's the other one coming from? MTSU is going to be worse than last year. WKU faces both new FBS teams and North Alabama. This is as easy as it can get in Conference USA.

College Football Futures - Over/Under Win Total Best Of The Rest

Penn State over 10.5 wins (EVEN):

Schedule: vs. Nevada, vs. Florida International, vs. Villanova, vs. Oregon, at UCLA, vs. Northwestern, at Iowa, at Ohio State, vs. Indiana, at Michigan State, vs. Nebraska, at Rutgers

The Athletic has Penn State at the very top in their 2025 college football preview and compares them to the last two champions, Michigan and Ohio State—teams who were loaded with talent that stayed another year to win it all. pic.twitter.com/oDcE7bSudu

— Nittany Sports Now (@NittanySN) August 19, 2025

This bet hinges on how much you believe in Drew Allar or James Franklin, as the case may be. Everything lines up for Penn State. They are allowed one loss to cash this bet, which would be at Ohio State. The other two ranked teams (Indiana and Oregon) are at home. I'm not a huge fan of this bet, but getting plus money on this schedule is very tempting.

Michigan under 8.5 wins (+165): 

Schedule: vs. New Mexico, at Oklahoma, vs. Central Michigan, at Nebraska, vs. Wisconsin, at USC, vs. Washington, at Michigan State, vs. Purdue, at Northwestern, at Maryland, vs. Ohio State

I'm not sold on this bet since it's a favorable schedule if Bryce Underwood is for real. If Michigan loses two games in September, I feel like we can cash this bet. I wouldn't go heavy on it, but the odds are too good to completely ignore this. I tend to think Michigan wins nine, but I'll throw a small wager on this just in case.

Kansas over 7.5 wins (+165):

Schedule: vs. Fresno State, vs. Wagner, at Missouri, vs. West Virginia, vs. Cincinnati, at Central Florida, at Texas Tech, vs. Kansas State, vs. Oklahoma State, at Arizona, at Iowa State, vs. Utah

Jalon Daniels. A dark horse Heisman candidate who is freakishly fast and has a cannon for an arm. pic.twitter.com/sT2PdqiJEF

— Savanah Tujague (@savanah2j) August 19, 2025

I am still a Jalon Daniels truther. Let's not forget that Kansas did not play a true home game last year. I've been to enough games in Lawrence to know that there is a home-field advantage there. I think Kansas goes well over this total, so taking this at plus money is nice.

Florida over 7.5 wins (+115)

Schedule: vs. Long Island, vs. South Florida, at LSU, at Miami (FL), vs. Texas, at Texas A&M, vs. Mississippi State, vs. Georgia, at Kentucky, at Mississippi, vs. Tennessee, vs. Florida State

I believe in Florida, but this schedule is brutal. The Gators play three top 10 teams before September is even over. Two of those are on the road. South Florida also could be a problem in Week 2. If this team somehow starts 1-4, they're sunk.

If they are 2-3 and win against A&M, I still think this bet cashes. The Gators have three sure wins in the second half of the season. Florida would have to pull a win against Mississippi, Tennessee, or Georgia to cash this.

Wake Forest over 4.5 wins (+105)

Schedule: vs. Kennesaw State, vs. Western Carolina, vs. North Carolina State, vs. Georgia Tech, at Virginia Tech, at Oregon State, vs. SMU, at Florida State, at Virginia, vs. North Carolina, vs. Delaware, at Duke

Former Gamecock QB Robby Ashford is trending to be the starting QB for Wake Forest this upcoming season after transferring from USC this past winter

Go Be Great RA1 💫 pic.twitter.com/h6vwMjM86N

— 𝕄𝕚𝕔𝕜𝕖𝕪🌴 (@beamerball212) August 14, 2025

Kennesaw, Western Carolina, Delaware, and Virginia should be sure wins. Wake only needs to win one of the other eight games. With former Auburn and South Carolina QB Robby Ashford under center, that feels likely.

Northern Illinois over 6.5 wins (+130)

Schedule: vs. Holy Cross, at Maryland, at Mississippi State, vs. San Diego State, vs. Miami (OH), at Eastern Michigan, at Ohio, vs. Ball State, at Toledo, at Massachusetts, vs. Western Michigan, vs. Kent State

There are a lot of unproven commodities on the Huskies this year, but this is a favorable schedule. UMass, Kent, and Eastern are in the bottom 10 of FBS teams. Holy Cross should be another win. NIU is good enough to beat both major conference teams. San Diego State could be in for another rough team. Ball State also isn't very good. NIU just needs to win two of Maryland, Mississippi State, and SDSU to cash this.

New Mexico State under 4.5 wins (+110)

Schedule: vs. Bryant, vs. Tulsa, at Louisiana Tech, at New Mexico, vs. Sam Houston, at Liberty, vs. Missouri State, at Western Kentucky, vs. Kennesaw State, at Tennessee, at UTEP, vs. Middle Tennessee State

Can QB Logan Fife really turn this team around? Five wins? Bryant is the only sure win I see. Missouri State and Tulsa are winnable home games. So is Kennesaw. Even if they win all three of those, the Aggies would have to take down rival New Mexico, Sam Houston, or Louisiana Tech on the road. This team isn't beating UTEP in El Paso.

Mississippi State under 3.5 wins (+135)

Schedule: vs. Southern Mississippi, vs. Arizona State, vs. Alcorn State, vs. Northern Illinois, vs. Tennessee, at Texas A&M, at Florida, vs. Texas, at Arkansas, vs. Georgia, at Missouri, vs. Mississippi

This team was a disaster last year and is only marginally better this year. They aren't beating Arizona State, so the Bulldogs would have to beat an SEC team. Which one? Hint: it's not happening.

College Football Conference Championship Betting Futures

James Madison to win Sun Belt Championship Game (+235):

Who is going to topple the Dukes? Transfers out of this conference made it weaker overall. The only team that may be close to James Madison is Texas State, and they're still a ways off.

Baylor to win Big 12 Championship Game (+850):

This is a wide-open conference, and Baylor has the most continuity. Utah and Arizona State scare me, but these are good enough odds to throw a few bucks at it.

College Football Playoffs Futures Bets

Baylor to make the CFP (+490):

Even if Baylor loses the Big 12 Championship, it should be enough to get them in the CFP.

Oregon, Penn State, and Texas all make CFP (+150): 

This is my favorite ready-made parlay. For those of you feeling adventurous, you can add Ohio State to the parlay to up the odds to +250.

More College Football Analysis